PMC:7346000 / 3907-4984
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T2 | 245-261 | Body_part | denotes | epithelial cells | http://purl.org/sig/ont/fma/fma66768 |
| T3 | 256-261 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T4 | 274-285 | Body_part | denotes | pneumocytes | http://purl.org/sig/ont/fma/fma62499 |
| T5 | 320-327 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T6 | 501-508 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T7 | 564-568 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T8 | 697-701 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T9 | 920-925 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T2 | 697-701 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T3 | 963-987 | Body_part | denotes | renin-angiotensin system | http://purl.obolibrary.org/obo/UBERON_0018229 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 144 | 335-366 | Gene | denotes | angiotensin-converting enzyme 2 | Gene:59272 |
| 145 | 368-372 | Gene | denotes | ACE2 | Gene:59272 |
| 146 | 456-463 | Gene | denotes | TMPRSS2 | Gene:7113 |
| 147 | 573-577 | Gene | denotes | ACE2 | Gene:59272 |
| 148 | 622-626 | Gene | denotes | ACE2 | Gene:59272 |
| 149 | 791-794 | Gene | denotes | ACE | Gene:1636 |
| 150 | 999-1009 | Gene | denotes | kallikrein | Gene:9622 |
| 151 | 133-143 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 152 | 194-212 | Species | denotes | SARS coronaviruses | Tax:694009 |
| 153 | 214-224 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 154 | 601-611 | Species | denotes | SARS virus | Tax:694009 |
| 155 | 899-909 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 156 | 118-127 | Disease | denotes | infection | MESH:D007239 |
| 157 | 697-708 | Disease | denotes | lung injury | MESH:D055370 |
| 158 | 712-716 | Disease | denotes | ARDS | MESH:D012128 |
| 159 | 824-828 | Disease | denotes | ARDS | MESH:D012128 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T52 | 39-43 | Disease | denotes | CAPA | http://purl.obolibrary.org/obo/MONDO_0007163 |
| T53 | 118-127 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T54 | 133-141 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T55 | 194-198 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T56 | 214-222 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T57 | 309-313 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T58 | 601-605 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T59 | 691-708 | Disease | denotes | acute lung injury | http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796 |
| T61 | 702-708 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T62 | 712-716 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T63 | 824-828 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T64 | 899-907 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T65 | 1058-1062 | Disease | denotes | CAPA | http://purl.obolibrary.org/obo/MONDO_0007163 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T22 | 53-54 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T23 | 245-255 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T24 | 256-270 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells and type |
| T25 | 385-387 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T26 | 406-408 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T27 | 409-411 | http://purl.obolibrary.org/obo/CLO_0008922 | denotes | S2 |
| T28 | 409-411 | http://purl.obolibrary.org/obo/CLO_0050052 | denotes | S2 |
| T29 | 477-487 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T30 | 564-568 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T31 | 599-600 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T32 | 606-611 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T33 | 697-701 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T34 | 697-701 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T35 | 795-803 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T36 | 920-925 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T20 | 271-273 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T21 | 320-327 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T22 | 335-346 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T23 | 409-411 | Chemical | denotes | S2 | http://purl.obolibrary.org/obo/CHEBI_29387 |
| T24 | 501-508 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T25 | 969-980 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T3 | 23-35 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
| T4 | 163-175 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
| T5 | 945-955 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T13 | 691-708 | Phenotype | denotes | acute lung injury | http://www.orpha.net/ORDO/Orphanet_178320 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T23 | 0-176 | Sentence | denotes | Dissecting the complex pathogenesis of CAPA requires a molecular understanding of the physiological processes whereby infection with SARS-CoV-2 facilitates fungal pathogenesis. |
| T24 | 177-389 | Sentence | denotes | Similar to other SARS coronaviruses, SARS-CoV-2 targets and invades epithelial cells and type II pneumocytes through binding of the SARS spike protein to the angiotensin-converting enzyme 2 (ACE2) receptors [11]. |
| T25 | 390-578 | Sentence | denotes | Cleavage of the S1/S2 domain by the type 2 transmembrane protease TMPRSS2 leads to the activation of the spike protein [12], thereby facilitating viral entry into the target cell via ACE2. |
| T26 | 579-722 | Sentence | denotes | Besides its role as a SARS virus receptor, ACE2 was also demonstrated to be required for protection from severe acute lung injury in ARDS [13]. |
| T27 | 723-861 | Sentence | denotes | In support of this, an insertion/deletion polymorphism that affects ACE activity was associated with ARDS susceptibility and outcome [14]. |
| T28 | 862-1077 | Sentence | denotes | Whether the preceding interaction of SARS-CoV-2 with host cells, by disrupting the regulation of the renin-angiotensin system and or the kallikrein-kinin system, contributes to the development of CAPA, is not known. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32599813-16007097-60095066 | 385-387 | 16007097 | denotes | 11 |
| 32599813-21325420-60095067 | 510-512 | 21325420 | denotes | 12 |
| 32599813-16001071-60095068 | 718-720 | 16001071 | denotes | 13 |
| 32599813-12204859-60095069 | 857-859 | 12204859 | denotes | 14 |