PMC:7335494 / 79838-85921
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T575 | 201-206 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T576 | 269-277 | Body_part | denotes | tyrosine | http://purl.org/sig/ont/fma/fma82768 |
| T577 | 282-288 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
| T578 | 289-298 | Body_part | denotes | threonine | http://purl.org/sig/ont/fma/fma82765 |
| T579 | 299-306 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T580 | 397-406 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T581 | 408-418 | Body_part | denotes | chemokines | http://purl.org/sig/ont/fma/fma241981 |
| T582 | 450-454 | Body_part | denotes | ICAM | http://purl.org/sig/ont/fma/fma67857 |
| T583 | 601-608 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T584 | 729-740 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
| T585 | 1132-1136 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T586 | 1228-1245 | Body_part | denotes | endothelial cells | http://purl.org/sig/ont/fma/fma66772 |
| T587 | 1240-1245 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T588 | 1497-1515 | Body_part | denotes | lipopolysaccharide | http://purl.org/sig/ont/fma/fma82785 |
| T589 | 1517-1520 | Body_part | denotes | LPS | http://purl.org/sig/ont/fma/fma82785 |
| T590 | 1664-1668 | Body_part | denotes | ICAM | http://purl.org/sig/ont/fma/fma67857 |
| T591 | 1672-1682 | Body_part | denotes | E-selectin | http://purl.org/sig/ont/fma/fma62932 |
| T592 | 1694-1704 | Body_part | denotes | macrophage | http://purl.org/sig/ont/fma/fma63261 |
| T593 | 1734-1737 | Body_part | denotes | CSF | http://purl.org/sig/ont/fma/fma20935 |
| T594 | 1914-1917 | Body_part | denotes | CSF | http://purl.org/sig/ont/fma/fma20935 |
| T595 | 1964-1973 | Body_part | denotes | monocytes | http://purl.org/sig/ont/fma/fma62864 |
| T596 | 1988-2005 | Body_part | denotes | endothelial cells | http://purl.org/sig/ont/fma/fma66772 |
| T597 | 2000-2005 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T598 | 2122-2136 | Body_part | denotes | myofibroblasts | http://purl.org/sig/ont/fma/fma0326458 |
| T599 | 2137-2142 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T600 | 2173-2177 | Body_part | denotes | mRNA | http://purl.org/sig/ont/fma/fma67122 |
| T601 | 2188-2192 | Body_part | denotes | ICAM | http://purl.org/sig/ont/fma/fma67857 |
| T602 | 2235-2238 | Body_part | denotes | LPS | http://purl.org/sig/ont/fma/fma82785 |
| T603 | 2558-2569 | Body_part | denotes | neutrophils | http://purl.org/sig/ont/fma/fma62860 |
| T604 | 2672-2676 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T605 | 2989-2993 | Body_part | denotes | ICAM | http://purl.org/sig/ont/fma/fma67857 |
| T606 | 3087-3119 | Body_part | denotes | retinal pigment epithelial cells | http://purl.org/sig/ont/fma/fma75802 |
| T607 | 3114-3119 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T608 | 3213-3216 | Body_part | denotes | eye | http://purl.org/sig/ont/fma/fma54448 |
| T609 | 3369-3378 | Body_part | denotes | platelets | http://purl.org/sig/ont/fma/fma62851 |
| T610 | 3401-3409 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
| T611 | 3496-3504 | Body_part | denotes | selectin | http://purl.org/sig/ont/fma/fma61795 |
| T612 | 3664-3673 | Body_part | denotes | platelets | http://purl.org/sig/ont/fma/fma62851 |
| T613 | 3705-3711 | Body_part | denotes | artery | http://purl.org/sig/ont/fma/fma50720 |
| T614 | 4128-4132 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T615 | 4235-4238 | Body_part | denotes | LPS | http://purl.org/sig/ont/fma/fma82785 |
| T616 | 4257-4268 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
| T617 | 4273-4289 | Body_part | denotes | microglial cells | http://purl.org/sig/ont/fma/fma54539 |
| T618 | 4284-4289 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T619 | 4428-4439 | Body_part | denotes | neutrophils | http://purl.org/sig/ont/fma/fma62860 |
| T620 | 4928-4938 | Body_part | denotes | E-selectin | http://purl.org/sig/ont/fma/fma62932 |
| T621 | 4940-4944 | Body_part | denotes | ICAM | http://purl.org/sig/ont/fma/fma67857 |
| T622 | 5154-5158 | Body_part | denotes | ICAM | http://purl.org/sig/ont/fma/fma67857 |
| T623 | 5476-5480 | Body_part | denotes | ICAM | http://purl.org/sig/ont/fma/fma67857 |
| T624 | 5768-5774 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T625 | 5856-5859 | Body_part | denotes | LDL | http://purl.org/sig/ont/fma/fma63170 |
| T626 | 5869-5873 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T98 | 3213-3216 | Body_part | denotes | eye | http://purl.obolibrary.org/obo/UBERON_0000970 |
| T99 | 3705-3711 | Body_part | denotes | artery | http://purl.obolibrary.org/obo/UBERON_0001637 |
| T100 | 5768-5774 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T232 | 1095-1107 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T233 | 2054-2069 | Disease | denotes | atherosclerosis | http://purl.obolibrary.org/obo/MONDO_0005311 |
| T234 | 2462-2465 | Disease | denotes | EGC | http://purl.obolibrary.org/obo/MONDO_0001060 |
| T235 | 3065-3077 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T236 | 3217-3229 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T237 | 3694-3719 | Disease | denotes | peripheral artery disease | http://purl.obolibrary.org/obo/MONDO_0005386 |
| T238 | 3705-3719 | Disease | denotes | artery disease | http://purl.obolibrary.org/obo/MONDO_0000473 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T833 | 178-188 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T834 | 192-193 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T835 | 199-206 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T-cells |
| T836 | 420-424 | http://purl.obolibrary.org/obo/CLO_0053704 | denotes | IL-8 |
| T837 | 487-488 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T838 | 846-851 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T839 | 898-908 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T840 | 962-967 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T841 | 988-998 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T842 | 1132-1141 | http://purl.obolibrary.org/obo/CLO_0000031 | denotes | cell line |
| T843 | 1150-1156 | http://purl.obolibrary.org/obo/NCBITaxon_33208 | denotes | animal |
| T844 | 1205-1206 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T845 | 1222-1227 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T846 | 1228-1245 | http://purl.obolibrary.org/obo/CL_0000115 | denotes | endothelial cells |
| T847 | 1641-1642 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T848 | 1770-1771 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T849 | 1802-1810 | http://purl.obolibrary.org/obo/CL_0000613 | denotes | B and AP |
| T850 | 1813-1823 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T851 | 1923-1929 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
| T852 | 1964-1973 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocytes |
| T853 | 1988-2005 | http://purl.obolibrary.org/obo/CL_0000115 | denotes | endothelial cells |
| T854 | 2018-2019 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T855 | 2113-2121 | http://purl.obolibrary.org/obo/CLO_0002309 | denotes | CCD-18Co |
| T856 | 2122-2142 | http://purl.obolibrary.org/obo/CL_0000186 | denotes | myofibroblasts cells |
| T857 | 2208-2209 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T858 | 2342-2348 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
| T859 | 2372-2373 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T860 | 2439-2441 | http://purl.obolibrary.org/obo/CLO_0002878 | denotes | EC |
| T861 | 2784-2794 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activities |
| T862 | 2848-2858 | http://purl.obolibrary.org/obo/CL_0000234 | denotes | phagocytic |
| T863 | 2958-2959 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T864 | 3081-3086 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T865 | 3095-3119 | http://purl.obolibrary.org/obo/CL_0000529 | denotes | pigment epithelial cells |
| T866 | 3213-3216 | http://www.ebi.ac.uk/efo/EFO_0000827 | denotes | eye |
| T867 | 3281-3282 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T868 | 3359-3368 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T869 | 3410-3415 | http://purl.obolibrary.org/obo/CLO_0004307 | denotes | HUVEC |
