PMC:7352545 / 48098-53918
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T409 | 5-9 | Body_part | denotes | Cell | http://purl.org/sig/ont/fma/fma68646 |
| T410 | 156-164 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T411 | 367-379 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T412 | 711-719 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T413 | 1032-1039 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T414 | 1199-1204 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T415 | 1268-1273 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T416 | 1475-1487 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T417 | 1503-1513 | Body_part | denotes | Intestinal | http://purl.org/sig/ont/fma/fma7199 |
| T418 | 1532-1536 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T419 | 1632-1637 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
| T420 | 1642-1651 | Body_part | denotes | intestine | http://purl.org/sig/ont/fma/fma7199 |
| T421 | 1853-1857 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T422 | 1858-1883 | Body_part | denotes | alveolar epithelial cells | http://purl.org/sig/ont/fma/fma62499 |
| T423 | 1878-1883 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T424 | 1929-1945 | Body_part | denotes | epithelial cells | http://purl.org/sig/ont/fma/fma66768 |
| T425 | 1940-1945 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T426 | 2201-2205 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T427 | 2245-2257 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T428 | 2486-2492 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
| T429 | 2583-2587 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T430 | 2600-2610 | Body_part | denotes | chromosome | http://purl.org/sig/ont/fma/fma67093 |
| T431 | 2625-2633 | Body_part | denotes | androgen | http://purl.org/sig/ont/fma/fma83375 |
| T432 | 2738-2746 | Body_part | denotes | androgen | http://purl.org/sig/ont/fma/fma83375 |
| T433 | 2777-2781 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T434 | 2794-2805 | Body_part | denotes | amino acids | http://purl.org/sig/ont/fma/fma82739 |
| T435 | 3045-3055 | Body_part | denotes | hepatocyte | http://purl.org/sig/ont/fma/fma14515 |
| T436 | 3166-3178 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T437 | 3268-3274 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
| T438 | 3286-3292 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
| T439 | 3338-3347 | Body_part | denotes | endosomal | http://purl.org/sig/ont/fma/fma67180 |
| T440 | 3382-3387 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T441 | 3425-3434 | Body_part | denotes | endosomal | http://purl.org/sig/ont/fma/fma67180 |
| T442 | 3463-3470 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T443 | 3537-3546 | Body_part | denotes | endosomal | http://purl.org/sig/ont/fma/fma67180 |
| T444 | 3573-3588 | Body_part | denotes | plasma membrane | http://purl.org/sig/ont/fma/fma63841 |
| T445 | 3652-3658 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
| T446 | 3750-3756 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
| T447 | 3891-3896 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T448 | 3954-3966 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T449 | 4053-4065 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T450 | 4080-4085 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T451 | 4121-4133 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T452 | 4221-4226 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T453 | 4568-4574 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
| T454 | 4629-4633 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T455 | 4689-4694 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T456 | 4863-4869 | Body_part | denotes | kidney | http://purl.org/sig/ont/fma/fma7203 |
| T457 | 4885-4890 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T458 | 4908-4911 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T459 | 4932-4937 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T460 | 4998-5008 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
| T461 | 5048-5053 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
| T462 | 5063-5069 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T22 | 1532-1536 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T23 | 1642-1651 | Body_part | denotes | intestine | http://purl.obolibrary.org/obo/UBERON_0000160 |
| T24 | 1853-1857 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T25 | 4863-4869 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/UBERON_0002113 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T167 | 356-364 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T168 | 855-876 | Disease | denotes | inflammatory diseases | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T169 | 1025-1029 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T170 | 1174-1182 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T171 | 1243-1251 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T172 | 1358-1366 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T173 | 1369-1378 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T174 | 1380-1388 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T175 | 1391-1400 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T176 | 1491-1499 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T177 | 1597-1605 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T178 | 1609-1617 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T179 | 1703-1711 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T180 | 1778-1786 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T181 | 1885-1893 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T182 | 1898-1906 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T183 | 2077-2085 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T184 | 2142-2150 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T185 | 2164-2174 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T186 | 2176-2184 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T187 | 2270-2279 | Disease | denotes | Infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T188 | 2292-2301 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T189 | 2306-2320 | Disease | denotes | H1N1 influenza | http://purl.obolibrary.org/obo/MONDO_0005460 |
| T190 | 2311-2320 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T191 | 3128-3136 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T192 | 3155-3163 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T193 | 3249-3252 | Disease | denotes | HAT | http://purl.obolibrary.org/obo/MONDO_0018048 |
| T194 | 3363-3371 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T195 | 3713-3731 | Disease | denotes | SARS-CoV infection | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T196 | 3722-3731 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T197 | 3866-3874 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T198 | 3943-3951 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T199 | 4042-4050 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T200 | 4110-4118 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T201 | 4173-4181 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T202 | 4253-4261 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T203 | 4272-4281 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T204 | 4311-4315 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T205 | 4330-4340 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T206 | 4538-4546 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T207 | 4603-4612 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T208 | 4711-4719 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T209 | 4763-4771 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T210 | 4952-4961 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T211 | 5130-5139 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T212 | 5221-5229 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T213 | 5264-5272 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T214 | 5332-5342 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T215 | 5346-5354 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T216 | 5502-5511 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T217 | 5523-5532 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T218 | 5588-5596 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T219 | 5610-5620 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T220 | 5810-5819 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T658 | 5-9 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | Cell |
| T659 | 55-56 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T660 | 147-155 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T661 | 191-192 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T662 | 380-389 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activates |
