PMC:7352545 / 24580-26133 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7352545","sourcedb":"PMC","sourceid":"7352545","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7352545","text":"4.2.2. SA C9-O-Acetyl Modification\nThe SA 9-O-acetylation in hosts allows hosts to evade influenza A virus hemagglutinin (HA) recognition and some lectins of factor H (FH), CD22/Siglec-2 and sialoadhesin/Siglec-1. Instead, the influenza C virus HA recognizes the hosts. β-elimination and permethylation eliminate the 9-O-acetyl group from SAs. Chemical modification of the C-9 position of Neu5,9Ac2 generates a 9-N-acetyl analog, 9-acetamido-9-deoxy-N-acetylneuraminic acid (Neu5Ac9NAc), a mimic of Neu5,9Ac2 with influenza C virus-binding capacity, which is not cleaved by the HE [42]. SA O-acetylesterase regulates the presence of 7,9-O-Ac and 9-O-Ac. SA O-acetylation and deacetylation are involved in development, cancer and immunology. SA O-acetylation alters host lectin bindings such as siglecs [29]. The presence of 9-O-Ac can also reduce the activity of NAs [43]. SA modifications regulate pathogen binding or pathogen NAs. Influenza A/B/C/D viruses use SA as their entry receptors. Influenza A and B subtypes bind to SAs via HA and NA to allow endocytosis of the virus and fusion of the viral envelope with endosomes. In contrast, influenza C and D subtypes bear only one coated glycoprotein, termed the HE fusion protein (HEF). The HEF acts as the HA and NA. HEF recognizes 9-O-acetyl SA for entry into cells, while the esterase domain removes 9-O-acetyl-groups and liberates the virus from mucus and mis-assembled virus aggregates after budding. The 9-O-Ac on cells prevents the NA activity and HA binding of the influenza A type virus [44].","divisions":[{"label":"title","span":{"begin":0,"end":34}}],"tracks":[{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T82","span":{"begin":7,"end":9},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T83","span":{"begin":39,"end":41},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T84","span":{"begin":450,"end":473},"obj":"https://glytoucan.org/Structures/Glycans/G50850NI"},{"id":"T85","span":{"begin":450,"end":473},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T86","span":{"begin":587,"end":589},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T87","span":{"begin":654,"end":656},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T88","span":{"begin":741,"end":743},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T89","span":{"begin":873,"end":875},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T90","span":{"begin":963,"end":965},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T91","span":{"begin":1296,"end":1298},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"}],"attributes":[{"subj":"T82","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T83","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T84","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T85","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T86","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T87","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T88","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T89","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T90","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T91","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T217","span":{"begin":450,"end":473},"obj":"Body_part"},{"id":"T218","span":{"begin":1117,"end":1126},"obj":"Body_part"},{"id":"T219","span":{"begin":1189,"end":1201},"obj":"Body_part"},{"id":"T220","span":{"begin":1224,"end":1231},"obj":"Body_part"},{"id":"T221","span":{"begin":1314,"end":1319},"obj":"Body_part"},{"id":"T222","span":{"begin":1402,"end":1407},"obj":"Body_part"},{"id":"T223","span":{"begin":1472,"end":1477},"obj":"Body_part"}],"attributes":[{"id":"A217","pred":"fma_id","subj":"T217","obj":"http://purl.org/sig/ont/fma/fma82788"},{"id":"A218","pred":"fma_id","subj":"T218","obj":"http://purl.org/sig/ont/fma/fma67180"},{"id":"A219","pred":"fma_id","subj":"T219","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A220","pred":"fma_id","subj":"T220","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A221","pred":"fma_id","subj":"T221","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A222","pred":"fma_id","subj":"T222","obj":"http://purl.org/sig/ont/fma/fma66938"},{"id":"A223","pred":"fma_id","subj":"T223","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T217","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T218","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T219","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T220","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T221","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T222","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T223","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T5","span":{"begin":1402,"end":1407},"obj":"Body