PMC:7352545 / 28726-30059
Annnotations
LitCovid_Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T103 | 130-132 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T104 | 187-189 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T105 | 259-261 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T106 | 745-747 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T107 | 765-767 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T108 | 963-969 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T109 | 1023-1029 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T110 | 1074-1080 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T111 | 1163-1169 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T112 | 1227-1233 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T113 | 1301-1307 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T234 | 16-24 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T235 | 145-152 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T236 | 211-226 | Body_part | denotes | red blood cells | http://purl.org/sig/ont/fma/fma62845 |
| T237 | 221-226 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T238 | 318-325 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T239 | 379-391 | Body_part | denotes | carbohydrate | http://purl.org/sig/ont/fma/fma82737 |
| T240 | 510-515 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T241 | 574-586 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T242 | 620-632 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T243 | 656-668 | Body_part | denotes | cell surface | http://purl.org/sig/ont/fma/fma67653 |
| T244 | 656-660 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T245 | 677-684 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T246 | 816-838 | Body_part | denotes | cell adhesion molecule | http://purl.org/sig/ont/fma/fma67214 |
| T247 | 816-820 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T248 | 932-936 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T6 | 215-220 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T112 | 695-704 | Disease | denotes | hepatitis | http://purl.obolibrary.org/obo/MONDO_0002251 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T376 | 0-3 | http://purl.obolibrary.org/obo/CLO_0053120 | denotes | HEs |
| T377 | 90-93 | http://purl.obolibrary.org/obo/CLO_0053120 | denotes | HEs |
| T378 | 110-115 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T379 | 211-226 | http://purl.obolibrary.org/obo/CL_0000232 | denotes | red blood cells |
| T380 | 246-248 | http://purl.obolibrary.org/obo/CLO_0001407 | denotes | 52 |
| T381 | 377-378 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T382 | 478-483 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T383 | 498-501 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T384 | 510-515 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T385 | 605-606 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T386 | 656-660 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T387 | 705-710 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T388 | 816-820 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T389 | 905-908 | http://purl.obolibrary.org/obo/CLO_0053120 | denotes | HEs |
| T390 | 932-936 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T391 | 996-999 | http://purl.obolibrary.org/obo/CLO_0053120 | denotes | HEs |
| T392 | 1015-1017 | http://purl.obolibrary.org/obo/CLO_0037284 | denotes | C4 |
| T393 | 1044-1049 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
| T394 | 1155-1157 | http://purl.obolibrary.org/obo/CLO_0037284 | denotes | C4 |
| T395 | 1209-1211 | http://purl.obolibrary.org/obo/CLO_0002131 | denotes | C5 |
| T396 | 1281-1285 | http://purl.obolibrary.org/obo/CLO_0053061 | denotes | a C5 |
| T397 | 1293-1295 | http://purl.obolibrary.org/obo/CLO_0037284 | denotes | C4 |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T796 | 16-24 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T797 | 130-132 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T802 | 145-152 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T803 | 187-189 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T808 | 259-261 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T813 | 318-325 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T814 | 356-363 | Chemical | denotes | glycans | http://purl.obolibrary.org/obo/CHEBI_18154 |
| T815 | 379-391 | Chemical | denotes | carbohydrate | http://purl.obolibrary.org/obo/CHEBI_16646 |
