PMC:7340597 / 11336-12573 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T53","span":{"begin":341,"end":346},"obj":"Body_part"},{"id":"T54","span":{"begin":418,"end":423},"obj":"Body_part"},{"id":"T55","span":{"begin":482,"end":487},"obj":"Body_part"},{"id":"T56","span":{"begin":547,"end":552},"obj":"Body_part"},{"id":"T57","span":{"begin":679,"end":683},"obj":"Body_part"},{"id":"T58","span":{"begin":748,"end":753},"obj":"Body_part"}],"attributes":[{"id":"A53","pred":"fma_id","subj":"T53","obj":"http://purl.org/sig/ont/fma/fma9576"},{"id":"A54","pred":"fma_id","subj":"T54","obj":"http://purl.org/sig/ont/fma/fma9576"},{"id":"A55","pred":"fma_id","subj":"T55","obj":"http://purl.org/sig/ont/fma/fma9576"},{"id":"A56","pred":"fma_id","subj":"T56","obj":"http://purl.org/sig/ont/fma/fma9576"},{"id":"A57","pred":"fma_id","subj":"T57","obj":"http://purl.org/sig/ont/fma/fma24043"},{"id":"A58","pred":"fma_id","subj":"T58","obj":"http://purl.org/sig/ont/fma/fma68877"}],"text":"To further investigate histopathologic findings we now present the detailed clinical course of four patients with four different histopathological characteristics. Because of complexity and importance of the distinct patterns and their relation with radiologic findings and treatment, we preferred to discuss them separately in more detail. Chest CT imaging of the four discussed patients are shown in Fig. 1 .\nFig. 1 Chest CT scans of case 1–4. For each patient image A represents chest CT at hospital admission, image B follow up CT-scan (note: chest CT of case 4 was not repeated). 1A: bilateral areas of GGO, patchy subpleural non-dependant consolidations 1B: progression of dens subpleural consolidations with air-bronchograms. 2A GGO in both lungs, combined with crazy-paving pattern, subtle bronchiectasis are present in affected areas. 2B GGO persisted, without progression to consolidations, more pronounced fibrotic reticulation with traction bronchiectasis. 3A diffuse bilateral GGO with large gravity dependant consolidations. 3B persistent GGO and consolidation, newly formed cyst-like lesions in middle and ventral regions. 4A bilateral areas of GGO, patchy non-dependant peripheral consolidations with mild bronchiectasis."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T22","span":{"begin":341,"end":346},"obj":"Body_part"},{"id":"T23","span":{"begin":418,"end":423},"obj":"Body_part"},{"id":"T24","span":{"begin":482,"end":487},"obj":"Body_part"},{"id":"T25","span":{"begin":547,"end":552},"obj":"Body_part"}],"attributes":[{"id":"A22","pred":"uberon_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/UBERON_0001443"},{"id":"A23","pred":"uberon_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/UBERON_0001443"},{"id":"A24","pred":"uberon_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/UBERON_0001443"},{"id":"A25","pred":"uberon_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/UBERON_0001443"}],"text":"To further investigate histopathologic findings we now present the detailed clinical course of four patients with four different histopathological characteristics. Because of complexity and importance of the distinct patterns and their relation with radiologic findings and treatment, we preferred to discuss them separately in more detail. Chest CT imaging of the four discussed patients are shown in Fig. 1 .\nFig. 1 Chest CT scans of case 1–4. For each patient image A represents chest CT at hospital admission, image B follow up CT-scan (note: chest CT of case 4 was not repeated). 1A: bilateral areas of GGO, patchy subpleural non-dependant consolidations 1B: progression of dens subpleural consolidations with air-bronchograms. 2A GGO in both lungs, combined with crazy-paving pattern, subtle bronchiectasis are present in affected areas. 2B GGO persisted, without progression to consolidations, more pronounced fibrotic reticulation with traction bronchiectasis. 3A diffuse bilateral GGO with large gravity dependant consolidations. 3B persistent GGO and consolidation, newly formed cyst-like lesions in middle and ventral regions. 4A bilateral areas of GGO, patchy non-dependant peripheral consolidations with mild bronchiectasis."}

{"project":"LitCovid-PubTator","denotations":[{"id":"330","span":{"begin":455,"end":462},"obj":"Species"},{"id":"331","span":{"begin":679,"end":683},"obj":"Chemical"},{"id":"334","span":{"begin":100,"end":108},"obj":"Species"},{"id":"335","span":{"begin":380,"end":388},"obj":"Species"}],"attributes":[{"id":"A330","pred":"tao:has_database_id","subj":"330","obj":"Tax:9606"},{"id":"A331","pred":"tao:has_database_id","subj":"331","obj":"MESH:D004052"},{"id":"A334","pred":"tao:has_database_id","subj":"334","obj":"Tax:9606"},{"id":"A335","pred":"tao:has_database_id","subj":"335","obj":"Tax:9606"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"To further investigate histopathologic findings we now present the detailed clinical course of four patients with four different histopathological characteristics. Because of complexity and importance of the distinct patterns and their relation with radiologic findings and treatment, we preferred to discuss them separately in more detail. Chest CT imaging of the four discussed patients are shown in Fig. 1 .