PMC:7340597 / 1949-4087 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7340597","sourcedb":"PMC","sourceid":"7340597","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7340597","text":"1 Introduction\nUp to 20% of hospitalized coronavirus disease 2019 (COVID-19) patients are admitted to the intensive care unit (ICU) because of acute hypoxemic respiratory failure. [[1], [2], [3], [4]] These patients usually present with bilateral patchy ground glass opacities on computed tomography (CT) thorax fulfilling the definition for acute respiratory distress syndrome (ARDS). Often an atypical high compliance phenotype (L-type) is observed during mechanical ventilation in COVID-19 patients in contrast to mechanical ventilation characteristics typically seen in ARDS with low lung compliance phenotype (H -type). [5,6] During ICU stay the radiologic presentation of bilateral patchy ground glass opacities as present at admission often progress to consolidations with or without fibrotic characteristics [7]. Two earlier observed features may play a critical role in the severity of this disease: thromboembolic complications and early onset aspergillosis. The cumulative incidence of venous thromboembolism reported was 49% in COVID-19 patients admitted to the ICU [8]. Presumed pulmonary aspergillosis may be present in as much as 19% of ICU COVID-19 patients [9]. Since the physiology in COVID-19 related ARDS as well as its complications seems to differ from “typical’ ARDS, an insight into the pulmonary tissue pathology of this new infectious disease is of the utmost importance. The scarcely available pathological data in COVID-19 patients show diffuse alveolar damage, closely related to ARDS [[10], [11], [12]]. The clinical relevance of COVID-19-associated pulmonary aspergillosis (CAPA) as well as survival benefit with antifungal treatment and associated mortality are under debate since histopathological evidence of CAPA is not obtained [13]. We examined postmortem obtained lung tissue in seven patients, with COVID related ARDS who needed mechanical ventilation. The histopathologic findings, together with clinical features, radiological and microbiological findings are reported here. This report may contribute to new insights in the pathogeneses of COVID-19 as well as suggestions for treatment strategy.","divisions":[{"label":"label","span":{"begin":0,"end":1}},{"label":"title","span":{"begin":3,"end":15}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T4","span":{"begin":306,"end":312},"obj":"Body_part"},{"id":"T5","span":{"begin":589,"end":593},"obj":"Body_part"},{"id":"T6","span":{"begin":1322,"end":1328},"obj":"Body_part"},{"id":"T7","span":{"begin":1474,"end":1482},"obj":"Body_part"},{"id":"T8","span":{"begin":1803,"end":1807},"obj":"Body_part"},{"id":"T9","span":{"begin":1808,"end":1814},"obj":"Body_part"}],"attributes":[{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma9576"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma264783"},{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma9637"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T3","span":{"begin":589,"end":593},"obj":"Body_part"},{"id":"T4","span":{"begin":1322,"end":1328},"obj":"Body_part"},{"id":"T5","span":{"begin":1803,"end":1807},"obj":"Body_part"},{"id":"T6","span":{"begin":1808,"end":1814},"obj":"Body_part"}],"attributes":[{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"119","span":{"begin":78,"end":86},"obj":"Species"},{"id":"120","span":{"begin":208,"end":216},"obj":"Species"},{"id":"121","span":{"begin":494,"end":502},"obj":"Species"},{"id":"122","span":{"begin":1050,"end":1058},"obj":"Species"},{"id":"123","span":{"begin":1166,"end":1174},"obj":"Species"},{"id":"124","span":{"begin":1452,"end":1460},"obj":"Species"},{"id":"125","span":{"begin":1824,"end":1832},"obj":"Species"},{"id":"126","span":{"begin":42,"end":66},"obj":"Disease"},{"id":"127","span":{"begin":68,"end":76},"obj":"Disease"},{"id":"128","span":{"begin":160,"end":179},"obj":"Disease"},{"id":"129","span":{"begin":343,"end":378},"obj":"Disease"},{"id":"130","span":{"begin":380,"end":384},"obj":"Disease"},{"id":"131","span":{"begin":485,"end":493},"obj":"Disease"},{"id":"132","span":{"begin":575,"end":579},"obj":"Disease"},{"id":"133","span":{"begin":910,"end":924},"obj":"Disease"},{"id":"134","span":{"begin":955,"end":968},"obj":"Disease"},{"id":"135","span":{"begin":998,"end":1020},"obj":"Disease"},{"id":"136","span":{"begin":1041,"end":1049},"obj":"Disease"},{"id":"137","span":{"begin":