PMC:7346000 / 6595-8462 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7346000","sourcedb":"PMC","sourceid":"7346000","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7346000","text":"A second possibility involves the collateral effects of recognition pathways required for the activation of antiviral immunity that may, paradoxically, contribute to an inflammatory environment that favors secondary infections. ACE2 is not well expressed on immune cells and SARS-CoV are recognized by TLR4 and TLR3, leading to the activation of MyD88- or TRIF-mediated signaling, respectively [20,21]. Of note, this may be potentiated in the presence of Aspergillus spp. which activate TLR4/MyD88/TRIF through the cleavage of fibrinogen [22]. It is likely that SARS-CoV-2 may elicit, to a large extent, overlapping signaling pathways towards the production of inflammatory cytokines. In addition, the activation of the inflammasome by SARS-CoV and the consequent production of IL-1β is an event that contributes further to the hyperinflammatory response [23]. A transcriptome analysis of COVID-19 patients revealed an early immune response characterized by a marked upregulation of the IL-1 pathway, even after respiratory function nadir [24]. The possibility that IL-1 and related pro-inflammatory pathways could serve as therapeutic targets was demonstrated by the favorable responses in severe COVID-19 patients with secondary hemophagocytic lymphohistiocytosis treated with the interleukin-1 receptor antagonist anakinra [25]. Similar findings were also disclosed in acute leukemia patients with COVID-19 [26]. Likewise, IL-1 blockade with anakinra has also been found to ameliorate inflammation in both chronic granulomatous disease [27] and cystic fibrosis [28], and in either case, to restrain susceptibility to infection or colonization by Aspergillus. Therefore, the early hyperactivation of the IL-1 pathway induced by the SARS-CoV-2 infection may be a major factor establishing a highly permissive inflammatory environment that favors fungal pathogenesis.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T17","span":{"begin":265,"end":270},"obj":"Body_part"},{"id":"T18","span":{"begin":674,"end":683},"obj":"Body_part"},{"id":"T19","span":{"begin":778,"end":782},"obj":"Body_part"},{"id":"T20","span":{"begin":987,"end":991},"obj":"Body_part"},{"id":"T21","span":{"begin":1066,"end":1070},"obj":"Body_part"},{"id":"T22","span":{"begin":1283,"end":1296},"obj":"Body_part"},{"id":"T23","span":{"begin":1426,"end":1430},"obj":"Body_part"},{"id":"T24","span":{"begin":1706,"end":1710},"obj":"Body_part"}],"attributes":[{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A20","pred":"fma_id","subj":"T20","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A21","pred":"fma_id","subj":"T21","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A22","pred":"fma_id","subj":"T22","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A23","pred":"fma_id","subj":"T23","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A24","pred":"fma_id","subj":"T24","obj":"http://purl.org/sig/ont/fma/fma86583"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T15","span":{"begin":1372,"end":1386},"obj":"Phenotype"},{"id":"T16","span":{"begin":1602,"end":1629},"obj":"Phenotype"}],"attributes":[{"id":"A15","pred":"hp_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/HP_0002488"},{"id":"A16","pred":"hp_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/HP_0002719"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T78","span":{"begin":216,"end":226},"obj":"Disease"},{"id":"T79","span":{"begin":275,"end":283},"obj":"Disease"},{"id":"T80","span":{"begin":562,"end":570},"obj":"Disease"},{"id":"T81","span":{"begin":736,"end":744},"obj":"Disease"},{"id":"T82","span":{"begin":889,"end":897},"obj":"Disease"},{"id":"T83","span":{"begin":1198,"end":1206},"obj":"Disease"},{"id":"T84","span":{"begin":1221,"end":1265},"obj":"Disease"},{"id":"T85","span":{"begin":1231,"end":1265},"obj":"Disease"},{"id":"T86","span":{"begin":1372,"end":1386},"obj":"Disease"},{"id":"T87","span":{"begin":1378,"end":1386},"obj":"Disease"},{"id":"T88","span":{"begin":1401,"end":1409},"obj":"Disease"},{"id":"T89","span":{"begin":1488,"end":1