2 may elicit, to a large extent, overlapping signaling pathways towards the production of inflammatory cytokines. In addition, the activation of the inflammasome by SARS-CoV and the consequent production of IL-1β is an event that contributes further to the hyperinflammatory response [23]. A transcriptome analysis of COVID-19 patients revealed an early immune response characterized by a marked upregulation of the IL-1 pathway, even after respiratory function nadir [24]. The possibility that IL-1 and related pro-inflammatory pathways could serve as therape