1093,"end":1116},"obj":"Disease"},{"id":"138","span":{"begin":1157,"end":1165},"obj":"Disease"},{"id":"139","span":{"begin":1204,"end":1212},"obj":"Disease"},{"id":"140","span":{"begin":1221,"end":1225},"obj":"Disease"},{"id":"141","span":{"begin":1286,"end":1290},"obj":"Disease"},{"id":"142","span":{"begin":1351,"end":1369},"obj":"Disease"},{"id":"143","span":{"begin":1443,"end":1451},"obj":"Disease"},{"id":"144","span":{"begin":1474,"end":1489},"obj":"Disease"},{"id":"145","span":{"begin":1510,"end":1514},"obj":"Disease"},{"id":"146","span":{"begin":1561,"end":1569},"obj":"Disease"},{"id":"147","span":{"begin":1581,"end":1604},"obj":"Disease"},{"id":"148","span":{"begin":1681,"end":1690},"obj":"Disease"},{"id":"149","span":{"begin":1839,"end":1844},"obj":"Disease"},{"id":"150","span":{"begin":1853,"end":1857},"obj":"Disease"},{"id":"151","span":{"begin":2083,"end":2091},"obj":"Disease"}],"attributes":[{"id":"A119","pred":"tao:has_database_id","subj":"119","obj":"Tax:9606"},{"id":"A120","pred":"tao:has_database_id","subj":"120","obj":"Tax:9606"},{"id":"A121","pred":"tao:has_database_id","subj":"121","obj":"Tax:9606"},{"id":"A122","pred":"tao:has_database_id","subj":"122","obj":"Tax:9606"},{"id":"A123","pred":"tao:has_database_id","subj":"123","obj":"Tax:9606"},{"id":"A124","pred":"tao:has_database_id","subj":"124","obj":"Tax:9606"},{"id":"A125","pred":"tao:has_database_id","subj":"125","obj":"Tax:9606"},{"id":"A126","pred":"tao:has_database_id","subj":"126","obj":"MESH:C000657245"},{"id":"A127","pred":"tao:has_database_id","subj":"127","obj":"MESH:C000657245"},{"id":"A128","pred":"tao:has_database_id","subj":"128","obj":"MESH:D012131"},{"id":"A129","pred":"tao:has_database_id","subj":"129","obj":"MESH:D012128"},{"id":"A130","pred":"tao:has_database_id","subj":"130","obj":"MESH:D012128"},{"id":"A131","pred":"tao:has_database_id","subj":"131","obj":"MESH:C000657245"},{"id":"A132","pred":"tao:has_database_id","subj":"132","obj":"MESH:D012128"},{"id":"A133","pred":"tao:has_database_id","subj":"133","obj":"MESH:D013923"},{"id":"A134","pred":"tao:has_database_id","subj":"134","obj":"MESH:D001228"},{"id":"A135","pred":"tao:has_database_id","subj":"135","obj":"MESH:D054556"},{"id":"A136","pred":"tao:has_database_id","subj":"136","obj":"MESH:C000657245"},{"id":"A137","pred":"tao:has_database_id","subj":"137","obj":"MESH:D055732"},{"id":"A138","pred":"tao:has_database_id","subj":"138","obj":"MESH:C000657245"},{"id":"A139","pred":"tao:has_database_id","subj":"139","obj":"MESH:C000657245"},{"id":"A140","pred":"tao:has_database_id","subj":"140","obj":"MESH:D012128"},{"id":"A141","pred":"tao:has_database_id","subj":"141","obj":"MESH:D012128"},{"id":"A142","pred":"tao:has_database_id","subj":"142","obj":"MESH:D003141"},{"id":"A143","pred":"tao:has_database_id","subj":"143","obj":"MESH:C000657245"},{"id":"A144","pred":"tao:has_database_id","subj":"144","obj":"MESH:D055370"},{"id":"A145","pred":"tao:has_database_id","subj":"145","obj":"MESH:D012128"},{"id":"A146","pred":"tao:has_database_id","subj":"146","obj":"MESH:C000657245"},{"id":"A147","pred":"tao:has_database_id","subj":"147","obj":"MESH:D055732"},{"id":"A148","pred":"tao:has_database_id","subj":"148","obj":"MESH:D003643"},{"id":"A149","pred":"tao:has_database_id","subj":"149","obj":"MESH:C000657245"},{"id":"A150","pred":"tao:has_database_id","subj":"150","obj":"MESH:D012128"},{"id":"A151","pred":"tao:has_database_id","subj":"151","obj":"MESH:C000657245"},{"subj":"119","pred":"source","obj":"LitCovid-PubTator"},{"subj":"120","pred":"source","obj":"LitCovid-PubTator"},{"subj":"121","pred":"source","obj":"LitCovid-PubTator"},{"subj":"122","pred":"source","obj":"LitCovid-PubTator"},{"subj":"123","pred":"source","obj":"LitCovid-PubTator"},{"subj":"124","pred":"source","obj":"LitCovid-PubTator"},{"subj":"125","pred":"source","obj":"LitCovid-PubTator"},{"subj":"126","pred":"source","obj":"LitCovid-PubTator"},{"subj":"127","pred":"source","obj":"LitCovid-PubTator"},{"subj":"128","pred":"source","obj":"LitCovid-PubTator"},{"subj":"129","pred":"source","obj":"LitCovid-PubTator"},{"subj":"130","pred":"source","obj":"LitCovid-PubTator"},{"subj":"131","pred":"source","obj":"LitCovid-PubTator"},{"subj":"132","pred":"source","obj":"LitCovid-PubTator"},{"subj":"133","pred":"source","obj":"LitCovid-PubTator"},{"subj":"134","pred":"source","obj":"LitCovid-PubTator"},{"subj":"135","pred":"source","obj":"LitCovid-PubTator"},{"subj":"136","pred":"source","obj":"LitCovid-PubTator"},{"subj":"137","pred":"source","obj":"LitCovid-PubTator"},{"subj":"138","pred":"source","obj":"LitCovid-PubTator"},{"subj":"139","pred":"source","obj":"LitCovid-PubTator"},{"subj":"140","pred":"source","obj":"LitCovid-PubTator"},{"subj":"141","pred":"source","obj":"LitCovid-PubTator"},{"subj":"142","pred":"source","obj":"LitCovid-PubTator"},{"subj":"143","pred":"source","obj":"LitCovid-PubTator"},{"subj":"144","pred":"source","obj":"LitCovid-PubTator"},{"subj":"145","pred":"source","obj":"LitCovid-PubTator"},{"subj":"146","pred":"source","obj":"LitCovid-PubTator"},{"subj":"147","pred":"source","obj":"LitCovid-PubTator"},{"subj":"148","pred":"source","obj":"LitCovid-PubTator"},{"subj":"149","pred":"source","obj":"LitCovid-PubTator"},{"subj":"150","pred":"source","obj":"LitCovid-PubTator"},{"subj":"151","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T35","span":{"begin":42,"end":66},"obj":"Disease"},{"id":"T36","span":{"begin":68,"end":76},"obj":"Disease"},{"id":"T37","span":{"begin":160,"end":179},"obj":"Disease"},{"id":"T38","span":{"begin":343,"end":378},"obj":"Disease"},{"id":"T39","span":{"begin":349,"end":378},"obj":"Disease"},{"id":"T40","span":{"begin":380,"end":384},"obj":"Disease"},{"id":"T41","span":{"begin":485,"end":493},"obj":"Disease"},{"id":"T42","span":{"begin":575,"end":579},"obj":"Disease"},{"id":"T43","span":{"begin":955,"end":968},"obj":"Disease"},{"id":"T44","span":{"begin":998,"end":1020},"obj":"Disease"},{"id":"T45","span":{"begin":1041,"end":1049},"obj":"Disease"},{"id":"T46","span":{"begin":1103,"end":1116},"obj":"Disease"},{"id":"T47","span":{"begin":1157,"end":1165},"obj":"Disease"},{"id":"T48","span":{"begin":1204,"end":1212},"obj":"Disease"},{"id":"T49","span":{"begin":1221,"end":1225},"obj":"Disease"},{"id":"T50","span":{"begin":1286,"end":1290},"obj":"Disease"},{"id":"T51","span":{"begin":1351,"end":1369},"obj":"Disease"},{"id":"T52","span":{"begin":1443,"end":1451},"obj":"Disease"},{"id":"T53","span":{"begin":1510,"end":1514},"obj":"Disease"},{"id":"T54","span":{"begin":1561,"end":1569},"obj":"Disease"},{"id":"T55","span":{"begin":1591,"end":1604},"obj":"Disease"},{"id":"T56","span":{"begin":1606,"end":1610},"obj":"Disease"},{"id":"T57","span":{"begin":1744,"end":1748},"obj":"Disease"},{"id":"T58","span":{"begin":1853,"end":1857},"obj":"Disease"},{"id":"T59","span":{"begin":2083,"end":2091},"obj":"Disease"}],"attributes":[{"id":"A35","pred":"mondo_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A36","pred":"mondo_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A37","pred":"mondo_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/MONDO_0021113"},{"id":"A38","pred":"mondo_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A39","pred":"mondo_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/MONDO_0009971"},{"id":"A40","pred":"mondo_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A41","pred":"mondo_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A42","pred":"mondo_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A43","pred":"mondo_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/MONDO_0005657"},{"id":"A44","pred":"mondo_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/MONDO_0005399"},{"id":"A45","pred":"mondo_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A46","pred":"mondo_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/MONDO_0005657"},{"id":"A47","pred":"mondo_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A48","pred":"mondo_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A49","pred":"mondo_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A50","pred":"mondo_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A51","pred":"mondo_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A52","pred":"mondo_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A53","pred":"mondo_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A54","pred":"mondo_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A55","pred":"mondo_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/MONDO_0005657"},{"id":"A56","pred":"mondo_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/MONDO_0007163"},{"id":"A57","pred":"mondo_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/MONDO_0007163"},{"id":"A58","pred":"mondo_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A59","pred":"mondo_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T35","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T36","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T42","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