PMC:7352545 / 28726-30059 JSONTXT

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T103","span":{"begin":130,"end":132},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T104","span":{"begin":187,"end":189},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T105","span":{"begin":259,"end":261},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T106","span":{"begin":745,"end":747},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T107","span":{"begin":765,"end":767},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T108","span":{"begin":963,"end":969},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T109","span":{"begin":1023,"end":1029},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T110","span":{"begin":1074,"end":1080},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T111","span":{"begin":1163,"end":1169},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T112","span":{"begin":1227,"end":1233},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T113","span":{"begin":1301,"end":1307},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"}],"text":"HEs as envelope proteins are found in CoVs, orthomyxoviruses and toroviruses. Coronaviral HEs are involved in virus attachment to SA species. HE protein in β-CoVs binds to Neu5,9Ac2 form SA and agglutinates the red blood cells (RBCs) of rodents [52]. As with SA-O-acetylesterase, HE potentiates viral entry with the S protein and spreading via the mucosal glycans. It contains a carbohydrate-recognizing domain (CRD) known in lectin. The HE glycan-binding domain (GBD) mediates virus attachment to SAs on host cells. HE is the only HA. This indicates that compared to the S glycoprotein, HE is only minor a HA and the S glycoprotein mainly attaches to the cell surface. The HE protein of murine hepatitis virus (MHV), an enveloped CoV, binds to SA-4-acetylester or SA-9-O-acetylester of the carcinoembryonic antigen cell adhesion molecule 1a (CEACAM; known as CD66a) as the key receptor [53]. Murine CoVs HEs acquired by horizontal gene transfer, bind to C9-O-Ac Neu5Ac. However, some murine CoV HEs cannot bind to C4-O-Ac Neu5Ac. The original mouse MHV HE binds to C9-O-Ac Neu5Ac, while the MHV S-strain HE evolutionarily acquired the ability to bind to C4-O-Ac Neu5Ac [12,53,54]. In terms of structure, the C5 N- and C9 O-Ac Neu5Ac-accomodating hydrophobic pocket was shifted to a C5 N- and C4-O-Ac Neu5Ac-accomodating pocket [55]."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T234","span":{"begin":16,"end":24},"obj":"Body_part"},{"id":"T235","span":{"begin":145,"end":152},"obj":"Body_part"},{"id":"T236","span":{"begin":211,"end":226},"obj":"Body_part"},{"id":"T237","span":{"begin":221,"end":226},"obj":"Body_part"},{"id":"T238","span":{"begin":318,"end":325},"obj":"Body_part"},{"id":"T239","span":{"begin":379,"end":391},"obj":"Body_part"},{"id":"T240","span":{"begin":510,"end":515},"obj":"Body_part"},{"id":"T241","span":{"begin":574,"end":586},"obj":"Body_part"},{"id":"T242","span":{"begin":620,"end":632},"obj":"Body_part"},{"id":"T243","span":{"begin":656,"end":668},"obj":"Body_part"},{"id":"T244","span":{"begin":656,"end":660},"obj":"Body_part"},{"id":"T245","span":{"begin":677,"end":684},"obj":"Body_part"},{"id":"T246","span":{"begin":816,"end":838},"obj":"Body_part"},{"id":"T247","span":{"begin":816,"end":820},"obj":"Body_part"},{"id":"T248","span":{"begin":932,"end":936},"obj":"Body_part"}],"attributes":[{"id":"A234","pred":"fma_id","subj":"T234","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A235","pred":"fma_id","subj":"T235","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A236","pred":"fma_id","subj":"T236","obj":"http://purl.org/sig/ont/fma/fma62845"},{"id":"A237","pred":"fma_id","subj":"T237","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A238","pred":"fma_id","subj":"T238","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A239","pred":"fma_id","subj":"T239","obj":"http://purl.org/sig/ont/fma/fma82737"},{"id":"A240","pred":"fma_id","subj":"T240","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A241","pred":"fma_id","subj":"T241","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A242","pred":"fma_id","subj":"T242","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A243","pred":"fma_id","subj":"T243","obj":"http://purl.org/sig/ont/fma/fma67653"},{"id":"A244","pred":"fma_id","subj":"T244","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A245","pred":"fma_id","subj":"T245","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A246","pred":"fma_id","subj":"T246","obj":"http://purl.org/sig/ont/fma/fma67214"},{"id":"A247","pred":"fma_id","subj":"T247","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A248","pred":"fma_id","subj":"T248","obj":"http://purl.org/sig/ont/fma/fma74402"}],"text":"HEs as envelope proteins are found in CoVs, orthomyxoviruses and toroviruses. Coronaviral HEs are involved in virus attachment to SA species. HE protein in β-CoVs binds to Neu5,9Ac2 form SA and agglutinates the red blood cells (RBCs) of rodents [52]. As with SA-O-acetylesterase, HE potentiates viral entry with the S protein and spreading via the mucosal glycans. It contains a carbohydrate-recognizing domain (CRD) known in lectin. The HE glycan-binding domain (GBD) mediates virus attachment to SAs on host cells. HE is the only HA. This indicates that compared to the S glycoprotein, HE is only minor a HA and the S glycoprotein mainly attaches to the cell surface. The HE protein of murine hepatitis virus (MHV), an enveloped CoV, binds to SA-4-acetylester or SA-9-O-acetylester of the carcinoembryonic antigen cell adhesion molecule 1a (CEACAM; known as CD66a) as the key receptor [53]. Murine CoVs HEs acquired by horizontal gene transfer, bind to C9-O-Ac Neu5Ac. However, some murine CoV HEs cannot bind to C4-O-Ac Neu5Ac. The original mouse MHV HE binds to C9-O-Ac Neu5Ac, while the MHV S-strain HE evolutionarily acquired the ability to bind to C4-O-Ac Neu5Ac [12,53,54]. In terms of structure, the C5 N- and C9 O-Ac Neu5Ac-accomodating hydrophobic pocket was shifted to a C5 N- and C4-O-Ac Neu5Ac-accomodating pocket [55]."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T6","span":{"begin":215,"end":220},"obj":"Body_part"}],"attributes":[{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"}],"text":"HEs as envelope proteins are found in CoVs, orthomyxoviruses and toroviruses. Coronaviral HEs are involved in virus attachment to SA species. HE protein in β-CoVs binds to Neu5,9Ac2 form SA and agglutinates the red blood cells (RBCs) of rodents [52]. As with SA-O-acetylesterase, HE potentiates viral entry with the S protein and spreading via the mucosal glycans. It contains a carbohydrate-recognizing domain (CRD) known in lectin. The HE glycan-binding domain (GBD) mediates virus attachment to SAs on host cells. HE is the only HA. This indicates that compared to the S glycoprotein, HE is only minor a HA and the S glycoprotein mainly attaches to the cell surface. The HE protein of murine hepatitis virus (MHV), an enveloped CoV, binds to SA-4-acetylester or SA-9-O-acetylester of the carcinoembryonic antigen cell adhesion molecule 1a (CEACAM; known as CD66a) as the key receptor [53]. Murine CoVs HEs acquired by horizontal gene transfer, bind to C9-O-Ac Neu5Ac. However, some murine CoV HEs