PMC:7352545 / 24580-26133
Annnotations
LitCovid_Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T82 | 7-9 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T83 | 39-41 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T84 | 450-473 | https://glytoucan.org/Structures/Glycans/G50850NI | denotes | N-acetylneuraminic acid |
| T85 | 450-473 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | N-acetylneuraminic acid |
| T86 | 587-589 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T87 | 654-656 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T88 | 741-743 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T89 | 873-875 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T90 | 963-965 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T91 | 1296-1298 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T217 | 450-473 | Body_part | denotes | N-acetylneuraminic acid | http://purl.org/sig/ont/fma/fma82788 |
| T218 | 1117-1126 | Body_part | denotes | endosomes | http://purl.org/sig/ont/fma/fma67180 |
| T219 | 1189-1201 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T220 | 1224-1231 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T221 | 1314-1319 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T222 | 1402-1407 | Body_part | denotes | mucus | http://purl.org/sig/ont/fma/fma66938 |
| T223 | 1472-1477 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T5 | 1402-1407 | Body_part | denotes | mucus | http://purl.obolibrary.org/obo/UBERON_0000912 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T92 | 89-98 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T93 | 168-170 | Disease | denotes | FH | http://purl.obolibrary.org/obo/MONDO_0016525 |
| T94 | 227-236 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T95 | 514-523 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T96 | 718-724 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T97 | 933-942 | Disease | denotes | Influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T98 | 992-1001 | Disease | denotes | Influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T99 | 1141-1150 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T100 | 1525-1534 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T313 | 99-100 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T314 | 101-106 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T315 | 239-244 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T316 | 339-342 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T317 | 409-412 | http://purl.obolibrary.org/obo/CLO_0001618 | denotes | a 9 |
| T318 | 409-412 | http://purl.obolibrary.org/obo/CLO_0001619 | denotes | a 9 |
| T319 | 409-412 | http://purl.obolibrary.org/obo/CLO_0001620 | denotes | a 9 |
| T320 | 488-489 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T321 | 526-531 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T322 | 578-584 | http://purl.obolibrary.org/obo/CLO_0050457 | denotes | HE [42 |
| T323 | 851-859 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T324 | 943-944 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T325 | 945-946 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T326 | 951-958 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T327 | 1002-1003 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T328 | 1008-1009 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T329 | 1027-1030 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T330 | 1073-1078 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T331 | 1314-1319 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T332 | 1391-1396 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T333 | 1426-1431 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T334 | 1472-1477 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T335 | 1494-1502 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T336 | 1535-1536 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T337 | 1542-1547 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T637 | 7-9 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T642 | 39-41 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T647 | 122-124 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T648 | 168-170 | Chemical | denotes | FH | http://purl.obolibrary.org/obo/CHEBI_73634 |
| T649 | 245-247 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T650 | 321-333 | Chemical | denotes | acetyl group | http://purl.obolibrary.org/obo/CHEBI_40574 |
| T651 | 321-327 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_46887 |
| T652 | 328-333 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T653 | 415-421 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887 |
| T655 | 432-441 | Chemical | denotes | acetamido | http://purl.obolibrary.org/obo/CHEBI_48374 |
| T656 | 450-473 | Chemical | denotes | N-acetylneuraminic acid | http://purl.obolibrary.org/obo/CHEBI_17012 |
| T657 | 469-473 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T658 | 587-589 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T663 | 639-641 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T665 | 650-652 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T667 | 654-656 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T672 | 741-743 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T677 | 828-830 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T679 | 873-875 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T684 | 963-965 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T689 | 1035-1037 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T690 | 1042-1044 | Chemical | denotes | NA | http://purl.obolibrary.org/obo/CHEBI_33696 |
| T691 | 1189-1201 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T692 | 1224-1231 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T693 | 1259-1261 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T694 | 1266-1268 | Chemical | denotes | NA | http://purl.obolibrary.org/obo/CHEBI_33696 |
| T695 | 1289-1295 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887 |
| T697 | 1296-1298 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T702 | 1359-1365 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887 |
| T704 | 1466-1468 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T706 | 1491-1493 | Chemical | denotes | NA | http://purl.obolibrary.org/obo/CHEBI_33696 |
| T707 | 1507-1509 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T44 | 1054-1065 | http://purl.obolibrary.org/obo/GO_0006897 | denotes | endocytosis |
| T45 | 1449-1456 | http://purl.obolibrary.org/obo/GO_0007114 | denotes | budding |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T233 | 0-6 | Sentence | denotes | 4.2.2. |
| T234 | 7-34 | Sentence | denotes | SA C9-O-Acetyl Modification |
| T235 | 35-213 | Sentence | denotes | The SA 9-O-acetylation in hosts allows hosts to evade influenza A virus hemagglutinin (HA) recognition and some lectins of factor H (FH), CD22/Siglec-2 and sialoadhesin/Siglec-1. |
| T236 | 214-343 | Sentence | denotes | Instead, the influenza C virus HA recognizes the hosts. β-elimination and permethylation eliminate the 9-O-acetyl group from SAs. |
| T237 | 344-586 | Sentence | denotes | Chemical modification of the C-9 position of Neu5,9Ac2 generates a 9-N-acetyl analog, 9-acetamido-9-deoxy-N-acetylneuraminic acid (Neu5Ac9NAc), a mimic of Neu5,9Ac2 with influenza C virus-binding capacity, which is not cleaved by the HE [42]. |
| T238 | 587-653 | Sentence | denotes | SA O-acetylesterase regulates the presence of 7,9-O-Ac and 9-O-Ac. |
| T239 | 654-740 | Sentence | denotes | SA O-acetylation and deacetylation are involved in development, cancer and immunology. |
| T240 | 741-807 | Sentence | denotes | SA O-acetylation alters host lectin bindings such as siglecs [29]. |
| T241 | 808-872 | Sentence | denotes | The presence of 9-O-Ac can also reduce the activity of NAs [43]. |
| T242 | 873-932 | Sentence | denotes | SA modifications regulate pathogen binding or pathogen NAs. |
| T243 | 933-991 | Sentence | denotes | Influenza A/B/C/D viruses use SA as their entry receptors. |
| T244 | 992-1127 | Sentence | denotes | Influenza A and B subtypes bind to SAs via HA and NA to allow endocytosis of the virus and fusion of the viral envelope with endosomes. |
| T245 | 1128-1238 | Sentence | denotes | In contrast, influenza C and D subtypes bear only one coated glycoprotein, termed the HE fusion protein (HEF). |
| T246 | 1239-1269 | Sentence | denotes | The HEF acts as the HA and NA. |
| T247 | 1270-1457 | Sentence | denotes | HEF recognizes 9-O-acetyl SA for entry into cells, while the esterase domain removes 9-O-acetyl-groups and liberates the virus from mucus and mis-assembled virus aggregates after budding. |
| T248 | 1458-1553 | Sentence | denotes | The 9-O-Ac on cells prevents the NA activity and HA binding of the influenza A type virus [44]. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32604730-29341588-51943984 | 868-870 | 29341588 | denotes | 43 |
| 32604730-31796537-51943985 | 1549-1551 | 31796537 | denotes | 44 |
| T17811 | 868-870 | 29341588 | denotes | 43 |
| T51599 | 1549-1551 | 31796537 | denotes | 44 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T8 | 718-724 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |