PMC:7352545 / 20518-21274 JSON TXT

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LitCovid_Glycan-Motif-Structure

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T55","span":{"begin":81,"end":83},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T56","span":{"begin":234,"end":236},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T57","span":{"begin":301,"end":303},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T58","span":{"begin":430,"end":432},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T59","span":{"begin":686,"end":692},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"}],"text":"The O-acetyl modification occurs in single positions of C-4, C-7, C-8 and C-9 of SA as well as in combined C-positions to yield Neu4,5Ac2, Neu5,9Ac2 and Neu5,7,9Ac3 SAs. Neu5Ac9NAc is a chemical and biologic mimic of Neu5,9Ac2 in the SA-glycans. The C-7 and/or C-9 O-acetylations are catalyzed by the SA O-acetyltransferase enzyme, Cas1 domain containing 1 (CasD1) (Figure 6). CasD1 catalyzes the addition of acetyl groups to the SA C-7 at the late Golgi apparatus compartment [31]. Thereafter, an enzyme termed “migrase” transfers the additional acetyl-group from C-7 to C-9, although this enzyme has not been identified [29]. CasD1 uses acetyl-coenzyme A as a donor substrate and CMP-Neu5Ac as an acceptor substrate, but with weak activity on CMP-Neu5Gc."}

LitCovid-PD-FMA-UBERON

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T209","span":{"begin":449,"end":464},"obj":"Body_part"},{"id":"T210","span":{"begin":465,"end":476},"obj":"Body_part"}],"attributes":[{"id":"A209","pred":"fma_id","subj":"T209","obj":"http://purl.org/sig/ont/fma/fma63843"},{"id":"A210","pred":"fma_id","subj":"T210","obj":"http://purl.org/sig/ont/fma/fma76577"}],"text":"The O-acetyl modification occurs in single positions of C-4, C-7, C-8 and C-9 of SA as well as in combined C-positions to yield Neu4,5Ac2, Neu5,9Ac2 and Neu5,7,9Ac3 SAs. Neu5Ac9NAc is a chemical and biologic mimic of Neu5,9Ac2 in the SA-glycans. The C-7 and/or C-9 O-acetylations are catalyzed by the SA O-acetyltransferase enzyme, Cas1 domain containing 1 (CasD1) (Figure 6). CasD1 catalyzes the addition of acetyl groups to the SA C-7 at the late Golgi apparatus compartment [31]. Thereafter, an enzyme termed “migrase” transfers the additional acetyl-group from C-7 to C-9, although this enzyme has not been identified [29]. CasD1 uses acetyl-coenzyme A as a donor substrate and CMP-Neu5Ac as an acceptor substrate, but with weak activity on CMP-Neu5Gc."}

LitCovid-PD-CLO

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T240","span":{"begin":56,"end":59},"obj":"http://purl.obolibrary.org/obo/CLO_0037284"},{"id":"T241","span":{"begin":61,"end":64},"obj":"http://purl.obolibrary.org/obo/CLO_0002147"},{"id":"T242","span":{"begin":61,"end":64},"obj":"http://purl.obolibrary.org/obo/CLO_0051562"},{"id":"T243","span":{"begin":165,"end":168},"obj":"http://purl.obolibrary.org/obo/CLO_0051568"},{"id":"T244","span":{"begin":184,"end":185},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T245","span":{"begin":250,"end":253},"obj":"http://purl.obolibrary.org/obo/CLO_0002147"},{"id":"T246","span":{"begin":250,"end":253},"obj":"http://purl.obolibrary.org/obo/CLO_0051562"},{"id":"T247","span":{"begin":332,"end":336},"obj":"http://purl.obolibrary.org/obo/CLO_0002200"},{"id":"T248","span":{"begin":430,"end":434},"obj":"http://purl.obolibrary.org/obo/UBERON_0009856"},{"id":"T249","span":{"begin":565,"end":568},"obj":"http://purl.obolibrary.org/obo/CLO_0002147"},{"id":"T250","span":{"begin":565,"end":568},"obj":"http://purl.obolibrary.org/obo/CLO_0051562"},{"id":"T251","span":{"begin":598,"end":601},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T252","span":{"begin":655,"end":661},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T253","span":{"begin":733,"end":741},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"The O-acetyl modification occurs in single positions of C-4, C-7, C-8 and C-9 of SA as well as in combined C-positions to yield Neu4,5Ac2, Neu5,9Ac2 and Neu5,7,9Ac3 SAs. Neu5Ac9NAc is a chemical and biologic mimic of Neu5,9Ac2 in the SA-glycans. The C-7 and/or C-9 O-acetylations are catalyzed by the SA O-acetyltransferase enzyme, Cas1 domain containing 1 (CasD1) (Figure 6). CasD1 catalyzes the addition of acetyl groups to the SA C-7 at the late Golgi apparatus compartment [31]. Thereafter, an enzyme termed “migrase” transfers the additional acetyl-group from C-7 to C-9, although this enzyme has not been identified [29]. CasD1 uses acetyl-coenzyme A as a donor substrate and CMP-Neu5Ac as an acceptor substrate, but with weak activity on CMP-Neu5Gc."}

LitCovid-PD-CHEBI

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T197","span":{"begin":0,"end":169},"obj":"Sentence"},{"id":"T198","span":{"begin":170,"end":245},"obj":"Sentence"},{"id":"T199","span":{"begin":246,"end":376},"obj":"Sentence"},{"id":"T200","span":{"begin":377,"end":482},"obj":"Sentence"},{"id":"T201","span":{"begin":483,"end":627},"obj":"Sentence"},{"id":"T202","span":{"begin":628,"end":756},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The O-acetyl modification occurs in single positions of C-4, C-7, C-8 and C-9 of SA as well as in combined C-positions to yield Neu4,5Ac2, Neu5,9Ac2 and Neu5,7,9Ac3 SAs. Neu5Ac9NAc is a chemical and biologic mimic of Neu5,9Ac2 in the SA-glycans. The C-7 and/or C-9 O-acetylations are catalyzed by the SA O-acetyltransferase enzyme, Cas1 domain containing 1 (CasD1) (Figure 6). CasD1 catalyzes the addition of acetyl groups to the SA C-7 at the late Golgi apparatus compartment [31]. Thereafter, an enzyme termed “migrase” transfers the additional acetyl-group from C-7 to C-9, although this enzyme has not been identified [29]. CasD1 uses acetyl-coenzyme A as a donor substrate and CMP-Neu5Ac as an acceptor substrate, but with weak activity on CMP-Neu5Gc."}

2_test

{"project":"2_test","denotations":[{"id":"32604730-26169044-51943971","span":{"begin":478,"end":480},"obj":"26169044"},{"id":"T96738","span":{"begin":478,"end":480},"obj":"26169044"}],"text":"The O-acetyl modification occurs in single positions of C-4, C-7, C-8 and C-9 of SA as well as in combined C-positions to yield Neu4,5Ac2, Neu5,9Ac2 and Neu5,7,9Ac3 SAs. Neu5Ac9NAc is a chemical and biologic mimic of Neu5,9Ac2 in the SA-glycans. The C-7 and/or C-9 O-acetylations are catalyzed by the SA O-acetyltransferase enzyme, Cas1 domain containing 1 (CasD1) (Figure 6). CasD1 catalyzes the addition of acetyl groups to the SA C-7 at the late Golgi apparatus compartment [31]. Thereafter, an enzyme termed “migrase” transfers the additional acetyl-group from C-7 to C-9, although this enzyme has not been identified [29]. CasD1 uses acetyl-coenzyme A as a donor substrate and CMP-Neu5Ac as an acceptor substrate, but with weak activity on CMP-Neu5Gc."}