| T663 | 433-438 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T664 | 581-589 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T665 | 640-648 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T666 | 682-683 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T667 | 1199-1204 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T668 | 1268-1273 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T669 | 1339-1344 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T670 | 1410-1418 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T671 | 1503-1513 | http://purl.obolibrary.org/obo/UBERON_0000160 | denotes | Intestinal |
| T672 | 1503-1513 | http://www.ebi.ac.uk/efo/EFO_0000834 | denotes | Intestinal |
| T673 | 1514-1522 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T674 | 1532-1536 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T675 | 1532-1536 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T676 | 1632-1637 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
| T677 | 1642-1651 | http://purl.obolibrary.org/obo/UBERON_0000160 | denotes | intestine |
| T678 | 1642-1651 | http://www.ebi.ac.uk/efo/EFO_0000834 | denotes | intestine |
| T679 | 1853-1857 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T680 | 1853-1857 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T681 | 1867-1877 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T682 | 1878-1883 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T683 | 1929-1939 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T684 | 1940-1945 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T685 | 2061-2062 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T686 | 2201-2205 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T687 | 2321-2322 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T688 | 2331-2338 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T689 | 2427-2428 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T690 | 2512-2513 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T691 | 2569-2574 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T692 | 2583-2587 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T693 | 2625-2642 | http://purl.obolibrary.org/obo/PR_000004191 | denotes | androgen receptor |
| T694 | 2777-2781 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T695 | 2851-2859 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T696 | 2901-2910 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activates |
| T697 | 2920-2929 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T698 | 2953-2962 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T699 | 3035-3044 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T700 | 3071-3074 | http://purl.obolibrary.org/obo/CLO_0003740 | denotes | HGF |
| T701 | 3099-3108 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T702 | 3118-3127 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activates |
| T703 | 3213-3218 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T704 | 3219-3225 | http://purl.obolibrary.org/obo/UBERON_0001005 | denotes | airway |
| T705 | 3360-3361 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T706 | 3382-3387 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T707 | 3447-3448 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T708 | 3455-3460 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | Virus |
| T709 | 3573-3579 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T710 | 3580-3588 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T711 | 3891-3896 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T712 | 4028-4037 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activates |
| T713 | 4080-4085 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T714 | 4163-4172 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T715 | 4204-4209 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T716 | 4221-4226 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T717 | 4394-4395 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T718 | 4566-4567 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T719 | 4613-4618 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T720 | 4629-4633 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T721 | 4682-4694 | http://purl.obolibrary.org/obo/CLO_0051840 | denotes | Calu-3 cells |
| T722 | 4682-4694 | http://purl.obolibrary.org/obo/CLO_0051841 | denotes | Calu-3 cells |
| T723 | 4682-4694 | http://purl.obolibrary.org/obo/CLO_0051842 | denotes | Calu-3 cells |
| T724 | 4682-4694 | http://purl.obolibrary.org/obo/CLO_0051843 | denotes | Calu-3 cells |
| T725 | 4682-4694 | http://purl.obolibrary.org/obo/CLO_0051844 | denotes | Calu-3 cells |
| T726 | 4682-4688 | http://purl.obolibrary.org/obo/CLO_0002192 | denotes | Calu-3 |
