PMC:7352545 / 30060-31564
Annnotations
LitCovid_Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T114 | 106-108 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T115 | 170-172 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T116 | 878-880 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T117 | 973-975 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T118 | 1244-1246 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T119 | 1400-1402 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T120 | 1463-1465 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T249 | 330-342 | Body_part | denotes | carbohydrate | http://purl.org/sig/ont/fma/fma82737 |
| T250 | 353-361 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T251 | 575-579 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T252 | 643-647 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T113 | 471-480 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T114 | 704-713 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T398 | 45-48 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T399 | 57-60 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T400 | 97-100 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T401 | 263-264 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T402 | 270-271 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T403 | 408-415 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T404 | 481-486 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T405 | 554-555 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T406 | 575-579 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T407 | 599-600 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T408 | 615-616 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T409 | 643-647 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T410 | 662-665 | http://purl.obolibrary.org/obo/CLO_0001618 | denotes | a 9 |
| T411 | 662-665 | http://purl.obolibrary.org/obo/CLO_0001619 | denotes | a 9 |
| T412 | 662-665 | http://purl.obolibrary.org/obo/CLO_0001620 | denotes | a 9 |
| T413 | 714-719 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T414 | 947-952 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T415 | 1060-1063 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T416 | 1079-1080 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T417 | 1120-1121 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T418 | 1150-1151 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T419 | 1218-1219 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T420 | 1335-1340 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T421 | 1487-1492 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T857 | 54-56 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T859 | 68-70 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T860 | 94-96 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T862 | 106-108 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T867 | 170-172 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T872 | 330-342 | Chemical | denotes | carbohydrate | http://purl.obolibrary.org/obo/CHEBI_16646 |
| T873 | 353-361 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T874 | 668-670 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T876 | 878-880 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T881 | 892-899 | Chemical | denotes | glycans | http://purl.obolibrary.org/obo/CHEBI_18154 |
| T882 | 973-975 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T887 | 1057-1059 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T889 | 1241-1243 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T891 | 1244-1246 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T896 | 1341-1346 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T897 | 1397-1399 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T899 | 1400-1402 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T904 | 1460-1462 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T906 | 1463-1465 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T911 | 1472-1474 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T912 | 1493-1498 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T298 | 0-62 | Sentence | denotes | Type I HE is specific for the 9-O-acetylated SAs (9-O-Ac-SAs). |
| T299 | 63-101 | Sentence | denotes | Type II HE is specific for 4-O-Ac-SAs. |
| T300 | 102-226 | Sentence | denotes | The SA-binding shift indicates quasi-synchronous adaptations of the SA-recognition sites of the lectin and esterase domains. |
| T301 | 227-362 | Sentence | denotes | Type I HE monomers of β-CoV lineage A have a bimodular enzyme–lectin domain similar to cellular glycan/carbohydrate-modifying proteins. |
| T302 | 363-567 | Sentence | denotes | Originally, HE homologs are found in various viruses including toroviruses and orthomyxoviruses such as the influenza virus C/D and isavirus, as well as the exceptional case of β-CoV lineage A among CoVs. |
| T303 | 568-724 | Sentence | denotes | The HE gene was transmitted to a β-CoV lineage A progenitor via horizontal gene transfer from a 9-O-Ac-Sia–recognizing HEF, as shown in influenza virus C/D. |
| T304 | 725-900 | Sentence | denotes | HE acquisition and expansion occurred by cross-species transmission over HE evolution and this phenomenon reflects viral evolutionary adaptation to host SA-containing glycans. |
| T305 | 901-1013 | Sentence | denotes | Therefore, CoV HE receptor switching precedes virus evolution driven by SA-containing glycan diversity of hosts. |
| T306 | 1014-1115 | Sentence | denotes | For instance, the BcoV HE prefers 7,9-di-O-Ac-SAs, which is also a target of the bovine torovirus HE. |
| T307 | 1116-1259 | Sentence | denotes | For a more outstanding case, such a switching event occurred in the murine CoVs for the β-CoV lineage A type switch toward O-Ac-SA recognition. |
| T308 | 1260-1504 | Sentence | denotes | In the HE specificity of murine CoVs, two different murine CoV subtypes of virus group exist with one subtype possessing the typical 9-O-Ac-SA (type I) attachment factor and the other exclusively 4-O-Ac-SA (type II) attachment virus group [56]. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32604730-27185912-51943999 | 1500-1502 | 27185912 | denotes | 56 |
| T81483 | 1500-1502 | 27185912 | denotes | 56 |