cannot bind to C4-O-Ac Neu5Ac. The original mouse MHV HE binds to C9-O-Ac Neu5Ac, while the MHV S-strain HE evolutionarily acquired the ability to bind to C4-O-Ac Neu5Ac [12,53,54]. In terms of structure, the C5 N- and C9 O-Ac Neu5Ac-accomodating hydrophobic pocket was shifted to a C5 N- and C4-O-Ac Neu5Ac-accomodating pocket [55]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T112","span":{"begin":695,"end":704},"obj":"Disease"}],"attributes":[{"id":"A112","pred":"mondo_id","subj":"T112","obj":"http://purl.obolibrary.org/obo/MONDO_0002251"}],"text":"HEs as envelope proteins are found in CoVs, orthomyxoviruses and toroviruses. Coronaviral HEs are involved in virus attachment to SA species. HE protein in β-CoVs binds to Neu5,9Ac2 form SA and agglutinates the red blood cells (RBCs) of rodents [52]. As with SA-O-acetylesterase, HE potentiates viral entry with the S protein and spreading via the mucosal glycans. It contains a carbohydrate-recognizing domain (CRD) known in lectin. The HE glycan-binding domain (GBD) mediates virus attachment to SAs on host cells. HE is the only HA. This indicates that compared to the S glycoprotein, HE is only minor a HA and the S glycoprotein mainly attaches to the cell surface. The HE protein of murine hepatitis virus (MHV), an enveloped CoV, binds to SA-4-acetylester or SA-9-O-acetylester of the carcinoembryonic antigen cell adhesion molecule 1a (CEACAM; known as CD66a) as the key receptor [53]. Murine CoVs HEs acquired by horizontal gene transfer, bind to C9-O-Ac Neu5Ac. However, some murine CoV HEs cannot bind to C4-O-Ac Neu5Ac. The original mouse MHV HE binds to C9-O-Ac Neu5Ac, while the MHV S-strain HE evolutionarily acquired the ability to bind to C4-O-Ac Neu5Ac [12,53,54]. In terms of structure, the C5 N- and C9 O-Ac Neu5Ac-accomodating hydrophobic pocket was shifted to a C5 N- and C4-O-Ac Neu5Ac-accomodating pocket [55]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T376","span":{"begin":0,"end":3},"obj":"http://purl.obolibrary.org/obo/CLO_0053120"},{"id":"T377","span":{"begin":90,"end":93},"obj":"http://purl.obolibrary.org/obo/CLO_0053120"},{"id":"T378","span":{"begin":110,"end":115},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T379","span":{"begin":211,"end":226},"obj":"http://purl.obolibrary.org/obo/CL_0000232"},{"id":"T380","span":{"begin":246,"end":248},"obj":"http://purl.obolibrary.org/obo/CLO_0001407"},{"id":"T381","span":{"begin":377,"end":378},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T382","span":{"begin":478,"end":483},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T383","span":{"begin":498,"end":501},"obj":"http://purl.obolibrary.org/obo/CLO_0051568"},{"id":"T384","span":{"begin":510,"end":515},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T385","span":{"begin":605,"end":606},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T386","span":{"begin":656,"end":660},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T387","span":{"begin":705,"end":710},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T388","span":{"begin":816,"end":820},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T389","span":{"begin":905,"end":908},"obj":"http://purl.obolibrary.org/obo/CLO_0053120"},{"id":"T390","span":{"begin":932,"end":936},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T391","span":{"begin":996,"end":999},"obj":"http://purl.obolibrary.org/obo/CLO_0053120"},{"id":"T392","span":{"begin":1015,"end":1017},"obj":"http://purl.obolibrary.org/obo/CLO_0037284"},{"id":"T393","span":{"begin":1044,"end":1049},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T394","span":{"begin":1155,"end":1157},"obj":"http://purl.obolibrary.org/obo/CLO_0037284"},{"id":"T395","span":{"begin":1209,"end":1211},"obj":"http://purl.obolibrary.org/obo/CLO_0002131"},{"id":"T396","span":{"begin":1281,"end":1285},"obj":"http://purl.obolibrary.org/obo/CLO_0053061"},{"id":"T397","span":{"begin":1293,"end":1295},"obj":"http://purl.obolibrary.org/obo/CLO_0037284"}],"text":"HEs as envelope proteins are found in CoVs, orthomyxoviruses and toroviruses. Coronaviral HEs are involved in virus attachment to SA species. HE protein in β-CoVs binds to Neu5,9Ac2 form SA and agglutinates the red blood cells (RBCs) of rodents [52]. As with SA-O-acetylesterase, HE potentiates viral entry with the S protein and spreading via the mucosal glycans. It contains a carbohydrate-recognizing domain (CRD) known in lectin. The HE glycan-binding domain (GBD) mediates virus attachment to SAs on host cells. HE is the only HA. This indicates that compared to the S glycoprotein, HE is only minor a HA and the S glycoprotein mainly attaches to the cell surface. The HE protein of murine hepatitis virus (MHV), an enveloped CoV, binds to SA-4-acetylester or SA-9-O-acetylester of the carcinoembryonic antigen cell adhesion molecule 1a (CEACAM; known as CD66a) as the key receptor [53]. Murine CoVs HEs acquired by horizontal gene transfer, bind to C9-O-Ac Neu5Ac. However, some murine CoV HEs cannot bind to C4-O-Ac Neu5Ac. The original mouse MHV HE binds to C9-O-Ac Neu5Ac, while the MHV S-strain HE evolutionarily acquired the ability to bind to C4-O-Ac Neu5Ac [12,53,54]. In terms of structure, the C5 N- and C9 O-Ac Neu5Ac-accomodating hydrophobic pocket was shifted to a C5 N- and C4-O-Ac Neu5Ac-accomodating pocket [55]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T796","span":{"begin":16,"end":24},"obj":"Chemical"},{"id":"T797","span":{"begin":130,"end":132},"obj":"Chemical"},{"id":"T802","span":{"begin":145,"end":152},"obj":"Chemical"},{"id":"T803","span":{"begin":187,"end":189},"obj":"Chemical"},{"id":"T808","span":{"begin":259,"end":261},"obj":"Chemical"},{"id":"T813","span":{"begin":318,"end":325},"obj":"Chemical"},{"id":"T814","span":{"begin":356,"end":363},"obj":"Chemical"},{"id":"T815","span":{"begin":379,"end":391},"obj":"Chemical"},{"id":"T816","span":{"begin":532,"end":534},"obj":"Chemical"},{"id":"T817","span":{"begin":574,"end":586},"obj":"Chemical"},{"id":"T818","span":{"begin":607,"end":609},"obj":"Chemical"},{"id":"T819","span":{"begin":620,"end":632},"obj":"Chemical"},{"id":"T820","span":{"begin":677,"end":684},"obj":"Chemical"},{"id":"T821","span":{"begin":745,"end":747},"obj":"Chemical"},{"id":"T826","span":{"begin":765,"end":767},"obj":"Chemical"},{"id":"T831","span":{"begin":808,"end":815},"obj":"Chemical"},{"id":"T832","span":{"begin":830,"end":838},"obj":"Chemical"},{"id":"T833","span":{"begin":960,"end":962},"obj":"Chemical"},{"id":"T835","span":{"begin":963,"end":969},"obj":"Chemical"},{"id":"T837","span":{"begin":1020,"end":1022},"obj":"Chemical"},{"id":"T839","span":{"begin":1023,"end":1029},"obj":"Chemical"},{"id":"T841","span":{"begin":1071,"end":1073},"obj":"Chemical"},{"id":"T843","span":{"begin":1074,"end":1080},"obj":"Chemical"},{"id":"T845","span":{"begin":1160,"end":1162},"obj":"Chemical"},{"id":"T847","span":{"begin":1163,"end":1169},"obj":"Chemical"},{"id":"T849","span":{"begin":1224,"end":1226},"obj":"Chemical"},{"id":"T851","span":{"begin":1227,"end":1233},"obj":"Chemical"},{"id":"T853","span":{"begin":1298,"end":1300},"obj":"Chemical"},{"id":"T855","span":{"begin":1301,"end":1307},"obj":"Chemical"}],"attributes":[{"id":"A796","pred":"chebi_id","subj":"T796","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