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PMC:7352545 / 23215-24578 JSONTXT

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LitCovid_Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T79 16-18 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T80 313-319 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac
T81 641-643 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T215 538-548 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T216 888-896 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T89 407-416 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T90 702-711 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T91 830-862 Disease denotes human parainfluenza virus type 3 http://purl.obolibrary.org/obo/MONDO_0042974

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T285 131-133 http://purl.obolibrary.org/obo/CLO_0037284 denotes C4
T286 282-285 http://purl.obolibrary.org/obo/CLO_0051568 denotes SAs
T287 307-309 http://purl.obolibrary.org/obo/CLO_0037284 denotes C4
T288 340-341 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T289 417-418 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T290 423-424 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T291 425-432 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T292 507-509 http://purl.obolibrary.org/obo/CLO_0037284 denotes C4
T293 572-578 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T294 617-619 http://purl.obolibrary.org/obo/CLO_0037284 denotes C4
T295 623-625 http://purl.obolibrary.org/obo/CLO_0002105 denotes C2
T296 623-625 http://purl.obolibrary.org/obo/CLO_0051742 denotes C2
T297 665-673 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T298 712-713 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T299 714-719 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T300 741-742 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T301 743-748 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T302 759-762 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T303 830-835 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T304 850-855 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T305 870-873 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T306 874-876 http://purl.obolibrary.org/obo/CLO_0003788 denotes HN
T307 907-909 http://purl.obolibrary.org/obo/CLO_0037284 denotes C4
T308 1005-1008 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T309 1009-1010 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T310 1029-1030 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T311 1116-1118 http://purl.obolibrary.org/obo/CLO_0037284 denotes C4
T312 1285-1287 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T591 16-18 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T596 136-138 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T598 166-168 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T600 184-186 Chemical denotes NA http://purl.obolibrary.org/obo/CHEBI_33696
T601 187-197 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T602 256-258 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T604 276-278 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T606 313-319 Chemical denotes Neu5Ac http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133
T608 393-403 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T609 492-494 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T611 495-500 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T612 538-548 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T613 538-543 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T614 544-548 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T615 549-552 Chemical denotes Glu http://purl.obolibrary.org/obo/CHEBI_16015|http://purl.obolibrary.org/obo/CHEBI_18237|http://purl.obolibrary.org/obo/CHEBI_29972
T618 623-625 Chemical denotes C2 http://purl.obolibrary.org/obo/CHEBI_30083
T619 641-643 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T624 888-896 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T625 942-954 Chemical denotes alkyl groups http://purl.obolibrary.org/obo/CHEBI_22323
T626 969-980 Chemical denotes ethyl group http://purl.obolibrary.org/obo/CHEBI_37807
T627 969-974 Chemical denotes ethyl http://purl.obolibrary.org/obo/CHEBI_62801
T628 975-980 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T629 1033-1048 Chemical denotes guanidino group http://purl.obolibrary.org/obo/CHEBI_48551
T630 1043-1048 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T631 1153-1164 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T632 1184-1191 Chemical denotes Tamiflu http://purl.obolibrary.org/obo/CHEBI_7798|http://purl.obolibrary.org/obo/CHEBI_7799
T634 1217-1226 Chemical denotes zanamivir http://purl.obolibrary.org/obo/CHEBI_50663
T635 1246-1253 Chemical denotes Relenza http://purl.obolibrary.org/obo/CHEBI_50663
T636 1296-1301 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T221 0-139 Sentence denotes The position of SA O-acetylation is linked to functions including substrate differentiation of enzymes such as NAs and esterase by C4 O-Ac.
T222 140-269 Sentence denotes Previous development of O-Ac site-selective NA inhibitors were based on the conceptual consideration of different O-Ac positions.
T223 270-378 Sentence denotes The O-Ac of SAs is site-specific, as C4 of Neu5Ac is considered to be a potential position for modification.
T224 379-487 Sentence denotes Historically, inhibitors of influenza A and B viruses-sialidases were designed by Von-Itzstein in 1993 [39].
T225 488-597 Sentence denotes The Ac group-based C4 substitution interacts with amino acid Glu-119 present in the active site of sialidase.
T226 598-767 Sentence denotes Guanidine-attached C4 of C2–C3 unsaturated SA (Neu5Ac2en) inhibits activity of sialidases isolated from influenza A virus (Singapore/1/57) and B virus (Victoria/102/85).
T227 768-902 Sentence denotes The same scenario was applied for sialidase inhibition of the human parainfluenza virus type 3, which has HN and fusion proteins [40].
T228 903-981 Sentence denotes The C4 of Neu5Ac2en was substituted by alkyl groups such as the O-ethyl group.
T229 982-1071 Sentence denotes For example, Zanamivir has a substitution with a 4-guanidino group with an IC50 of 25 μM.
T230 1072-1145 Sentence denotes Thus, sialidase inhibition is important for C4 modification of Neu5Ac2en.
T231 1146-1289 Sentence denotes Later, oseltamivir with the tradename Tamiflu (Basel, Switzerland) and zanamivir with the tradename Relenza (London, UK) were established [41].
T232 1290-1363 Sentence denotes These drugs exhibit some adverse side effects that restrict clinical use.

2_test

Id Subject Object Predicate Lexical cue
32604730-8502295-51943981 483-485 8502295 denotes 39
32604730-17236768-51943982 898-900 17236768 denotes 40
32604730-19770846-51943983 1285-1287 19770846 denotes 41
T21609 483-485 8502295 denotes 39
T5112 898-900 17236768 denotes 40
T69375 1285-1287 19770846 denotes 41