_part"}],"attributes":[{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_0000912"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T92","span":{"begin":89,"end":98},"obj":"Disease"},{"id":"T93","span":{"begin":168,"end":170},"obj":"Disease"},{"id":"T94","span":{"begin":227,"end":236},"obj":"Disease"},{"id":"T95","span":{"begin":514,"end":523},"obj":"Disease"},{"id":"T96","span":{"begin":718,"end":724},"obj":"Disease"},{"id":"T97","span":{"begin":933,"end":942},"obj":"Disease"},{"id":"T98","span":{"begin":992,"end":1001},"obj":"Disease"},{"id":"T99","span":{"begin":1141,"end":1150},"obj":"Disease"},{"id":"T100","span":{"begin":1525,"end":1534},"obj":"Disease"}],"attributes":[{"id":"A92","pred":"mondo_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A93","pred":"mondo_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/MONDO_0016525"},{"id":"A94","pred":"mondo_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A95","pred":"mondo_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A96","pred":"mondo_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"A97","pred":"mondo_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A98","pred":"mondo_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A99","pred":"mondo_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A100","pred":"mondo_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"subj":"T92","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T93","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T94","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T95","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T96","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T97","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T98","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T99","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T100","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T313","span":{"begin":99,"end":100},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T314","span":{"begin":101,"end":106},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T315","span":{"begin":239,"end":244},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T316","span":{"begin":339,"end":342},"obj":"http://purl.obolibrary.org/obo/CLO_0051568"},{"id":"T317","span":{"begin":409,"end":412},"obj":"http://purl.obolibrary.org/obo/CLO_0001618"},{"id":"T318","span":{"begin":409,"end":412},"obj":"http://purl.obolibrary.org/obo/CLO_0001619"},{"id":"T319","span":{"begin":409,"end":412},"obj":"http://purl.obolibrary.org/obo/CLO_0001620"},{"id":"T320","span":{"begin":488,"end":489},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T321","span":{"begin":526,"end":531},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T322","span":{"begin":578,"end":584},"obj":"http://purl.obolibrary.org/obo/CLO_0050457"},{"id":"T323","span":{"begin":851,"end":859},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T324","span":{"begin":943,"end":944},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T325","span":{"begin":945,"end":946},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T326","span":{"begin":951,"end":958},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T327","span":{"begin":1002,"end":1003},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T328","span":{"begin":1008,"end":1009},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T329","span":{"begin":1027,"end":1030},"obj":"http://purl.obolibrary.org/obo/CLO_0051568"},{"id":"T330","span":{"begin":1073,"end":1078},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T331","span":{"begin":1314,"end":1319},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T332","span":{"begin":1391,"end":1396},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T333","span":{"begin":1426,"end":1431},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T334","span":{"begin":1472,"end":1477},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T335","span":{"begin":1494,"end":1502},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T336","span":{"begin":1535,"end":1536},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T337","span":{"begin":1542,"end":1547},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"attributes":[{"subj":"T313","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T314","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T315","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T316","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T317","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T318","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T319","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T320","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T321","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T322","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T323","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T324","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