A797","pred":"chebi_id","subj":"T797","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A798","pred":"chebi_id","subj":"T797","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A799","pred":"chebi_id","subj":"T797","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A800","pred":"chebi_id","subj":"T797","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A801","pred":"chebi_id","subj":"T797","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A802","pred":"chebi_id","subj":"T802","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A803","pred":"chebi_id","subj":"T803","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A804","pred":"chebi_id","subj":"T803","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A805","pred":"chebi_id","subj":"T803","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A806","pred":"chebi_id","subj":"T803","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A807","pred":"chebi_id","subj":"T803","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A808","pred":"chebi_id","subj":"T808","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A809","pred":"chebi_id","subj":"T808","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A810","pred":"chebi_id","subj":"T808","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A811","pred":"chebi_id","subj":"T808","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A812","pred":"chebi_id","subj":"T808","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A813","pred":"chebi_id","subj":"T813","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A814","pred":"chebi_id","subj":"T814","obj":"http://purl.obolibrary.org/obo/CHEBI_18154"},{"id":"A815","pred":"chebi_id","subj":"T815","obj":"http://purl.obolibrary.org/obo/CHEBI_16646"},{"id":"A816","pred":"chebi_id","subj":"T816","obj":"http://purl.obolibrary.org/obo/CHEBI_73924"},{"id":"A817","pred":"chebi_id","subj":"T817","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A818","pred":"chebi_id","subj":"T818","obj":"http://purl.obolibrary.org/obo/CHEBI_73924"},{"id":"A819","pred":"chebi_id","subj":"T819","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A820","pred":"chebi_id","subj":"T820","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A821","pred":"chebi_id","subj":"T821","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A822","pred":"chebi_id","subj":"T821","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A823","pred":"chebi_id","subj":"T821","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A824","pred":"chebi_id","subj":"T821","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A825","pred":"chebi_id","subj":"T821","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A826","pred":"chebi_id","subj":"T826","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A827","pred":"chebi_id","subj":"T826","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A828","pred":"chebi_id","subj":"T826","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A829","pred":"chebi_id","subj":"T826","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A830","pred":"chebi_id","subj":"T826","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A831","pred":"chebi_id","subj":"T831","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A832","pred":"chebi_id","subj":"T832","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A833","pred":"chebi_id","subj":"T833","obj":"http://purl.obolibrary.org/obo/CHEBI_33337"},{"id":"A834","pred":"chebi_id","subj":"T833","obj":"http://purl.obolibrary.org/obo/CHEBI_40574"},{"id":"A835","pred":"chebi_id","subj":"T835","obj":"http://purl.obolibrary.org/obo/CHEBI_17012"},{"id":"A836","pred":"chebi_id","subj":"T