| T870 | 3433-3439 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
| T871 | 3458-3459 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T872 | 3705-3711 | http://purl.obolibrary.org/obo/UBERON_0001637 | denotes | artery |
| T873 | 3705-3711 | http://www.ebi.ac.uk/efo/EFO_0000814 | denotes | artery |
| T874 | 3807-3813 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
| T875 | 3893-3894 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T876 | 4060-4061 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T877 | 4273-4289 | http://purl.obolibrary.org/obo/CL_0000129 | denotes | microglial cells |
| T878 | 4543-4551 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T879 | 4752-4758 | http://purl.obolibrary.org/obo/CLO_0004307 | denotes | HUVECs |
| T880 | 5098-5104 | http://purl.obolibrary.org/obo/CLO_0004307 | denotes | HUVECs |
| T881 | 5138-5142 | http://purl.obolibrary.org/obo/CLO_0053704 | denotes | IL-8 |
| T882 | 5275-5281 | http://purl.obolibrary.org/obo/NCBITaxon_33208 | denotes | animal |
| T883 | 5450-5451 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T884 | 5496-5497 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T885 | 5539-5540 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T886 | 5694-5695 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T887 | 5869-5873 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T888 | 5892-5893 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T1058 | 269-277 | Chemical | denotes | tyrosine | http://purl.obolibrary.org/obo/CHEBI_18186 |
| T1059 | 282-288 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
| T1060 | 289-298 | Chemical | denotes | threonine | http://purl.obolibrary.org/obo/CHEBI_26986 |
| T1061 | 299-306 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T1062 | 327-338 | Chemical | denotes | polyphenols | http://purl.obolibrary.org/obo/CHEBI_26195 |
| T1063 | 420-422 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T1065 | 426-428 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T1067 | 483-485 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T1070 | 601-608 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T1071 | 753-764 | Chemical | denotes | resveratrol | http://purl.obolibrary.org/obo/CHEBI_27881 |
| T1072 | 870-881 | Chemical | denotes | resveratrol | http://purl.obolibrary.org/obo/CHEBI_27881 |
| T1073 | 1069-1080 | Chemical | denotes | polyphenols | http://purl.obolibrary.org/obo/CHEBI_26195 |
| T1074 | 1317-1326 | Chemical | denotes | stilbenes | http://purl.obolibrary.org/obo/CHEBI_26776 |
| T1075 | 1328-1345 | Chemical | denotes | trans-resveratrol | http://purl.obolibrary.org/obo/CHEBI_45713 |
| T1076 | 1334-1345 | Chemical | denotes | resveratrol | http://purl.obolibrary.org/obo/CHEBI_27881 |
| T1077 | 1347-1359 | Chemical | denotes | trans-piceid | http://purl.obolibrary.org/obo/CHEBI_8198 |
| T1078 | 1362-1383 | Chemical | denotes | hydroxycinnamic acids | http://purl.obolibrary.org/obo/CHEBI_24689 |
| T1079 | 1378-1383 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T1080 | 1419-1424 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T1081 | 1426-1435 | Chemical | denotes | flavonols | http://purl.obolibrary.org/obo/CHEBI_28802 |
| T1082 | 1437-1447 | Chemical | denotes | kaempferol | http://purl.obolibrary.org/obo/CHEBI_28499|http://purl.obolibrary.org/obo/CHEBI_58573 |
| T1084 | 1449-1458 | Chemical | denotes | quercetin | http://purl.obolibrary.org/obo/CHEBI_16243|http://purl.obolibrary.org/obo/CHEBI_57694 |
| T1086 | 1460-1469 | Chemical | denotes | myricetin | http://purl.obolibrary.org/obo/CHEBI_18152|http://purl.obolibrary.org/obo/CHEBI_58395 |
| T1088 | 1497-1515 | Chemical | denotes | lipopolysaccharide | http://purl.obolibrary.org/obo/CHEBI_16412 |
| T1089 | 1517-1520 | Chemical | denotes | LPS | http://purl.obolibrary.org/obo/CHEBI_16412|http://purl.obolibrary.org/obo/CHEBI_52603|http://purl.obolibrary.org/obo/CHEBI_89981 |
| T1092 | 1567-1576 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T1093 | 1684-1687 | Chemical | denotes | MCP | http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099 |
