PMC:7352545 / 4959-7607 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7352545","sourcedb":"PMC","sourceid":"7352545","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7352545","text":"The CoVs as enveloped forms can also infect the gastrointestinal track (GIT), although most other enteric viruses are naked in morphology [5,6]. CoVs can also rarely infect neural cells [7]. There is, unfortunately, no solid information on how the coronaviruses infect humans and animals with reciprocal infectivity and cause a zoonotic viral outbreak. This is in contrast to influenza viruses, which are known to selectively utilize sialic acid (SA) linkages [8]. Currently, only limited information is available on β-CoVs, such as SARS-CoV and its receptor usage and infectible cell types from different species. Host cell surface O-acetylated SAs are recognized by the lectin-like spike proteins of SARS CoV-2 for the first step of attachment to host cells. Infectious virus interaction with the host cell surface is mediated by sialoglycans as the most important phenomenon in eukaryote-parasite co-evolution. O-GlcNAc, a minor glycan source, is mainly found in the nucleus and cytosol (Figure 1). Apart from the general roles of glycans, CoVs recognize host cells and attach to host cell surface molecules to enter the host cells. For example, activity of the hemagglutinin-esterase (HE) enzyme relies on the typical carbohydrate-binding lectin and receptor-destroying enzyme (RDE) domains. Most β-CoVs target 9-O-acetylated SAs, but certain species have switched to recognizing 4-O-acetyl SA instead [8,9]. Crystallographic data for the molecular structure of type II HE provides an explanation for the switching mechanism to acquire 4-O acetyl SA binding. This event follows the orthodox ligand–receptor interaction (LRI), lectin–carbohydrate interaction (LCI), lectin–glycan interaction (LGI), lectin–sphingolipid interaction (LSI), protein–glycan interaction (PGI), protein–carbohydrate interaction (PCI), and also protein–protein interaction (PPI). Recently, 332 protein candidates were suggested to be SARS-CoV-2-human protein interacting proteins through PPIs. Among these, 66 human proteins, as druggable host factors, were further characterized as possible FDA-approvable drugs [10]. If PPI is involved, however, carbohydrates or glycans may serve as co-receptors or co-determinants. Previous reports suggest that carbohydrates act as receptor determinants in most cases. The general principles of PCI stereochemistry potentiate the SA–ligand switch by way of simple conformational shifts for the lectin and esterase domain. This indicates that our examination of natural adaptation should be directed to how carbohydrate-binding proteins measure and observe carbohydrates, leading to virus evolution toward transitional host tropism.","tracks":[{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T16","span":{"begin":434,"end":445},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T17","span":{"begin":447,"end":449},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T18","span":{"begin":914,"end":922},"obj":"https://glytoucan.org/Structures/Glycans/G49108TO"},{"id":"T19","span":{"begin":914,"end":922},"obj":"https://glytoucan.org/Structures/Glycans/G89565QL"},{"id":"T20","span":{"begin":1395,"end":1397},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T21","span":{"begin":1551,"end":1553},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T22","span":{"begin":2347,"end":2349},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"}],"attributes":[{"subj":"T16","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T17","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T18","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T19","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T20","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T21","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T22","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T15","span":{"begin":173,"end":185},"obj":"Body_part"},{"id":"T16","span":{"begin":180,"end":185},"obj":"Body_part"},{"id":"T17","span":{"begin":580,"end":584},"obj":"Body_part"},{"id":"T18","span":{"begin":620,"end":632},"obj":"Body_part"},{"id":"T19","span":{"begin":620,"end":624},"obj":"Body_part"},{"id":"T20","span":{"begin":690,"end":