500},"obj":"Disease"},{"id":"T90","span":{"begin":1509,"end":1538},"obj":"Disease"},{"id":"T91","span":{"begin":1548,"end":1563},"obj":"Disease"},{"id":"T92","span":{"begin":1620,"end":1629},"obj":"Disease"},{"id":"T93","span":{"begin":1734,"end":1742},"obj":"Disease"},{"id":"T94","span":{"begin":1745,"end":1754},"obj":"Disease"}],"attributes":[{"id":"A78","pred":"mondo_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A79","pred":"mondo_id","subj":"T79","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A80","pred":"mondo_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A81","pred":"mondo_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A82","pred":"mondo_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A83","pred":"mondo_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A84","pred":"mondo_id","subj":"T84","obj":"http://purl.obolibrary.org/obo/MONDO_0015542"},{"id":"A85","pred":"mondo_id","subj":"T85","obj":"http://purl.obolibrary.org/obo/MONDO_0015540"},{"id":"A86","pred":"mondo_id","subj":"T86","obj":"http://purl.obolibrary.org/obo/MONDO_0010643"},{"id":"A87","pred":"mondo_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/MONDO_0005059"},{"id":"A88","pred":"mondo_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A89","pred":"mondo_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A90","pred":"mondo_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/MONDO_0018305"},{"id":"A91","pred":"mondo_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/MONDO_0009061"},{"id":"A92","pred":"mondo_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A93","pred":"mondo_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A94","pred":"mondo_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"subj":"T78","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T79","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T80","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T81","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T82","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T83","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T84","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T85","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T86","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T87","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T88","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T89","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T90","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T91","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T92","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T93","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T94","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T49","span":{"begin":0,"end":1},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T50","span":{"begin":94,"end":104},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T51","span":{"begin":265,"end":270},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T52","span":{"begin":332,"end":342},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T53","span":{"begin":370,"end":379},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T54","span":{"begin":478,"end":486},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T55","span":{"begin":539,"end":541},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"},{"id":"T56","span":{"begin":588,"end":589},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T57","span":{"begin":616,"end":625},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T58","span":{"begin":702,"end":712},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T59","span":{"begin":861,"end":862},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T60","span":{"begin":958,"end":959},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T61","span":{"begin":1283,"end":1296},"obj":"http://purl.obolibrary.org/obo/PR_000001091"},{"id":"T62","span":{"begin":1454,"end":1457},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T63","span":{"begin":1540,"end":1542},"obj":"http://purl.obolibrary.org/obo/CLO_0050509"},{"id":"T64","span":{"begin":1633,"end":1645},"obj":"http://purl.obolibrary.org/obo/UBERON_0001155"},{"id":"T65","span":{"begin":1