| T727 | 4787-4788 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T728 | 4856-4862 | http://purl.obolibrary.org/obo/NCBITaxon_9479 | denotes | monkey |
| T729 | 4863-4869 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidney |
| T730 | 4863-4869 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidney |
| T731 | 4863-4869 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidney |
| T732 | 4871-4875 | http://purl.obolibrary.org/obo/CLO_0009524 | denotes | Vero |
| T733 | 4871-4875 | http://purl.obolibrary.org/obo/CLO_0050515 | denotes | Vero |
| T734 | 4885-4890 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T735 | 4925-4937 | http://purl.obolibrary.org/obo/CLO_0051840 | denotes | Calu-3 cells |
| T736 | 4925-4937 | http://purl.obolibrary.org/obo/CLO_0051841 | denotes | Calu-3 cells |
| T737 | 4925-4937 | http://purl.obolibrary.org/obo/CLO_0051842 | denotes | Calu-3 cells |
| T738 | 4925-4937 | http://purl.obolibrary.org/obo/CLO_0051843 | denotes | Calu-3 cells |
| T739 | 4925-4937 | http://purl.obolibrary.org/obo/CLO_0051844 | denotes | Calu-3 cells |
| T740 | 4925-4931 | http://purl.obolibrary.org/obo/CLO_0002192 | denotes | Calu-3 |
| T741 | 4976-4977 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T742 | 4998-5017 | http://purl.obolibrary.org/obo/CHEBI_33708 | denotes | amino acid residues |
| T743 | 4998-5017 | http://purl.obolibrary.org/obo/PR_000036907 | denotes | amino acid residues |
| T744 | 5048-5053 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
| T745 | 5533-5538 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T746 | 5550-5551 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T747 | 5570-5571 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T748 | 5758-5759 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T52126 | 114-116 | Chemical | denotes | Zn | http://purl.obolibrary.org/obo/CHEBI_27363 |
| T21109 | 156-164 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T46115 | 367-379 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T4 | 801-811 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T5 | 1032-1039 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T6 | 1475-1487 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T7 | 1850-1852 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T77723 | 1926-1928 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T89893 | 2245-2257 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T10 | 2439-2448 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T41117 | 2486-2492 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
| T12 | 2519-2521 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T59805 | 2522-2524 | Chemical | denotes | TM | http://purl.obolibrary.org/obo/CHEBI_55460|http://purl.obolibrary.org/obo/CHEBI_74861 |
| T15 | 2525-2528 | Chemical | denotes | Ser | http://purl.obolibrary.org/obo/CHEBI_17115|http://purl.obolibrary.org/obo/CHEBI_29999 |
| T17 | 2625-2633 | Chemical | denotes | androgen | http://purl.obolibrary.org/obo/CHEBI_50113 |
| T53240 | 2738-2746 | Chemical | denotes | androgen | http://purl.obolibrary.org/obo/CHEBI_50113 |
| T19 | 2794-2805 | Chemical | denotes | amino acids | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T85427 | 2794-2799 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T76775 | 2800-2805 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T22 | 3009-3012 | Chemical | denotes | MMP | http://purl.obolibrary.org/obo/CHEBI_340824|http://purl.obolibrary.org/obo/CHEBI_59761 |
| T24 | 3020-3023 | Chemical | denotes | MMP | http://purl.obolibrary.org/obo/CHEBI_340824|http://purl.obolibrary.org/obo/CHEBI_59761 |
| T26 | 3086-3089 | Chemical | denotes | Met | http://purl.obolibrary.org/obo/CHEBI_16044|http://purl.obolibrary.org/obo/CHEBI_16643|http://purl.obolibrary.org/obo/CHEBI_16811 |
| T29 | 3166-3178 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T30 | 3255-3257 | Chemical | denotes | TM | http://purl.obolibrary.org/obo/CHEBI_55460|http://purl.obolibrary.org/obo/CHEBI_74861 |
| T32 | 3268-3274 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
| T49801 | 3286-3292 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
| T34 | 3463-3470 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T72751 | 3652-3677 | Chemical | denotes | serine protease inhibitor | http://purl.obolibrary.org/obo/CHEBI_64926 |
| T36 | 3652-3658 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
| T68391 | 3659-3677 | Chemical | denotes | protease inhibitor | http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258 |
| T39 | 3668-3677 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T40 | 3678-3686 | Chemical | denotes | camostat | http://purl.obolibrary.org/obo/CHEBI_135632 |