835","obj":"http://purl.obolibrary.org/obo/CHEBI_75133"},{"id":"A837","pred":"chebi_id","subj":"T837","obj":"http://purl.obolibrary.org/obo/CHEBI_33337"},{"id":"A838","pred":"chebi_id","subj":"T837","obj":"http://purl.obolibrary.org/obo/CHEBI_40574"},{"id":"A839","pred":"chebi_id","subj":"T839","obj":"http://purl.obolibrary.org/obo/CHEBI_17012"},{"id":"A840","pred":"chebi_id","subj":"T839","obj":"http://purl.obolibrary.org/obo/CHEBI_75133"},{"id":"A841","pred":"chebi_id","subj":"T841","obj":"http://purl.obolibrary.org/obo/CHEBI_33337"},{"id":"A842","pred":"chebi_id","subj":"T841","obj":"http://purl.obolibrary.org/obo/CHEBI_40574"},{"id":"A843","pred":"chebi_id","subj":"T843","obj":"http://purl.obolibrary.org/obo/CHEBI_17012"},{"id":"A844","pred":"chebi_id","subj":"T843","obj":"http://purl.obolibrary.org/obo/CHEBI_75133"},{"id":"A845","pred":"chebi_id","subj":"T845","obj":"http://purl.obolibrary.org/obo/CHEBI_33337"},{"id":"A846","pred":"chebi_id","subj":"T845","obj":"http://purl.obolibrary.org/obo/CHEBI_40574"},{"id":"A847","pred":"chebi_id","subj":"T847","obj":"http://purl.obolibrary.org/obo/CHEBI_17012"},{"id":"A848","pred":"chebi_id","subj":"T847","obj":"http://purl.obolibrary.org/obo/CHEBI_75133"},{"id":"A849","pred":"chebi_id","subj":"T849","obj":"http://purl.obolibrary.org/obo/CHEBI_33337"},{"id":"A850","pred":"chebi_id","subj":"T849","obj":"http://purl.obolibrary.org/obo/CHEBI_40574"},{"id":"A851","pred":"chebi_id","subj":"T851","obj":"http://purl.obolibrary.org/obo/CHEBI_17012"},{"id":"A852","pred":"chebi_id","subj":"T851","obj":"http://purl.obolibrary.org/obo/CHEBI_75133"},{"id":"A853","pred":"chebi_id","subj":"T853","obj":"http://purl.obolibrary.org/obo/CHEBI_33337"},{"id":"A854","pred":"chebi_id","subj":"T853","obj":"http://purl.obolibrary.org/obo/CHEBI_40574"},{"id":"A855","pred":"chebi_id","subj":"T855","obj":"http://purl.obolibrary.org/obo/CHEBI_17012"},{"id":"A856","pred":"chebi_id","subj":"T855","obj":"http://purl.obolibrary.org/obo/CHEBI_75133"}],"text":"HEs as envelope proteins are found in CoVs, orthomyxoviruses and toroviruses. Coronaviral HEs are involved in virus attachment to SA species. HE protein in β-CoVs binds to Neu5,9Ac2 form SA and agglutinates the red blood cells (RBCs) of rodents [52]. As with SA-O-acetylesterase, HE potentiates viral entry with the S protein and spreading via the mucosal glycans. It contains a carbohydrate-recognizing domain (CRD) known in lectin. The HE glycan-binding domain (GBD) mediates virus attachment to SAs on host cells. HE is the only HA. This indicates that compared to the S glycoprotein, HE is only minor a HA and the S glycoprotein mainly attaches to the cell surface. The HE protein of murine hepatitis virus (MHV), an enveloped CoV, binds to SA-4-acetylester or SA-9-O-acetylester of the carcinoembryonic antigen cell adhesion molecule 1a (CEACAM; known as CD66a) as the key receptor [53]. Murine CoVs HEs acquired by horizontal gene transfer, bind to C9-O-Ac Neu5Ac. However, some murine CoV HEs cannot bind to C4-O-Ac Neu5Ac. The original mouse MHV HE binds to C9-O-Ac Neu5Ac, while the MHV S-strain HE evolutionarily acquired the ability to bind to C4-O-Ac Neu5Ac [12,53,54]. In terms of structure, the C5 N- and C9 O-Ac Neu5Ac-accomodating hydrophobic pocket was shifted to a C5 N- and C4-O-Ac Neu5Ac-accomodating pocket [55]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T50","span":{"begin":816,"end":838},"obj":"http://purl.obolibrary.org/obo/GO_0098631"},{"id":"T51","span":{"begin":816,"end":829},"obj":"http://purl.obolibrary.org/obo/GO_0007155"}],"text":"HEs as envelope proteins are found in CoVs, orthomyxoviruses and