PMC:7346000 / 2647-3891
Annnotations
LitCovid-PubTator
{"project":"LitCovid-PubTator","denotations":[{"id":"105","span":{"begin":74,"end":82},"obj":"Species"},{"id":"106","span":{"begin":496,"end":504},"obj":"Species"},{"id":"107","span":{"begin":605,"end":613},"obj":"Species"},{"id":"108","span":{"begin":64,"end":73},"obj":"Species"},{"id":"109","span":{"begin":328,"end":337},"obj":"Species"},{"id":"110","span":{"begin":720,"end":731},"obj":"Species"},{"id":"111","span":{"begin":879,"end":888},"obj":"Species"},{"id":"112","span":{"begin":106,"end":141},"obj":"Disease"},{"id":"113","span":{"begin":143,"end":147},"obj":"Disease"},{"id":"114","span":{"begin":242,"end":251},"obj":"Disease"},{"id":"115","span":{"begin":420,"end":442},"obj":"Disease"},{"id":"116","span":{"begin":458,"end":466},"obj":"Disease"},{"id":"117","span":{"begin":472,"end":480},"obj":"Disease"},{"id":"118","span":{"begin":539,"end":545},"obj":"Disease"},{"id":"119","span":{"begin":583,"end":591},"obj":"Disease"},{"id":"120","span":{"begin":626,"end":630},"obj":"Disease"},{"id":"121","span":{"begin":681,"end":691},"obj":"Disease"},{"id":"122","span":{"begin":766,"end":779},"obj":"Disease"},{"id":"123","span":{"begin":822,"end":835},"obj":"Disease"},{"id":"124","span":{"begin":958,"end":967},"obj":"Disease"},{"id":"125","span":{"begin":1009,"end":1017},"obj":"Disease"},{"id":"126","span":{"begin":1084,"end":1092},"obj":"Disease"},{"id":"127","span":{"begin":1104,"end":1127},"obj":"Disease"}],"attributes":[{"id":"A105","pred":"tao:has_database_id","subj":"105","obj":"Tax:9606"},{"id":"A106","pred":"tao:has_database_id","subj":"106","obj":"Tax:9606"},{"id":"A107","pred":"tao:has_database_id","subj":"107","obj":"Tax:9606"},{"id":"A108","pred":"tao:has_database_id","subj":"108","obj":"Tax:11309"},{"id":"A109","pred":"tao:has_database_id","subj":"109","obj":"Tax:11309"},{"id":"A110","pred":"tao:has_database_id","subj":"110","obj":"Tax:746128"},{"id":"A111","pred":"tao:has_database_id","subj":"111","obj":"Tax:11309"},{"id":"A112","pred":"tao:has_database_id","subj":"112","obj":"MESH:D012128"},{"id":"A113","pred":"tao:has_database_id","subj":"113","obj":"MESH:D012128"},{"id":"A114","pred":"tao:has_database_id","subj":"114","obj":"MESH:D003643"},{"id":"A115","pred":"tao:has_database_id","subj":"115","obj":"MESH:C000657245"},{"id":"A116","pred":"tao:has_database_id","subj":"116","obj":"MESH:C000657245"},{"id":"A117","pred":"tao:has_database_id","subj":"117","obj":"MESH:D007239"},{"id":"A118","pred":"tao:has_database_id","subj":"118","obj":"MESH:D003643"},{"id":"A119","pred":"tao:has_database_id","subj":"119","obj":"MESH:C000657245"},{"id":"A120","pred":"tao:has_database_id","subj":"120","obj":"MESH:D012128"},{"id":"A121","pred":"tao:has_database_id","subj":"121","obj":"MESH:D007239"},{"id":"A122","pred":"tao:has_database_id","subj":"122","obj":"MESH:D060085"},{"id":"A123","pred":"tao:has_database_id","subj":"123","obj":"MESH:D060085"},{"id":"A124","pred":"tao:has_database_id","subj":"124","obj":"MESH:D003643"},{"id":"A125","pred":"tao:has_database_id","subj":"125","obj":"MESH:C000657245"},{"id":"A126","pred":"tao:has_database_id","subj":"126","obj":"MESH:C000657245"},{"id":"A127","pred":"tao:has_database_id","subj":"127","obj":"MESH:D055732"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Recently, it has been reported that a relatively high number of influenza patients presenting with severe acute respiratory distress syndrome (ARDS) also rapidly develop IPA, which is associated with increased duration of hospitalization and mortality [4,5]. Corticosteroid use and pulmonary epithelial damages caused by severe influenza are the main risk factors for developing IPA [4,5]. The recent global pandemic of coronavirus disease-19, also known as COVID-19, has infected over 6 million patients worldwide, with more than 360,000 deaths. It has been shown that up to 40% of COVID-19 hospitalized patients can develop ARDS [6], and thereby become susceptible to acquire co-infections caused by bacteria and also Aspergillus spp. [7,8], although frequency of co-infections seems to vary between centers and overall co-infections may occur less frequently than with severe influenza [9]. Once they occur, these superinfections are associated with high mortality rates and may prolong the acute phase of COVID-19 [10]. In this comprehensive review, we discuss various aspects of COVID-19 associated pulmonary aspergillosis (CAPA), focusing specifically on immunology, risk factors, prevalence, diagnosis, treatment, and current challenges."}
