PMC:7346000 / 6595-8462
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T17 | 265-270 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T18 | 674-683 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T19 | 778-782 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T20 | 987-991 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T21 | 1066-1070 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T22 | 1283-1296 | Body_part | denotes | interleukin-1 | http://purl.org/sig/ont/fma/fma86583 |
| T23 | 1426-1430 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T24 | 1706-1710 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 223 | 228-232 | Gene | denotes | ACE2 | Gene:59272 |
| 224 | 302-306 | Gene | denotes | TLR4 | Gene:7099 |
| 225 | 311-315 | Gene | denotes | TLR3 | Gene:7098 |
| 226 | 346-351 | Gene | denotes | MyD88 | Gene:4615 |
| 227 | 356-360 | Gene | denotes | TRIF | Gene:148022 |
| 228 | 487-491 | Gene | denotes | TLR4 | Gene:7099 |
| 229 | 492-497 | Gene | denotes | MyD88 | Gene:17874 |
| 230 | 498-502 | Gene | denotes | TRIF | Gene:148022 |
| 231 | 527-537 | Gene | denotes | fibrinogen | Gene:2244 |
| 232 | 778-783 | Gene | denotes | IL-1β | Gene:3552 |
| 233 | 987-991 | Gene | denotes | IL-1 | Gene:3552 |
| 234 | 1066-1070 | Gene | denotes | IL-1 | Gene:3552 |
| 235 | 1426-1430 | Gene | denotes | IL-1 | Gene:3552 |
| 236 | 1706-1710 | Gene | denotes | IL-1 | Gene:3552 |
| 237 | 275-283 | Species | denotes | SARS-CoV | Tax:694009 |
| 238 | 562-572 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 239 | 736-744 | Species | denotes | SARS-CoV | Tax:694009 |
| 240 | 898-906 | Species | denotes | patients | Tax:9606 |
| 241 | 1207-1215 | Species | denotes | patients | Tax:9606 |
| 242 | 1387-1395 | Species | denotes | patients | Tax:9606 |
| 243 | 455-466 | Species | denotes | Aspergillus | Tax:746128 |
| 244 | 1649-1660 | Species | denotes | Aspergillus | Tax:746128 |
| 245 | 216-226 | Disease | denotes | infections | MESH:D007239 |
| 246 | 889-897 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 247 | 1198-1206 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 248 | 1221-1265 | Disease | denotes | secondary hemophagocytic lymphohistiocytosis | MESH:D051359 |
| 249 | 1372-1386 | Disease | denotes | acute leukemia | MESH:D015470 |
| 250 | 1401-1409 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 251 | 1488-1500 | Disease | denotes | inflammation | MESH:D007249 |
| 252 | 1509-1538 | Disease | denotes | chronic granulomatous disease | MESH:D006105 |
| 253 | 1548-1563 | Disease | denotes | cystic fibrosis | MESH:D003550 |
| 254 | 1620-1629 | Disease | denotes | infection | MESH:D007239 |
| 255 | 1734-1754 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T78 | 216-226 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T79 | 275-283 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T80 | 562-570 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T81 | 736-744 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T82 | 889-897 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T83 | 1198-1206 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T84 | 1221-1265 | Disease | denotes | secondary hemophagocytic lymphohistiocytosis | http://purl.obolibrary.org/obo/MONDO_0015542 |
| T85 | 1231-1265 | Disease | denotes | hemophagocytic lymphohistiocytosis | http://purl.obolibrary.org/obo/MONDO_0015540 |
| T86 | 1372-1386 | Disease | denotes | acute leukemia | http://purl.obolibrary.org/obo/MONDO_0010643 |
| T87 | 1378-1386 | Disease | denotes | leukemia | http://purl.obolibrary.org/obo/MONDO_0005059 |
| T88 | 1401-1409 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T89 | 1488-1500 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T90 | 1509-1538 | Disease | denotes | chronic granulomatous disease | http://purl.obolibrary.org/obo/MONDO_0018305 |
| T91 | 1548-1563 | Disease | denotes | cystic fibrosis | http://purl.obolibrary.org/obo/MONDO_0009061 |
| T92 | 1620-1629 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T93 | 1734-1742 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T94 | 1745-1754 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T49 | 0-1 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T50 | 94-104 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T51 | 265-270 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T52 | 332-342 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T53 | 370-379 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T54 | 478-486 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activate |
| T55 | 539-541 | http://purl.obolibrary.org/obo/CLO_0050507 | denotes | 22 |