T325","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T326","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T327","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T328","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T329","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T330","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T331","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T332","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T333","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T334","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T335","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T336","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T337","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T637","span":{"begin":7,"end":9},"obj":"Chemical"},{"id":"T642","span":{"begin":39,"end":41},"obj":"Chemical"},{"id":"T647","span":{"begin":122,"end":124},"obj":"Chemical"},{"id":"T648","span":{"begin":168,"end":170},"obj":"Chemical"},{"id":"T649","span":{"begin":245,"end":247},"obj":"Chemical"},{"id":"T650","span":{"begin":321,"end":333},"obj":"Chemical"},{"id":"T651","span":{"begin":321,"end":327},"obj":"Chemical"},{"id":"T652","span":{"begin":328,"end":333},"obj":"Chemical"},{"id":"T653","span":{"begin":415,"end":421},"obj":"Chemical"},{"id":"T655","span":{"begin":432,"end":441},"obj":"Chemical"},{"id":"T656","span":{"begin":450,"end":473},"obj":"Chemical"},{"id":"T657","span":{"begin":469,"end":473},"obj":"Chemical"},{"id":"T658","span":{"begin":587,"end":589},"obj":"Chemical"},{"id":"T663","span":{"begin":639,"end":641},"obj":"Chemical"},{"id":"T665","span":{"begin":650,"end":652},"obj":"Chemical"},{"id":"T667","span":{"begin":654,"end":656},"obj":"Chemical"},{"id":"T672","span":{"begin":741,"end":743},"obj":"Chemical"},{"id":"T677","span":{"begin":828,"end":830},"obj":"Chemical"},{"id":"T679","span":{"begin":873,"end":875},"obj":"Chemical"},{"id":"T684","span":{"begin":963,"end":965},"obj":"Chemical"},{"id":"T689","span":{"begin":1035,"end":1037},"obj":"Chemical"},{"id":"T690","span":{"begin":1042,"end":1044},"obj":"Chemical"},{"id":"T691","span":{"begin":1189,"end":1201},"obj":"Chemical"},{"id":"T692","span":{"begin":1224,"end":1231},"obj":"Chemical"},{"id":"T693","span":{"begin":1259,"end":1261},"obj":"Chemical"},{"id":"T694","span":{"begin":1266,"end":1268},"obj":"Chemical"},{"id":"T695","span":{"begin":1289,"end":1295},"obj":"Chemical"},{"id":"T697","span":{"begin":1296,"end":1298},"obj":"Chemical"},{"id":"T702","span":{"begin":1359,"end":1365},"obj":"Chemical"},{"id":"T704","span":{"begin":1466,"end":1468},"obj":"Chemical"},{"id":"T706","span":{"begin":1491,"end":1493},"obj":"Chemical"},{"id":"T707","span":{"begin":1507,"end":1509},"obj":"Chemical"}],"attributes":[{"id":"A637","pred":"chebi_id","subj":"T637","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A638","pred":"chebi_id","subj":"T637","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A639","pred":"chebi_id","subj":"T637","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A640","pred":"chebi_id","subj":"T637","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A641","pred":"chebi_id","subj":"T637","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A642","pred":"chebi_id","subj":"T642","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A643","pred":"chebi_id","subj":"T642","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A644","pred":"chebi_id","subj":"T642","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A645","pred":"chebi_id","subj":"T642","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A646","pred":"chebi_id","subj":"T642","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A647","pred":"chebi_id","subj":"T647","obj":"http://purl.obolibrary.org/obo/CHEBI_73924"},{"id":"A648","pred":"chebi_id","subj":"T648","obj":"http://purl.obolibrary.org/obo/CHEBI_73634"},{"id":"A649","pred":"chebi_id","subj":"T649","obj":"http://purl.obolibrary.org/obo/CHEBI_73924"},{"id":"A650","pred":"chebi_id","subj":"T650","obj":"http://purl.obolibrary.org/obo/CHEBI_40574"},{"id":"A651","pred":"chebi_id","subj":"T651","obj":"http://purl.obolibrary.org/obo/CHEBI_46887"},{"id":"A652","pred":"chebi_id","subj":"T652","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A653","pred":"chebi_id","subj":"T653","obj":"http://purl.obolibrary.org/obo/CHEBI_40574"},{"id":"A654","pred":"chebi_id","subj":"T653","obj":"http://purl.obolibrary.org/obo/CHEBI_46887"},{"id":"A655","pred":"chebi_id","subj":"T655","obj":"http://purl.obolibrary.org/obo/CHEBI_48374"},{"id":"A656","pred":"chebi_id","subj":"T656","obj":"http://purl.obolibrary.org/obo/CHEBI_17012"},{"id":"A657","pred":"chebi_id","subj":"T657","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A658","pred":"chebi_id","subj":"T658","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A659","pred":"chebi_id","subj":"T658","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