toroviruses. Coronaviral HEs are involved in virus attachment to SA species. HE protein in β-CoVs binds to Neu5,9Ac2 form SA and agglutinates the red blood cells (RBCs) of rodents [52]. As with SA-O-acetylesterase, HE potentiates viral entry with the S protein and spreading via the mucosal glycans. It contains a carbohydrate-recognizing domain (CRD) known in lectin. The HE glycan-binding domain (GBD) mediates virus attachment to SAs on host cells. HE is the only HA. This indicates that compared to the S glycoprotein, HE is only minor a HA and the S glycoprotein mainly attaches to the cell surface. The HE protein of murine hepatitis virus (MHV), an enveloped CoV, binds to SA-4-acetylester or SA-9-O-acetylester of the carcinoembryonic antigen cell adhesion molecule 1a (CEACAM; known as CD66a) as the key receptor [53]. Murine CoVs HEs acquired by horizontal gene transfer, bind to C9-O-Ac Neu5Ac. However, some murine CoV HEs cannot bind to C4-O-Ac Neu5Ac. The original mouse MHV HE binds to C9-O-Ac Neu5Ac, while the MHV S-strain HE evolutionarily acquired the ability to bind to C4-O-Ac Neu5Ac [12,53,54]. In terms of structure, the C5 N- and C9 O-Ac Neu5Ac-accomodating hydrophobic pocket was shifted to a C5 N- and C4-O-Ac Neu5Ac-accomodating pocket [55]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T285","span":{"begin":0,"end":77},"obj":"Sentence"},{"id":"T286","span":{"begin":78,"end":141},"obj":"Sentence"},{"id":"T287","span":{"begin":142,"end":250},"obj":"Sentence"},{"id":"T288","span":{"begin":251,"end":364},"obj":"Sentence"},{"id":"T289","span":{"begin":365,"end":433},"obj":"Sentence"},{"id":"T290","span":{"begin":434,"end":516},"obj":"Sentence"},{"id":"T291","span":{"begin":517,"end":535},"obj":"Sentence"},{"id":"T292","span":{"begin":536,"end":669},"obj":"Sentence"},{"id":"T293","span":{"begin":670,"end":892},"obj":"Sentence"},{"id":"T294","span":{"begin":893,"end":970},"obj":"Sentence"},{"id":"T295","span":{"begin":971,"end":1030},"obj":"Sentence"},{"id":"T296","span":{"begin":1031,"end":1181},"obj":"Sentence"},{"id":"T297","span":{"begin":1182,"end":1333},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"HEs as envelope proteins are found in CoVs, orthomyxoviruses and toroviruses. Coronaviral HEs are involved in virus attachment to SA species. HE protein in β-CoVs binds to Neu5,9Ac2 form SA and agglutinates the red blood cells (RBCs) of rodents [52]. As with SA-O-acetylesterase, HE potentiates viral entry with the S protein and spreading via the mucosal glycans. It contains a carbohydrate-recognizing domain (CRD) known in lectin. The HE glycan-binding domain (GBD) mediates virus attachment to SAs on host cells. HE is the only HA. This indicates that compared to the S glycoprotein, HE is only minor a HA and the S glycoprotein mainly attaches to the cell surface. The HE protein of murine hepatitis virus (MHV), an enveloped CoV, binds to SA-4-acetylester or SA-9-O-acetylester of the carcinoembryonic antigen cell adhesion molecule 1a (CEACAM; known as CD66a) as the key receptor [53]. Murine CoVs HEs acquired by horizontal gene transfer, bind to C9-O-Ac Neu5Ac. However, some murine CoV HEs cannot bind to C4-O-Ac Neu5Ac. The original mouse MHV HE binds to C9-O-Ac Neu5Ac, while the MHV S-strain HE evolutionarily acquired the ability to bind to C4-O-Ac Neu5Ac [12,53,54]. In terms of structure, the C5 N- and C9 O-Ac Neu5Ac-accomodating hydrophobic pocket was shifted to a C5 N- and C4-O-Ac Neu5Ac-accomodating pocket [55]."}