| T56 | 588-589 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T57 | 616-625 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T58 | 702-712 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T59 | 861-862 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T60 | 958-959 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T61 | 1283-1296 | http://purl.obolibrary.org/obo/PR_000001091 | denotes | interleukin-1 |
| T62 | 1454-1457 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T63 | 1540-1542 | http://purl.obolibrary.org/obo/CLO_0050509 | denotes | 27 |
| T64 | 1633-1645 | http://purl.obolibrary.org/obo/UBERON_0001155 | denotes | colonization |
| T65 | 1762-1763 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T66 | 1790-1791 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T31 | 108-117 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T32 | 778-780 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T34 | 987-989 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T36 | 1066-1068 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T38 | 1306-1316 | Chemical | denotes | antagonist | http://purl.obolibrary.org/obo/CHEBI_48706 |
| T39 | 1426-1428 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T41 | 1706-1708 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T17 | 370-379 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T18 | 616-634 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signaling pathways |
| T19 | 616-625 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T20 | 925-940 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T21 | 1488-1500 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T22 | 1854-1866 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T15 | 1372-1386 | Phenotype | denotes | acute leukemia | http://purl.obolibrary.org/obo/HP_0002488 |
| T16 | 1602-1629 | Phenotype | denotes | susceptibility to infection | http://purl.obolibrary.org/obo/HP_0002719 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T37 | 0-227 | Sentence | denotes | A second possibility involves the collateral effects of recognition pathways required for the activation of antiviral immunity that may, paradoxically, contribute to an inflammatory environment that favors secondary infections. |
| T38 | 228-402 | Sentence | denotes | ACE2 is not well expressed on immune cells and SARS-CoV are recognized by TLR4 and TLR3, leading to the activation of MyD88- or TRIF-mediated signaling, respectively [20,21]. |
| T39 | 403-543 | Sentence | denotes | Of note, this may be potentiated in the presence of Aspergillus spp. which activate TLR4/MyD88/TRIF through the cleavage of fibrinogen [22]. |
| T40 | 544-684 | Sentence | denotes | It is likely that SARS-CoV-2 may elicit, to a large extent, overlapping signaling pathways towards the production of inflammatory cytokines. |
| T41 | 685-860 | Sentence | denotes | In addition, the activation of the inflammasome by SARS-CoV and the consequent production of IL-1β is an event that contributes further to the hyperinflammatory response [23]. |
| T42 | 861-1044 | Sentence | denotes | A transcriptome analysis of COVID-19 patients revealed an early immune response characterized by a marked upregulation of the IL-1 pathway, even after respiratory function nadir [24]. |
| T43 | 1045-1331 | Sentence | denotes | The possibility that IL-1 and related pro-inflammatory pathways could serve as therapeutic targets was demonstrated by the favorable responses in severe COVID-19 patients with secondary hemophagocytic lymphohistiocytosis treated with the interleukin-1 receptor antagonist anakinra [25]. |
| T44 | 1332-1415 | Sentence | denotes | Similar findings were also disclosed in acute leukemia patients with COVID-19 [26]. |
| T45 | 1416-1661 | Sentence | denotes | Likewise, IL-1 blockade with anakinra has also been found to ameliorate inflammation in both chronic granulomatous disease [27] and cystic fibrosis [28], and in either case, to restrain susceptibility to infection or colonization by Aspergillus. |
| T46 | 1662-1867 | Sentence | denotes | Therefore, the early hyperactivation of the IL-1 pathway induced by the SARS-CoV-2 infection may be a major factor establishing a highly permissive inflammatory environment that favors fungal pathogenesis. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32599813-26015500-60095075 | 395-397 | 26015500 | denotes | 20 |
| 32599813-19079579-60095076 | 398-400 | 19079579 | denotes | 21 |
| 32599813-23950537-60095077 | 539-541 | 23950537 | denotes | 22 |
| 32599813-31231549-60095078 | 856-858 | 31231549 | denotes | 23 |
| 32599813-32359396-60095079 | 1040-1042 | 32359396 | denotes | 24 |
| 32599813-32411313-60095080 | 1327-1329 | 32411313 | denotes | 25 |
| 32599813-32438450-60095081 | 1411-1413 | 32438450 | denotes | 26 |
| 32599813-24550444-60095082 | 1540-1542 | 24550444 | denotes | 27 |
| 32599813-26972847-60095083 | 1565-1567 | 26972847 | denotes | 28 |