T43","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T44","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T50","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T51","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T52","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T53","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T54","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T55","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T57","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T58","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T59","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T15","span":{"begin":193,"end":199},"obj":"http://purl.obolibrary.org/obo/CLO_0001302"},{"id":"T16","span":{"begin":306,"end":312},"obj":"http://www.ebi.ac.uk/efo/EFO_0000965"},{"id":"T17","span":{"begin":589,"end":593},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T18","span":{"begin":589,"end":593},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T19","span":{"begin":861,"end":862},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T20","span":{"begin":1523,"end":1525},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T21","span":{"begin":1803,"end":1807},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T22","span":{"begin":1803,"end":1807},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"}],"attributes":[{"subj":"T15","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T2","span":{"begin":1645,"end":1655},"obj":"Chemical"}],"attributes":[{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_35718"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T7","span":{"begin":160,"end":179},"obj":"Phenotype"},{"id":"T8","span":{"begin":349,"end":369},"obj":"Phenotype"},{"id":"T9","span":{"begin":910,"end":924},"obj":"Phenotype"},{"id":"T10","span":{"begin":1005,"end":1020},"obj":"Phenotype"},{"id":"T11","span":{"begin":1466,"end":1489},"obj":"Phenotype"}],"attributes":[{"id":"A7","pred":"hp_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/HP_0002878"},{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0002098"},{"id":"A9","pred":"hp_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/HP_0001907"},{"id":"A10","pred":"hp_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/HP_0001907"},{"id":"A11","pred":"hp_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/HP_0033006"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T23","span":{"begin":0,"end":15},"obj":"Sentence"},{"id":"T24","span":{"begin":16,"end":386},"obj":"Sentence"},{"id":"T25","span":{"begin":387,"end":821},"obj":"Sentence"},{"id":"T26","span":{"begin":822,"end":969},"obj":"Sentence"},{"id":"T27","span":{"begin":970,"end":1083},"obj":"Sentence"},{"id":"T28","span":{"begin":1084,"end":1179},"obj":"Sentence"},{"id":"T29","span":{"begin":1180,"end":1398},"obj":"Sentence"},{"id":"T30","span":{"begin":1399,"end":1534},"obj":"Sentence"},{"id":"T31","span":{"begin":1535,"end":1770},"obj":"Sentence"},{"id":"T32","span":{"begin":1771,"end":1892},"obj":"Sentence"},{"id":"T33","span":{"begin":1893,"end":2016},"obj":"Sentence"},{"id":"T34","span":{"begin":2017,"end":2138},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T23","pred":"source","obj":"LitCovid-sentences"},{"subj":"T24","pred":"source","obj":"LitCovid-sentences"},{"subj":"T25","pred":"source","obj":"LitCovid-sentences"},{"subj":"T26","pred":"source","obj":"LitCovid-sentences"},{"subj":"T27","pred":"source","obj":"LitCovid-sentences"},{"subj":"T28","pred":"source","obj":"LitCovid-sentences"},{"subj":"T29","pred":"source","obj":"LitCovid-sentences"},{"subj":"T30","pred":"source","obj":"LitCovid-sentences"},{"subj":"T31","pred":"source","obj":"LitCovid-sentences"},{"subj":"T32","pred":"source","obj":"LitCovid-sentences"},{"subj":"T33","pred":"source","obj":"LitCovid-sentences"},{"subj":"T34","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T44","span":{"begin":1443,"end":1451},"obj":"SP_7"},{"id":"T27","span":{"begin":42,"end":53},"obj":"NCBITaxon:11118"},{"id":"T28","span":{"begin":68,"end":76},"obj":"SP_7"},{"id":"T29","span":{"begin":117,"end":121},"obj":"UBERON:0007221"},{"id":"T30","span":{"begin":160,"end":171},"obj":"UBERON:0001004"},{"id":"T31","span":{"begin":306,"end":312},"obj":"UBERON:0000915"},{"id":"T32","span":{"begin":349,"end":360},"obj":"UBERON:0001004"},{"id":"T33","span":{"begin":485,"end":493},"obj":"SP_7"},{"id":"T34","span":{"begin":589,"end":593},"obj":"UBERON:0002048"},{"id":"T35","span":{"begin":910,"end":924},"obj":"GO:0007