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LitCovid_Glycan-Motif-Structure

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T121","span":{"begin":147,"end":149},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T122","span":{"begin":209,"end":211},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T123","span":{"begin":257,"end":263},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T124","span":{"begin":365,"end":367},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T125","span":{"begin":393,"end":395},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T126","span":{"begin":572,"end":574},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T127","span":{"begin":619,"end":621},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T128","span":{"begin":654,"end":656},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T129","span":{"begin":868,"end":870},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T130","span":{"begin":937,"end":939},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"}],"text":"The first coronaviral HE proteins identified were from the porcine hemagglutinating encephalomyelitis virus (PHEV), BCoV and HCoV-OC43, which bear SA-9-O-acetylesterases similar to HEF [8]. Rat CoV (RCoV) has SA-4-O-acetylesterases, converting Neu4,5Ac2 to Neu5Ac [53,57,58]. Some murine CoVs prefer 4-O-Ac-SAs and others 9-O-Ac-SAs. HCoV-OC43 and BCoV prefer α2-6-SA 9-O-acetylation by their SA-O-acetyleseterases. The S glycoproteins of BCoV and HCoV-OC43 are Neu5,9Ac2-recognizing lectins and agglutinate murine, rat and chicken erythrocytes due to the enriched 9-O-Ac-SA species [52]. BCoV and HCoV-OC43 adapted to SA receptor determinants of 9-O-Ac-SA receptors [59]. For a second receptor, the binding of S glycoprotein to Neu5,9Ac2 receptor is essential for entry into cells. BCoV-infection is prevented by prior treatment of cells with NA enzyme or with viral SA-O-acetylesterases, blocking the roles of HE and S glycoprotein in SA-dependent entry to host cells."}

LitCovid-PD-FMA-UBERON

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T253","span":{"begin":25,"end":33},"obj":"Body_part"},{"id":"T254","span":{"begin":422,"end":435},"obj":"Body_part"},{"id":"T255","span":{"begin":532,"end":544},"obj":"Body_part"},{"id":"T256","span":{"begin":713,"end":725},"obj":"Body_part"},{"id":"T257","span":{"begin":776,"end":781},"obj":"Body_part"},{"id":"T258","span":{"begin":833,"end":838},"obj":"Body_part"},{"id":"T259","span":{"begin":921,"end":933},"obj":"Body_part"},{"id":"T260","span":{"begin":964,"end":969},"obj":"Body_part"}],"attributes":[{"id":"A253","pred":"fma_id","subj":"T253","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A254","pred":"fma_id","subj":"T254","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A255","pred":"fma_id","subj":"T255","obj":"http://purl.org/sig/ont/fma/fma62845"},{"id":"A256","pred":"fma_id","subj":"T256","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A257","pred":"fma_id","subj":"T257","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A258","pred":"fma_id","subj":"T258","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A259","pred":"fma_id","subj":"T259","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A260","pred":"fma_id","subj":"T260","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"The first coronaviral HE proteins identified were from the porcine hemagglutinating encephalomyelitis virus (PHEV), BCoV and HCoV-OC43, which bear SA-9-O-acetylesterases similar to HEF [8]. Rat CoV (RCoV) has SA-4-O-acetylesterases, converting Neu4,5Ac2 to Neu5Ac [53,57,58]. Some murine CoVs prefer 4-O-Ac-SAs and others 9-O-Ac-SAs. HCoV-OC43 and BCoV prefer α2-6-SA 9-O-acetylation by their SA-O-acetyleseterases. The S glycoproteins of BCoV and HCoV-OC43 are Neu5,9Ac2-recognizing lectins and agglutinate murine, rat and chicken erythrocytes due to the enriched 9-O-Ac-SA species [52]. BCoV and HCoV-OC43 adapted to SA receptor determinants of 9-O-Ac-SA receptors [59]. For a second receptor, the binding of S glycoprotein to Neu5,9Ac2 receptor is essential for entry into cells. BCoV-infection is prevented by prior treatment of cells with NA enzyme or with viral SA-O-acetylesterases, blocking the roles of HE and S glycoprotein in SA-dependent entry to host cells."}

LitCovid-PD-MONDO

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T115","span":{"begin":84,"end":101},"obj":"Disease"},{"id":"T116","span":{"begin":788,"end":797},"obj":"Disease"}],"attributes":[{"id":"A115","pred":"mondo_id","subj":"T115","obj":"http://purl.obolibrary.org/obo/MONDO_0005156"},{"id":"A116","pred":"mondo_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"The first coronaviral HE proteins identified were from the porcine hemagglutinating encephalomyelitis virus (PHEV), BCoV and HCoV-OC43, which bear SA-9-O-acetylesterases similar to HEF [8]. Rat CoV (RCoV) has SA-4-O-acetylesterases, converting Neu4,5Ac2 to Neu5Ac [53,57,58]. Some murine CoVs prefer 4-O-Ac-SAs and others 9-O-Ac-SAs. HCoV-OC43 and BCoV prefer α2-6-SA 9-O-acetylation by their SA-O-acetyleseterases. The S glycoproteins of BCoV and HCoV-OC43 are Neu5,9Ac2-recognizing lectins and agglutinate murine, rat and chicken erythrocytes due to the enriched 9-O-Ac-SA species [52]. BCoV and HCoV-OC43 adapted to SA receptor determinants of 9-O-Ac-SA receptors [59]. For a second receptor, the binding of S glycoprotein to Neu5,9Ac2 receptor is essential for entry into cells. BCoV-infection is prevented by prior treatment of cells with NA enzyme or with viral SA-O-acetylesterases, blocking the roles of HE and S glycoprotein in SA-dependent entry to host cells."}

LitCovid-PD-CLO

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T422","span":{"begin":102,"end":107},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T423","span":{"begin":205,"end":208},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T424","span":{"begin":307,"end":310},"obj":"http://purl.obolibrary.org/obo/CLO_0051568"},{"id":"T425","span":{"begin":329,"end":332},"obj":"http://purl.obolibrary.org/obo/CLO_0051568"},{"id":"T426","span":{"begin":524,"end":531},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9031"},{"id":"T427","span":{"begin":532,"end":544},"obj":"http://purl.obolibrary.org/obo/CL_0000232"},{"id":"T428","span":{"begin":584,"end":586},"obj":"http://purl.obolibrary.org/obo/CLO_0001407"},{"id":"T429","span":{"begin":677,"end":678},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T430","span":{"begin":776,"end":781},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T431","span":{"begin":833,"end":838},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T432","span":{"begin":964,"end":969},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"The first coronaviral HE proteins identified were from the porcine hemagglutinating encephalomyelitis virus (PHEV), BCoV and HCoV-OC43, which bear SA-9-O-acetylesterases similar to HEF [8]. Rat CoV (RCoV) has SA-4-O-acetylesterases, converting Neu4,5Ac2 to Neu5Ac [53,57,58]. Some murine CoVs prefer 4-O-Ac-SAs and others 9-O-Ac-SAs. HCoV-OC43 and BCoV prefer α2-6-SA 9-O-acetylation by their SA-O-acetyleseterases. The S glycoproteins of BCoV and HCoV-OC43 are Neu5,9Ac2-recognizing lectins and agglutinate murine, rat and chicken erythrocytes due to the enriched 9-O-Ac-SA species [52]. BCoV and HCoV-OC43 adapted to SA receptor determinants of 9-O-Ac-SA receptors [59]. For a second receptor, the binding of S glycoprotein to Neu5,9Ac2 receptor is essential for entry into cells. BCoV-infection is prevented by prior treatment of cells with NA enzyme or with viral SA-O-acetylesterases, blocking the roles of HE and S glycoprotein in SA-dependent entry to host cells."}

LitCovid-PD-CHEBI

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T52","span":{"begin":950,"end":963},"obj":"http://purl.obolibrary.org/obo/GO_0044409"}],"text":"The first coronaviral HE proteins identified were from the porcine hemagglutinating encephalomyelitis virus (PHEV), BCoV and HCoV-OC43, which bear SA-9-O-acetylesterases similar to HEF [8]. Rat CoV (RCoV) has SA-4-O-acetylesterases, converting Neu4,5Ac2 to Neu5Ac [53,57,58]. Some murine CoVs prefer 4-O-Ac-SAs and others 9-O-Ac-SAs. HCoV-OC43 and BCoV prefer α2-6-SA 9-O-acetylation by their SA-O-acetyleseterases. The S glycoproteins of BCoV and HCoV-OC43 are Neu5,9Ac2-recognizing lectins and agglutinate murine, rat and chicken erythrocytes due to the enriched 9-O-Ac-SA species [52]. BCoV and HCoV-OC43 adapted to SA receptor determinants of 9-O-Ac-SA receptors [59]. For a second receptor, the binding of S glycoprotein to Neu5,9Ac2 receptor is essential for entry into cells. BCoV-infection is prevented by prior treatment of cells with NA enzyme or with viral SA-O-acetylesterases, blocking the roles of HE and S glycoprotein in SA-dependent entry to host cells."}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T309","span":{"begin":0,"end":189},"obj":"Sentence"},{"id":"T310","span":{"begin":190,"end":275},"obj":"Sentence"},{"id":"T311","span":{"begin":276,"end":333},"obj":"Sentence"},{"id":"T312","span":{"begin":334,"end":415},"obj":"Sentence"},{"id":"T313","span":{"begin":416,"end":588},"obj":"Sentence"},{"id":"T314","span":{"begin":589,"end":672},"obj":"Sentence"},{"id":"T315","span":{"begin":673,"end":782},"obj":"Sentence"},{"id":"T316","span":{"begin":783,"end":970},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The first coronaviral HE proteins identified were from the porcine hemagglutinating encephalomyelitis virus (PHEV), BCoV and HCoV-OC43, which bear SA-9-O-acetylesterases similar to HEF [8]. Rat CoV (RCoV) has SA-4-O-acetylesterases, converting Neu4,5Ac2 to Neu5Ac [53,57,58]. Some murine CoVs prefer 4-O-Ac-SAs and others 9-O-Ac-SAs. HCoV-OC43 and BCoV prefer α2-6-SA 9-O-acetylation by their SA-O-acetyleseterases. The S glycoproteins of BCoV and HCoV-OC43 are Neu5,9Ac2-recognizing lectins and agglutinate murine, rat and chicken erythrocytes due to the enriched 9-O-Ac-SA species [52]. BCoV and HCoV-OC43 adapted to SA receptor determinants of 9-O-Ac-SA receptors [59]. For a second receptor, the binding of S glycoprotein to Neu5,9Ac2 receptor is essential for entry into cells. BCoV-infection is prevented by prior treatment of cells with NA enzyme or with viral SA-O-acetylesterases, blocking the roles of HE and S glycoprotein in SA-dependent entry to host cells."}

2_test

{"project":"2_test","denotations":[{"id":"32604730-3380803-51944000","span":{"begin":186,"end":187},"obj":"3380803"},{"id":"32604730-10233932-51944001","span":{"begin":265,"end":267},"obj":"10233932"},{"id":"32604730-11807232-51944002","span":{"begin":268,"end":270},"obj":"11807232"},{"id":"32604730-1920630-51944003","span":{"begin":584,"end":586},"obj":"1920630"},{"id":"32604730-1321878-51944004","span":{"begin":668,"end":670},"obj":"1321878"},{"id":"T74157","span":{"begin":186,"end":187},"obj":"3380803"},{"id":"T77726","span":{"begin":265,"end":267},"obj":"10233932"},{"id":"T52426","span":{"begin":268,"end":270},"obj":"11807232"},{"id":"T22208","span":{"begin":584,"end":586},"obj":"1920630"},{"id":"T60367","span":{"begin":668,"end":670},"obj":"1321878"}],"text":"The first coronaviral HE proteins identified were from the porcine hemagglutinating encephalomyelitis virus (PHEV), BCoV and HCoV-OC43, which bear SA-9-O-acetylesterases similar to HEF [8]. Rat CoV (RCoV) has SA-4-O-acetylesterases, converting Neu4,5Ac2 to Neu5Ac [53,57,58]. Some murine CoVs prefer 4-O-Ac-SAs and others 9-O-Ac-SAs. HCoV-OC43 and BCoV prefer α2-6-SA 9-O-acetylation by their SA-O-acetyleseterases. The S glycoproteins of BCoV and HCoV-OC43 are Neu5,9Ac2-recognizing lectins and agglutinate murine, rat and chicken erythrocytes due to the enriched 9-O-Ac-SA species [52]. BCoV and HCoV-OC43 adapted to SA receptor determinants of 9-O-Ac-SA receptors [59]. For a second receptor, the binding of S glycoprotein to Neu5,9Ac2 receptor is essential for entry into cells. BCoV-infection is prevented by prior treatment of cells with NA enzyme or with viral SA-O-acetylesterases, blocking the roles of HE and S glycoprotein in SA-dependent entry to host cells."}

PMC:7352545 / 31565-32535 JSONTXT

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PMC:7352545 / 31565-32535 JSON TXT