| T1095 | 1740-1743 | Chemical | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 |
| T1096 | 1798-1800 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T1099 | 1808-1810 | Chemical | denotes | AP | http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_73393|http://purl.obolibrary.org/obo/CHEBI_81686 |
| T1102 | 1831-1842 | Chemical | denotes | resveratrol | http://purl.obolibrary.org/obo/CHEBI_27881 |
| T1103 | 2204-2206 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T1106 | 2235-2238 | Chemical | denotes | LPS | http://purl.obolibrary.org/obo/CHEBI_16412|http://purl.obolibrary.org/obo/CHEBI_52603|http://purl.obolibrary.org/obo/CHEBI_89981 |
| T1109 | 2374-2381 | Chemical | denotes | mixture | http://purl.obolibrary.org/obo/CHEBI_60004 |
| T1110 | 2395-2404 | Chemical | denotes | catechins | http://purl.obolibrary.org/obo/CHEBI_23053 |
| T1111 | 2484-2491 | Chemical | denotes | gallate | http://purl.obolibrary.org/obo/CHEBI_16918 |
| T1112 | 2494-2498 | Chemical | denotes | EGCG | http://purl.obolibrary.org/obo/CHEBI_4806 |
| T1113 | 2512-2519 | Chemical | denotes | gallate | http://purl.obolibrary.org/obo/CHEBI_16918 |
| T1114 | 2606-2614 | Chemical | denotes | catechin | http://purl.obolibrary.org/obo/CHEBI_23053 |
| T1115 | 2672-2674 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T1117 | 2682-2684 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T1119 | 2695-2699 | Chemical | denotes | HOCl | http://purl.obolibrary.org/obo/CHEBI_24757 |
| T1120 | 2765-2776 | Chemical | denotes | antioxidant | http://purl.obolibrary.org/obo/CHEBI_22586 |
| T1121 | 2811-2818 | Chemical | denotes | calcium | http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320 |
| T1123 | 2976-2980 | Chemical | denotes | EGCG | http://purl.obolibrary.org/obo/CHEBI_4806 |
| T1124 | 2997-2999 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T1127 | 3035-3038 | Chemical | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 |
| T1128 | 3087-3094 | Chemical | denotes | retinal | http://purl.obolibrary.org/obo/CHEBI_15035 |
| T1129 | 3181-3185 | Chemical | denotes | EGCG | http://purl.obolibrary.org/obo/CHEBI_4806 |
| T1130 | 3330-3338 | Chemical | denotes | catechin | http://purl.obolibrary.org/obo/CHEBI_23053 |
| T1131 | 3342-3358 | Chemical | denotes | arachidonic acid | http://purl.obolibrary.org/obo/CHEBI_15843 |
| T1132 | 3354-3358 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T1133 | 3785-3797 | Chemical | denotes | Ellagic acid | http://purl.obolibrary.org/obo/CHEBI_4775 |
| T1134 | 3793-3797 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T1135 | 3799-3801 | Chemical | denotes | EA | http://purl.obolibrary.org/obo/CHEBI_73849|http://purl.obolibrary.org/obo/CHEBI_4775 |
| T1137 | 4035-4051 | Chemical | denotes | Chlorogenic acid | http://purl.obolibrary.org/obo/CHEBI_16112 |
| T1138 | 4047-4051 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T1139 | 4128-4130 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T1141 | 4145-4147 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T1143 | 4235-4238 | Chemical | denotes | LPS | http://purl.obolibrary.org/obo/CHEBI_16412|http://purl.obolibrary.org/obo/CHEBI_52603|http://purl.obolibrary.org/obo/CHEBI_89981 |
| T1146 | 4376-4386 | Chemical | denotes | flavonoids | http://purl.obolibrary.org/obo/CHEBI_47916|http://purl.obolibrary.org/obo/CHEBI_72544 |
| T1148 | 4394-4410 | Chemical | denotes | arachidonic acid | http://purl.obolibrary.org/obo/CHEBI_15843 |
| T1149 | 4406-4410 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T1150 | 4441-4451 | Chemical | denotes | kaempferol | http://purl.obolibrary.org/obo/CHEBI_28499|http://purl.obolibrary.org/obo/CHEBI_58573 |
| T1152 | 4453-4461 | Chemical | denotes | luteolin | http://purl.obolibrary.org/obo/CHEBI_15864|http://purl.obolibrary.org/obo/CHEBI_57545 |
| T1154 | 4463-4472 | Chemical | denotes | quercetin | http://purl.obolibrary.org/obo/CHEBI_16243|http://purl.obolibrary.org/obo/CHEBI_57694 |