A660","pred":"chebi_id","subj":"T658","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A661","pred":"chebi_id","subj":"T658","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A662","pred":"chebi_id","subj":"T658","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A663","pred":"chebi_id","subj":"T663","obj":"http://purl.obolibrary.org/obo/CHEBI_33337"},{"id":"A664","pred":"chebi_id","subj":"T663","obj":"http://purl.obolibrary.org/obo/CHEBI_40574"},{"id":"A665","pred":"chebi_id","subj":"T665","obj":"http://purl.obolibrary.org/obo/CHEBI_33337"},{"id":"A666","pred":"chebi_id","subj":"T665","obj":"http://purl.obolibrary.org/obo/CHEBI_40574"},{"id":"A667","pred":"chebi_id","subj":"T667","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A668","pred":"chebi_id","subj":"T667","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A669","pred":"chebi_id","subj":"T667","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A670","pred":"chebi_id","subj":"T667","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A671","pred":"chebi_id","subj":"T667","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A672","pred":"chebi_id","subj":"T672","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A673","pred":"chebi_id","subj":"T672","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A674","pred":"chebi_id","subj":"T672","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A675","pred":"chebi_id","subj":"T672","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A676","pred":"chebi_id","subj":"T672","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A677","pred":"chebi_id","subj":"T677","obj":"http://purl.obolibrary.org/obo/CHEBI_33337"},{"id":"A678","pred":"chebi_id","subj":"T677","obj":"http://purl.obolibrary.org/obo/CHEBI_40574"},{"id":"A679","pred":"chebi_id","subj":"T679","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A680","pred":"chebi_id","subj":"T679","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A681","pred":"chebi_id","subj":"T679","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A682","pred":"chebi_id","subj":"T679","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A683","pred":"chebi_id","subj":"T679","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A684","pred":"chebi_id","subj":"T684","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A685","pred":"chebi_id","subj":"T684","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A686","pred":"chebi_id","subj":"T684","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A687","pred":"chebi_id","subj":"T684","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A688","pred":"chebi_id","subj":"T684","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A689","pred":"chebi_id","subj":"T689","obj":"http://purl.obolibrary.org/obo/CHEBI_73924"},{"id":"A690","pred":"chebi_id","subj":"T690","obj":"http://purl.obolibrary.org/obo/CHEBI_33696"},{"id":"A691","pred":"chebi_id","subj":"T691","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A692","pred":"chebi_id","subj":"T692","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A693","pred":"chebi_id","subj":"T693","obj":"http://purl.obolibrary.org/obo/CHEBI_73924"},{"id":"A694","pred":"chebi_id","subj":"T694","obj":"http://purl.obolibrary.org/obo/CHEBI_33696"},{"id":"A695","pred":"chebi_id","subj":"T695","obj":"http://purl.obolibrary.org/obo/CHEBI_40574"},{"id":"A696","pred":"chebi_id","subj":"T695","obj":"http://purl.obolibrary.org/obo/CHEBI_46887"},{"id":"A697","pred":"chebi_id","subj":"T697","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A698","pred":"chebi_id","subj":"T697","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A699","pred":"chebi_id","subj":"T697","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A700","pred":"chebi_id","subj":"T697","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A701","pred":"chebi_id","subj":"T697","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A702","pred":"chebi_id","subj":"T702","obj":"http://purl.obolibrary.org/obo/CHEBI_40574"},{"id":"A703","pred":"chebi_id","subj":"T702","obj":"http://purl.obolibrary.org/obo/CHEBI_46887"},{"id":"A704","pred":"chebi_id","subj":"T704","obj":"http://purl.obolibrary.org/obo/CHEBI_33337"},{"id":"A705","pred":"chebi_id","subj":"T704","obj":"http://purl.obolibrary.org/obo/CHEBI_40574"},{"id":"A706","pred":"chebi_id","subj":"T706","obj":"http://purl.obolibrary.org/obo/CHEBI_33696"},{"id":"A707","pred":"chebi_id","subj":"T707","obj":"http://purl.obolibrary.org/obo/CHEBI_73924"},{"subj":"T637","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T642","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T647","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T648","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T649","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T650","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T651","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T652","