PMC:7352545 / 69110-70654
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T658 | 175-178 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T659 | 452-465 | Body_part | denotes | cell surfaces | http://purl.org/sig/ont/fma/fma67653 |
| T660 | 452-456 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T661 | 489-496 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T662 | 594-606 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T663 | 673-678 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T664 | 722-734 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T665 | 858-863 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T666 | 899-904 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T667 | 937-941 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T668 | 942-945 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T669 | 1051-1056 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T670 | 1072-1077 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T671 | 1090-1098 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T672 | 1141-1146 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
| T673 | 1152-1160 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T674 | 1212-1223 | Body_part | denotes | pneumocytes | http://purl.org/sig/ont/fma/fma62499 |
| T675 | 1232-1241 | Body_part | denotes | intestine | http://purl.org/sig/ont/fma/fma7199 |
| T676 | 1251-1259 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T677 | 1284-1300 | Body_part | denotes | epithelial cells | http://purl.org/sig/ont/fma/fma66768 |
| T678 | 1295-1300 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T679 | 1307-1311 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T680 | 1379-1383 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T681 | 1384-1389 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T682 | 1502-1507 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T683 | 1535-1543 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T36 | 1232-1241 | Body_part | denotes | intestine | http://purl.obolibrary.org/obo/UBERON_0000160 |
| T37 | 1379-1383 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T264 | 553-561 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T265 | 761-776 | Disease | denotes | virus infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T266 | 767-776 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T267 | 1002-1011 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T268 | 1112-1120 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T269 | 1123-1132 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T270 | 1196-1200 | Disease | denotes | sacs | http://purl.obolibrary.org/obo/MONDO_0010041 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T985 | 146-152 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | humans |
| T986 | 203-205 | http://purl.obolibrary.org/obo/CLO_0008922 | denotes | S2 |
| T987 | 203-205 | http://purl.obolibrary.org/obo/CLO_0050052 | denotes | S2 |
| T988 | 452-456 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T989 | 506-507 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T990 | 645-646 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T991 | 667-678 | http://purl.obolibrary.org/obo/CLO_0053065 | denotes | human cells |
| T992 | 680-685 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | Human |
| T993 | 735-745 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T994 | 761-766 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T995 | 803-813 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T996 | 847-852 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T997 | 858-863 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T998 | 865-870 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | Mouse |
| T999 | 881-888 | http://purl.obolibrary.org/obo/NCBITaxon_9443 | denotes | primate |
| T1000 | 893-904 | http://purl.obolibrary.org/obo/CLO_0053065 | denotes | human cells |
| T1001 | 937-941 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T1002 | 996-1001 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T1003 | 1051-1056 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T1004 | 1072-1077 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T1005 | 1141-1146 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
| T1006 | 1196-1200 | http://purl.obolibrary.org/obo/UBERON_0009856 | denotes | sacs |
| T1007 | 1232-1241 | http://purl.obolibrary.org/obo/UBERON_0000160 | denotes | intestine |
| T1008 | 1232-1241 | http://www.ebi.ac.uk/efo/EFO_0000834 | denotes | intestine |
| T1009 | 1284-1294 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T1010 | 1295-1300 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T1011 | 1307-1311 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T1012 | 1355-1360 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T1013 | 1379-1383 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T1014 | 1379-1383 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T1015 | 1384-1389 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T1016 | 1502-1507 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T389 | 163-173 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T390 | 188-198 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T64374 | 203-205 | Chemical | denotes | S2 | http://purl.obolibrary.org/obo/CHEBI_29387 |
| T392 | 206-216 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T393 | 312-317 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T394 | 489-496 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T395 | 594-606 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T77170 | 722-734 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T397 | 1090-1098 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T398 | 1152-1160 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T399 | 1209-1211 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T400 | 1251-1259 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T13740 | 1535-1543 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T128 | 1307-1322 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | gene expression |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T669 | 0-153 | Sentence | denotes | The emerging CoV-pandemic requires therapeutic agents to block the recognition, binding, replication, amplification and propagation of the CoV in humans. |
| T670 | 154-289 | Sentence | denotes | Protease inhibitors, RNA synthase inhibitors and S2 inhibitors are potential targets, and several agents are currently being evaluated. |
| T671 | 290-360 | Sentence | denotes | Efficient therapeutic drugs are the most reliable option for patients. |
| T672 | 361-497 | Sentence | denotes | The first attachment step of the viral amplification cycle is initiated on the respiratory cell surfaces, driven by the viral S protein. |
| T673 | 498-537 | Sentence | denotes | This is a potential therapeutic target. |
| T674 | 538-679 | Sentence | denotes | Soon after the SARS-CoV-2 outbreak initiated, the CoV S glycoprotein was demonstrated to recognize ACE2 as a binding receptor on human cells. |
| T675 | 680-777 | Sentence | denotes | Human TMPRSS2 enzyme influences the CoV S glycoprotein activation, to facilitate virus infection. |
| T676 | 778-864 | Sentence | denotes | ACE2 binding and TMPRSS2 activation facilitate the CoVs to attach to human host cells. |
| T677 | 865-978 | Sentence | denotes | Mouse, nonhuman primate and human cells have been analyzed using single-cell RNA new generation sequencing (NGS). |
| T678 | 979-1133 | Sentence | denotes | For example, for human infection, CoVs can enter nasal goblet secretory cells, because these cells express the proteins required for SARS-CoV-2 infection. |
| T679 | 1134-1224 | Sentence | denotes | In the lungs, the proteins are stored in the alveoli like air sacs of type II pneumocytes. |
| T680 | 1225-1301 | Sentence | denotes | In the intestine, the two proteins are expressed in entero-epithelial cells. |
| T681 | 1302-1367 | Sentence | denotes | ACE2 gene expression correlates with the IFN-related genes [137]. |
| T682 | 1368-1418 | Sentence | denotes | ACE2 helps lung cells to tolerate cellular damage. |
| T683 | 1419-1544 | Sentence | denotes | Therefore, CoVs may evolutionally take advantage of the defense mechanisms of host cells, hijacking such host-borne proteins. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32604730-32413319-51944103 | 1362-1365 | 32413319 | denotes | 137 |
| T60531 | 1362-1365 | 32413319 | denotes | 137 |