| T41 | 3750-3756 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
| T61271 | 3780-3790 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T43553 | 3954-3966 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T20578 | 4053-4065 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T80689 | 4121-4133 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T46 | 4458-4461 | Chemical | denotes | Ser | http://purl.obolibrary.org/obo/CHEBI_17115|http://purl.obolibrary.org/obo/CHEBI_29999 |
| T48 | 4462-4481 | Chemical | denotes | protease inhibitors | http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258 |
| T50 | 4471-4481 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T51 | 4490-4507 | Chemical | denotes | camostat mesylate | http://purl.obolibrary.org/obo/CHEBI_135632 |
| T76162 | 4556-4564 | Chemical | denotes | camostat | http://purl.obolibrary.org/obo/CHEBI_135632 |
| T53 | 4568-4593 | Chemical | denotes | serine protease inhibitor | http://purl.obolibrary.org/obo/CHEBI_64926 |
| T54 | 4568-4574 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
| T55 | 4575-4593 | Chemical | denotes | protease inhibitor | http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258 |
| T23789 | 4584-4593 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T43182 | 4643-4651 | Chemical | denotes | camostat | http://purl.obolibrary.org/obo/CHEBI_135632 |
| T59 | 4808-4816 | Chemical | denotes | camostat | http://purl.obolibrary.org/obo/CHEBI_135632 |
| T60 | 4978-4989 | Chemical | denotes | polypeptide | http://purl.obolibrary.org/obo/CHEBI_15841 |
| T61 | 4998-5008 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T62 | 4998-5003 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T62698 | 5004-5008 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T64 | 5063-5088 | Chemical | denotes | serine protease inhibitor | http://purl.obolibrary.org/obo/CHEBI_64926 |
| T65 | 5063-5069 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
| T66 | 5070-5088 | Chemical | denotes | protease inhibitor | http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258 |
| T57087 | 5079-5088 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T93241 | 5090-5100 | Chemical | denotes | nafamostat | http://purl.obolibrary.org/obo/CHEBI_135466 |
| T70 | 5168-5187 | Chemical | denotes | nafamostat mesylate | http://purl.obolibrary.org/obo/CHEBI_135466 |
| T84586 | 5241-5243 | Chemical | denotes | PM | http://purl.obolibrary.org/obo/CHEBI_141444|http://purl.obolibrary.org/obo/CHEBI_16410|http://purl.obolibrary.org/obo/CHEBI_53551 |
| T74 | 5287-5306 | Chemical | denotes | nafamostat mesylate | http://purl.obolibrary.org/obo/CHEBI_135466 |
| T75 | 5392-5401 | Chemical | denotes | mucolytic | http://purl.obolibrary.org/obo/CHEBI_77034 |
| T76 | 5402-5419 | Chemical | denotes | cough suppressant | http://purl.obolibrary.org/obo/CHEBI_51177 |
| T77 | 5421-5445 | Chemical | denotes | Bromhexine hydrochloride | http://purl.obolibrary.org/obo/CHEBI_31303 |
| T78217 | 5432-5445 | Chemical | denotes | hydrochloride | http://purl.obolibrary.org/obo/CHEBI_36807 |
| T79 | 5643-5653 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T77 | 763-789 | http://purl.obolibrary.org/obo/GO_0050728 | denotes | anti-inflammatory response |
| T78 | 768-789 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory response |
| T79 | 1183-1198 | http://purl.obolibrary.org/obo/GO_0044409 | denotes | entry into host |
| T80 | 1252-1267 | http://purl.obolibrary.org/obo/GO_0044409 | denotes | entry into host |
| T81 | 1282-1293 | http://purl.obolibrary.org/obo/GO_0006897 | denotes | endocytosis |
| T82 | 3056-3062 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T83 | 3099-3108 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T84 | 3875-3890 | http://purl.obolibrary.org/obo/GO_0044409 | denotes | entry into host |
| T85 | 4908-4921 | http://purl.obolibrary.org/obo/GO_0032774 | denotes | RNA synthesis |
| T86 | 4912-4921 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T465 | 0-54 | Sentence | denotes | Host Cell ADAM17 and TMPRSS2 Competitively Cleave ACE2 |
| T466 | 55-165 | Sentence | denotes | A disintegrin and metallopeptidase domain (ADAM) family of Zn-metalloproteinases belongs to membrane proteins. |
| T467 | 166-255 | Sentence | denotes | The well-known ADAM17 is a TNF-α-converting enzyme (TACE), called the sheddase for TNF-α. |
| T468 | 256-324 | Sentence | denotes | Other ADAM sheddase family members include ADAM9, ADAM10 and ADAM12. |
| T469 | 325-355 | Sentence | denotes | ADAM17 mediates ACE2 shedding. |
