PMC:7352545 / 43164-44265 JSONTXT

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T186","span":{"begin":639,"end":641},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T187","span":{"begin":652,"end":654},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"}],"text":"CoV S spikes recognize diverse surface molecules as the attachment or entry site. Animal and human coronaviruses evolve to acquire the same host receptors and attachment factors and overcome the interspecies barrier from animals to human. Specifically, S glycoprotein interaction with its binding receptor determines host tropism, pathogenicity and therapeutic clues [80]. CoVs recognize multiple host receptors via distinct S domains. The host receptors for β-CoV SARS-CoV includes angiotensin-converting enzyme 2 (ACE2). As a lineage C β-CoV, the MERS-CoV S glycoprotein binds to DPP4 [81,82,83]. MERS-CoV S glycoprotein recognizes α2,3-SA over α2,6-SA-bearing receptors. The N-terminal subunits of the S1/S1A/S1B/S1D complex of MERS-CoV recognize DPP4. MERS-CoV recognizes CEACAM5 as the attachment factor for entry [78]. Among the six HCoVs, the α-CoV HCoV-229E S protein recognizes human APN (hAPN) [84]. α-CoV HCoV-NL63 and the lineage B β-CoV SARS-CoV S glycoproteins bind to ACE2. Meanwhile the protein receptors specific for lineage A β-CoVs such as HCoV-HKU1 and HCoV-OC43 are not known yet."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T365","span":{"begin":255,"end":267},"obj":"Body_part"},{"id":"T366","span":{"begin":560,"end":572},"obj":"Body_part"},{"id":"T367","span":{"begin":610,"end":622},"obj":"Body_part"},{"id":"T368","span":{"begin":868,"end":875},"obj":"Body_part"},{"id":"T369","span":{"begin":961,"end":974},"obj":"Body_part"},{"id":"T370","span":{"begin":1003,"end":1010},"obj":"Body_part"}],"attributes":[{"id":"A365","pred":"fma_id","subj":"T365","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A366","pred":"fma_id","subj":"T366","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A367","pred":"fma_id","subj":"T367","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A368","pred":"fma_id","subj":"T368","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A369","pred":"fma_id","subj":"T369","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A370","pred":"fma_id","subj":"T370","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"CoV S spikes recognize diverse surface molecules as the attachment or entry site. Animal and human coronaviruses evolve to acquire the same host receptors and attachment factors and overcome the interspecies barrier from animals to human. Specifically, S glycoprotein interaction with its binding receptor determines host tropism, pathogenicity and therapeutic clues [80]. CoVs recognize multiple host receptors via distinct S domains. The host receptors for β-CoV SARS-CoV includes angiotensin-converting enzyme 2 (ACE2). As a lineage C β-CoV, the MERS-CoV S glycoprotein binds to DPP4 [81,82,83]. MERS-CoV S glycoprotein recognizes α2,3-SA over α2,6-SA-bearing receptors. The N-terminal subunits of the S1/S1A/S1B/S1D complex of MERS-CoV recognize DPP4. MERS-CoV recognizes CEACAM5 as the attachment factor for entry [78]. Among the six HCoVs, the α-CoV HCoV-229E S protein recognizes human APN (hAPN) [84]. α-CoV HCoV-NL63 and the lineage B β-CoV SARS-CoV S glycoproteins bind to ACE2. Meanwhile the protein receptors specific for lineage A β-CoVs such as HCoV-HKU1 and HCoV-OC43 are not known yet."