PMC:7352545 / 33312-34870
Annnotations
LitCovid_Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T136 | 78-80 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T137 | 129-131 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T138 | 349-351 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T139 | 714-716 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T140 | 796-798 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T141 | 858-860 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T142 | 1050-1052 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T143 | 1106-1108 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T144 | 1284-1286 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T145 | 1362-1364 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T146 | 1476-1478 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T263 | 190-202 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T264 | 368-378 | Body_part | denotes | Nucleotide | http://purl.org/sig/ont/fma/fma82740 |
| T265 | 392-396 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T266 | 462-474 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T267 | 542-552 | Body_part | denotes | nucleotide | http://purl.org/sig/ont/fma/fma82740 |
| T268 | 577-587 | Body_part | denotes | nucleotide | http://purl.org/sig/ont/fma/fma82740 |
| T269 | 641-653 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T270 | 739-751 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T271 | 781-788 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T272 | 836-848 | Body_part | denotes | goblet cells | http://purl.org/sig/ont/fma/fma13148 |
| T273 | 843-848 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T274 | 896-901 | Body_part | denotes | mucus | http://purl.org/sig/ont/fma/fma66938 |
| T275 | 915-925 | Body_part | denotes | intestinal | http://purl.org/sig/ont/fma/fma7199 |
| T276 | 926-937 | Body_part | denotes | enterocytes | http://purl.org/sig/ont/fma/fma62122 |
| T277 | 966-978 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T278 | 1075-1087 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T279 | 1355-1360 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T280 | 1414-1419 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T281 | 1537-1547 | Body_part | denotes | intestinal | http://purl.org/sig/ont/fma/fma7199 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T7 | 896-901 | Body_part | denotes | mucus | http://purl.obolibrary.org/obo/UBERON_0000912 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T123 | 1508-1517 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T124 | 1548-1557 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T445 | 48-56 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T446 | 93-101 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T447 | 217-220 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T448 | 290-293 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T449 | 392-396 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T450 | 538-541 | http://purl.obolibrary.org/obo/CLO_0001602 | denotes | a 6 |
| T451 | 538-541 | http://purl.obolibrary.org/obo/CLO_0001603 | denotes | a 6 |
| T452 | 538-541 | http://purl.obolibrary.org/obo/CLO_0050248 | denotes | a 6 |
| T453 | 538-541 | http://purl.obolibrary.org/obo/CLO_0052463 | denotes | a 6 |
| T454 | 759-760 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T455 | 843-848 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T456 | 876-881 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T457 | 915-925 | http://purl.obolibrary.org/obo/UBERON_0000160 | denotes | intestinal |
| T458 | 915-925 | http://www.ebi.ac.uk/efo/EFO_0000834 | denotes | intestinal |
| T459 | 994-997 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T460 | 1018-1026 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T461 | 1117-1125 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T462 | 1172-1175 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T463 | 1273-1278 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T464 | 1299-1307 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T465 | 1332-1337 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T466 | 1355-1360 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T467 | 1373-1381 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T468 | 1414-1419 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T469 | 1452-1453 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T470 | 1487-1495 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T471 | 1537-1547 | http://purl.obolibrary.org/obo/UBERON_0000160 | denotes | intestinal |
| T472 | 1537-1547 | http://www.ebi.ac.uk/efo/EFO_0000834 | denotes | intestinal |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T1001 | 45-47 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T1002 | 78-80 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1007 | 110-115 | Chemical | denotes | NeuGc | http://purl.obolibrary.org/obo/CHEBI_62084 |
