PMC:7346000 / 7166-7726 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7346000","sourcedb":"PMC","sourceid":"7346000","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7346000","text":"2 may elicit, to a large extent, overlapping signaling pathways towards the production of inflammatory cytokines. In addition, the activation of the inflammasome by SARS-CoV and the consequent production of IL-1β is an event that contributes further to the hyperinflammatory response [23]. A transcriptome analysis of COVID-19 patients revealed an early immune response characterized by a marked upregulation of the IL-1 pathway, even after respiratory function nadir [24]. The possibility that IL-1 and related pro-inflammatory pathways could serve as therape","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T18","span":{"begin":103,"end":112},"obj":"Body_part"},{"id":"T19","span":{"begin":207,"end":211},"obj":"Body_part"},{"id":"T20","span":{"begin":416,"end":420},"obj":"Body_part"},{"id":"T21","span":{"begin":495,"end":499},"obj":"Body_part"}],"attributes":[{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A20","pred":"fma_id","subj":"T20","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A21","pred":"fma_id","subj":"T21","obj":"http://purl.org/sig/ont/fma/fma86583"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"232","span":{"begin":207,"end":212},"obj":"Gene"},{"id":"233","span":{"begin":416,"end":420},"obj":"Gene"},{"id":"234","span":{"begin":495,"end":499},"obj":"Gene"},{"id":"239","span":{"begin":165,"end":173},"obj":"Species"},{"id":"240","span":{"begin":327,"end":335},"obj":"Species"},{"id":"246","span":{"begin":318,"end":326},"obj":"Disease"}],"attributes":[{"id":"A232","pred":"tao:has_database_id","subj":"232","obj":"Gene:3552"},{"id":"A233","pred":"tao:has_database_id","subj":"233","obj":"Gene:3552"},{"id":"A234","pred":"tao:has_database_id","subj":"234","obj":"Gene:3552"},{"id":"A239","pred":"tao:has_database_id","subj":"239","obj":"Tax:694009"},{"id":"A240","pred":"tao:has_database_id","subj":"240","obj":"Tax:9606"},{"id":"A246","pred":"tao:has_database_id","subj":"246","obj":"MESH:C000657245"},{"subj":"232","pred":"source","obj":"LitCovid-PubTator"},{"subj":"233","pred":"source","obj":"LitCovid-PubTator"},{"subj":"234","pred":"source","obj":"LitCovid-PubTator"},{"subj":"239","pred":"source","obj":"LitCovid-PubTator"},{"subj":"240","pred":"source","obj":"LitCovid-PubTator"},{"subj":"246","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T81","span":{"begin":165,"end":173},"obj":"Disease"},{"id":"T82","span":{"begin":318,"end":326},"obj":"Disease"}],"attributes":[{"id":"A81","pred":"mondo_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A82","pred":"mondo_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T81","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T82","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T56","span":{"begin":17,"end":18},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T57","span":{"begin":45,"end":54},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T58","span":{"begin":131,"end":141},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T59","span":{"begin":290,"end":291},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T60","span":{"begin":387,"end":388},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T56","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T57","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T58","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T59","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T60","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T32","span":{"begin":207,"end":209},"obj":"Chemical"},{"id":"T34","span":{"begin":416,"end":418},"obj":"Chemical"},{"id":"T36","span":{"begin":495,"end":497},"obj":"Chemical"}],"attributes":[{"id":"A32","pred":"chebi_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A33","pred":"chebi_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A34","pred":"chebi_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A35","pred":"chebi_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A36","pred":"chebi_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A37","pred":"chebi_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"subj":"T32","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T34","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T36","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T18","span":{"begin":45,"end":63},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T19","span":{"begin":45,"end":54},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T20","span":{"begin":354,"end":369},"obj":"http://purl.obolibrary.org/obo/GO_0006955"}],"attributes":[{"subj":"T18","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T41","span":{"begin":114,"end":289},"obj":"Sentence"},{"id":"T42","span":{"begin":290,"end":473},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T41","pred":"source","obj":"LitCovid-sentences"},{"subj":"T42","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32599813-31231549-60095078","span":{"begin":285,"end":287},"obj":"31231549"},{"id":"32599813-32359396-60095079","span":{"begin":469,"end":471},"obj":"32359396"}],"attributes":[{"subj":"32599813-31231549-60095078","pred":"source","obj":"2_test"},{"subj":"32599813-32359396-60095079","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93ecc1","default":true},{"id":"LitCovid-PubTator","color":"#eca793"},{"id":"LitCovid-PD-MONDO","color":"#9399ec"},{"id":"LitCovid-PD-CLO","color":"#b3ec93"},{"id":"LitCovid-PD-CHEBI","color":"#ec93cd"},{"id":"LitCovid-PD-GO-BP","color":"#93e7ec"},{"id":"LitCovid-sentences","color":"#ecd793"},{"id":"2_test","color":"#bd93ec"}]}]}}