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T147","span":{"begin":465,"end":473},"obj":"Disease"},{"id":"T148","span":{"begin":950,"end":958},"obj":"Disease"}],"attributes":[{"id":"A147","pred":"mondo_id","subj":"T147","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A148","pred":"mondo_id","subj":"T148","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"CoV S spikes recognize diverse surface molecules as the attachment or entry site. Animal and human coronaviruses evolve to acquire the same host receptors and attachment factors and overcome the interspecies barrier from animals to human. Specifically, S glycoprotein interaction with its binding receptor determines host tropism, pathogenicity and therapeutic clues [80]. CoVs recognize multiple host receptors via distinct S domains. The host receptors for β-CoV SARS-CoV includes angiotensin-converting enzyme 2 (ACE2). As a lineage C β-CoV, the MERS-CoV S glycoprotein binds to DPP4 [81,82,83]. MERS-CoV S glycoprotein recognizes α2,3-SA over α2,6-SA-bearing receptors. The N-terminal subunits of the S1/S1A/S1B/S1D complex of MERS-CoV recognize DPP4. MERS-CoV recognizes CEACAM5 as the attachment factor for entry [78]. Among the six HCoVs, the α-CoV HCoV-229E S protein recognizes human APN (hAPN) [84]. α-CoV HCoV-NL63 and the lineage B β-CoV SARS-CoV S glycoproteins bind to ACE2. Meanwhile the protein receptors specific for lineage A β-CoVs such as HCoV-HKU1 and HCoV-OC43 are not known yet."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T586","span":{"begin":82,"end":88},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"},{"id":"T587","span":{"begin":93,"end":98},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T588","span":{"begin":221,"end":228},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"},{"id":"T589","span":{"begin":232,"end":237},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T590","span":{"begin":526,"end":527},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T591","span":{"begin":705,"end":707},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T592","span":{"begin":887,"end":892},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T593","span":{"begin":942,"end":943},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T594","span":{"begin":1042,"end":1043},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"CoV S spikes recognize diverse surface molecules as the attachment or entry site. Animal and human coronaviruses evolve to acquire the same host receptors and attachment factors and overcome the interspecies barrier from animals to human. Specifically, S glycoprotein interaction with its binding receptor determines host tropism, pathogenicity and therapeutic clues [80]. CoVs recognize multiple host receptors via distinct S domains. The host receptors for β-CoV SARS-CoV includes angiotensin-converting enzyme 2 (ACE2). As a lineage C β-CoV, the MERS-CoV S glycoprotein binds to DPP4 [81,82,83]. MERS-CoV S glycoprotein recognizes α2,3-SA over α2,6-SA-bearing receptors. The N-terminal subunits of the S1/S1A/S1B/S1D complex of MERS-CoV recognize DPP4. MERS-CoV recognizes CEACAM5 as the attachment factor for entry [78]. Among the six HCoVs, the α-CoV HCoV-229E S protein recognizes human APN (hAPN) [84]. α-CoV HCoV-NL63 and the lineage B β-CoV SARS-CoV S glycoproteins bind to ACE2. Meanwhile the protein receptors specific for lineage A β-CoVs such as HCoV-HKU1 and HCoV-OC43 are not known yet."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1384","span":{"begin":39,"end":48},"obj":"Chemical"},{"id":"T1385","span":{"begin":255,"end":267},"obj":"Chemical"},{"id":"T1386","span":{"begin":483,"end":494},"obj":"Chemical"},{"id":"T1387","span":{"begin":560,"end":572},"obj":"Chemical"},{"id":"T1388","span":{"begin":610,"end":622},"obj":"Chemical"},{"id":"T1389","span":{"begin":639,"end":641},"obj":"Chemical"},{"id":"T1394","span":{"begin":652,"end":654},"obj":"Chemical"},{"id":"T1399","span":{"begin":868,"end":875},"obj":"Chemical"},{"id":"T1400","span":{"begin":961,"end":974},"obj":"Chemical"},{"id":"T1401","span":{"begin":1003,"end":1010},"obj":"Chemical"}],"attributes":[{"id":"A1384","pred":"chebi_id","subj":"T1384","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