PMC:7352545 / 37831-39004 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7352545","sourcedb":"PMC","sourceid":"7352545","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7352545","text":"6.1.4. Torovirus\nIn torovirus, which belongs to the family Coronaviridae, the toroviruses are grouped into the Torovirinae subfamily and the Torovirus genus. The known toroviruses can infect four species of hosts, constituting bovine, equine, porcine and human toroviruses. They mildly infect swine and cattle through the HE protein, which is similar to the β-CoV HE protein [68]. The HE protein is a class I membrane glycoprotein which forms homodimers with a MW of 65 kDa. The RDE protein HE reversibly binds to glycans [15] through binding to SAs. The acetyl-esterase activity disrupts SA binding. HE hemagglutinates mouse erythrocytes and cleaves the acetyl-ester linkage of glycans and acetylated synthetic substrate p-nitrophenyl acetate (pNPA) [69]. Similar to CoV, torovirus HE is an acetylesterase type, which cleaves the O-acetyl group from the SA C-9 position using Neu5,9Ac2 and N-acetyl-7(8),9-O-NeuAc [64]. However, torovirus HE exhibits a restricted specificity for the Neu5,9Ac2 substrate, but not for the Neu5,7(8),9Ac3 substrate, with a unique SA-binding site generated by a single amino acid difference in porcine Thr73 and bovine Ser64 for each HE [70].","divisions":[{"label":"title","span":{"begin":0,"end":16}}],"tracks":[{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T160","span":{"begin":589,"end":591},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T161","span":{"begin":855,"end":857},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T162","span":{"begin":1062,"end":1064},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"}],"attributes":[{"subj":"T160","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T161","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T162","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T314","span":{"begin":325,"end":332},"obj":"Body_part"},{"id":"T315","span":{"begin":367,"end":374},"obj":"Body_part"},{"id":"T316","span":{"begin":388,"end":395},"obj":"Body_part"},{"id":"T317","span":{"begin":418,"end":430},"obj":"Body_part"},{"id":"T318","span":{"begin":483,"end":490},"obj":"Body_part"},{"id":"T319","span":{"begin":626,"end":638},"obj":"Body_part"},{"id":"T320","span":{"begin":1100,"end":1110},"obj":"Body_part"}],"attributes":[{"id":"A314","pred":"fma_id","subj":"T314","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A315","pred":"fma_id","subj":"T315","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A316","pred":"fma_id","subj":"T316","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A317","pred":"fma_id","subj":"T317","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A318","pred":"fma_id","subj":"T318","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A319","pred":"fma_id","subj":"T319","obj":"http://purl.org/sig/ont/fma/fma62845"},{"id":"A320","pred":"fma_id","subj":"T320","obj":"http://purl.org/sig/ont/fma/fma82739"},{"subj":"T314","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T315","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T316","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T317","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T318","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T319","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T320","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T516","span":{"begin":235,"end":241},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9796"},{"id":"T517","span":{"begin":255,"end":260},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T518","span":{"begin":399,"end":400},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T519","span":{"begin":409,"end":417},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T520","span":{"begin":459,"end":460},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T521","span":{"begin":546,"end":549},"obj":"http://purl.obolibrary.org/obo/CLO_0051568"},{"id":"T522","span":{"begin":571,"end":579},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T523","span":{"begin":620,"end":625},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T524","span":{"begin":626,"end":638},"obj":"http://purl.obolibrary.org/obo/CL_0000232"},{"id":"T525","span":{"begin":855,"end":859},"obj":"http://purl.obolibrary.org/obo/UBERON_0009856"},{"id":"T526","span":{"begin":952,"end":953},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T527","span":{"begin":1053,"end":1054},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T528","span":{"begin":1091,"end":1092},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T516","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T517","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T518","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T519","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T520","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T521","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T522","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T523","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T524","