PMC:7352545 / 12447-14467
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T95 | 4-7 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T96 | 139-147 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T97 | 162-169 | Body_part | denotes | cytosol | http://purl.org/sig/ont/fma/fma66836 |
| T98 | 341-344 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T99 | 345-351 | Body_part | denotes | genome | http://purl.org/sig/ont/fma/fma84116 |
| T100 | 357-364 | Body_part | denotes | genomes | http://purl.org/sig/ont/fma/fma84116 |
| T101 | 488-496 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T102 | 666-673 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T103 | 694-699 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T104 | 758-765 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T105 | 827-834 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T106 | 906-913 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T107 | 968-976 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T108 | 1104-1120 | Body_part | denotes | scaffold protein | http://purl.org/sig/ont/fma/fma62376 |
| T109 | 1260-1276 | Body_part | denotes | scaffold protein | http://purl.org/sig/ont/fma/fma62376 |
| T110 | 1296-1304 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T111 | 1369-1372 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T112 | 1432-1435 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T113 | 1444-1451 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T114 | 1467-1471 | Body_part | denotes | ExoN | http://purl.org/sig/ont/fma/fma84120 |
| T115 | 1623-1626 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T116 | 1707-1711 | Body_part | denotes | ExoN | http://purl.org/sig/ont/fma/fma84120 |
| T117 | 1831-1834 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T118 | 1835-1841 | Body_part | denotes | genome | http://purl.org/sig/ont/fma/fma84116 |
| T119 | 1953-1956 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T120 | 1998-2005 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 467 | 1022-1025 | Gene | denotes | PDB | Gene:5131 |
| 468 | 353-356 | Species | denotes | CoV | Tax:11118 |
| 469 | 1962-1970 | Disease | denotes | melanoma | MESH:D008545 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T59 | 1962-1970 | Disease | denotes | melanoma | http://purl.obolibrary.org/obo/MONDO_0005105 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T133 | 392-397 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T134 | 694-699 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T135 | 793-794 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T136 | 848-858 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activities |
| T137 | 951-959 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T138 | 1063-1068 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T139 | 1099-1100 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T140 | 1132-1140 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T141 | 1165-1168 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T142 | 1169-1170 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T143 | 1211-1216 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T144 | 1255-1256 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T145 | 1403-1404 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T146 | 1457-1466 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activates |
| T147 | 1513-1521 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T148 | 1562-1563 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T149 | 1669-1670 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T150 | 1684-1688 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 3′-5 |
| T151 | 1858-1859 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T152 | 1902-1905 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T153 | 1923-1931 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T275 | 139-147 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T276 | 488-496 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T277 | 666-673 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T278 | 758-765 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T279 | 823-825 | Chemical | denotes | TM | http://purl.obolibrary.org/obo/CHEBI_55460|http://purl.obolibrary.org/obo/CHEBI_74861 |
| T281 | 827-834 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T282 | 906-913 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T283 | 918-921 | Chemical | denotes | ADP | http://purl.obolibrary.org/obo/CHEBI_16761|http://purl.obolibrary.org/obo/CHEBI_456216|http://purl.obolibrary.org/obo/CHEBI_73342 |