LitCovid-PD-MONDO
{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T36","span":{"begin":64,"end":73},"obj":"Disease"},{"id":"T37","span":{"begin":106,"end":141},"obj":"Disease"},{"id":"T38","span":{"begin":112,"end":141},"obj":"Disease"},{"id":"T39","span":{"begin":143,"end":147},"obj":"Disease"},{"id":"T40","span":{"begin":328,"end":337},"obj":"Disease"},{"id":"T41","span":{"begin":458,"end":466},"obj":"Disease"},{"id":"T42","span":{"begin":583,"end":591},"obj":"Disease"},{"id":"T43","span":{"begin":626,"end":630},"obj":"Disease"},{"id":"T44","span":{"begin":681,"end":691},"obj":"Disease"},{"id":"T45","span":{"begin":769,"end":779},"obj":"Disease"},{"id":"T46","span":{"begin":825,"end":835},"obj":"Disease"},{"id":"T47","span":{"begin":879,"end":888},"obj":"Disease"},{"id":"T48","span":{"begin":1009,"end":1017},"obj":"Disease"},{"id":"T49","span":{"begin":1084,"end":1092},"obj":"Disease"},{"id":"T50","span":{"begin":1114,"end":1127},"obj":"Disease"},{"id":"T51","span":{"begin":1129,"end":1133},"obj":"Disease"}],"attributes":[{"id":"A36","pred":"mondo_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A37","pred":"mondo_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A38","pred":"mondo_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/MONDO_0009971"},{"id":"A39","pred":"mondo_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A40","pred":"mondo_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A41","pred":"mondo_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A42","pred":"mondo_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A43","pred":"mondo_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A44","pred":"mondo_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A45","pred":"mondo_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A46","pred":"mondo_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A47","pred":"mondo_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A48","pred":"mondo_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A49","pred":"mondo_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A50","pred":"mondo_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/MONDO_0005657"},{"id":"A51","pred":"mondo_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/MONDO_0007163"}],"text":"Recently, it has been reported that a relatively high number of influenza patients presenting with severe acute respiratory distress syndrome (ARDS) also rapidly develop IPA, which is associated with increased duration of hospitalization and mortality [4,5]. Corticosteroid use and pulmonary epithelial damages caused by severe influenza are the main risk factors for developing IPA [4,5]. The recent global pandemic of coronavirus disease-19, also known as COVID-19, has infected over 6 million patients worldwide, with more than 360,000 deaths. It has been shown that up to 40% of COVID-19 hospitalized patients can develop ARDS [6], and thereby become susceptible to acquire co-infections caused by bacteria and also Aspergillus spp. [7,8], although frequency of co-infections seems to vary between centers and overall co-infections may occur less frequently than with severe influenza [9]. Once they occur, these superinfections are associated with high mortality rates and may prolong the acute phase of COVID-19 [10]. In this comprehensive review, we discuss various aspects of COVID-19 associated pulmonary aspergillosis (CAPA), focusing specifically on immunology, risk factors, prevalence, diagnosis, treatment, and current challenges."}
LitCovid-PD-CLO