{"project":"2_test","denotations":[{"id":"32604730-1920630-51943993","span":{"begin":246,"end":248},"obj":"1920630"},{"id":"32604730-10233932-51943994","span":{"begin":888,"end":890},"obj":"10233932"},{"id":"32604730-16575523-51943995","span":{"begin":1171,"end":1173},"obj":"16575523"},{"id":"32604730-10233932-51943996","span":{"begin":1174,"end":1176},"obj":"10233932"},{"id":"32604730-20538854-51943997","span":{"begin":1177,"end":1179},"obj":"20538854"},{"id":"32604730-16306577-51943998","span":{"begin":1329,"end":1331},"obj":"16306577"},{"id":"T60595","span":{"begin":246,"end":248},"obj":"1920630"},{"id":"T4696","span":{"begin":888,"end":890},"obj":"10233932"},{"id":"T80351","span":{"begin":1171,"end":1173},"obj":"16575523"},{"id":"T34204","span":{"begin":1174,"end":1176},"obj":"10233932"},{"id":"T1499","span":{"begin":1177,"end":1179},"obj":"20538854"},{"id":"T25059","span":{"begin":1329,"end":1331},"obj":"16306577"}],"text":"HEs as envelope proteins are found in CoVs, orthomyxoviruses and toroviruses. Coronaviral HEs are involved in virus attachment to SA species. HE protein in β-CoVs binds to Neu5,9Ac2 form SA and agglutinates the red blood cells (RBCs) of rodents [52]. As with SA-O-acetylesterase, HE potentiates viral entry with the S protein and spreading via the mucosal glycans. It contains a carbohydrate-recognizing domain (CRD) known in lectin. The HE glycan-binding domain (GBD) mediates virus attachment to SAs on host cells. HE is the only HA. This indicates that compared to the S glycoprotein, HE is only minor a HA and the S glycoprotein mainly attaches to the cell surface. The HE protein of murine hepatitis virus (MHV), an enveloped CoV, binds to SA-4-acetylester or SA-9-O-acetylester of the carcinoembryonic antigen cell adhesion molecule 1a (CEACAM; known as CD66a) as the key receptor [53]. Murine CoVs HEs acquired by horizontal gene transfer, bind to C9-O-Ac Neu5Ac. However, some murine CoV HEs cannot bind to C4-O-Ac Neu5Ac. The original mouse MHV HE binds to C9-O-Ac Neu5Ac, while the MHV S-strain HE evolutionarily acquired the ability to bind to C4-O-Ac Neu5Ac [12,53,54]. In terms of structure, the C5 N- and C9 O-Ac Neu5Ac-accomodating hydrophobic pocket was shifted to a C5 N- and C4-O-Ac Neu5Ac-accomodating pocket [55]."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T9","span":{"begin":695,"end":704},"obj":"Phenotype"}],"attributes":[{"id":"A9","pred":"hp_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/HP_0012115"}],"text":"HEs as envelope proteins are found in CoVs, orthomyxoviruses and toroviruses. Coronaviral HEs are involved in virus attachment to SA species. HE protein in β-CoVs binds to Neu5,9Ac2 form SA and agglutinates the red blood cells (RBCs) of rodents [52]. As with SA-O-acetylesterase, HE potentiates viral entry with the S protein and spreading via the mucosal glycans. It contains a carbohydrate-recognizing domain (CRD) known in lectin. The HE glycan-binding domain (GBD) mediates virus attachment to SAs on host cells. HE is the only HA. This indicates that compared to the S glycoprotein, HE is only minor a HA and the S glycoprotein mainly attaches to the cell surface. The HE protein of murine hepatitis virus (MHV), an enveloped CoV, binds to SA-4-acetylester or SA-9-O-acetylester of the carcinoembryonic antigen cell adhesion molecule 1a (CEACAM; known as CD66a) as the key receptor [53]. Murine CoVs HEs acquired by horizontal gene transfer, bind to C9-O-Ac Neu5Ac. However, some murine CoV HEs cannot bind to C4-O-Ac Neu5Ac. The original mouse MHV HE binds to C9-O-Ac Neu5Ac, while the MHV S-strain HE evolutionarily acquired the ability to bind to C4-O-Ac Neu5Ac [12,53,54]. In terms of structure, the C5 N- and C9 O-Ac Neu5Ac-accomodating hydrophobic pocket was shifted to a C5 N- and C4-O-Ac Neu5Ac-accomodating pocket [55]."}