| T470 | 356-445 | Sentence | denotes | SARS-CoV S glycoprotein activates cellular TACE and consequently facilitates virus entry. |
| T471 | 446-595 | Sentence | denotes | Soluble ACE2 as the N-terminal carboxypeptidase domain form is derived from the original ACE2 form by an ADAM17 metalloprotease in the membrane [89]. |
| T472 | 596-720 | Sentence | denotes | ADAM17 is indeed an enzyme that can convert membrane type pro-TNF-α to soluble TNF-α, a functional proinflammatory cytokine. |
| T473 | 721-877 | Sentence | denotes | Therefore, ADAM17 inhibition indicates an anti-inflammatory response and ADAM17 inhibitors are promising candidates for TNF-α-induced inflammatory diseases. |
| T474 | 878-947 | Sentence | denotes | The short C-terminal domain of ACE2 is removed by ADAM17 and TMPRSS2. |
| T475 | 948-1024 | Sentence | denotes | However, TMPRSS2 cleaves ACE2 competitively with the ADAM17 metalloprotease. |
| T476 | 1025-1213 | Sentence | denotes | SARS-S protein-ACE2 binding leads to ADAM17/TNF-α-converting enzyme (TACE)-cleavage of ACE2, facilitating extracellular ACE2 shedding and consequent SARS-CoV entry into host cells [90,91]. |
| T477 | 1214-1305 | Sentence | denotes | Only TMPRSS2 cleavage allows SARS-CoV entry into host cells through endocytosis and fusion. |
| T478 | 1306-1379 | Sentence | denotes | Soluble ACE2 also recognizes the virus and prevents SARS-CoV-2 infection. |
| T479 | 1380-1436 | Sentence | denotes | SARS-CoV-2 infection requires membrane ACE2 and TMPRSS2. |
| T480 | 1437-1502 | Sentence | denotes | The ACE2–B0AT1 complex binds to the S glycoprotein of SARS-CoV-2. |
| T481 | 1503-1608 | Sentence | denotes | Intestinal membrane ACE2 and lung TMPRSS2-shedded ACE2 can act as alternative entry sites for SARS-CoV-2. |
| T482 | 1609-1677 | Sentence | denotes | SARS-CoV-2 infects the lungs and intestine via TMPRSS2-cleaved ACE2. |
| T483 | 1678-1798 | Sentence | denotes | If TMPRSS2 is engaged in SARS-CoV-2 entry and ACE2 downregulation, TMPRSS2 inhibition would lead to COVID-19 prevention. |
| T484 | 1799-1982 | Sentence | denotes | Although ACE2 is expressed both in type I and type II lung alveolar epithelial cells, SARS-CoV and SARS-CoV-2 target only type II epithelial cells due to the ACE2–TMPRSS2 interaction. |
| T485 | 1983-2105 | Sentence | denotes | Therefore, supplementation of ACE2 (soluble ACE2) or Ang-1 to Ang-7 should be a way to reduce SARS-CoV-2-related symptoms. |
| T486 | 2106-2175 | Sentence | denotes | TMPRSS2-cleaved ACE2 is involved in SARS-CoV and MERS-CoV infections. |
| T487 | 2176-2269 | Sentence | denotes | SARS-CoV-2 uses ACE2 for cell entry through TMPRSS2 priming of the S glycoprotein (Figure 7). |
| T488 | 2270-2381 | Sentence | denotes | Infection of the H7N9 influenza and H1N1 influenza A subtype viruses are also mediated by TMPRSS2-cleaved ACE2. |
| T489 | 2382-2462 | Sentence | denotes | This implies that TMPRSS2 can be targeted as a strategic antiviral therapy [92]. |
| T490 | 2463-2564 | Sentence | denotes | Transmembrane protease serine 2, termed TMPRSS2, a type II TM Ser protease (TTSP), also cleaves ACE2. |
| T491 | 2565-2699 | Sentence | denotes | The human TMPRSS2 gene, located on chromosome 21, comprises androgen receptor elements (AREs) in the upstream 5′-flanking region [93]. |
| T492 | 2700-2764 | Sentence | denotes | TMPRSS2 expression is regulated in an androgen-dependent manner. |
| T493 | 2765-2806 | Sentence | denotes | The TMPRSS2 gene encodes 492 amino acids. |
| T494 | 2807-2892 | Sentence | denotes | The original form is cleaved into the major membrane form and the minor soluble form. |
| T495 | 2893-3026 | Sentence | denotes | TMPRSS2 activates protease activated receptor 2 (PAR-2) and activated PAR-2 upregulates matrix metalloproteinase-2 (MMP-2) and MMP-9. |
| T496 | 3027-3109 | Sentence | denotes | TMPRSS2-activated hepatocyte growth factor (HGF) induces c-Met receptor signaling. |
| T497 | 3110-3150 | Sentence | denotes | TMPRSS2 activates SARS-CoV and MERS-CoV. |
| T498 | 3151-3362 | Sentence | denotes | The SARS-CoV S glycoprotein is cleaved by host-borne TMPRSS2, human airway trypsin-like protease (HAT), TM protease, serine 13 (MSPL), serine protease DESC1 (DESC1), furin, factor Xa and endosomal cathepsin L/B. |
| T499 | 3363-3454 | Sentence | denotes | SARS-CoV can enter cells upon cleavage by protease TMPRSS2 or endosomal cathepsin L/B [90]. |
| T500 | 3455-3510 | Sentence | denotes | Virus S protein precursor is cleaved by host proteases. |