698},"obj":"Body_part"},{"id":"T21","span":{"begin":754,"end":759},"obj":"Body_part"},{"id":"T22","span":{"begin":804,"end":816},"obj":"Body_part"},{"id":"T23","span":{"begin":804,"end":808},"obj":"Body_part"},{"id":"T24","span":{"begin":982,"end":989},"obj":"Body_part"},{"id":"T25","span":{"begin":1063,"end":1068},"obj":"Body_part"},{"id":"T26","span":{"begin":1088,"end":1100},"obj":"Body_part"},{"id":"T27","span":{"begin":1088,"end":1092},"obj":"Body_part"},{"id":"T28","span":{"begin":1129,"end":1134},"obj":"Body_part"},{"id":"T29","span":{"begin":1222,"end":1234},"obj":"Body_part"},{"id":"T30","span":{"begin":1637,"end":1649},"obj":"Body_part"},{"id":"T31","span":{"begin":1741,"end":1748},"obj":"Body_part"},{"id":"T32","span":{"begin":1775,"end":1782},"obj":"Body_part"},{"id":"T33","span":{"begin":1783,"end":1795},"obj":"Body_part"},{"id":"T34","span":{"begin":1824,"end":1831},"obj":"Body_part"},{"id":"T35","span":{"begin":1832,"end":1839},"obj":"Body_part"},{"id":"T36","span":{"begin":1873,"end":1880},"obj":"Body_part"},{"id":"T37","span":{"begin":1930,"end":1937},"obj":"Body_part"},{"id":"T38","span":{"begin":1950,"end":1958},"obj":"Body_part"},{"id":"T39","span":{"begin":1995,"end":2003},"obj":"Body_part"},{"id":"T40","span":{"begin":2127,"end":2140},"obj":"Body_part"},{"id":"T41","span":{"begin":2228,"end":2241},"obj":"Body_part"},{"id":"T42","span":{"begin":2523,"end":2535},"obj":"Body_part"},{"id":"T43","span":{"begin":2544,"end":2552},"obj":"Body_part"},{"id":"T44","span":{"begin":2573,"end":2586},"obj":"Body_part"}],"attributes":[{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma70333"},{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma67653"},{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A20","pred":"fma_id","subj":"T20","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A21","pred":"fma_id","subj":"T21","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A22","pred":"fma_id","subj":"T22","obj":"http://purl.org/sig/ont/fma/fma67653"},{"id":"A23","pred":"fma_id","subj":"T23","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A24","pred":"fma_id","subj":"T24","obj":"http://purl.org/sig/ont/fma/fma66836"},{"id":"A25","pred":"fma_id","subj":"T25","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A26","pred":"fma_id","subj":"T26","obj":"http://purl.org/sig/ont/fma/fma67653"},{"id":"A27","pred":"fma_id","subj":"T27","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A28","pred":"fma_id","subj":"T28","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A29","pred":"fma_id","subj":"T29","obj":"http://purl.org/sig/ont/fma/fma82737"},{"id":"A30","pred":"fma_id","subj":"T30","obj":"http://purl.org/sig/ont/fma/fma82737"},{"id":"A31","pred":"fma_id","subj":"T31","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A32","pred":"fma_id","subj":"T32","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A33","pred":"fma_id","subj":"T33","obj":"http://purl.org/sig/ont/fma/fma82737"},{"id":"A34","pred":"fma_id","subj":"T34","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A35","pred":"fma_id","subj":"T35","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A36","pred":"fma_id","subj":"T36","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A37","pred":"fma_id","subj":"T37","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A38","pred":"fma_id","subj":"T38","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A39","pred":"fma_id","subj":"T39","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A40","pred":"fma_id","subj":"T40","obj":"http://purl.org/sig/ont/fma/fma82737"},{"id":"A41","pred":"fma_id","subj":"T41","obj":"http://purl.org/sig/ont/fma/fma82737"},{"id":"A42","pred":"fma_id","subj":"T42","obj":"http://purl.org/sig/ont/fma/fma82737"},{"id":"A43","pred":"fma_id","subj":"T43","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A44","pred":"fma_id","subj":"T44","obj":"http://purl.org/sig/ont/fma/fma82737"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T28","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T29","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T32","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T33","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T34","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T35","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T36","