762,"end":1763},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T66","span":{"begin":1790,"end":1791},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T49","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T50","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T51","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T52","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T53","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T54","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T55","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T57","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T58","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T59","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T60","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T61","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T62","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T63","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T64","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T65","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T66","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T31","span":{"begin":108,"end":117},"obj":"Chemical"},{"id":"T32","span":{"begin":778,"end":780},"obj":"Chemical"},{"id":"T34","span":{"begin":987,"end":989},"obj":"Chemical"},{"id":"T36","span":{"begin":1066,"end":1068},"obj":"Chemical"},{"id":"T38","span":{"begin":1306,"end":1316},"obj":"Chemical"},{"id":"T39","span":{"begin":1426,"end":1428},"obj":"Chemical"},{"id":"T41","span":{"begin":1706,"end":1708},"obj":"Chemical"}],"attributes":[{"id":"A31","pred":"chebi_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A32","pred":"chebi_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A33","pred":"chebi_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A34","pred":"chebi_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A35","pred":"chebi_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A36","pred":"chebi_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A37","pred":"chebi_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A38","pred":"chebi_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/CHEBI_48706"},{"id":"A39","pred":"chebi_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A40","pred":"chebi_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A41","pred":"chebi_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A42","pred":"chebi_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T32","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T34","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T36","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T17","span":{"begin":370,"end":379},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T18","span":{"begin":616,"end":634},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T19","span":{"begin":616,"end":625},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T20","span":{"begin":925,"end":940},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T21","span":{"begin":1488,"end":1500},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T22","span":{"begin":1854,"end":1866},"obj":"http://purl.obolibrary.org/obo/GO_0009405"}],"attributes":[{"subj":"T17","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T37","span":{"begin":0,"end":227},"obj":"Sentence"},{"id":"T38","span":{"begin":228,"end":402},"obj":"Sentence"},{"id":"T39","span":{"begin":403,"end":543},"obj":"Sentence"},{"id":"T40","span":{"begin":544,"end":684},"obj":"Sentence"},{"id":"T41","span":{"begin":685,"end":860},"obj":"Sentence"},{"id":"T42","span":{"begin":861,"end":1044},"obj":"Sentence"},{"id":"T43","span":{"begin":1045,"end":1331},"obj":"Sentence"},{"id":"T44","span":{"begin":1332,"end":1415},"obj":"Sentence"},{"id":"T45","span":{"begin":1416,"end":1661},"obj":"Sentence"},{"id":"T46","span":{"begin":1662,"end":1867},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T37","pred":"source","obj":"LitCovid-sentences"},{"subj":"T38","pred":"source","obj":"LitCovid-sentences"},{"subj":"T39","pred":"source","obj":"LitCovid-sentences"},{"subj":"T40","pred":"source","obj":"LitCovid-sentences"},{"subj":"T41","pred":"source","obj":"LitCovid-sentences"},{"subj":"T42","