A1385","pred":"chebi_id","subj":"T1385","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A1386","pred":"chebi_id","subj":"T1386","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A1387","pred":"chebi_id","subj":"T1387","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A1388","pred":"chebi_id","subj":"T1388","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A1389","pred":"chebi_id","subj":"T1389","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A1390","pred":"chebi_id","subj":"T1389","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A1391","pred":"chebi_id","subj":"T1389","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A1392","pred":"chebi_id","subj":"T1389","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A1393","pred":"chebi_id","subj":"T1389","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A1394","pred":"chebi_id","subj":"T1394","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A1395","pred":"chebi_id","subj":"T1394","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A1396","pred":"chebi_id","subj":"T1394","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A1397","pred":"chebi_id","subj":"T1394","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A1398","pred":"chebi_id","subj":"T1394","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A1399","pred":"chebi_id","subj":"T1399","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A1400","pred":"chebi_id","subj":"T1400","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A1401","pred":"chebi_id","subj":"T1401","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"CoV S spikes recognize diverse surface molecules as the attachment or entry site. Animal and human coronaviruses evolve to acquire the same host receptors and attachment factors and overcome the interspecies barrier from animals to human. Specifically, S glycoprotein interaction with its binding receptor determines host tropism, pathogenicity and therapeutic clues [80]. CoVs recognize multiple host receptors via distinct S domains. The host receptors for β-CoV SARS-CoV includes angiotensin-converting enzyme 2 (ACE2). As a lineage C β-CoV, the MERS-CoV S glycoprotein binds to DPP4 [81,82,83]. MERS-CoV S glycoprotein recognizes α2,3-SA over α2,6-SA-bearing receptors. The N-terminal subunits of the S1/S1A/S1B/S1D complex of MERS-CoV recognize DPP4. MERS-CoV recognizes CEACAM5 as the attachment factor for entry [78]. Among the six HCoVs, the α-CoV HCoV-229E S protein recognizes human APN (hAPN) [84]. α-CoV HCoV-NL63 and the lineage B β-CoV SARS-CoV S glycoproteins bind to ACE2. Meanwhile the protein receptors specific for lineage A β-CoVs such as HCoV-HKU1 and HCoV-OC43 are not known yet."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T69","span":{"begin":322,"end":329},"obj":"http://purl.obolibrary.org/obo/GO_0009606"}],"text":"CoV S spikes recognize diverse surface molecules as the attachment or entry site. Animal and human coronaviruses evolve to acquire the same host receptors and attachment factors and overcome the interspecies barrier from animals to human. Specifically, S glycoprotein interaction with its binding receptor determines host tropism, pathogenicity and therapeutic clues [80]. CoVs recognize multiple host receptors via distinct S domains. The host receptors for β-CoV SARS-CoV includes angiotensin-converting enzyme 2 (ACE2). As a lineage C β-CoV, the MERS-CoV S glycoprotein binds to DPP4 [81,82,83]. MERS-CoV S glycoprotein recognizes α2,3-SA over α2,6-SA-bearing receptors. The N-terminal subunits of the S1/S1A/S1B/S1D complex of MERS-CoV recognize DPP4. MERS-CoV recognizes CEACAM5 as the attachment factor for entry [78]. Among the six HCoVs, the α-CoV HCoV-229E S protein recognizes human APN (hAPN) [84]. α-CoV HCoV-NL63 and the lineage B β-CoV SARS-CoV S glycoproteins bind to ACE2. Meanwhile the protein receptors specific for lineage A β-CoVs such as HCoV-HKU1 and HCoV-OC43 are not known yet."}