596"},{"id":"T36","span":{"begin":998,"end":1004},"obj":"UBERON:0001638"},{"id":"T37","span":{"begin":1005,"end":1020},"obj":"GO:0007596"},{"id":"T38","span":{"begin":1041,"end":1049},"obj":"SP_7"},{"id":"T39","span":{"begin":1093,"end":1102},"obj":"UBERON:0002048"},{"id":"T40","span":{"begin":1157,"end":1165},"obj":"SP_7"},{"id":"T41","span":{"begin":1204,"end":1212},"obj":"SP_7"},{"id":"T42","span":{"begin":1312,"end":1321},"obj":"UBERON:0002048"},{"id":"T43","span":{"begin":1322,"end":1328},"obj":"UBERON:0000479"},{"id":"T45","span":{"begin":1474,"end":1482},"obj":"UBERON:0003215"},{"id":"T46","span":{"begin":1561,"end":1569},"obj":"SP_7"},{"id":"T47","span":{"begin":1581,"end":1590},"obj":"UBERON:0002048"},{"id":"T48","span":{"begin":1783,"end":1793},"obj":"GO:0016265"},{"id":"T49","span":{"begin":1803,"end":1807},"obj":"UBERON:0002048"},{"id":"T50","span":{"begin":1808,"end":1814},"obj":"UBERON:0000479"},{"id":"T51","span":{"begin":2083,"end":2091},"obj":"SP_7"},{"id":"T62119","span":{"begin":1839,"end":1844},"obj":"SP_7"},{"id":"T66936","span":{"begin":225,"end":233},"obj":"SP_7"},{"id":"T35906","span":{"begin":363,"end":375},"obj":"SP_7"},{"id":"T89649","span":{"begin":376,"end":386},"obj":"SP_7;UBERON:0001004"},{"id":"T80423","span":{"begin":387,"end":410},"obj":"SP_7"},{"id":"T77332","span":{"begin":412,"end":422},"obj":"SP_7"},{"id":"T23414","span":{"begin":467,"end":477},"obj":"UBERON:0001004"},{"id":"T23002","span":{"begin":545,"end":555},"obj":"GO:0016265"},{"id":"T60852","span":{"begin":583,"end":587},"obj":"UBERON:0002048"},{"id":"T36899","span":{"begin":637,"end":647},"obj":"SP_7"},{"id":"T82912","span":{"begin":678,"end":699},"obj":"GO:0001171"},{"id":"T17380","span":{"begin":738,"end":744},"obj":"UBERON:0007311"},{"id":"T17660","span":{"begin":752,"end":759},"obj":"UBERON:0004242"},{"id":"T50696","span":{"begin":833,"end":842},"obj":"GO:0007586;UBERON:0001555"},{"id":"T86112","span":{"begin":843,"end":848},"obj":"UBERON:0001555"},{"id":"T42737","span":{"begin":872,"end":883},"obj":"CHEBI:3638;DG_10;CHEBI:3638"},{"id":"T83979","span":{"begin":1018,"end":1033},"obj":"GO:0050817"},{"id":"T7331","span":{"begin":1060,"end":1067},"obj":"CHEBI:24505;CHEBI:24505"},{"id":"T34114","span":{"begin":1165,"end":1174},"obj":"UBERON:0002048"},{"id":"T52553","span":{"begin":1250,"end":1259},"obj":"UBERON:0002048"},{"id":"T21703","span":{"begin":1352,"end":1365},"obj":"CHEBI:27680;CHEBI:27680"},{"id":"T97231","span":{"begin":1367,"end":1372},"obj":"UBERON:0001977"},{"id":"T41661","span":{"begin":1377,"end":1383},"obj":"UBERON:0007311"},{"id":"T93902","span":{"begin":1386,"end":1394},"obj":"UBERON:0003126"},{"id":"T75668","span":{"begin":1398,"end":1405},"obj":"UBERON:0004242"},{"id":"T99671","span":{"begin":1419,"end":1432},"obj":"CHEBI:27680;CHEBI:27680"},{"id":"T86981","span":{"begin":1451,"end":1466},"obj":"UBERON:0002031"},{"id":"T51837","span":{"begin":1467,"end":1473},"obj":"UBERON:0004821"},{"id":"T19506","span":{"begin":1507,"end":1514},"obj":"CHEBI:59132;CHEBI:59132"},{"id":"T9649","span":{"begin":1593,"end":1602},"obj":"UBERON:0002048"},{"id":"T41715","span":{"begin":1824,"end":1829},"obj":"UBERON:0001977"},{"id":"T81615","span":{"begin":1834,"end":1845},"obj":"NCBITaxon:5052"},{"id":"T80302","span":{"begin":1874,"end":1884},"obj":"GO:0016265"},{"id":"T65199","span":{"begin":1911,"end":1915},"obj":"UBERON:0002048"},{"id":"T43236","span":{"begin":1961,"end":1971},"obj":"GO:0016265"},{"id":"T69714","span":{"begin":2014,"end":2019},"obj":"UBERON:0000170"},{"id":"T56052","span":{"begin":2041,"end":2046},"obj":"GO:0016265"},{"id":"T98173","span":{"begin":2048,"end":2052},"obj":"UBERON:0002048"},{"id":"T61880","span":{"begin":2116,"end":2124},"obj":"UBERON:0001062"}],"attributes":[{"subj":"T44","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T27","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T28","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T29","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T30","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T31","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T32","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T33","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T34","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T35","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T36","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T37","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T38","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