| T816 | 532-534 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T817 | 574-586 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T818 | 607-609 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T819 | 620-632 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T820 | 677-684 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T821 | 745-747 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T826 | 765-767 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T831 | 808-815 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
| T832 | 830-838 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T833 | 960-962 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T835 | 963-969 | Chemical | denotes | Neu5Ac | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133 |
| T837 | 1020-1022 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T839 | 1023-1029 | Chemical | denotes | Neu5Ac | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133 |
| T841 | 1071-1073 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T843 | 1074-1080 | Chemical | denotes | Neu5Ac | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133 |
| T845 | 1160-1162 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T847 | 1163-1169 | Chemical | denotes | Neu5Ac | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133 |
| T849 | 1224-1226 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T851 | 1227-1233 | Chemical | denotes | Neu5Ac | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133 |
| T853 | 1298-1300 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T855 | 1301-1307 | Chemical | denotes | Neu5Ac | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T50 | 816-838 | http://purl.obolibrary.org/obo/GO_0098631 | denotes | cell adhesion molecule |
| T51 | 816-829 | http://purl.obolibrary.org/obo/GO_0007155 | denotes | cell adhesion |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T285 | 0-77 | Sentence | denotes | HEs as envelope proteins are found in CoVs, orthomyxoviruses and toroviruses. |
| T286 | 78-141 | Sentence | denotes | Coronaviral HEs are involved in virus attachment to SA species. |
| T287 | 142-250 | Sentence | denotes | HE protein in β-CoVs binds to Neu5,9Ac2 form SA and agglutinates the red blood cells (RBCs) of rodents [52]. |
| T288 | 251-364 | Sentence | denotes | As with SA-O-acetylesterase, HE potentiates viral entry with the S protein and spreading via the mucosal glycans. |
| T289 | 365-433 | Sentence | denotes | It contains a carbohydrate-recognizing domain (CRD) known in lectin. |
| T290 | 434-516 | Sentence | denotes | The HE glycan-binding domain (GBD) mediates virus attachment to SAs on host cells. |
| T291 | 517-535 | Sentence | denotes | HE is the only HA. |
| T292 | 536-669 | Sentence | denotes | This indicates that compared to the S glycoprotein, HE is only minor a HA and the S glycoprotein mainly attaches to the cell surface. |
| T293 | 670-892 | Sentence | denotes | The HE protein of murine hepatitis virus (MHV), an enveloped CoV, binds to SA-4-acetylester or SA-9-O-acetylester of the carcinoembryonic antigen cell adhesion molecule 1a (CEACAM; known as CD66a) as the key receptor [53]. |
| T294 | 893-970 | Sentence | denotes | Murine CoVs HEs acquired by horizontal gene transfer, bind to C9-O-Ac Neu5Ac. |
| T295 | 971-1030 | Sentence | denotes | However, some murine CoV HEs cannot bind to C4-O-Ac Neu5Ac. |
| T296 | 1031-1181 | Sentence | denotes | The original mouse MHV HE binds to C9-O-Ac Neu5Ac, while the MHV S-strain HE evolutionarily acquired the ability to bind to C4-O-Ac Neu5Ac [12,53,54]. |
| T297 | 1182-1333 | Sentence | denotes | In terms of structure, the C5 N- and C9 O-Ac Neu5Ac-accomodating hydrophobic pocket was shifted to a C5 N- and C4-O-Ac Neu5Ac-accomodating pocket [55]. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32604730-1920630-51943993 | 246-248 | 1920630 | denotes | 52 |
| 32604730-10233932-51943994 | 888-890 | 10233932 | denotes | 53 |
| 32604730-16575523-51943995 | 1171-1173 | 16575523 | denotes | 12 |
| 32604730-10233932-51943996 | 1174-1176 | 10233932 | denotes | 53 |
| 32604730-20538854-51943997 | 1177-1179 | 20538854 | denotes | 54 |
| 32604730-16306577-51943998 | 1329-1331 | 16306577 | denotes | 55 |
| T60595 | 246-248 | 1920630 | denotes | 52 |
| T4696 | 888-890 | 10233932 | denotes | 53 |
| T80351 | 1171-1173 | 16575523 | denotes | 12 |
| T34204 | 1174-1176 | 10233932 | denotes | 53 |
| T1499 | 1177-1179 | 20538854 | denotes | 54 |
| T25059 | 1329-1331 | 16306577 | denotes | 55 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T9 | 695-704 | Phenotype | denotes | hepatitis | http://purl.obolibrary.org/obo/HP_0012115 |