{"project":"LitCovid-sentences","denotations":[{"id":"T412","span":{"begin":0,"end":81},"obj":"Sentence"},{"id":"T413","span":{"begin":82,"end":238},"obj":"Sentence"},{"id":"T414","span":{"begin":239,"end":372},"obj":"Sentence"},{"id":"T415","span":{"begin":373,"end":435},"obj":"Sentence"},{"id":"T416","span":{"begin":436,"end":522},"obj":"Sentence"},{"id":"T417","span":{"begin":523,"end":598},"obj":"Sentence"},{"id":"T418","span":{"begin":599,"end":673},"obj":"Sentence"},{"id":"T419","span":{"begin":674,"end":755},"obj":"Sentence"},{"id":"T420","span":{"begin":756,"end":824},"obj":"Sentence"},{"id":"T421","span":{"begin":825,"end":988},"obj":"Sentence"},{"id":"T422","span":{"begin":989,"end":1101},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"CoV S spikes recognize diverse surface molecules as the attachment or entry site. Animal and human coronaviruses evolve to acquire the same host receptors and attachment factors and overcome the interspecies barrier from animals to human. Specifically, S glycoprotein interaction with its binding receptor determines host tropism, pathogenicity and therapeutic clues [80]. CoVs recognize multiple host receptors via distinct S domains. The host receptors for β-CoV SARS-CoV includes angiotensin-converting enzyme 2 (ACE2). As a lineage C β-CoV, the MERS-CoV S glycoprotein binds to DPP4 [81,82,83]. MERS-CoV S glycoprotein recognizes α2,3-SA over α2,6-SA-bearing receptors. The N-terminal subunits of the S1/S1A/S1B/S1D complex of MERS-CoV recognize DPP4. MERS-CoV recognizes CEACAM5 as the attachment factor for entry [78]. Among the six HCoVs, the α-CoV HCoV-229E S protein recognizes human APN (hAPN) [84]. α-CoV HCoV-NL63 and the lineage B β-CoV SARS-CoV S glycoproteins bind to ACE2. Meanwhile the protein receptors specific for lineage A β-CoVs such as HCoV-HKU1 and HCoV-OC43 are not known yet."}

{"project":"2_test","denotations":[{"id":"32604730-23486063-51944038","span":{"begin":588,"end":590},"obj":"23486063"},{"id":"32604730-32264791-51944039","span":{"begin":591,"end":593},"obj":"32264791"},{"id":"32604730-32094589-51944040","span":{"begin":594,"end":596},"obj":"32094589"},{"id":"32604730-29684066-51944041","span":{"begin":820,"end":822},"obj":"29684066"},{"id":"32604730-31650956-51944042","span":{"begin":905,"end":907},"obj":"31650956"},{"id":"T81414","span":{"begin":588,"end":590},"obj":"23486063"},{"id":"T60977","span":{"begin":591,"end":593},"obj":"32264791"},{"id":"T60147","span":{"begin":594,"end":596},"obj":"32094589"},{"id":"T11222","span":{"begin":820,"end":822},"obj":"29684066"},{"id":"T35004","span":{"begin":905,"end":907},"obj":"31650956"}],"text":"CoV S spikes recognize diverse surface molecules as the attachment or entry site. Animal and human coronaviruses evolve to acquire the same host receptors and attachment factors and overcome the interspecies barrier from animals to human. Specifically, S glycoprotein interaction with its binding receptor determines host tropism, pathogenicity and therapeutic clues [80]. CoVs recognize multiple host receptors via distinct S domains. The host receptors for β-CoV SARS-CoV includes angiotensin-converting enzyme 2 (ACE2). As a lineage C β-CoV, the MERS-CoV S glycoprotein binds to DPP4 [81,82,83]. MERS-CoV S glycoprotein recognizes α2,3-SA over α2,6-SA-bearing receptors. The N-terminal subunits of the S1/S1A/S1B/S1D complex of MERS-CoV recognize DPP4. MERS-CoV recognizes CEACAM5 as the attachment factor for entry [78]. Among the six HCoVs, the α-CoV HCoV-229E S protein recognizes human APN (hAPN) [84]. α-CoV HCoV-NL63 and the lineage B β-CoV SARS-CoV S glycoproteins bind to ACE2. Meanwhile the protein receptors specific for lineage A β-CoVs such as HCoV-HKU1 and HCoV-OC43 are not known yet."}