T39","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T40","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T41","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T42","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T43","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T45","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T46","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T47","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T48","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T49","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T50","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T51","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T62119","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T66936","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T35906","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T89649","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T80423","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T77332","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T23414","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T23002","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T60852","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T36899","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T82912","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T17380","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T17660","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T50696","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T86112","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T42737","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T83979","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T7331","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T34114","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T52553","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T21703","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T97231","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T41661","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T93902","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T75668","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T99671","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T86981","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T51837","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T19506","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T9649","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T41715","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T81615","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T80302","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T65199","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T43236","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T69714","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T56052","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T98173","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T61880","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"2_test","denotations":[{"id":"32674001-32109013-58631465","span":{"begin":183,"end":184},"obj":"32109013"},{"id":"32674001-32320003-58631466","span":{"begin":193,"end":194},"obj":"32320003"},{"id":"32674001-32091533-58631467","span":{"begin":198,"end":199},"obj":"32091533"},{"id":"32674001-32228035-58631468","span":{"begin":627,"end":628},"obj":"32228035"},{"id":"32674001-32105637-58631469","span":{"begin":818,"end":819},"obj":"32105637"},{"id":"32674001-32381264-58631470","span":{"begin":1080,"end":1081},"obj":"32381264"}],"attributes":[{"subj":"32674001-32109013-58631465","pred":"source","obj":"2_test"},{"subj":"32674001-32320003-58631466","pred":"source","obj":"2_test"},{"subj":"32674001-32091533-58631467","pred":"source","obj":"2_test"},{"subj":"32674001-32228035-58631468","pred":"source","obj":"2_test"},{"subj":"32674001-32105637-58631469","pred":"source","obj":"2_test"},{"subj":"32674001-32381264-58631470","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93ecb6","default":true},{"id":"LitCovid-PD-UBERON","color":"#ec9c93"},{"id":"LitCovid-PubTator","color":"#93a3ec"},{"id":"LitCovid-PD-MONDO","color":"#bdec93"},{"id":"LitCovid-PD-CLO","color":"#ec93d7"},{"id":"LitCovid-PD-CHEBI","color":"#93ece7"},{"id":"LitCovid-PD-HP","color":"#eccd93"},{"id":"LitCovid-sentences","color":"#b393ec"},{"id":"LitCovid-PMC-OGER-BB","color":"#93ec99"},{"id":"2_test","color":"#ec93a7"}]}]}}