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T42","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T43","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T44","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"203","span":{"begin":1165,"end":1187},"obj":"Gene"},{"id":"204","span":{"begin":2347,"end":2349},"obj":"Gene"},{"id":"205","span":{"begin":4,"end":8},"obj":"Species"},{"id":"206","span":{"begin":145,"end":149},"obj":"Species"},{"id":"207","span":{"begin":248,"end":261},"obj":"Species"},{"id":"208","span":{"begin":269,"end":275},"obj":"Species"},{"id":"209","span":{"begin":376,"end":393},"obj":"Species"},{"id":"210","span":{"begin":519,"end":523},"obj":"Species"},{"id":"211","span":{"begin":533,"end":541},"obj":"Species"},{"id":"212","span":{"begin":702,"end":712},"obj":"Species"},{"id":"213","span":{"begin":1043,"end":1047},"obj":"Species"},{"id":"214","span":{"begin":1303,"end":1307},"obj":"Species"},{"id":"215","span":{"begin":1913,"end":1923},"obj":"Species"},{"id":"216","span":{"begin":1924,"end":1929},"obj":"Species"},{"id":"217","span":{"begin":1989,"end":1994},"obj":"Species"},{"id":"218","span":{"begin":761,"end":771},"obj":"Species"},{"id":"219","span":{"begin":684,"end":689},"obj":"Gene"},{"id":"220","span":{"begin":434,"end":445},"obj":"Chemical"},{"id":"221","span":{"begin":914,"end":922},"obj":"Chemical"},{"id":"222","span":{"begin":932,"end":938},"obj":"Chemical"},{"id":"223","span":{"begin":1034,"end":1041},"obj":"Chemical"},{"id":"224","span":{"begin":1222,"end":1234},"obj":"Chemical"},{"id":"225","span":{"begin":1384,"end":1397},"obj":"Chemical"},{"id":"226","span":{"begin":1544,"end":1553},"obj":"Chemical"},{"id":"227","span":{"begin":1637,"end":1649},"obj":"Chemical"},{"id":"228","span":{"begin":1676,"end":1682},"obj":"Chemical"},{"id":"229","span":{"begin":1709,"end":1721},"obj":"Chemical"},{"id":"230","span":{"begin":1749,"end":1755},"obj":"Chemical"},{"id":"231","span":{"begin":1783,"end":1795},"obj":"Chemical"},{"id":"232","span":{"begin":2127,"end":2140},"obj":"Chemical"},{"id":"233","span":{"begin":2144,"end":2151},"obj":"Chemical"},{"id":"234","span":{"begin":2228,"end":2241},"obj":"Chemical"},{"id":"235","span":{"begin":2523,"end":2535},"obj":"Chemical"},{"id":"236","span":{"begin":2573,"end":2586},"obj":"Chemical"},{"id":"237","span":{"begin":328,"end":336},"obj":"Disease"}],"attributes":[{"id":"A203","pred":"tao:has_database_id","subj":"203","obj":"Gene:17603139"},{"id":"A204","pred":"tao:has_database_id","subj":"204","obj":"Gene:6296"},{"id":"A205","pred":"tao:has_database_id","subj":"205","obj":"Tax:11118"},{"id":"A206","pred":"tao:has_database_id","subj":"206","obj":"Tax:11118"},{"id":"A207","pred":"tao:has_database_id","subj":"207","obj":"Tax:11118"},{"id":"A208","pred":"tao:has_database_id","subj":"208","obj":"Tax:9606"},{"id":"A209","pred":"tao:has_database_id","subj":"209","obj":"Tax:11308"},{"id":"A210","pred":"tao:has_database_id","subj":"210","obj":"Tax:11118"},{"id":"A211","pred":"tao:has_database_id","subj":"211","obj":"Tax:694009"},{"id":"A212","pred":"tao:has_database_id","subj":"212","obj":"Tax:2697049"},{"id":"A213","pred":"tao:has_database_id","subj":"213","obj":"Tax:11118"},{"id":"A214","pred":"tao:has_database_id","subj":"214","obj":"Tax:11118"},{"id":"A215","pred":"tao:has_database_id","subj":"215","obj":"Tax:2697049"},{"id":"A216","pred":"tao:has_database_id","subj":"216","obj":"Tax:9606"},{"id":"A217","pred":"tao:has_database_id","subj":"217","obj":"Tax:9606"},{"id":"A218","pred":"tao:has_database_id","subj":"218","obj":"Tax:55987"},{"id":"A219","pred":"tao:has_database_id","subj":"219","obj":"Gene:43740568"},{"id":"A220","pred":"tao:has_database_id","subj":"220","obj":"MESH:D019158"},{"id":"A222","pred":"tao:has_database_id","subj":"222","obj":"MESH:D011134"},{"id":"A223","pred":"tao:has_database_id","subj":"223","obj":"MESH:D011134"},{"id":"A224","pred":"tao:has_database_id","subj":"224","obj":"MESH:D002241"},{"id":"A227","pred":"tao:has_database_id","subj":"227","obj":"MESH:D002241"},{"id":"A228","pred":"tao:has_database_id","subj":"228","obj":"MESH:D011134"},{"id":"A229","pred":"tao:has_database_id","subj":"229","obj":"MESH:D013107"},{"id":"A230","pred":"tao:has_database_id","subj":"230","obj":"MESH:D011134"},{"id":"A231","pred":"tao:has_database_id","subj":"231","obj":"MESH:D002241"},{"