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T653","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T655","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T656","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T657","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T658","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T663","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T665","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T667","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T672","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T677","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T679","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T684","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T689","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T690","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T691","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T692","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T693","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T694","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T695","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T697","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T702","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T704","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T706","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T707","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T44","span":{"begin":1054,"end":1065},"obj":"http://purl.obolibrary.org/obo/GO_0006897"},{"id":"T45","span":{"begin":1449,"end":1456},"obj":"http://purl.obolibrary.org/obo/GO_0007114"}],"attributes":[{"subj":"T44","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T233","span":{"begin":0,"end":6},"obj":"Sentence"},{"id":"T234","span":{"begin":7,"end":34},"obj":"Sentence"},{"id":"T235","span":{"begin":35,"end":213},"obj":"Sentence"},{"id":"T236","span":{"begin":214,"end":343},"obj":"Sentence"},{"id":"T237","span":{"begin":344,"end":586},"obj":"Sentence"},{"id":"T238","span":{"begin":587,"end":653},"obj":"Sentence"},{"id":"T239","span":{"begin":654,"end":740},"obj":"Sentence"},{"id":"T240","span":{"begin":741,"end":807},"obj":"Sentence"},{"id":"T241","span":{"begin":808,"end":872},"obj":"Sentence"},{"id":"T242","span":{"begin":873,"end":932},"obj":"Sentence"},{"id":"T243","span":{"begin":933,"end":991},"obj":"Sentence"},{"id":"T244","span":{"begin":992,"end":1127},"obj":"Sentence"},{"id":"T245","span":{"begin":1128,"end":1238},"obj":"Sentence"},{"id":"T246","span":{"begin":1239,"end":1269},"obj":"Sentence"},{"id":"T247","span":{"begin":1270,"end":1457},"obj":"Sentence"},{"id":"T248","span":{"begin":1458,"end":1553},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T233","pred":"source","obj":"LitCovid-sentences"},{"subj":"T234","pred":"source","obj":"LitCovid-sentences"},{"subj":"T235","pred":"source","obj":"LitCovid-sentences"},{"subj":"T236","pred":"source","obj":"LitCovid-sentences"},{"subj":"T237","pred":"source","obj":"LitCovid-sentences"},{"subj":"T238","pred":"source","obj":"LitCovid-sentences"},{"subj":"T239","pred":"source","obj":"LitCovid-sentences"},{"subj":"T240","pred":"source","obj":"LitCovid-sentences"},{"subj":"T241","pred":"source","obj":"LitCovid-sentences"},{"subj":"T242","pred":"source","obj":"LitCovid-sentences"},{"subj":"T243","pred":"source","obj":"LitCovid-sentences"},{"subj":"T244","pred":"source","obj":"LitCovid-sentences"},{"subj":"T245","pred":"source","obj":"LitCovid-sentences"},{"subj":"T246","pred":"source","obj":"LitCovid-sentences"},{"subj":"T247","pred":"source","obj":"LitCovid-sentences"},{"subj":"T248","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32604730-29341588-51943984","span":{"begin":868,"end":870},"obj":"29341588"},{"id":"32604730-31796537-51943985","span":{"begin":1549,"end":1551},"obj":"31796537"},{"id":"T17811","span":{"begin":868,"end":870},"obj":"29341588"},{"id":"T51599","span":{"begin":1549,"end":1551},"obj":"31796537"}],"attributes":[{"subj":"32604730-29341588-51943984","pred":"source","obj":"2_test"},{"subj":"32604730-31796537-51943985","pred":"source","obj":"2_test"},{"subj":"T17811","pred":"source","obj":"2_test"},{"subj":"T51599","pred":"source","obj":"2_test"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T8","span":{"begin":718,"end":724},"obj":"Phenotype"}],"attributes":[{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-HP"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid_Glycan-Motif-Structure","color":"#ec93cc","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#93e6ec"},{"id":"LitCovid-PD-UBERON","color":"#ecd893"},{"id":"LitCovid-PD-MONDO","color":"#be93ec"},{"id":"LitCovid-PD-CLO","color":"#93eca4"},{"id":"LitCovid-PD-CHEBI","color":"#ec939c"},{"id":"LitCovid-PD-GO-BP","color":"#93b6ec"},{"id":"LitCovid-sentences","color":"#d0ec93"},{"id":"2_test","color":"#ec93ea"},{"id":"LitCovid-PD-HP","color":"#93ecd4"}]}]}}