pred":"source","obj":"LitCovid-sentences"},{"subj":"T43","pred":"source","obj":"LitCovid-sentences"},{"subj":"T44","pred":"source","obj":"LitCovid-sentences"},{"subj":"T45","pred":"source","obj":"LitCovid-sentences"},{"subj":"T46","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"223","span":{"begin":228,"end":232},"obj":"Gene"},{"id":"224","span":{"begin":302,"end":306},"obj":"Gene"},{"id":"225","span":{"begin":311,"end":315},"obj":"Gene"},{"id":"226","span":{"begin":346,"end":351},"obj":"Gene"},{"id":"227","span":{"begin":356,"end":360},"obj":"Gene"},{"id":"228","span":{"begin":487,"end":491},"obj":"Gene"},{"id":"229","span":{"begin":492,"end":497},"obj":"Gene"},{"id":"230","span":{"begin":498,"end":502},"obj":"Gene"},{"id":"231","span":{"begin":527,"end":537},"obj":"Gene"},{"id":"232","span":{"begin":778,"end":783},"obj":"Gene"},{"id":"233","span":{"begin":987,"end":991},"obj":"Gene"},{"id":"234","span":{"begin":1066,"end":1070},"obj":"Gene"},{"id":"235","span":{"begin":1426,"end":1430},"obj":"Gene"},{"id":"236","span":{"begin":1706,"end":1710},"obj":"Gene"},{"id":"237","span":{"begin":275,"end":283},"obj":"Species"},{"id":"238","span":{"begin":562,"end":572},"obj":"Species"},{"id":"239","span":{"begin":736,"end":744},"obj":"Species"},{"id":"240","span":{"begin":898,"end":906},"obj":"Species"},{"id":"241","span":{"begin":1207,"end":1215},"obj":"Species"},{"id":"242","span":{"begin":1387,"end":1395},"obj":"Species"},{"id":"243","span":{"begin":455,"end":466},"obj":"Species"},{"id":"244","span":{"begin":1649,"end":1660},"obj":"Species"},{"id":"245","span":{"begin":216,"end":226},"obj":"Disease"},{"id":"246","span":{"begin":889,"end":897},"obj":"Disease"},{"id":"247","span":{"begin":1198,"end":1206},"obj":"Disease"},{"id":"248","span":{"begin":1221,"end":1265},"obj":"Disease"},{"id":"249","span":{"begin":1372,"end":1386},"obj":"Disease"},{"id":"250","span":{"begin":1401,"end":1409},"obj":"Disease"},{"id":"251","span":{"begin":1488,"end":1500},"obj":"Disease"},{"id":"252","span":{"begin":1509,"end":1538},"obj":"Disease"},{"id":"253","span":{"begin":1548,"end":1563},"obj":"Disease"},{"id":"254","span":{"begin":1620,"end":1629},"obj":"Disease"},{"id":"255","span":{"begin":1734,"end":1754},"obj":"Disease"}],"attributes":[{"id":"A223","pred":"tao:has_database_id","subj":"223","obj":"Gene:59272"},{"id":"A224","pred":"tao:has_database_id","subj":"224","obj":"Gene:7099"},{"id":"A225","pred":"tao:has_database_id","subj":"225","obj":"Gene:7098"},{"id":"A226","pred":"tao:has_database_id","subj":"226","obj":"Gene:4615"},{"id":"A227","pred":"tao:has_database_id","subj":"227","obj":"Gene:148022"},{"id":"A228","pred":"tao:has_database_id","subj":"228","obj":"Gene:7099"},{"id":"A229","pred":"tao:has_database_id","subj":"229","obj":"Gene:17874"},{"id":"A230","pred":"tao:has_database_id","subj":"230","obj":"Gene:148022"},{"id":"A231","pred":"tao:has_database_id","subj":"231","obj":"Gene:2244"},{"id":"A232","pred":"tao:has_database_id","subj":"232","obj":"Gene:3552"},{"id":"A233","pred":"tao:has_database_id","subj":"233","obj":"Gene:3552"},{"id":"A234","pred":"tao:has_database_id","subj":"234","obj":"Gene:3552"},{"id":"A235","pred":"tao:has_database_id","subj":"235","obj":"Gene:3552"},{"id":"A236","pred":"tao:has_database_id","subj":"236","obj":"Gene:3552"},{"id":"A237","pred":"tao:has_database_id","subj":"237","obj":"Tax:694009"},{"id":"A238","pred":"tao:has_database_id","subj":"238","obj":"Tax:2697049"},{"id":"A239","pred":"tao:has_database_id","subj":"239","obj":"Tax:694009"},{"id":"A240","pred":"tao:has_database_id","subj":"240","obj":"Tax:9606"},{"id":"A241","pred":"tao:has_database_id","subj":"241","obj":"Tax:9606"},{"id":"A242","pred":"tao:has_database_id","subj":"242","obj":"Tax:9606"},{"id":"A243","pred":"tao:has_database_id","subj":"243","obj":"Tax:746128"},{"id":"A244","pred":"tao:has_database_id","subj":"244","obj":"Tax:746128"},{"id":"A245","pred":"tao:has_database_id","subj":"245","obj":"MESH:D007239"},{"id":"A246","pred":"tao:has_database_id","subj":"246","obj":"MESH:C000657245"},{"id":"A247","pred":"tao:has_database_id","subj":"247","obj":"MESH:C000657245"},{"id":"A248","pred":"tao:has_database_id","subj":"248","obj":"MESH:D051359"},{"id":"A249","pred":"tao:has_database_id","subj":"249","obj":"MESH:D015470"},{"id":"A250","pred":"tao:has_database_id","subj":"250","obj":"MESH:C000657245"},{"id":"A251","pred":"tao:has_database_id","subj":"251","obj":"MESH:D007249"},{"id":"A252","pred":"tao:has_database_id","subj":"252","obj":"MESH:D006105"},{"id":"A253","pred":"tao:has_database_id","subj":"253","obj":"MESH:D003550"},{"id":"A254","pred":"tao:has_database_id","subj":"254","obj":"MESH:D007239"},{"id":"A255","pred":"tao:has_database_id","subj":"255","obj":"MESH:C000657245"},{"subj":"223","pred":"source","obj":"LitCovid-PubTator"},{"subj":"224","pred":"source","obj":"LitCovid-PubTator"},{"subj":"225","pred":"source","obj":"LitCovid-PubTator"},{"subj":"226","pred":"source","obj":"LitCovid-PubTator"},{"subj":"227","pred":"source","obj":"LitCovid-PubTator"},{"subj":"228","pred":"source","obj":"LitCovid-PubTator"},{"subj":"229","pred":"source","obj":"LitCovid-PubTator"},{"subj":"230","pred":"source","obj":"LitCovid-PubTator"},{"subj":"231","pred":"source","obj":"LitCovid-PubTator"},{"subj":"232","pred":"source","obj":"LitCovid-PubTator"},{"subj":"233","pred":"source","obj":"LitCovid-PubTator"},{"subj":"234","pred":"source","obj":"LitCovid-PubTator"},{"subj":"235","pred":"source","obj":"LitCovid-PubTator"},{"subj":"236","pred":"source","obj":"LitCovid-PubTator"},{"subj":"237","pred":"source","obj":"LitCovid-PubTator"},{"subj":"238","pred":"source","obj":"LitCovid-PubTator"},{"subj":"239","pred":"source","obj":"LitCovid-PubTator"},{"subj":"240","pred":"source","obj":"LitCovid-PubTator"},{"subj":"241","pred":"source","obj":"LitCovid-PubTator"},{"subj":"242","pred":"source","obj":"LitCovid-PubTator"},{"subj":"243","pred":"source","obj":"LitCovid-PubTator"},{"subj":"244","pred":"source","obj":"LitCovid-PubTator"},{"subj":"245","pred":"source","obj":"LitCovid-PubTator"},{"subj":"246","pred":"source","obj":"LitCovid-PubTator"},{"subj":"247","pred":"source","obj":"LitCovid-PubTator"},{"subj":"248","pred":"source","obj":"LitCovid-PubTator"},{"subj":"249","pred":"source","obj":"LitCovid-PubTator"},{"subj":"250","pred":"source","obj":"LitCovid-PubTator"},{"subj":"251","pred":"source","obj":"LitCovid-PubTator"},{"subj":"252","pred":"source","obj":"LitCovid-PubTator"},{"subj":"253","pred":"source","obj":"LitCovid-PubTator"},{"subj":"254","pred":"source","obj":"LitCovid-PubTator"},{"subj":"255","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"2_test","denotations":[{"id":"32599813-26015500-60095075","span":{"begin":395,"end":397},"obj":"26015500"},{"id":"32599813-19079579-60095076","span":{"begin":398,"end":400},"obj":"19079579"},{"id":"32599813-23950537-60095077","span":{"begin":539,"end":541},"obj":"23950537"},{"id":"32599813-31231549-60095078","span":{"begin":856,"end":858},"obj":"31231549"},{"id":"32599813-32359396-60095079","span":{"begin":1040,"end":1042},"obj":"32359396"},{"id":"32599813-32411313-60095080","span":{"begin":1327,"end":1329},"obj":"32411313"},{"id":"32599813-32438450-60095081","span":{"begin":1411,"end":1413},"obj":"32438450"},{"id":"32599813-24550444-60095082","span":{"begin":1540,"end":1542},"obj":"24550444"},{"id":"32599813-26972847-60095083","span":{"begin":1565,"end":1567},"obj":"26972847"}],"attributes":[{"subj":"32599813-26015500-60095075","pred":"source","obj":"2_test"},{"subj":"32599813-19079579-60095076","pred":"source","obj":"2_test"},{"subj":"32599813-23950537-60095077","pred":"source","obj":"2_test"},{"subj":"32599813-31231549-60095078","pred":"source","obj":"2_test"},{"subj":"32599813-32359396-60095079","pred":"source","obj":"2_test"},{"subj":"32599813-32411313-60095080","pred":"source","obj":"2_test"},{"subj":"32599813-32438450-60095081","pred":"source","obj":"2_test"},{"subj":"32599813-24550444-60095082","pred":"source","obj":"2_test"},{"subj":"32599813-26972847-60095083","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93a2ec","default":true},{"id":"LitCovid-PD-HP","color":"#bcec93"},{"id":"LitCovid-PD-MONDO","color":"#ec93d6"},{"id":"LitCovid-PD-CLO","color":"#93ece8"},{"id":"LitCovid-PD-CHEBI","color":"#ecce93"},{"id":"LitCovid-PD-GO-BP","color":"#b493ec"},{"id":"LitCovid-sentences","color":"#93ec9a"},{"id":"LitCovid-PubTator","color":"#ec93a6"},{"id":"2_test","color":"#93c0ec"}]}]}}