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T525","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T526","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T527","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T528","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1170","span":{"begin":325,"end":332},"obj":"Chemical"},{"id":"T1171","span":{"begin":367,"end":374},"obj":"Chemical"},{"id":"T1172","span":{"begin":388,"end":395},"obj":"Chemical"},{"id":"T1173","span":{"begin":418,"end":430},"obj":"Chemical"},{"id":"T1174","span":{"begin":461,"end":463},"obj":"Chemical"},{"id":"T1175","span":{"begin":483,"end":490},"obj":"Chemical"},{"id":"T1176","span":{"begin":514,"end":521},"obj":"Chemical"},{"id":"T1177","span":{"begin":555,"end":561},"obj":"Chemical"},{"id":"T1179","span":{"begin":589,"end":591},"obj":"Chemical"},{"id":"T1184","span":{"begin":655,"end":661},"obj":"Chemical"},{"id":"T1186","span":{"begin":662,"end":667},"obj":"Chemical"},{"id":"T1187","span":{"begin":679,"end":686},"obj":"Chemical"},{"id":"T1188","span":{"begin":722,"end":743},"obj":"Chemical"},{"id":"T1189","span":{"begin":722,"end":735},"obj":"Chemical"},{"id":"T1190","span":{"begin":736,"end":743},"obj":"Chemical"},{"id":"T1192","span":{"begin":745,"end":749},"obj":"Chemical"},{"id":"T1193","span":{"begin":833,"end":845},"obj":"Chemical"},{"id":"T1194","span":{"begin":833,"end":839},"obj":"Chemical"},{"id":"T1195","span":{"begin":840,"end":845},"obj":"Chemical"},{"id":"T1196","span":{"begin":855,"end":857},"obj":"Chemical"},{"id":"T1201","span":{"begin":893,"end":899},"obj":"Chemical"},{"id":"T1203","span":{"begin":909,"end":914},"obj":"Chemical"},{"id":"T1205","span":{"begin":1062,"end":1064},"obj":"Chemical"},{"id":"T1210","span":{"begin":1100,"end":1110},"obj":"Chemical"},{"id":"T1211","span":{"begin":1100,"end":1105},"obj":"Chemical"},{"id":"T1212","span":{"begin":1106,"end":1110},"obj":"Chemical"}],"attributes":[{"id":"A1170","pred":"chebi_id","subj":"T1170","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A1171","pred":"chebi_id","subj":"T1171","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A1172","pred":"chebi_id","subj":"T1172","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A1173","pred":"chebi_id","subj":"T1173","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A1174","pred":"chebi_id","subj":"T1174","obj":"http://purl.obolibrary.org/obo/CHEBI_74709"},{"id":"A1175","pred":"chebi_id","subj":"T1175","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A1176","pred":"chebi_id","subj":"T1176","obj":"http://purl.obolibrary.org/obo/CHEBI_18154"},{"id":"A1177","pred":"chebi_id","subj":"T1177","obj":"http://purl.obolibrary.org/obo/CHEBI_40574"},{"id":"A1178","pred":"chebi_id","subj":"T1177","obj":"http://purl.obolibrary.org/obo/CHEBI_46887"},{"id":"A1179","pred":"chebi_id","subj":"T1179","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A1180","pred":"chebi_id","subj":"T1179","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A1181","pred":"chebi_id","subj":"T1179","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A1182","pred":"chebi_id","subj":"T1179","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A1183","pred":"chebi_id","subj":"T1179","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A1184","pred":"chebi_id","subj":"T1184","obj":"http://purl.obolibrary.org/obo/CHEBI_40574"},{"id":"A1185","pred":"chebi_id","subj":"T1184","obj":"http://purl.obolibrary.org/obo/CHEBI_46887"},{"id":"A1186","pred":"chebi_id","subj":"T1186","obj":"http://purl.obolibrary.org/obo/CHEBI_35701"},{"id":"A1187","pred":"chebi_id","subj":"T1187","obj":"http://purl.obolibrary.org/obo/CHEBI_18154"},{"id":"A1188","pred":"chebi_id","subj":"T1188","obj":"http://purl.obolibrary.org/obo/CHEBI_82635"},{"id":"A1189","pred":"chebi_id","subj":"T1189","obj":"http://purl.obolibrary.org/obo/CHEBI_61595"},{"id":"A1190","pred":"chebi_id","subj":"T1190","obj":"http://purl.obolibrary.org/obo/CHEBI_30089"},{"id":"A1191","pred":"chebi_id","subj":"T1190","obj":"http://purl.obolibrary.org/obo/CHEBI_47622"},{"id":"A1192","pred":"chebi_id","subj":"T1192","obj":"http://purl.obolibrary.org/obo/CHEBI_82635"},{"id":"A1193","pred":"chebi_id","subj":"T1193","obj":"http://purl.obolibrary.org/obo/CHEBI_40574"},{"id":"A1194","pred":"chebi_id","subj":"T1194","obj":"http://purl.obolibrary.org/obo/CHEBI_46887"},{"id":"A1195","pred":"chebi_id","subj":"T1195","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A1196","pred":"chebi_id","subj":"T1196","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A1197","pred":"chebi_id","subj":"T1196","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A1198","pred":"chebi_id","subj":"T1196","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A1199","pred":"chebi_id","subj":"T1196","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A1200","pred":"chebi_id","subj":"T1196","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A1201","pred":"chebi_id","subj":"T1201","obj":"http://purl.obolibrary.org/obo/CHEBI_40574"},{"id":"A1202","pred":"chebi_id","subj":"T1201","obj":"http://purl.obolibrary.org/obo/CHEBI_46887"},{"id":"A1203","pred":"chebi_id","subj":"T1203","obj":"http://purl