PMC:7352545 / 48153-50203
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T410 | 101-109 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T411 | 312-324 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T412 | 656-664 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T413 | 977-984 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T414 | 1144-1149 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T415 | 1213-1218 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T416 | 1420-1432 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T417 | 1448-1458 | Body_part | denotes | Intestinal | http://purl.org/sig/ont/fma/fma7199 |
| T418 | 1477-1481 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T419 | 1577-1582 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
| T420 | 1587-1596 | Body_part | denotes | intestine | http://purl.org/sig/ont/fma/fma7199 |
| T421 | 1798-1802 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T422 | 1803-1828 | Body_part | denotes | alveolar epithelial cells | http://purl.org/sig/ont/fma/fma62499 |
| T423 | 1823-1828 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T424 | 1874-1890 | Body_part | denotes | epithelial cells | http://purl.org/sig/ont/fma/fma66768 |
| T425 | 1885-1890 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T22 | 1477-1481 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T23 | 1587-1596 | Body_part | denotes | intestine | http://purl.obolibrary.org/obo/UBERON_0000160 |
| T24 | 1798-1802 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T167 | 301-309 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T168 | 800-821 | Disease | denotes | inflammatory diseases | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T169 | 970-974 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T170 | 1119-1127 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T171 | 1188-1196 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T172 | 1303-1311 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T173 | 1314-1323 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T174 | 1325-1333 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T175 | 1336-1345 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T176 | 1436-1444 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T177 | 1542-1550 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T178 | 1554-1562 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T179 | 1648-1656 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T180 | 1723-1731 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T181 | 1830-1838 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T182 | 1843-1851 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T183 | 2022-2030 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T659 | 0-1 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T660 | 92-100 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T661 | 136-137 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T662 | 325-334 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activates |
| T663 | 378-383 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T664 | 526-534 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T665 | 585-593 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T666 | 627-628 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T667 | 1144-1149 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T668 | 1213-1218 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T669 | 1284-1289 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T670 | 1355-1363 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T671 | 1448-1458 | http://purl.obolibrary.org/obo/UBERON_0000160 | denotes | Intestinal |
| T672 | 1448-1458 | http://www.ebi.ac.uk/efo/EFO_0000834 | denotes | Intestinal |
| T673 | 1459-1467 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T674 | 1477-1481 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T675 | 1477-1481 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T676 | 1577-1582 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
| T677 | 1587-1596 | http://purl.obolibrary.org/obo/UBERON_0000160 | denotes | intestine |
| T678 | 1587-1596 | http://www.ebi.ac.uk/efo/EFO_0000834 | denotes | intestine |
| T679 | 1798-1802 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T680 | 1798-1802 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T681 | 1812-1822 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T682 | 1823-1828 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T683 | 1874-1884 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T684 | 1885-1890 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T685 | 2006-2007 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T52126 | 59-61 | Chemical | denotes | Zn | http://purl.obolibrary.org/obo/CHEBI_27363 |
| T21109 | 101-109 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T46115 | 312-324 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T4 | 746-756 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T5 | 977-984 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T6 | 1420-1432 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T7 | 1795-1797 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T77723 | 1871-1873 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T77 | 708-734 | http://purl.obolibrary.org/obo/GO_0050728 | denotes | anti-inflammatory response |
| T78 | 713-734 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory response |
| T79 | 1128-1143 | http://purl.obolibrary.org/obo/GO_0044409 | denotes | entry into host |
| T80 | 1197-1212 | http://purl.obolibrary.org/obo/GO_0044409 | denotes | entry into host |
| T81 | 1227-1238 | http://purl.obolibrary.org/obo/GO_0006897 | denotes | endocytosis |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T466 | 0-110 | Sentence | denotes | A disintegrin and metallopeptidase domain (ADAM) family of Zn-metalloproteinases belongs to membrane proteins. |
| T467 | 111-200 | Sentence | denotes | The well-known ADAM17 is a TNF-α-converting enzyme (TACE), called the sheddase for TNF-α. |
| T468 | 201-269 | Sentence | denotes | Other ADAM sheddase family members include ADAM9, ADAM10 and ADAM12. |
| T469 | 270-300 | Sentence | denotes | ADAM17 mediates ACE2 shedding. |
| T470 | 301-390 | Sentence | denotes | SARS-CoV S glycoprotein activates cellular TACE and consequently facilitates virus entry. |
| T471 | 391-540 | Sentence | denotes | Soluble ACE2 as the N-terminal carboxypeptidase domain form is derived from the original ACE2 form by an ADAM17 metalloprotease in the membrane [89]. |
| T472 | 541-665 | Sentence | denotes | ADAM17 is indeed an enzyme that can convert membrane type pro-TNF-α to soluble TNF-α, a functional proinflammatory cytokine. |
| T473 | 666-822 | Sentence | denotes | Therefore, ADAM17 inhibition indicates an anti-inflammatory response and ADAM17 inhibitors are promising candidates for TNF-α-induced inflammatory diseases. |
| T474 | 823-892 | Sentence | denotes | The short C-terminal domain of ACE2 is removed by ADAM17 and TMPRSS2. |
| T475 | 893-969 | Sentence | denotes | However, TMPRSS2 cleaves ACE2 competitively with the ADAM17 metalloprotease. |
| T476 | 970-1158 | Sentence | denotes | SARS-S protein-ACE2 binding leads to ADAM17/TNF-α-converting enzyme (TACE)-cleavage of ACE2, facilitating extracellular ACE2 shedding and consequent SARS-CoV entry into host cells [90,91]. |
| T477 | 1159-1250 | Sentence | denotes | Only TMPRSS2 cleavage allows SARS-CoV entry into host cells through endocytosis and fusion. |
| T478 | 1251-1324 | Sentence | denotes | Soluble ACE2 also recognizes the virus and prevents SARS-CoV-2 infection. |
| T479 | 1325-1381 | Sentence | denotes | SARS-CoV-2 infection requires membrane ACE2 and TMPRSS2. |
| T480 | 1382-1447 | Sentence | denotes | The ACE2–B0AT1 complex binds to the S glycoprotein of SARS-CoV-2. |
| T481 | 1448-1553 | Sentence | denotes | Intestinal membrane ACE2 and lung TMPRSS2-shedded ACE2 can act as alternative entry sites for SARS-CoV-2. |
| T482 | 1554-1622 | Sentence | denotes | SARS-CoV-2 infects the lungs and intestine via TMPRSS2-cleaved ACE2. |
| T483 | 1623-1743 | Sentence | denotes | If TMPRSS2 is engaged in SARS-CoV-2 entry and ACE2 downregulation, TMPRSS2 inhibition would lead to COVID-19 prevention. |
| T484 | 1744-1927 | Sentence | denotes | Although ACE2 is expressed both in type I and type II lung alveolar epithelial cells, SARS-CoV and SARS-CoV-2 target only type II epithelial cells due to the ACE2–TMPRSS2 interaction. |
| T485 | 1928-2050 | Sentence | denotes | Therefore, supplementation of ACE2 (soluble ACE2) or Ang-1 to Ang-7 should be a way to reduce SARS-CoV-2-related symptoms. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32604730-10924499-51944047 | 536-538 | 10924499 | denotes | 89 |
| 32604730-24227843-51944048 | 1151-1153 | 24227843 | denotes | 90 |
| 32604730-19995578-51944049 | 1154-1156 | 19995578 | denotes | 91 |
| T58896 | 536-538 | 10924499 | denotes | 89 |
| T39582 | 1151-1153 | 24227843 | denotes | 90 |
| T57089 | 1154-1156 | 19995578 | denotes | 91 |