| T1156 | 4477-4490 | Chemical | denotes | amentoflavone | http://purl.obolibrary.org/obo/CHEBI_2631 |
| T1157 | 4673-4678 | Chemical | denotes | water | http://purl.obolibrary.org/obo/CHEBI_15377 |
| T1158 | 4683-4691 | Chemical | denotes | methanol | http://purl.obolibrary.org/obo/CHEBI_17790 |
| T1159 | 5132-5134 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T1161 | 5138-5140 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T1163 | 5368-5382 | Chemical | denotes | apolipoprotein | http://purl.obolibrary.org/obo/CHEBI_39015 |
| T1164 | 5554-5565 | Chemical | denotes | cholesterol | http://purl.obolibrary.org/obo/CHEBI_16113 |
| T1165 | 5709-5712 | Chemical | denotes | MCP | http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099 |
| T1167 | 5746-5749 | Chemical | denotes | MMP | http://purl.obolibrary.org/obo/CHEBI_340824|http://purl.obolibrary.org/obo/CHEBI_59761 |
| T1169 | 5775-5784 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T1170 | 5856-5859 | Chemical | denotes | LDL | http://purl.obolibrary.org/obo/CHEBI_39026 |
| T1171 | 5907-5918 | Chemical | denotes | cholesterol | http://purl.obolibrary.org/obo/CHEBI_16113 |
| T1172 | 5987-5991 | Chemical | denotes | heme | http://purl.obolibrary.org/obo/CHEBI_26355|http://purl.obolibrary.org/obo/CHEBI_30413 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T254 | 349-358 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T255 | 593-597 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | MAPK |
| T256 | 616-623 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | C (PKC) |
| T257 | 923-943 | http://purl.obolibrary.org/obo/GO_0000981 | denotes | transcription factor |
| T258 | 923-936 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T259 | 1095-1107 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T260 | 2700-2709 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T261 | 3065-3077 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T262 | 3217-3229 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T263 | 4189-4198 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T264 | 4503-4524 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory response |
| T265 | 5368-5382 | http://purl.obolibrary.org/obo/GO_0005319 | denotes | apolipoprotein |
| T266 | 5856-5868 | http://purl.obolibrary.org/obo/GO_0005041 | denotes | LDL receptor |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T486 | 0-21 | Sentence | denotes | 7.1 Cellular effects |
| T487 | 22-95 | Sentence | denotes | Polyphenols interfere with the inflammatory process in multiple pathways. |
| T488 | 96-316 | Sentence | denotes | For example, they alter the enzymatic processes involved in the proliferation and activation of B- and T-cells, as key components of the inflammatory pathway (by inhibiting tyrosine and serine-threonine protein kinases). |
| T489 | 317-497 | Sentence | denotes | Likewise, polyphenols blunt the synthesis of pro-inflammatory mediators such as cytokines, chemokines (IL-8, IL-6, TNF-α, VCAM-1 and ICAM-1), and angiogenic factors, NF-кB or iNOS. |
| T490 | 498-701 | Sentence | denotes | Further, an inhibitory effect on several pro-inflammatory enzymes was reported, such as COX-2, MAPK or protein kinase-C (PKC) (Alvarez-Suarez et al., 2017; Gasparrini et al., 2017; Hussain et al., 2016). |
| T491 | 702-852 | Sentence | denotes | Thus, studies performed on macrophages proved that resveratrol inhibited the IFN-γ-induced NO production and down-regulated the IFN-γ inducible genes. |
| T492 | 853-1020 | Sentence | denotes | In this respect, resveratrol decreased STAT1 activation (an important transcription factor for IFN-γ-induced genes) and hindered JAK-2 activation (Chung et al., 2011). |
| T493 | 1021-1201 | Sentence | denotes | Experimental studies arguing the involvement of polyphenols in mitigating inflammation are either performed on cell line models, animal models or have direct clinical implications. |