{"project":"LitCovid-PD-CLO","denotations":[{"id":"T15","span":{"begin":13,"end":16},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T16","span":{"begin":36,"end":37},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T17","span":{"begin":292,"end":302},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T18","span":{"begin":468,"end":471},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T19","span":{"begin":550,"end":553},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T20","span":{"begin":702,"end":710},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_2"},{"id":"T21","span":{"begin":1136,"end":1144},"obj":"http://purl.obolibrary.org/obo/CLO_0009985"}],"text":"Recently, it has been reported that a relatively high number of influenza patients presenting with severe acute respiratory distress syndrome (ARDS) also rapidly develop IPA, which is associated with increased duration of hospitalization and mortality [4,5]. Corticosteroid use and pulmonary epithelial damages caused by severe influenza are the main risk factors for developing IPA [4,5]. The recent global pandemic of coronavirus disease-19, also known as COVID-19, has infected over 6 million patients worldwide, with more than 360,000 deaths. It has been shown that up to 40% of COVID-19 hospitalized patients can develop ARDS [6], and thereby become susceptible to acquire co-infections caused by bacteria and also Aspergillus spp. [7,8], although frequency of co-infections seems to vary between centers and overall co-infections may occur less frequently than with severe influenza [9]. Once they occur, these superinfections are associated with high mortality rates and may prolong the acute phase of COVID-19 [10]. In this comprehensive review, we discuss various aspects of COVID-19 associated pulmonary aspergillosis (CAPA), focusing specifically on immunology, risk factors, prevalence, diagnosis, treatment, and current challenges."}
LitCovid-PD-CHEBI
{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T16","span":{"begin":170,"end":173},"obj":"Chemical"},{"id":"T18","span":{"begin":379,"end":382},"obj":"Chemical"}],"attributes":[{"id":"A16","pred":"chebi_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/CHEBI_17824"},{"id":"A17","pred":"chebi_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/CHEBI_30802"},{"id":"A18","pred":"chebi_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/CHEBI_17824"},{"id":"A19","pred":"chebi_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/CHEBI_30802"}],"text":"Recently, it has been reported that a relatively high number of influenza patients presenting with severe acute respiratory distress syndrome (ARDS) also rapidly develop IPA, which is associated with increased duration of hospitalization and mortality [4,5]. Corticosteroid use and pulmonary epithelial damages caused by severe influenza are the main risk factors for developing IPA [4,5]. The recent global pandemic of coronavirus disease-19, also known as COVID-19, has infected over 6 million patients worldwide, with more than 360,000 deaths. It has been shown that up to 40% of COVID-19 hospitalized patients can develop ARDS [6], and thereby become susceptible to acquire co-infections caused by bacteria and also Aspergillus spp. [7,8], although frequency of co-infections seems to vary between centers and overall co-infections may occur less frequently than with severe influenza [9]. Once they occur, these superinfections are associated with high mortality rates and may prolong the acute phase of COVID-19 [10]. In this comprehensive review, we discuss various aspects of COVID-19 associated pulmonary aspergillosis (CAPA), focusing specifically on immunology, risk factors, prevalence, diagnosis, treatment, and current challenges."}
LitCovid-PD-HP
{"project":"LitCovid-PD-HP","denotations":[{"id":"T10","span":{"begin":112,"end":132},"obj":"Phenotype"},{"id":"T11","span":{"begin":170,"end":173},"obj":"Phenotype"},{"id":"T12","span":{"begin":379,"end":382},"obj":"Phenotype"}],"attributes":[{"id":"A10","pred":"hp_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/HP_0002098"},{"id":"A11","pred":"hp_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/HP_0020103"},{"id":"A12","pred":"hp_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/HP_0020103"}],"text":"Recently, it has been reported that a relatively high number of influenza patients presenting with severe acute respiratory distress syndrome (ARDS) also rapidly develop IPA, which is associated with increased duration of hospitalization and mortality [4,5]. Corticosteroid use and pulmonary epithelial damages caused by severe influenza are