\nFig. 1 Chest CT scans of case 1–4. For each patient image A represents chest CT at hospital admission, image B follow up CT-scan (note: chest CT of case 4 was not repeated). 1A: bilateral areas of GGO, patchy subpleural non-dependant consolidations 1B: progression of dens subpleural consolidations with air-bronchograms. 2A GGO in both lungs, combined with crazy-paving pattern, subtle bronchiectasis are present in affected areas. 2B GGO persisted, without progression to consolidations, more pronounced fibrotic reticulation with traction bronchiectasis. 3A diffuse bilateral GGO with large gravity dependant consolidations. 3B persistent GGO and consolidation, newly formed cyst-like lesions in middle and ventral regions. 4A bilateral areas of GGO, patchy non-dependant peripheral consolidations with mild bronchiectasis."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T121","span":{"begin":798,"end":812},"obj":"Disease"},{"id":"T122","span":{"begin":953,"end":967},"obj":"Disease"},{"id":"T123","span":{"begin":1222,"end":1236},"obj":"Disease"}],"attributes":[{"id":"A121","pred":"mondo_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/MONDO_0004822"},{"id":"A122","pred":"mondo_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/MONDO_0004822"},{"id":"A123","pred":"mondo_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/MONDO_0004822"}],"text":"To further investigate histopathologic findings we now present the detailed clinical course of four patients with four different histopathological characteristics. Because of complexity and importance of the distinct patterns and their relation with radiologic findings and treatment, we preferred to discuss them separately in more detail. Chest CT imaging of the four discussed patients are shown in Fig. 1 .\nFig. 1 Chest CT scans of case 1–4. For each patient image A represents chest CT at hospital admission, image B follow up CT-scan (note: chest CT of case 4 was not repeated). 1A: bilateral areas of GGO, patchy subpleural non-dependant consolidations 1B: progression of dens subpleural consolidations with air-bronchograms. 2A GGO in both lungs, combined with crazy-paving pattern, subtle bronchiectasis are present in affected areas. 2B GGO persisted, without progression to consolidations, more pronounced fibrotic reticulation with traction bronchiectasis. 3A diffuse bilateral GGO with large gravity dependant consolidations. 3B persistent GGO and consolidation, newly formed cyst-like lesions in middle and ventral regions. 4A bilateral areas of GGO, patchy non-dependant peripheral consolidations with mild bronchiectasis."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T84","span":{"begin":341,"end":346},"obj":"http://www.ebi.ac.uk/efo/EFO_0000965"},{"id":"T85","span":{"begin":418,"end":423},"obj":"http://www.ebi.ac.uk/efo/EFO_0000965"},{"id":"T86","span":{"begin":469,"end":470},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T87","span":{"begin":482,"end":487},"obj":"http://www.ebi.ac.uk/efo/EFO_0000965"},{"id":"T88","span":{"begin":520,"end":521},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T89","span":{"begin":547,"end":552},"obj":"http://www.ebi.ac.uk/efo/EFO_0000965"},{"id":"T90","span":{"begin":733,"end":735},"obj":"http://purl.obolibrary.org/obo/CLO_0001236"},{"id":"T91","span":{"begin":748,"end":753},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"}],"text":"To further investigate histopathologic findings we now present the detailed clinical course of four patients with four different histopathological characteristics. Because of complexity and importance of the distinct patterns and their relation with radiologic findings and treatment, we preferred to discuss them separately in more detail. Chest CT imaging of the four discussed patients are shown in Fig. 1 .\nFig. 1 Chest CT scans of case 1–4. For each patient image A represents chest CT at hospital admission, image B follow up CT-scan (note: chest CT of case 4 was not repeated). 1A: bilateral areas of GGO, patchy subpleural non-dependant consolidations 1B: progression of dens subpleural consolidations with air-bronchograms. 2A GGO in both lungs, combined with crazy-paving pattern, subtle bronchiectasis are present in affected areas. 2B GGO persisted, without progression to consolidations, more pronounced fibrotic reticulation with traction bronchiectasis. 3A diffuse bilateral GGO with large gravity dependant consolidations. 3B persistent GGO and consolidation, newly formed cyst-like lesions in middle and ventral regions. 4A bilateral areas of GGO, patchy non-dependant peripheral consolidations with mild bronchiectasis."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T27","span":{"begin":798,"end":812},"obj":"Phenotype"},{"id":"T28","span":{"begin":944,"end":967},"obj":"Phenotype"},{"id":"T29","span":{"begin":1222,"end":1236},"obj":"Phenotype"}],"attributes":[{"id":"A27","pred":"hp_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/HP_0002110"},{"id":"A28","pred":"hp_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/HP_0032969"},{"id":"A29","pred":"hp_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/HP_0002110"}],"text":"To further investigate histopathologic findings we now present the detailed clinical course of four patients with four different histopathological characteristics. Because of complexity and importance of the distinct patterns and their relation with radiologic findings and treatment, we preferred to discuss them separately in more detail. Chest CT imaging of the four discussed patients are shown in Fig. 1 .