| T494 | 1202-1594 | Sentence | denotes | In a study exposing human endothelial cells to the effect of Negroamaro and Primitivo extracts or pure compounds - stilbenes (trans-resveratrol, trans-piceid), hydroxycinnamic acids (p-coumaric, caffeic, and caftaric acids) flavonols (kaempferol, quercetin, myricetin) – before stimulation with lipopolysaccharide (LPS), an inhibition in the expression of adhesion molecules was demonstrated. |
| T495 | 1595-1824 | Sentence | denotes | The anti-inflammatory effect was sustained by a reduction of VCAM-1, ICAM-1, E-selectin, MCP-1 and macrophage colony-stimulating factor (M-CSF), ROS intracellular levels with a correlated attenuation of NF-κB and AP-1 activation. |
| T496 | 1825-1918 | Sentence | denotes | Trans-resveratrol also significantly reduced the endothelial expression and release of M-CSF. |
| T497 | 1919-2095 | Sentence | denotes | All tested compounds reduced the adhesion of monocytes to stimulated endothelial cells, this being a key element in the development of atherosclerosis (Calabriso et al., 2016). |
| T498 | 2096-2327 | Sentence | denotes | The treatment of CCD-18Co myofibroblasts cells with red wine extract reduced mRNA levels of ICAM-1, VCAM-1, NF-κB, and PECAM-1, induced by LPS the anti-inflammatory mechanism being dependent on miR-126 (Angel-Morales et al., 2012). |
| T499 | 2328-2601 | Sentence | denotes | Another study tested the effects induced by a mixture of four main catechins found in green tea (epicatechin – EC, epigallocatechin – EGC, epigallocatechin gallate – EGCG, epicatechin gallate – GCG), as well as each one alone, on neutrophils isolated from healthy subjects. |
| T500 | 2602-2954 | Sentence | denotes | The catechin compounds induced anti-inflammatory effect (reduction of IL-1β and IL-6, TNF-α, HOCl synthesis and mieloperoxisase), together with the stimulation of antioxidant enzyme activities and Nrf2, along calcium release as well as increased phagocytic capacity, thus proving anti-inflammatory and immunomodulatory actions (Marinovic et al., 2015). |
| T501 | 2955-3120 | Sentence | denotes | In a separate study, EGCG reduced ICAM-1, NF-ĸB and IĸB expressions and reduced ROS levels upon TNF-α-induced inflammation in human retinal pigment epithelial cells. |
| T502 | 3121-3267 | Sentence | denotes | The results suggest the possible therapeutic involvement of EGCG in blocking TNF-α-mediated eye inflammation (Thichanpiang and Wongprasert, 2015). |
| T503 | 3268-3784 | Sentence | denotes | Moreover, in a study evaluating the effect of epicatechin and catechin on arachidonic acid-activated platelets and, respectively, on platelet-HUVEC interaction, the tested compounds induced a reduction of sICAM1, sVCAM1, and sE-selectin levels, as well as an increase of NO bioavailability, proving an anti-inflammatory effect and the ability to counteract endothelial dysfunction, but only when platelets were harvested from peripheral artery disease patients and not from healthy subjects (Carnevale et al., 2014). |
| T504 | 3785-4034 | Sentence | denotes | Ellagic acid (EA) was tested for its ability to inhibit MIF-induced chemotactic migration of PBMCs, showing a failure to inhibit this response when PBMCs were stimulated with MIP-1α, but high specificity for MIF-induced effect (Sarkar et al., 2015). |
| T505 | 4035-4311 | Sentence | denotes | Chlorogenic acid exerted a dose depended anti-inflammatory effect showed by the reduction of IL-1β, TNF-α and IL-6 levels as well as the inhibition of NO synthesis and expression of COX-1 and iNOS in LPS-stimulated murine macrophages and microglial cells (Hwang et al., 2014). |
| T506 | 4312-4607 | Sentence | denotes | An in vitro experiment evaluated the results induced by various flavonoids on the arachidonic acid release from rat neutrophils; kaempferol, luteolin, quercetin and amentoflavone reduced the inflammatory response and inhibited the activity of β-glucuronidase and lysozyme (Tordera et al., 1994). |
| T507 | 4608-4825 | Sentence | denotes | Furthermore, the positive outcome of Brassica oleracea extracts (water and methanol respectively) for CVD risk were examined; for this purpose, HUVECs were exposed to the extracts (24 h) and then to TNF-α stimulation. |