.obolibrary.org/obo/CHEBI_17012"},{"id":"A1204","pred":"chebi_id","subj":"T1203","obj":"http://purl.obolibrary.org/obo/CHEBI_49018"},{"id":"A1205","pred":"chebi_id","subj":"T1205","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A1206","pred":"chebi_id","subj":"T1205","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A1207","pred":"chebi_id","subj":"T1205","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A1208","pred":"chebi_id","subj":"T1205","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A1209","pred":"chebi_id","subj":"T1205","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A1210","pred":"chebi_id","subj":"T1210","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A1211","pred":"chebi_id","subj":"T1211","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A1212","pred":"chebi_id","subj":"T1212","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"subj":"T1170","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1171","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1172","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1173","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1174","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1175","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1176","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1177","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1179","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1184","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1186","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1187","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1188","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1189","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1190","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1192","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1193","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1194","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1195","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1196","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1201","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1203","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1205","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1210","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1211","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1212","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T371","span":{"begin":0,"end":6},"obj":"Sentence"},{"id":"T372","span":{"begin":7,"end":16},"obj":"Sentence"},{"id":"T373","span":{"begin":17,"end":157},"obj":"Sentence"},{"id":"T374","span":{"begin":158,"end":273},"obj":"Sentence"},{"id":"T375","span":{"begin":274,"end":380},"obj":"Sentence"},{"id":"T376","span":{"begin":381,"end":474},"obj":"Sentence"},{"id":"T377","span":{"begin":475,"end":550},"obj":"Sentence"},{"id":"T378","span":{"begin":551,"end":600},"obj":"Sentence"},{"id":"T379","span":{"begin":601,"end":756},"obj":"Sentence"},{"id":"T380","span":{"begin":757,"end":920},"obj":"Sentence"},{"id":"T381","span":{"begin":921,"end":1173},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T371","pred":"source","obj":"LitCovid-sentences"},{"subj":"T372","pred":"source","obj":"LitCovid-sentences"},{"subj":"T373","pred":"source","obj":"LitCovid-sentences"},{"subj":"T374","pred":"source","obj":"LitCovid-sentences"},{"subj":"T375","pred":"source","obj":"LitCovid-sentences"},{"subj":"T376","pred":"source","obj":"LitCovid-sentences"},{"subj":"T377","pred":"source","obj":"LitCovid-sentences"},{"subj":"T378","pred":"source","obj":"LitCovid-sentences"},{"subj":"T379","pred":"source","obj":"LitCovid-sentences"},{"subj":"T380","pred":"source","obj":"LitCovid-sentences"},{"subj":"T381","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32604730-19721004-51944022","span":{"begin":376,"end":378},"obj":"19721004"},{"id":"32604730-32007145-51944023","span":{"begin":523,"end":525},"obj":"32007145"},{"id":"32604730-23749172-51944024","span":{"begin":752,"end":754},"obj":"23749172"},{"id":"32604730-15507445-51944025","span":{"begin":916,"end":918},"obj":"15507445"},{"id":"T61681","span":{"begin":376,"end":378},"obj":"19721004"},{"id":"T84222","span":{"begin":523,"end":525},"obj":"32007145"},{"id":"T69975","span":{"begin":752,"end":754},"obj":"23749172"},{"id":"T70146","span":{"begin":916,"end":918},"obj":"15507445"}],"attributes":[{"subj":"32604730-19721004-51944022","pred":"source","obj":"2_test"},{"subj":"32604730-32007145-51944023","pred":"source","obj":"2_test"},{"subj":"32604730-23749172-51944024","pred":"source","obj":"2_test"},{"subj":"32604730-15507445-51944025","pred":"source","obj":"2_test"},{"subj":"T61681","pred":"source","obj":"2_test"},{"subj":"T84222","pred":"source","obj":"2_test"},{"subj":"T69975","pred":"source","obj":"2_test"},{"subj":"T70146","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid_Glycan-Motif-Structure","color":"#a4ec93","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#ec93be"},{"id":"LitCovid-PD-CLO","color":"#93d9ec"},{"id":"LitCovid-PD-CHEBI","color":"#ece593"},{"id":"LitCovid-sentences","color":"#cb93ec"},{"id":"2_test","color":"#93ecb1"}]}]}}