id":"A232","pred":"tao:has_database_id","subj":"232","obj":"MESH:D002241"},{"id":"A233","pred":"tao:has_database_id","subj":"233","obj":"MESH:D011134"},{"id":"A234","pred":"tao:has_database_id","subj":"234","obj":"MESH:D002241"},{"id":"A235","pred":"tao:has_database_id","subj":"235","obj":"MESH:D002241"},{"id":"A236","pred":"tao:has_database_id","subj":"236","obj":"MESH:D002241"},{"id":"A237","pred":"tao:has_database_id","subj":"237","obj":"MESH:D015047"},{"subj":"203","pred":"source","obj":"LitCovid-PubTator"},{"subj":"204","pred":"source","obj":"LitCovid-PubTator"},{"subj":"205","pred":"source","obj":"LitCovid-PubTator"},{"subj":"206","pred":"source","obj":"LitCovid-PubTator"},{"subj":"207","pred":"source","obj":"LitCovid-PubTator"},{"subj":"208","pred":"source","obj":"LitCovid-PubTator"},{"subj":"209","pred":"source","obj":"LitCovid-PubTator"},{"subj":"210","pred":"source","obj":"LitCovid-PubTator"},{"subj":"211","pred":"source","obj":"LitCovid-PubTator"},{"subj":"212","pred":"source","obj":"LitCovid-PubTator"},{"subj":"213","pred":"source","obj":"LitCovid-PubTator"},{"subj":"214","pred":"source","obj":"LitCovid-PubTator"},{"subj":"215","pred":"source","obj":"LitCovid-PubTator"},{"subj":"216","pred":"source","obj":"LitCovid-PubTator"},{"subj":"217","pred":"source","obj":"LitCovid-PubTator"},{"subj":"218","pred":"source","obj":"LitCovid-PubTator"},{"subj":"219","pred":"source","obj":"LitCovid-PubTator"},{"subj":"220","pred":"source","obj":"LitCovid-PubTator"},{"subj":"221","pred":"source","obj":"LitCovid-PubTator"},{"subj":"222","pred":"source","obj":"LitCovid-PubTator"},{"subj":"223","pred":"source","obj":"LitCovid-PubTator"},{"subj":"224","pred":"source","obj":"LitCovid-PubTator"},{"subj":"225","pred":"source","obj":"LitCovid-PubTator"},{"subj":"226","pred":"source","obj":"LitCovid-PubTator"},{"subj":"227","pred":"source","obj":"LitCovid-PubTator"},{"subj":"228","pred":"source","obj":"LitCovid-PubTator"},{"subj":"229","pred":"source","obj":"LitCovid-PubTator"},{"subj":"230","pred":"source","obj":"LitCovid-PubTator"},{"subj":"231","pred":"source","obj":"LitCovid-PubTator"},{"subj":"232","pred":"source","obj":"LitCovid-PubTator"},{"subj":"233","pred":"source","obj":"LitCovid-PubTator"},{"subj":"234","pred":"source","obj":"LitCovid-PubTator"},{"subj":"235","pred":"source","obj":"LitCovid-PubTator"},{"subj":"236","pred":"source","obj":"LitCovid-PubTator"},{"subj":"237","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T31","span":{"begin":376,"end":385},"obj":"Disease"},{"id":"T32","span":{"begin":533,"end":541},"obj":"Disease"},{"id":"T33","span":{"begin":702,"end":706},"obj":"Disease"},{"id":"T34","span":{"begin":761,"end":771},"obj":"Disease"},{"id":"T35","span":{"begin":1913,"end":1921},"obj":"Disease"}],"attributes":[{"id":"A31","pred":"mondo_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A32","pred":"mondo_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A33","pred":"mondo_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A34","pred":"mondo_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A35","pred":"mondo_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T32","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T33","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T34","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T35","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T53","span":{"begin":106,"end":113},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T54","span":{"begin":180,"end":185},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T55","span":{"begin":269,"end":275},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T56","span":{"begin":280,"end":287},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"},{"id":"T57","span":{"begin":326,"end":327},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T58","span":{"begin":386,"end":393},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T59","span":{"begin":580,"end":590},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T60","span":{"begin":620,"end":624},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T61","span":{"begin":646,"end":649},"obj":"http://purl.obolibrary.org/obo/CLO_0051568"},{"id":"T62","span":{"begin":754,"end":759},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T63","span":{"begin":772,"end":777},