| T508 | 4826-4981 | Sentence | denotes | Exposure to the extracts from Brassica oleracea significantly reduced the TNF-α induced expression of E-selectin, ICAM-1 and VCAM-1 (Kuntz and Kunz, 2014). |
| T509 | 4982-5253 | Sentence | denotes | Another study demonstrated the capacity of extracts from Mango (Mangifera indica L.) to counteract TNF-α effects on HUVECs, through the inhibition of IL-6, IL-8, COX-2 and ICAM-1, while restoring the expression of eNOS usually down-regulated by TNF-α (Mura et al., 2015). |
| T510 | 5254-5634 | Sentence | denotes | Interestingly, in an animal model, for example, supplementation of standard chow with cacao phenolic compounds in apolipoprotein E-deficient mice, lead to an anti-inflammatory effect justified by a reduction of VCAM-1 and ICAM-1 expressions, a decrease of oxidative stress markers and a reduction of cholesterol accumulation in plaque compared to control (Natsume and Baba, 2014). |
| T511 | 5635-6083 | Sentence | denotes | Likewise, propolis (green, red or brown) treatment induced a reduction of MCP-1, VCAM, PECAM, FGF, PDGF, VEGF, MMP-9 and upregulated tissue inhibitor of metalloproteinases 1 (TIMP-1) in initial atherosclerotic lesions in LDL receptor gene knockout mice fed a diet rich in cholesterol for inducing atherosclerotic lesions; only red propolis upregulated heme oxygenase 1 (HO-1) and TIMP-1 in advanced atherosclerotic lesions (Daleprane et al., 2012). |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T135 | 2054-2069 | Phenotype | denotes | atherosclerosis | http://purl.obolibrary.org/obo/HP_0002621 |
| T136 | 3625-3648 | Phenotype | denotes | endothelial dysfunction | http://purl.obolibrary.org/obo/HP_0032654 |
| T137 | 3694-3719 | Phenotype | denotes | peripheral artery disease | http://purl.obolibrary.org/obo/HP_0004950 |
| T138 | 5510-5526 | Phenotype | denotes | oxidative stress | http://purl.obolibrary.org/obo/HP_0025464 |
| T139 | 5829-5852 | Phenotype | denotes | atherosclerotic lesions | http://purl.obolibrary.org/obo/HP_0031678 |
| T140 | 5932-5955 | Phenotype | denotes | atherosclerotic lesions | http://purl.obolibrary.org/obo/HP_0031678 |
| T141 | 6034-6057 | Phenotype | denotes | atherosclerotic lesions | http://purl.obolibrary.org/obo/HP_0031678 |
MyTest
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32640331-28137607-30721021 | 648-652 | 28137607 | denotes | 2017 |
| 32640331-28130090-30721022 | 673-677 | 28130090 | denotes | 2017 |
| 32640331-21189227-30721023 | 1014-1018 | 21189227 | denotes | 2011 |
| 32640331-25724173-30721024 | 2089-2093 | 25724173 | denotes | 2016 |
| 32640331-22572890-30721025 | 2321-2325 | 22572890 | denotes | 2012 |
| 32640331-25644976-30721026 | 3261-3265 | 25644976 | denotes | 2015 |
| 32640331-25929447-30721027 | 4028-4032 | 25929447 | denotes | 2015 |
| 32640331-24127072-30721028 | 4305-4309 | 24127072 | denotes | 2014 |
| 32640331-8018254-30721029 | 4601-4605 | 8018254 | denotes | 1994 |
| 32640331-24683602-30721030 | 4975-4979 | 24683602 | denotes | 2014 |
| 32640331-25589236-30721031 | 5247-5251 | 25589236 | denotes | 2015 |
| 32640331-24374929-30721032 | 5628-5632 | 24374929 | denotes | 2014 |
| 32640331-21764281-30721033 | 6077-6081 | 21764281 | denotes | 2012 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32640331-28137607-30721021 | 648-652 | 28137607 | denotes | 2017 |
| 32640331-28130090-30721022 | 673-677 | 28130090 | denotes | 2017 |
| 32640331-21189227-30721023 | 1014-1018 | 21189227 | denotes | 2011 |
| 32640331-25724173-30721024 | 2089-2093 | 25724173 | denotes | 2016 |
| 32640331-22572890-30721025 | 2321-2325 | 22572890 | denotes | 2012 |
| 32640331-25644976-30721026 | 3261-3265 | 25644976 | denotes | 2015 |
| 32640331-25929447-30721027 | 4028-4032 | 25929447 | denotes | 2015 |
| 32640331-24127072-30721028 | 4305-4309 | 24127072 | denotes | 2014 |
| 32640331-8018254-30721029 | 4601-4605 | 8018254 | denotes | 1994 |
| 32640331-24683602-30721030 | 4975-4979 | 24683602 | denotes | 2014 |
| 32640331-25589236-30721031 | 5247-5251 | 25589236 | denotes | 2015 |
| 32640331-24374929-30721032 | 5628-5632 | 24374929 | denotes | 2014 |
| 32640331-21764281-30721033 | 6077-6081 | 21764281 | denotes | 2012 |