the main risk factors for developing IPA [4,5]. The recent global pandemic of coronavirus disease-19, also known as COVID-19, has infected over 6 million patients worldwide, with more than 360,000 deaths. It has been shown that up to 40% of COVID-19 hospitalized patients can develop ARDS [6], and thereby become susceptible to acquire co-infections caused by bacteria and also Aspergillus spp. [7,8], although frequency of co-infections seems to vary between centers and overall co-infections may occur less frequently than with severe influenza [9]. Once they occur, these superinfections are associated with high mortality rates and may prolong the acute phase of COVID-19 [10]. In this comprehensive review, we discuss various aspects of COVID-19 associated pulmonary aspergillosis (CAPA), focusing specifically on immunology, risk factors, prevalence, diagnosis, treatment, and current challenges."}
LitCovid-sentences
{"project":"LitCovid-sentences","denotations":[{"id":"T15","span":{"begin":0,"end":258},"obj":"Sentence"},{"id":"T16","span":{"begin":259,"end":389},"obj":"Sentence"},{"id":"T17","span":{"begin":390,"end":546},"obj":"Sentence"},{"id":"T18","span":{"begin":547,"end":893},"obj":"Sentence"},{"id":"T19","span":{"begin":894,"end":1023},"obj":"Sentence"},{"id":"T20","span":{"begin":1024,"end":1244},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Recently, it has been reported that a relatively high number of influenza patients presenting with severe acute respiratory distress syndrome (ARDS) also rapidly develop IPA, which is associated with increased duration of hospitalization and mortality [4,5]. Corticosteroid use and pulmonary epithelial damages caused by severe influenza are the main risk factors for developing IPA [4,5]. The recent global pandemic of coronavirus disease-19, also known as COVID-19, has infected over 6 million patients worldwide, with more than 360,000 deaths. It has been shown that up to 40% of COVID-19 hospitalized patients can develop ARDS [6], and thereby become susceptible to acquire co-infections caused by bacteria and also Aspergillus spp. [7,8], although frequency of co-infections seems to vary between centers and overall co-infections may occur less frequently than with severe influenza [9]. Once they occur, these superinfections are associated with high mortality rates and may prolong the acute phase of COVID-19 [10]. In this comprehensive review, we discuss various aspects of COVID-19 associated pulmonary aspergillosis (CAPA), focusing specifically on immunology, risk factors, prevalence, diagnosis, treatment, and current challenges."}
2_test
{"project":"2_test","denotations":[{"id":"32599813-30076119-60095062","span":{"begin":253,"end":254},"obj":"30076119"},{"id":"32599813-22895826-60095063","span":{"begin":255,"end":256},"obj":"22895826"},{"id":"32599813-30076119-60095064","span":{"begin":384,"end":385},"obj":"30076119"},{"id":"32599813-22895826-60095065","span":{"begin":386,"end":387},"obj":"22895826"}],"text":"Recently, it has been reported that a relatively high number of influenza patients presenting with severe acute respiratory distress syndrome (ARDS) also rapidly develop IPA, which is associated with increased duration of hospitalization and mortality [4,5]. Corticosteroid use and pulmonary epithelial damages caused by severe influenza are the main risk factors for developing IPA [4,5]. The recent global pandemic of coronavirus disease-19, also known as COVID-19, has infected over 6 million patients worldwide, with more than 360,000 deaths. It has been shown that up to 40% of COVID-19 hospitalized patients can develop ARDS [6], and thereby become susceptible to acquire co-infections caused by bacteria and also Aspergillus spp. [7,8], although frequency of co-infections seems to vary between centers and overall co-infections may occur less frequently than with severe influenza [9]. Once they occur, these superinfections are associated with high mortality rates and may prolong the acute phase of COVID-19 [10]. In this comprehensive review, we discuss various aspects of COVID-19 associated pulmonary aspergillosis (CAPA), focusing specifically on immunology, risk factors, prevalence, diagnosis, treatment, and current challenges."}