| T1008 | 129-131 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1013 | 190-202 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T1014 | 349-351 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1019 | 368-378 | Chemical | denotes | Nucleotide | http://purl.obolibrary.org/obo/CHEBI_36976 |
| T1020 | 462-474 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T1021 | 542-552 | Chemical | denotes | nucleotide | http://purl.obolibrary.org/obo/CHEBI_36976 |
| T1022 | 577-587 | Chemical | denotes | nucleotide | http://purl.obolibrary.org/obo/CHEBI_36976 |
| T1023 | 641-653 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T1024 | 714-716 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1029 | 739-751 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T1030 | 781-788 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T1031 | 796-798 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1036 | 858-860 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1041 | 966-978 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T1042 | 1050-1052 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1047 | 1075-1087 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T1048 | 1106-1108 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1053 | 1188-1190 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T1054 | 1284-1286 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1059 | 1362-1364 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T1064 | 1476-1478 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T53 | 260-267 | http://purl.obolibrary.org/obo/GO_0009606 | denotes | tropism |
| T54 | 422-429 | http://purl.obolibrary.org/obo/GO_0009606 | denotes | tropism |
| T55 | 510-517 | http://purl.obolibrary.org/obo/GO_0009606 | denotes | tropism |
| T56 | 685-692 | http://purl.obolibrary.org/obo/GO_0009606 | denotes | tropism |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T327 | 0-20 | Sentence | denotes | 6.1.1. α-Coronavirus |
| T328 | 21-124 | Sentence | denotes | In α-CoVs such as TGEV, HA-activity is attributed to the SA-recognizing activity to α2,3-NeuGc [61,62]. |
| T329 | 125-211 | Sentence | denotes | The SA-binding site is present on the N-terminal region of the S-glycoprotein of TGEV. |
| T330 | 212-268 | Sentence | denotes | TGEV has two types with enteric and respiratory tropism. |
| T331 | 269-367 | Sentence | denotes | The respiratory TGEV has the porcine aminopeptidase N (pAPN)-binding domain and SA-binding domain. |
| T332 | 368-524 | Sentence | denotes | Nucleotide 655 of the S gene is essential for enteric tropism and the S219A mutation of the S glycoprotein confers the enteric to respiratory tropism shift. |
| T333 | 525-693 | Sentence | denotes | In addition, a 6-nucleotide insertional mutation at nucleotide 1124, which yields the Y374-T375insND shift of the S glycoprotein, causes enhanced enteric tract tropism. |
| T334 | 694-853 | Sentence | denotes | TGEV interacts with SA species on mucin-like glycoprotein (MGP), a highly glycosylated protein, in an SA-dependent manner, on mucin-secreting goblet cells [6]. |
| T335 | 854-938 | Sentence | denotes | MGP SA-binding allows virus entry via the mucus layer to the intestinal enterocytes. |
| T336 | 939-1093 | Sentence | denotes | Different from TGEV, the S glycoprotein of porcine CoV has no hemagglutination activity due to deletion of the SA-binding site of the S glycoprotein [61]. |
| T337 | 1094-1171 | Sentence | denotes | The loss of SA-binding activity is correlated to the non-enteropathogenicity. |
| T338 | 1172-1361 | Sentence | denotes | SAs function as HA-mediated entry determinants for TGEV, causing the enteropathogenic outcome of the virus, and SA-recognition activity is also responsible for virus amplification in cells. |
| T339 | 1362-1471 | Sentence | denotes | SA-binding activity-deficient TGEV can propagate in cells through pAPN, known as CD13, as a receptor [62,63]. |
| T340 | 1472-1558 | Sentence | denotes | The SA-binding activity potentiates infection and is crucial for intestinal infection. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32604730-8764078-51944005 | 117-119 | 8764078 | denotes | 61 |
| 32604730-9060696-51944006 | 120-122 | 9060696 | denotes | 62 |
| 32604730-14557669-51944007 | 850-851 | 14557669 | denotes | 6 |
| 32604730-8764078-51944008 | 1089-1091 | 8764078 | denotes | 61 |
| 32604730-9060696-51944009 | 1464-1466 | 9060696 | denotes | 62 |
| 32604730-10644848-51944010 | 1467-1469 | 10644848 | denotes | 63 |
| T88722 | 117-119 | 8764078 | denotes | 61 |
| T67423 | 120-122 | 9060696 | denotes | 62 |
| T29243 | 850-851 | 14557669 | denotes | 6 |
| T8143 | 1089-1091 | 8764078 | denotes | 61 |
| T44658 | 1464-1466 | 9060696 | denotes | 62 |
| T73054 | 1467-1469 | 10644848 | denotes | 63 |