\nFig. 1 Chest CT scans of case 1–4. For each patient image A represents chest CT at hospital admission, image B follow up CT-scan (note: chest CT of case 4 was not repeated). 1A: bilateral areas of GGO, patchy subpleural non-dependant consolidations 1B: progression of dens subpleural consolidations with air-bronchograms. 2A GGO in both lungs, combined with crazy-paving pattern, subtle bronchiectasis are present in affected areas. 2B GGO persisted, without progression to consolidations, more pronounced fibrotic reticulation with traction bronchiectasis. 3A diffuse bilateral GGO with large gravity dependant consolidations. 3B persistent GGO and consolidation, newly formed cyst-like lesions in middle and ventral regions. 4A bilateral areas of GGO, patchy non-dependant peripheral consolidations with mild bronchiectasis."}

{"project":"LitCovid-sentences","denotations":[{"id":"T91","span":{"begin":0,"end":163},"obj":"Sentence"},{"id":"T92","span":{"begin":164,"end":340},"obj":"Sentence"},{"id":"T93","span":{"begin":341,"end":410},"obj":"Sentence"},{"id":"T94","span":{"begin":411,"end":445},"obj":"Sentence"},{"id":"T95","span":{"begin":446,"end":584},"obj":"Sentence"},{"id":"T96","span":{"begin":585,"end":732},"obj":"Sentence"},{"id":"T97","span":{"begin":733,"end":843},"obj":"Sentence"},{"id":"T98","span":{"begin":844,"end":968},"obj":"Sentence"},{"id":"T99","span":{"begin":969,"end":1038},"obj":"Sentence"},{"id":"T100","span":{"begin":1039,"end":1137},"obj":"Sentence"},{"id":"T101","span":{"begin":1138,"end":1237},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"To further investigate histopathologic findings we now present the detailed clinical course of four patients with four different histopathological characteristics. Because of complexity and importance of the distinct patterns and their relation with radiologic findings and treatment, we preferred to discuss them separately in more detail. Chest CT imaging of the four discussed patients are shown in Fig. 1 .\nFig. 1 Chest CT scans of case 1–4. For each patient image A represents chest CT at hospital admission, image B follow up CT-scan (note: chest CT of case 4 was not repeated). 1A: bilateral areas of GGO, patchy subpleural non-dependant consolidations 1B: progression of dens subpleural consolidations with air-bronchograms. 2A GGO in both lungs, combined with crazy-paving pattern, subtle bronchiectasis are present in affected areas. 2B GGO persisted, without progression to consolidations, more pronounced fibrotic reticulation with traction bronchiectasis. 3A diffuse bilateral GGO with large gravity dependant consolidations. 3B persistent GGO and consolidation, newly formed cyst-like lesions in middle and ventral regions. 4A bilateral areas of GGO, patchy non-dependant peripheral consolidations with mild bronchiectasis."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T326","span":{"begin":180,"end":207},"obj":"UBERON:0001852"},{"id":"T327","span":{"begin":329,"end":339},"obj":"GO:0015671"},{"id":"T328","span":{"begin":567,"end":621},"obj":"NCBITaxon:746128"},{"id":"T329","span":{"begin":669,"end":730},"obj":"NCBITaxon:1352"},{"id":"T330","span":{"begin":885,"end":905},"obj":"UBERON:0002048"},{"id":"T201","span":{"begin":20,"end":24},"obj":"UBERON:0004096"},{"id":"T202","span":{"begin":91,"end":96},"obj":"UBERON:0000170"},{"id":"T203","span":{"begin":780,"end":785},"obj":"UBERON:0001443"},{"id":"T15177","span":{"begin":902,"end":912},"obj":"UBERON:0002106"},{"id":"T205","span":{"begin":1086,"end":1091},"obj":"UBERON:0002113"},{"id":"T36509","span":{"begin":1110,"end":1115},"obj":"UBERON:0002113"},{"id":"T207","span":{"begin":1192,"end":1197},"obj":"UBERON:0001443"},{"id":"T30186","span":{"begin":1220,"end":1231},"obj":"UBERON:0002048"}],"text":"To further investigate histopathologic findings we now present the detailed clinical course of four patients with four different histopathological characteristics. Because of complexity and importance of the distinct patterns and their relation with radiologic findings and treatment, we preferred to discuss them separately in more detail. Chest CT imaging of the four discussed patients are shown in Fig. 1 .\nFig. 1 Chest CT scans of case 1–4. For each patient image A represents chest CT at hospital admission, image B follow up CT-scan (note: chest CT of case 4 was not repeated). 1A: bilateral areas of GGO, patchy subpleural non-dependant consolidations 1B: progression of dens subpleural consolidations with air-bronchograms. 2A GGO in both lungs, combined with crazy-paving pattern, subtle bronchiectasis are present in affected areas. 2B GGO persisted, without progression to consolidations, more pronounced fibrotic reticulation with traction bronchiectasis. 3A diffuse bilateral GGO with large gravity dependant consolidations. 3B persistent GGO and consolidation, newly formed cyst-like lesions in middle and ventral regions. 4A bilateral areas of GGO, patchy non-dependant peripheral consolidations with mild bronchiectasis."}