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T64","span":{"begin":804,"end":808},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T65","span":{"begin":881,"end":890},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_2759"},{"id":"T66","span":{"begin":924,"end":925},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T67","span":{"begin":1063,"end":1068},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T68","span":{"begin":1088,"end":1092},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T69","span":{"begin":1129,"end":1134},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T70","span":{"begin":1149,"end":1157},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T71","span":{"begin":1330,"end":1333},"obj":"http://purl.obolibrary.org/obo/CLO_0051568"},{"id":"T72","span":{"begin":1924,"end":1937},"obj":"http://purl.obolibrary.org/obo/PR_000029067"},{"id":"T73","span":{"begin":1989,"end":2003},"obj":"http://purl.obolibrary.org/obo/PR_000029067"},{"id":"T74","span":{"begin":2599,"end":2604},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"attributes":[{"subj":"T53","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T54","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T55","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T57","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T58","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T59","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T60","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T61","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T62","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T63","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T64","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T65","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T66","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T67","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T68","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T69","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T70","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T71","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T72","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T73","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T74","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T119","span":{"begin":434,"end":445},"obj":"Chemical"},{"id":"T120","span":{"begin":441,"end":445},"obj":"Chemical"},{"id":"T121","span":{"begin":447,"end":449},"obj":"Chemical"},{"id":"T126","span":{"begin":690,"end":698},"obj":"Chemical"},{"id":"T127","span":{"begin":916,"end":922},"obj":"Chemical"},{"id":"T129","span":{"begin":970,"end":977},"obj":"Chemical"},{"id":"T130","span":{"begin":1034,"end":1041},"obj":"Chemical"},{"id":"T131","span":{"begin":1101,"end":1110},"obj":"Chemical"},{"id":"T132","span":{"begin":1222,"end":1234},"obj":"Chemical"},{"id":"T133","span":{"begin":1388,"end":1394},"obj":"Chemical"},{"id":"T135","span":{"begin":1395,"end":1397},"obj":"Chemical"},{"id":"T140","span":{"begin":1471,"end":1473},"obj":"Chemical"},{"id":"T141","span":{"begin":1544,"end":1550},"obj":"Chemical"},{"id":"T143","span":{"begin":1551,"end":1553},"obj":"Chemical"},{"id":"T148","span":{"begin":1595,"end":1601},"obj":"Chemical"},{"id":"T149","span":{"begin":1637,"end":1649},"obj":"Chemical"},{"id":"T150","span":{"begin":1709,"end":1721},"obj":"Chemical"},{"id":"T151","span":{"begin":1741,"end":1748},"obj":"Chemical"},{"id":"T152","span":{"begin":1769,"end":1772},"obj":"Chemical"},{"id":"T153","span":{"begin":1775,"end":1782},"obj":"Chemical"},{"id":"T154","span":{"begin":1783,"end":1795},"obj":"Chemical"},{"id":"T155","span":{"begin":1824,"end":1831},"obj":"Chemical"},{"id":"T156","span":{"begin":1832,"end":1839},"obj":"Chemical"},{"id":"T157","span":{"begin":1853,"end":1856},"obj":"Chemical"},{"id":"T159","span":{"begin":1873,"end":1880},"obj":"Chemical"},{"id":"T160","span":{"begin":1930,"end":1937},"obj":"Chemical"},{"id":"T161","span":{"begin":1950,"end":1958},"obj":"Chemical"},{"id":"T162","span":{"begin":1995,"end":2003},"obj":"Chemical"},{"id":"T163","span":{"begin":2086,"end":2091},"obj":"Chemical"},{"id":"T164","span":{"begin":2101,"end":2104},"obj":"Chemical"},{"id":"T166","span":{"begin":2127,"end":2140},"obj":"Chemical"},{"id":"T167","span":{"begin":2144,"end":2151},"obj":"Chemical"},{"id":"T168","span":{"begin":2228,"end":2241},"obj":"Chemical"},{"id":"T169","span":{"begin":2347,"end":2349},"obj":"Chemical"},{"id":"T174","span":{"begin":2350,"end":2356},"obj":"Chemical"},{"id":"T175","span":{"begin":2523,"end":2535},"obj":"Chemical"},{"id":"T176","span":{"begin":2544,"end":2552},"obj":"Chemical"},{"id":"T177","span":{"begin":2573,"end":2586},"obj":"Chemical"}],"attributes":[{"id":"A119","pred":"chebi_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A120","pred":"chebi_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A121","pred":"chebi_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A122","pred":"chebi_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A123","pred":"chebi_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A124","pred":"chebi_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A125","pred":"chebi_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A126","pred":"chebi_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A127","pred":"chebi_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/CHEBI_506227"},{"id":"A128","pred":"chebi_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/CHEBI_73685"},{"id":"A129","pred":"chebi_id","subj":"T129","obj":"http://purl.obolibrary.org/obo/CHEBI_33252"},{"id":"A130","pred":"chebi_id","subj":"T130","obj":"http://purl.obolibrary.org/obo/CHEBI_18154"},{"id":"A131","pred":"chebi_id","subj":"T131","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A132","pred":"chebi_id","subj":"T132","obj":"http://purl.obolibrary.org/obo/CHEBI_16646"},{"id":"A133","pred":"chebi_id","subj":"T133","obj":"http://purl.obolibrary.org/obo/CHEBI_40574"},{"id":"A134","pred":"chebi_id","subj":"T133","obj":"http://purl.obolibrary.org/obo/CHEBI_46887"},{"id":"A135","pred":"chebi_id","subj":"T135","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A136","pred":"chebi_id","subj":"T135","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A137","pred":"chebi_id","subj":"T135","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A138","pred":"chebi_id","subj":"T135","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A139","pred":"chebi_id","subj":"T135","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A140","pred":"chebi_id","subj":"T140","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A141","pred":"chebi_id","subj":"T141","obj":"http://purl.obolibrary.org/obo/CHEBI_40574"},{"id":"A142","pred":"chebi_id","subj":"T141","obj":"http://purl.obolibrary.org/obo/CHEBI_46887"},{"id":"A143","pred":"chebi_id","subj":"T143","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A144","pred":"chebi_id","subj":"T143","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A145","pred":"chebi_id","subj":"T143","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A146","pred":"chebi_id","subj":"T143","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A147","pred":"chebi_id","subj":"T143","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A148","pred":"chebi_id","subj":"T148","obj":"http://purl.obolibrary.org/obo/CHEBI_52214"},{"id":"A149","pred":"chebi_id","subj":"T149","obj":"http://purl.obolibrary.org/obo/CHEBI_16646"},{"id":"A150","pred":"chebi_id","subj":"T150","obj":"http://purl.obolibrary.org/obo/CHEBI_26739"},{"id":"A151","pred":"chebi_id","subj":"T151","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A152","pred":"chebi_id","subj":"T152","obj":"http://purl.obolibrary.org/obo/CHEBI_26345"},{"id":"A153","pred":"chebi_id","subj":"T153","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A154","pred":"chebi_id","subj":"T154","obj":"http://purl.obolibrary.org/obo/CHEBI_16646"},{"id":"A155","pred":"chebi_id","subj":"T155","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A156","pred":"chebi_id","subj":"T156","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A157","pred":"chebi_id","subj":"T157","obj":"http://purl.obolibrary.org/obo/CHEBI_53266"},{"id":"A158","pred":"chebi_id","subj":"T157","obj":"http://purl.obolibrary.org/obo/CHEBI_60614"},{"id":"A159","pred":"chebi_id","subj":"T159","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A160","pred":"chebi_id","subj":"T160","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A161","pred":"chebi_id","subj":"T161","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A162","pred":"chebi_id","subj":"T162","