PMC:7352545 / 24615-26133
Annnotations
LitCovid_Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T83 | 4-6 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T84 | 415-438 | https://glytoucan.org/Structures/Glycans/G50850NI | denotes | N-acetylneuraminic acid |
| T85 | 415-438 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | N-acetylneuraminic acid |
| T86 | 552-554 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T87 | 619-621 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T88 | 706-708 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T89 | 838-840 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T90 | 928-930 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T91 | 1261-1263 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T217 | 415-438 | Body_part | denotes | N-acetylneuraminic acid | http://purl.org/sig/ont/fma/fma82788 |
| T218 | 1082-1091 | Body_part | denotes | endosomes | http://purl.org/sig/ont/fma/fma67180 |
| T219 | 1154-1166 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T220 | 1189-1196 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T221 | 1279-1284 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T222 | 1367-1372 | Body_part | denotes | mucus | http://purl.org/sig/ont/fma/fma66938 |
| T223 | 1437-1442 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T5 | 1367-1372 | Body_part | denotes | mucus | http://purl.obolibrary.org/obo/UBERON_0000912 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T92 | 54-63 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T93 | 133-135 | Disease | denotes | FH | http://purl.obolibrary.org/obo/MONDO_0016525 |
| T94 | 192-201 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T95 | 479-488 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T96 | 683-689 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T97 | 898-907 | Disease | denotes | Influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T98 | 957-966 | Disease | denotes | Influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T99 | 1106-1115 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T100 | 1490-1499 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T313 | 64-65 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T314 | 66-71 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T315 | 204-209 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T316 | 304-307 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T317 | 374-377 | http://purl.obolibrary.org/obo/CLO_0001618 | denotes | a 9 |
| T318 | 374-377 | http://purl.obolibrary.org/obo/CLO_0001619 | denotes | a 9 |
| T319 | 374-377 | http://purl.obolibrary.org/obo/CLO_0001620 | denotes | a 9 |
| T320 | 453-454 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T321 | 491-496 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T322 | 543-549 | http://purl.obolibrary.org/obo/CLO_0050457 | denotes | HE [42 |
| T323 | 816-824 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T324 | 908-909 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T325 | 910-911 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T326 | 916-923 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T327 | 967-968 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T328 | 973-974 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T329 | 992-995 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T330 | 1038-1043 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T331 | 1279-1284 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T332 | 1356-1361 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T333 | 1391-1396 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T334 | 1437-1442 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T335 | 1459-1467 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T336 | 1500-1501 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T337 | 1507-1512 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T642 | 4-6 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T647 | 87-89 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T648 | 133-135 | Chemical | denotes | FH | http://purl.obolibrary.org/obo/CHEBI_73634 |
| T649 | 210-212 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T650 | 286-298 | Chemical | denotes | acetyl group | http://purl.obolibrary.org/obo/CHEBI_40574 |
| T651 | 286-292 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_46887 |
| T652 | 293-298 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T653 | 380-386 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887 |
| T655 | 397-406 | Chemical | denotes | acetamido | http://purl.obolibrary.org/obo/CHEBI_48374 |
| T656 | 415-438 | Chemical | denotes | N-acetylneuraminic acid | http://purl.obolibrary.org/obo/CHEBI_17012 |
| T657 | 434-438 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T658 | 552-554 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T663 | 604-606 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T665 | 615-617 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T667 | 619-621 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T672 | 706-708 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T677 | 793-795 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T679 | 838-840 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T684 | 928-930 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T689 | 1000-1002 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T690 | 1007-1009 | Chemical | denotes | NA | http://purl.obolibrary.org/obo/CHEBI_33696 |
| T691 | 1154-1166 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T692 | 1189-1196 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T693 | 1224-1226 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T694 | 1231-1233 | Chemical | denotes | NA | http://purl.obolibrary.org/obo/CHEBI_33696 |
| T695 | 1254-1260 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887 |
| T697 | 1261-1263 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T702 | 1324-1330 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887 |
| T704 | 1431-1433 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T706 | 1456-1458 | Chemical | denotes | NA | http://purl.obolibrary.org/obo/CHEBI_33696 |
| T707 | 1472-1474 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T44 | 1019-1030 | http://purl.obolibrary.org/obo/GO_0006897 | denotes | endocytosis |
| T45 | 1414-1421 | http://purl.obolibrary.org/obo/GO_0007114 | denotes | budding |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T235 | 0-178 | Sentence | denotes | The SA 9-O-acetylation in hosts allows hosts to evade influenza A virus hemagglutinin (HA) recognition and some lectins of factor H (FH), CD22/Siglec-2 and sialoadhesin/Siglec-1. |
| T236 | 179-308 | Sentence | denotes | Instead, the influenza C virus HA recognizes the hosts. β-elimination and permethylation eliminate the 9-O-acetyl group from SAs. |
| T237 | 309-551 | Sentence | denotes | Chemical modification of the C-9 position of Neu5,9Ac2 generates a 9-N-acetyl analog, 9-acetamido-9-deoxy-N-acetylneuraminic acid (Neu5Ac9NAc), a mimic of Neu5,9Ac2 with influenza C virus-binding capacity, which is not cleaved by the HE [42]. |
| T238 | 552-618 | Sentence | denotes | SA O-acetylesterase regulates the presence of 7,9-O-Ac and 9-O-Ac. |
| T239 | 619-705 | Sentence | denotes | SA O-acetylation and deacetylation are involved in development, cancer and immunology. |
| T240 | 706-772 | Sentence | denotes | SA O-acetylation alters host lectin bindings such as siglecs [29]. |
| T241 | 773-837 | Sentence | denotes | The presence of 9-O-Ac can also reduce the activity of NAs [43]. |
| T242 | 838-897 | Sentence | denotes | SA modifications regulate pathogen binding or pathogen NAs. |
| T243 | 898-956 | Sentence | denotes | Influenza A/B/C/D viruses use SA as their entry receptors. |
| T244 | 957-1092 | Sentence | denotes | Influenza A and B subtypes bind to SAs via HA and NA to allow endocytosis of the virus and fusion of the viral envelope with endosomes. |
| T245 | 1093-1203 | Sentence | denotes | In contrast, influenza C and D subtypes bear only one coated glycoprotein, termed the HE fusion protein (HEF). |
| T246 | 1204-1234 | Sentence | denotes | The HEF acts as the HA and NA. |
| T247 | 1235-1422 | Sentence | denotes | HEF recognizes 9-O-acetyl SA for entry into cells, while the esterase domain removes 9-O-acetyl-groups and liberates the virus from mucus and mis-assembled virus aggregates after budding. |
| T248 | 1423-1518 | Sentence | denotes | The 9-O-Ac on cells prevents the NA activity and HA binding of the influenza A type virus [44]. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32604730-29341588-51943984 | 833-835 | 29341588 | denotes | 43 |
| 32604730-31796537-51943985 | 1514-1516 | 31796537 | denotes | 44 |
| T17811 | 833-835 | 29341588 | denotes | 43 |
| T51599 | 1514-1516 | 31796537 | denotes | 44 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T8 | 683-689 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |