PMC:7352545 / 18413-19469 JSONTXT

Annnotations TAB JSON ListView MergeView

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7352545","sourcedb":"PMC","sourceid":"7352545","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7352545","text":"HE hemagglutinates and destroys receptors. As RNA viruses, CoVs bear RDEs, which are used in effective attachment to hosts and also reversely in detachment from the hosts. For example, enveloped RNA viruses evade the hosts via their RDEs. Currently, RDE-related functional enzymes such as neuraminidase (NA) and SA-O-acetyl-esterase are known. SA-O-acetyl-esterase was originally identified in influenza C virus and in nidoviruses (CoV and torovirus) as well as in salmon anemia virus (teleost orthomyxovirus). The origin and evolution of CoV SA-O-acetylesterases are correlated to other viruses. The fusion event of S glycoprotein and HE is specific for HCoV attachment to SA-associated receptors in the host [25]. The HE has acetylesterase activity [26]. In early SA-related biology, influenza A/B viruses were found to recognize chicken erythrocytes in 1942 [27]. They caused hemagglutination through clumping by virus-borne hemagglutinin. These phenomena were widely found in influenza viruses, paramyxoviruses, Newcastle disease (NDV) and mumps virus.","tracks":[{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T34","span":{"begin":312,"end":314},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T35","span":{"begin":344,"end":346},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T36","span":{"begin":543,"end":545},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T37","span":{"begin":674,"end":676},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T38","span":{"begin":766,"end":768},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"}],"attributes":[{"subj":"T34","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T35","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T36","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T37","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T38","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T201","span":{"begin":46,"end":49},"obj":"Body_part"},{"id":"T202","span":{"begin":195,"end":198},"obj":"Body_part"},{"id":"T203","span":{"begin":619,"end":631},"obj":"Body_part"},{"id":"T204","span":{"begin":840,"end":852},"obj":"Body_part"}],"attributes":[{"id":"A201","pred":"fma_id","subj":"T201","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A202","pred":"fma_id","subj":"T202","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A203","pred":"fma_id","subj":"T203","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A204","pred":"fma_id","subj":"T204","obj":"http://purl.org/sig/ont/fma/fma62845"},{"subj":"T201","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T202","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T203","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T204","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"552","span":{"begin":766,"end":768},"obj":"Gene"},{"id":"553","span":{"begin":59,"end":63},"obj":"Species"},{"id":"554","span":{"begin":394,"end":411},"obj":"Species"},{"id":"555","span":{"begin":432,"end":435},"obj":"Species"},{"id":"556","span":{"begin":539,"end":542},"obj":"Species"},{"id":"557","span":{"begin":832,"end":839},"obj":"Species"},{"id":"558","span":{"begin":980,"end":997},"obj":"Species"},{"id":"559","span":{"begin":1044,"end":1055},"obj":"Species"},{"id":"560","span":{"begin":786,"end":795},"obj":"Species"},{"id":"561","span":{"begin":1016,"end":1025},"obj":"Species"},{"id":"562","span":{"begin":0,"end":18},"obj":"Chemical"},{"id":"563","span":{"begin":465,"end":484},"obj":"Disease"}],"attributes":[{"id":"A552","pred":"tao:has_database_id","subj":"552","obj":"Gene:6296"},{"id":"A553","pred":"tao:has_database_id","subj":"553","obj":"Tax:11118"},{"id":"A554","pred":"tao:has_database_id","subj":"554","obj":"Tax:11552"},{"id":"A555","pred":"tao:has_database_id","subj":"555","obj":"Tax:11118"},{"id":"A556","pred":"tao:has_database_id","subj":"556","obj":"Tax:11118"},{"id":"A557","pred":"tao:has_database_id","subj":"557","obj":"Tax:9031"},{"id":"A558","pred":"tao:has_database_id","subj":"558","obj":"Tax:11308"},{"id":"A559","pred":"tao:has_database_id","subj":"559","obj":"Tax:11161"},{"id":"A560","pred":"tao:has_database_id","subj":"560","obj":"Tax:11552"},{"id":"A561","pred":"tao:has_database_id","subj":"561","obj":"Tax:11176"},{"id":"A563","pred":"tao:has_database_id","subj":"563","obj":"MESH:D000740"},{"subj":"552","pred":"source","obj":"LitCovid-PubTator"},{"subj":"553","pred":"source","obj":"LitCovid-PubTator"},{"subj":"554","pred":"source","obj":"LitCovid-PubTator"},{"subj":"555","pred":"source","obj":"LitCovid-PubTator"},{"subj":"556","pred":"source","obj":"LitCovid-PubTator"},{"subj":"557","pred":"source","obj":"LitCovid-PubTator"},{"subj":"558","pred":"source","obj":"LitCovid-PubTator"},{"subj":"559","pred":"source","obj":"LitCovid-PubTator"},{"subj":"560","pred":"source","obj":"LitCovid-PubTator"},{"subj":"561","pred":"source","obj":"LitCovid-PubTator"},{"subj":"562","pred":"source","obj":"LitCovid-PubTator"},{"subj":"563","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T78","span":{"begin":394,"end":403},"obj":"Disease"},{"id":"T79","span":{"begin":472,"end":478},"obj":"Disease"},{"id":"T80","span":{"begin":786,"end":795},"obj":"Disease"},{"id":"T81","span":{"begin":980,"end":989},"obj":"Disease"},{"id":"T82","span":{"begin":1016,"end":1033},"obj":"Disease"},{"id":"T83","span":{"begin":1044,"end":1049},"obj":"Disease"}],"attributes":[{"id":"A78","pred":"mondo_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A79","pred":"mondo_id","subj":"T79","obj":"http://purl.obolibrary.org/obo/MONDO_0002280"},{"id":"A80","pred":"mondo_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A81","pred":"mondo_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A82","pred":"mondo_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/MONDO_0005875"},{"id":"A83","pred":"mondo_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/MONDO_0000989"},{"subj":"T78","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T79","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T80","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T81","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T82","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T83","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T211","span":{"begin":50,"end":57},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T212","span":{"begin":69,"end":73},"obj":"http://purl.obolibrary.org/obo/CLO_0008774"},{"id":"T213","span":{"begin":199,"end":206},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T214","span":{"begin":233,"end":237},"obj":"http://purl.obolibrary.org/obo/CLO_0008774"},{"id":"T215","span":{"begin":406,"end":411},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T216","span":{"begin":479,"end":484},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T217","span":{"begin":588,"end":595},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T218","span":{"begin":723,"end":726},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T219","span":{"begin":742,"end":750},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T220","span":{"begin":796,"end":797},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T221","span":{"begin":798,"end":799},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T222","span":{"begin":800,"end":807},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T223","span":{"begin":832,"end":839},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9031"},{"id":"T224","span":{"begin":840,"end":852},"obj":"http://purl.obolibrary.org/obo/CL_0000232"},{"id":"T225","span":{"begin":862,"end":864},"obj":"http://purl.obolibrary.org/obo/CLO_0050509"},{"id":"T226","span":{"begin":916,"end":921},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T227","span":{"begin":990,"end":997},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T228","span":{"begin":1050,"end":1055},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"attributes":[{"subj":"T211","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T212","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T213","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T214","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T215","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T216","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T217","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T218","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T219","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T220","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T221","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T222","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T223","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T224","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T225","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T226","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T227","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T228","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T365","span":{"begin":304,"end":306},"obj":"Chemical"},{"id":"T366","span":{"begin":312,"end":314},"obj":"Chemical"},{"id":"T371","span":{"begin":317,"end":323},"obj":"Chemical"},{"id":"T373","span":{"begin":344,"end":346},"obj":"Chemical"},{"id":"T378","span":{"begin":349,"end":355},"obj":"Chemical"},{"id":"T380","span":{"begin":543,"end":545},"obj":"Chemical"},{"id":"T385","span":{"begin":619,"end":631},"obj":"Chemical"},{"id":"T386","span":{"begin":674,"end":676},"obj":"Chemical"},{"id":"T391","span":{"begin":766,"end":768},"obj":"Chemical"}],"attributes":[{"id":"A365","pred":"chebi_id","subj":"T365","obj":"http://purl.obolibrary.org/obo/CHEBI_33696"},{"id":"A366","pred":"chebi_id","subj":"T366","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A367","pred":"chebi_id","subj":"T366","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A368","pred":"chebi_id","subj":"T366","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A369","pred":"chebi_id","subj":"T366","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A370","pred":"chebi_id","subj":"T366","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A371","pred":"chebi_id","subj":"T371","obj":"http://purl.obolibrary.org/obo/CHEBI_40574"},{"id":"A372","pred":"chebi_id","subj":"T371","obj":"http://purl.obolibrary.org/obo/CHEBI_46887"},{"id":"A373","pred":"chebi_id","subj":"T373","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A374","pred":"chebi_id","subj":"T373","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A375","pred":"chebi_id","subj":"T373","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A376","pred":"chebi_id","subj":"T373","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A377","pred":"chebi_id","subj":"T373","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A378","pred":"chebi_id","subj":"T378","obj":"http://purl.obolibrary.org/obo/CHEBI_40574"},{"id":"A379","pred":"chebi_id","subj":"T378","obj":"http://purl.obolibrary.org/obo/CHEBI_46887"},{"id":"A380","pred":"chebi_id","subj":"T380","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A381","pred":"chebi_id","subj":"T380","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A382","pred":"chebi_id","subj":"T380","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A383","pred":"chebi_id","subj":"T380","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A384","pred":"chebi_id","subj":"T380","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A385","pred":"chebi_id","subj":"T385","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A386","pred":"chebi_id","subj":"T386","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A387","pred":"chebi_id","subj":"T386","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A388","pred":"chebi_id","subj":"T386","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A389","pred":"chebi_id","subj":"T386","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A390","pred":"chebi_id","subj":"T386","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A391","pred":"chebi_id","subj":"T391","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A392","pred":"chebi_id","subj":"T391","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A393","pred":"chebi_id","subj":"T391","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A394","pred":"chebi_id","subj":"T391","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A395","pred":"chebi_id","subj":"T391","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"subj":"T365","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T366","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T371","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T373","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T378","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T380","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T385","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T386","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T391","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T172","span":{"begin":0,"end":42},"obj":"Sentence"},{"id":"T173","span":{"begin":43,"end":171},"obj":"Sentence"},{"id":"T174","span":{"begin":172,"end":238},"obj":"Sentence"},{"id":"T175","span":{"begin":239,"end":343},"obj":"Sentence"},{"id":"T176","span":{"begin":344,"end":510},"obj":"Sentence"},{"id":"T177","span":{"begin":511,"end":596},"obj":"Sentence"},{"id":"T178","span":{"begin":597,"end":715},"obj":"Sentence"},{"id":"T179","span":{"begin":716,"end":756},"obj":"Sentence"},{"id":"T180","span":{"begin":757,"end":866},"obj":"Sentence"},{"id":"T181","span":{"begin":867,"end":942},"obj":"Sentence"},{"id":"T182","span":{"begin":943,"end":1056},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T172","pred":"source","obj":"LitCovid-sentences"},{"subj":"T173","pred":"source","obj":"LitCovid-sentences"},{"subj":"T174","pred":"source","obj":"LitCovid-sentences"},{"subj":"T175","pred":"source","obj":"LitCovid-sentences"},{"subj":"T176","pred":"source","obj":"LitCovid-sentences"},{"subj":"T177","pred":"source","obj":"LitCovid-sentences"},{"subj":"T178","pred":"source","obj":"LitCovid-sentences"},{"subj":"T179","pred":"source","obj":"LitCovid-sentences"},{"subj":"T180","pred":"source","obj":"LitCovid-sentences"},{"subj":"T181","pred":"source","obj":"LitCovid-sentences"},{"subj":"T182","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32604730-25926653-51943968","span":{"begin":752,"end":754},"obj":"25926653"},{"id":"32604730-19871229-51943969","span":{"begin":862,"end":864},"obj":"19871229"},{"id":"T97535","span":{"begin":752,"end":754},"obj":"25926653"},{"id":"T59612","span":{"begin":862,"end":864},"obj":"19871229"}],"attributes":[{"subj":"32604730-25926653-51943968","pred":"source","obj":"2_test"},{"subj":"32604730-19871229-51943969","pred":"source","obj":"2_test"},{"subj":"T97535","pred":"source","obj":"2_test"},{"subj":"T59612","pred":"source","obj":"2_test"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T6","span":{"begin":472,"end":478},"obj":"Phenotype"}],"attributes":[{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0001903"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-HP"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid_Glycan-Motif-Structure","color":"#ec93c9","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#93e3ec"},{"id":"LitCovid-PubTator","color":"#ecdb93"},{"id":"LitCovid-PD-MONDO","color":"#c193ec"},{"id":"LitCovid-PD-CLO","color":"#93eca7"},{"id":"LitCovid-PD-CHEBI","color":"#ec9399"},{"id":"LitCovid-sentences","color":"#93b3ec"},{"id":"2_test","color":"#cdec93"},{"id":"LitCovid-PD-HP","color":"#ec93e7"}]}]}}