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A163","pred":"chebi_id","subj":"T163","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A164","pred":"chebi_id","subj":"T164","obj":"http://purl.obolibrary.org/obo/CHEBI_53266"},{"id":"A165","pred":"chebi_id","subj":"T164","obj":"http://purl.obolibrary.org/obo/CHEBI_60614"},{"id":"A166","pred":"chebi_id","subj":"T166","obj":"http://purl.obolibrary.org/obo/CHEBI_16646"},{"id":"A167","pred":"chebi_id","subj":"T167","obj":"http://purl.obolibrary.org/obo/CHEBI_18154"},{"id":"A168","pred":"chebi_id","subj":"T168","obj":"http://purl.obolibrary.org/obo/CHEBI_16646"},{"id":"A169","pred":"chebi_id","subj":"T169","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A170","pred":"chebi_id","subj":"T169","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A171","pred":"chebi_id","subj":"T169","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A172","pred":"chebi_id","subj":"T169","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A173","pred":"chebi_id","subj":"T169","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A174","pred":"chebi_id","subj":"T174","obj":"http://purl.obolibrary.org/obo/CHEBI_52214"},{"id":"A175","pred":"chebi_id","subj":"T175","obj":"http://purl.obolibrary.org/obo/CHEBI_16646"},{"id":"A176","pred":"chebi_id","subj":"T176","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A177","pred":"chebi_id","subj":"T177","obj":"http://purl.obolibrary.org/obo/CHEBI_16646"},{"subj":"T119","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T120","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T121","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T126","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T127","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T129","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T130","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T131","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T132","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T133","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T135","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T140","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T141","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T143","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T148","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T149","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T150","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T151","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T152","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T153","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T154","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T155","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T156","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T157","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T159","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T160","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T161","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T162","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T163","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T164","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T166","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T167","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T168","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T169","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T174","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T175","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T176","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T177","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T6","span":{"begin":778,"end":803},"obj":"http://purl.obolibrary.org/obo/GO_0051701"},{"id":"T7","span":{"begin":2640,"end":2647},"obj":"http://purl.obolibrary.org/obo/GO_0009606"}],"attributes":[{"subj":"T6","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T38","span":{"begin":0,"end":144},"obj":"Sentence"},{"id":"T39","span":{"begin":145,"end":190},"obj":"Sentence"},{"id":"T40","span":{"begin":191,"end":352},"obj":"Sentence"},{"id":"T41","span":{"begin":353,"end":464},"obj":"Sentence"},{"id":"T42","span":{"begin":465,"end":614},"obj":"Sentence"},{"id":"T43","span":{"begin":615,"end":760},"obj