| T501 | 3511-3647 | Sentence | denotes | The spikes are cleaved by endosomal cathepsin and by Golgi or plasma membrane TMPRSS2 in the step of assembly or attachment and release. |
| T502 | 3648-3740 | Sentence | denotes | The serine protease inhibitor camostat effectively blocks lethal SARS-CoV infection to mice. |
| T503 | 3741-3809 | Sentence | denotes | However, serine protease and cathepsin inhibitors are not effective. |
| T504 | 3810-3919 | Sentence | denotes | Thus, TMPRSS2 is suggested to be an acting protease for SARS-CoV entry into host cells, but not by cathepsin. |
| T505 | 3920-4012 | Sentence | denotes | Cis-cleavage liberates SARS-CoV S glycoprotein fragments into the extracellular supernatant. |
| T506 | 4013-4154 | Sentence | denotes | Trans-cleavage activates the SARS-CoV S glycoprotein on the target cells, potentiating efficient SARS-CoV S glycoprotein-driven viral fusion. |
| T507 | 4155-4227 | Sentence | denotes | TMPRSS2-activated SARS-CoV facilitates enveloped virus entry into cells. |
| T508 | 4228-4296 | Sentence | denotes | TMPRSS2 is important for SARS-CoV entry and infection [81,94,95,96]. |
| T509 | 4297-4436 | Sentence | denotes | The fact that SARS- and MERS-CoV infections are potentiated by TMPRSS2 indicates that TMPRSS2 is a promising target for therapeutic agents. |
| T510 | 4437-4786 | Sentence | denotes | For example, several Ser protease inhibitors such as camostat mesylate inhibit TMPRSS2–ACE2-involved SARS-CoV-2 entry. camostat, a serine protease inhibitor, reduces influenza virus titers in cell culture. camostat-treated TMPRSS2 inhibition in Calu-3 cells greatly reduces SARS-CoV viral titers and improves survival rate in SARS-CoV infected mice. |
| T511 | 4787-4962 | Sentence | denotes | A treatment of 10-μM camostat blocks MERS-CoV entry to African green monkey kidney (Vero)-TMPRSS2 cells and blocks viral RNA synthesis in Calu-3 cells upon MERS-CoV infection. |
| T512 | 4963-5054 | Sentence | denotes | Aprotinin is a polypeptide with 58 amino acid residues that was isolated from bovine lungs. |
| T513 | 5055-5364 | Sentence | denotes | Another serine protease inhibitor, nafamostat, inhibits MERS-CoV entry and infection by TMPRSS2 inhibition [93]. nafamostat mesylate blocks the TMPRSS2–ACE2-involved SARS-CoV-2 envelope–PM fusion and prevents SARS-CoV-2 entry [95]. nafamostat mesylate inhibits viral entry and thrombosis in COVID-19 patients. |
| T514 | 5365-5539 | Sentence | denotes | Similarly, an FDA-approved mucolytic cough suppressant, Bromhexine hydrochloride (BHH), inhibits TMPRSS2 (IC50 0.75 μM) and hence blocks infection of CoV and influenza virus. |
| T515 | 5540-5621 | Sentence | denotes | MPRSS2 as a host factor plays a pivotal role in SARS-CoV and MERS-CoV infections. |
| T516 | 5622-5680 | Sentence | denotes | FDA-approved TMPRSS2 inhibitors are yet under development. |
| T517 | 5681-5820 | Sentence | denotes | Because TMPRSS2 mediates efficient viral entry and replication, it should be a promising target for new therapeutics against CoV infection. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32604730-10924499-51944047 | 591-593 | 10924499 | denotes | 89 |
| 32604730-24227843-51944048 | 1206-1208 | 24227843 | denotes | 90 |
| 32604730-19995578-51944049 | 1209-1211 | 19995578 | denotes | 91 |
| 32604730-28778717-51944050 | 2458-2460 | 28778717 | denotes | 92 |
| 32604730-10485450-51944051 | 2695-2697 | 10485450 | denotes | 93 |
| 32604730-24227843-51944052 | 3450-3452 | 24227843 | denotes | 90 |
| 32604730-23486063-51944053 | 4283-4285 | 23486063 | denotes | 81 |
| 32604730-27550352-51944054 | 4286-4288 | 27550352 | denotes | 94 |
| 32604730-32139904-51944055 | 4289-4291 | 32139904 | denotes | 95 |
| 32604730-27791014-51944056 | 4292-4294 | 27791014 | denotes | 96 |
| 32604730-10485450-51944057 | 5163-5165 | 10485450 | denotes | 93 |
| 32604730-32139904-51944058 | 5282-5284 | 32139904 | denotes | 95 |
| T58896 | 591-593 | 10924499 | denotes | 89 |
| T39582 | 1206-1208 | 24227843 | denotes | 90 |
| T57089 | 1209-1211 | 19995578 | denotes | 91 |
| T40327 | 2458-2460 | 28778717 | denotes | 92 |
| T67110 | 2695-2697 | 10485450 | denotes | 93 |
| T4756 | 3450-3452 | 24227843 | denotes | 90 |
| T32605 | 4283-4285 | 23486063 | denotes | 81 |
| T99544 | 4286-4288 | 27550352 | denotes | 94 |
| T97300 | 4289-4291 | 32139904 | denotes | 95 |
| T93094 | 4292-4294 | 27791014 | denotes | 96 |
| T88382 | 5163-5165 | 10485450 | denotes | 93 |
| T92226 | 5282-5284 | 32139904 | denotes | 95 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T14 | 5402-5407 | Phenotype | denotes | cough | http://purl.obolibrary.org/obo/HP_0012735 |