| T286 | 922-928 | Chemical | denotes | ribose | http://purl.obolibrary.org/obo/CHEBI_33942|http://purl.obolibrary.org/obo/CHEBI_47013 |
| T288 | 1101-1103 | Chemical | denotes | TM | http://purl.obolibrary.org/obo/CHEBI_55460|http://purl.obolibrary.org/obo/CHEBI_74861 |
| T290 | 1113-1120 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T291 | 1257-1259 | Chemical | denotes | TM | http://purl.obolibrary.org/obo/CHEBI_55460|http://purl.obolibrary.org/obo/CHEBI_74861 |
| T293 | 1269-1276 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T294 | 1296-1304 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T295 | 1444-1451 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T296 | 1998-2005 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T13 | 216-229 | http://purl.obolibrary.org/obo/GO_0003968 | denotes | transcriptase |
| T14 | 216-229 | http://purl.obolibrary.org/obo/GO_0003899 | denotes | transcriptase |
| T15 | 309-322 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T16 | 666-685 | http://purl.obolibrary.org/obo/GO_0006412 | denotes | protein translation |
| T17 | 704-727 | http://purl.obolibrary.org/obo/GO_0045087 | denotes | innate immune responses |
| T18 | 932-943 | http://purl.obolibrary.org/obo/GO_0016791 | denotes | phosphatase |
| T19 | 1033-1047 | http://purl.obolibrary.org/obo/GO_0004843 | denotes | deubiquitinase |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T104 | 0-68 | Sentence | denotes | The RNA generates the replicase as two polyproteins, pp1a and pp1ab. |
| T105 | 69-244 | Sentence | denotes | The replicase-encoded viral proteases generate up to 16 nonstructural proteins (Nsps) in the cytosol to produce replicase enzyme and the replicase–transcriptase complex (RTC). |
| T106 | 245-352 | Sentence | denotes | These enzymes including RTC synthesize RNAs for replication and transcription to generate viral RNA genome. |
| T107 | 353-443 | Sentence | denotes | CoV genomes bear two or three protease genes and the coding enzymes cleave the replicases. |
| T108 | 444-541 | Sentence | denotes | Together with the replicases, nonstructural proteins, termed Nsps, assemble into the RTC complex. |
| T109 | 542-598 | Sentence | denotes | Nsp1 to Nsp16 are known to have multiple enzyme regions. |
| T110 | 599-728 | Sentence | denotes | For example, Nsp1 degrades cellular mRNAs and, consequently blocks protein translation in host cells and innate immune responses. |
| T111 | 729-784 | Sentence | denotes | Nsp2 recognizes the specific protein called prohibitin. |
| T112 | 785-859 | Sentence | denotes | Nsp3 is a multi-domain transmembrane (TM) protein with diverse activities. |
| T113 | 860-988 | Sentence | denotes | Ubiquitin-like 1 and acidic domains bind to N protein and ADP-ribose-1′-phosphatase (ADRP) activity induces cytokine expression. |
| T114 | 989-1090 | Sentence | denotes | The papain-like protease (PLpro)(PDB:6WX4)/ deubiquitinase domain cleaves virus-produced polyprotein. |
| T115 | 1091-1159 | Sentence | denotes | Nsp4 is a TM scaffold protein for double-membrane vesicle structure. |
| T116 | 1160-1277 | Sentence | denotes | Nsp5 has a main protease domain which also cleaves virus-produced polyprotein and Nsp6 acts as a TM scaffold protein. |
| T117 | 1278-1420 | Sentence | denotes | The Nsp7 and Nsp8 proteins form the Nsp7-Nsp8 hexadecameric complex, which functions as an RNA polymerase-specific clamp and a primase enzyme. |
| T118 | 1421-1522 | Sentence | denotes | Nsp9 is an RNA-binding protein that activates ExoN and 2-O-methyltrnasferase (MTase) enzyme activity. |
| T119 | 1523-1586 | Sentence | denotes | Nsp10 binds to Nsp16 and Nsp14 to form a heterodimeric complex. |
| T120 | 1587-1658 | Sentence | denotes | Nsp12 is the RdRp and Nsps13 is the RNA helicase and 5′ triphosphatase. |
| T121 | 1659-1706 | Sentence | denotes | Nsps14 is a N7 MTase and 3′-5′ exoribonuclease. |
| T122 | 1707-1780 | Sentence | denotes | ExoN of Nsap14 acts as an N7 MTase and attaches the 5′ cap to viral RNAs. |
| T123 | 1781-1888 | Sentence | denotes | Viral exoribonuclease enzyme proofreads the viral RNA genome, where Nsp15 is a viral endoribonuclease (PDB: |
| T124 | 1889-1895 | Sentence | denotes | 6VWW). |
| T125 | 1896-2020 | Sentence | denotes | Nsp16 has 2-O-MTase enzyme activity, which shields viral RNA from melanoma differentiation associated protein-5 recognition. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T5 | 1962-1970 | Phenotype | denotes | melanoma | http://purl.obolibrary.org/obo/HP_0002861 |