":"Sentence"},{"id":"T44","span":{"begin":761,"end":913},"obj":"Sentence"},{"id":"T45","span":{"begin":914,"end":1001},"obj":"Sentence"},{"id":"T46","span":{"begin":1002,"end":1135},"obj":"Sentence"},{"id":"T47","span":{"begin":1136,"end":1295},"obj":"Sentence"},{"id":"T48","span":{"begin":1296,"end":1412},"obj":"Sentence"},{"id":"T49","span":{"begin":1413,"end":1562},"obj":"Sentence"},{"id":"T50","span":{"begin":1563,"end":1858},"obj":"Sentence"},{"id":"T51","span":{"begin":1859,"end":1972},"obj":"Sentence"},{"id":"T52","span":{"begin":1973,"end":2097},"obj":"Sentence"},{"id":"T53","span":{"begin":2098,"end":2197},"obj":"Sentence"},{"id":"T54","span":{"begin":2198,"end":2285},"obj":"Sentence"},{"id":"T55","span":{"begin":2286,"end":2438},"obj":"Sentence"},{"id":"T56","span":{"begin":2439,"end":2648},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T38","pred":"source","obj":"LitCovid-sentences"},{"subj":"T39","pred":"source","obj":"LitCovid-sentences"},{"subj":"T40","pred":"source","obj":"LitCovid-sentences"},{"subj":"T41","pred":"source","obj":"LitCovid-sentences"},{"subj":"T42","pred":"source","obj":"LitCovid-sentences"},{"subj":"T43","pred":"source","obj":"LitCovid-sentences"},{"subj":"T44","pred":"source","obj":"LitCovid-sentences"},{"subj":"T45","pred":"source","obj":"LitCovid-sentences"},{"subj":"T46","pred":"source","obj":"LitCovid-sentences"},{"subj":"T47","pred":"source","obj":"LitCovid-sentences"},{"subj":"T48","pred":"source","obj":"LitCovid-sentences"},{"subj":"T49","pred":"source","obj":"LitCovid-sentences"},{"subj":"T50","pred":"source","obj":"LitCovid-sentences"},{"subj":"T51","pred":"source","obj":"LitCovid-sentences"},{"subj":"T52","pred":"source","obj":"LitCovid-sentences"},{"subj":"T53","pred":"source","obj":"LitCovid-sentences"},{"subj":"T54","pred":"source","obj":"LitCovid-sentences"},{"subj":"T55","pred":"source","obj":"LitCovid-sentences"},{"subj":"T56","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T1","span":{"begin":914,"end":922},"obj":"GlycoEpitope"}],"attributes":[{"id":"A1","pred":"glyco_epitope_db_id","subj":"T1","obj":"http://www.glycoepitope.jp/epitopes/EP0004"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-GlycoEpitope"}]},{"project":"2_test","denotations":[{"id":"32604730-24524838-51943949","span":{"begin":139,"end":140},"obj":"24524838"},{"id":"32604730-14557669-51943950","span":{"begin":141,"end":142},"obj":"14557669"},{"id":"32604730-24227863-51943951","span":{"begin":187,"end":188},"obj":"24227863"},{"id":"32604730-3380803-51943952","span":{"begin":461,"end":462},"obj":"3380803"},{"id":"32604730-3380803-51943953","span":{"begin":1407,"end":1408},"obj":"3380803"},{"id":"32604730-1984649-51943954","span":{"begin":1409,"end":1410},"obj":"1984649"},{"id":"T53109","span":{"begin":139,"end":140},"obj":"24524838"},{"id":"T96251","span":{"begin":141,"end":142},"obj":"14557669"},{"id":"T80079","span":{"begin":187,"end":188},"obj":"24227863"},{"id":"T76200","span":{"begin":461,"end":462},"obj":"3380803"},{"id":"T31655","span":{"begin":1407,"end":1408},"obj":"3380803"},{"id":"T65223","span":{"begin":1409,"end":1410},"obj":"1984649"}],"attributes":[{"subj":"32604730-24524838-51943949","pred":"source","obj":"2_test"},{"subj":"32604730-14557669-51943950","pred":"source","obj":"2_test"},{"subj":"32604730-24227863-51943951","pred":"source","obj":"2_test"},{"subj":"32604730-3380803-51943952","pred":"source","obj":"2_test"},{"subj":"32604730-3380803-51943953","pred":"source","obj":"2_test"},{"subj":"32604730-1984649-51943954","pred":"source","obj":"2_test"},{"subj":"T53109","pred":"source","obj":"2_test"},{"subj":"T96251","pred":"source","obj":"2_test"},{"subj":"T80079","pred":"source","obj":"2_test"},{"subj":"T76200","pred":"source","obj":"2_test"},{"subj":"T31655","pred":"source","obj":"2_test"},{"subj":"T65223","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid_Glycan-Motif-Structure","color":"#c9ec93","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#ec93e3"},{"id":"LitCovid-PubTator","color":"#93ecdb"},{"id":"LitCovid-PD-MONDO","color":"#ecc193"},{"id":"LitCovid-PD-CLO","color":"#a793ec"},{"id":"LitCovid-PD-CHEBI","color":"#98ec93"},{"id":"LitCovid-PD-GO-BP","color":"#ec93b2"},{"id":"LitCovid-sentences","color":"#93ccec"},{"id":"LitCovid-PD-GlycoEpitope","color":"#e7ec93"},{"id":"2_test","color":"#d793ec"}]}]}}