PMC:7335494 / 78734-79836 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T568","span":{"begin":366,"end":369},"obj":"Body_part"},{"id":"T569","span":{"begin":671,"end":675},"obj":"Body_part"},{"id":"T570","span":{"begin":679,"end":689},"obj":"Body_part"},{"id":"T571","span":{"begin":716,"end":725},"obj":"Body_part"},{"id":"T572","span":{"begin":733,"end":744},"obj":"Body_part"},{"id":"T573","span":{"begin":810,"end":818},"obj":"Body_part"},{"id":"T574","span":{"begin":914,"end":926},"obj":"Body_part"}],"attributes":[{"id":"A568","pred":"fma_id","subj":"T568","obj":"http://purl.org/sig/ont/fma/fma63170"},{"id":"A569","pred":"fma_id","subj":"T569","obj":"http://purl.org/sig/ont/fma/fma67857"},{"id":"A570","pred":"fma_id","subj":"T570","obj":"http://purl.org/sig/ont/fma/fma62932"},{"id":"A571","pred":"fma_id","subj":"T571","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A572","pred":"fma_id","subj":"T572","obj":"http://purl.org/sig/ont/fma/fma63916"},{"id":"A573","pred":"fma_id","subj":"T573","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A574","pred":"fma_id","subj":"T574","obj":"http://purl.org/sig/ont/fma/fma86578"}],"text":"Polyphenols are key dietary components extensively studied for their involvement in preventing CVD, comorbidities of metabolic syndrome, malignancies, etc, all these diseases having an important etiological inflammatory component. For example, a central stage in the expansion of atherosclerosis is dyslipidemia, which together with increased ROS formation leads to LDL oxidation, which was correlated with the activation of pro-inflammatory pathways in the vascular wall. Likewise, it is well established that ROS and pro-inflammatory molecules generate a microenvironment predisposing to endothelial dysfunction. The increased expression of adhesion molecules (VCAM-1, ICAM-1, E-selectin) favours the adherence of monocytes to the endothelium and their infiltration within the vascular wall. As a result, of monocyte diapedesis pro-inflammatory molecules are released (TNF-α, IFNγ, MCP-1), NFκB is up-regulated, interleukins (IL-6 and IL-8) and metalloproteinases (MMPs) are synthesized (Gradinaru et al., 2017, 2018; Hansson and Libby, 2006; Libby, 2012; Libby et al., 2014; Ungurianu et al., 2019)."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T97","span":{"begin":733,"end":744},"obj":"Body_part"}],"attributes":[{"id":"A97","pred":"uberon_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/UBERON_0001986"}],"text":"Polyphenols are key dietary components extensively studied for their involvement in preventing CVD, comorbidities of metabolic syndrome, malignancies, etc, all these diseases having an important etiological inflammatory component. For example, a central stage in the expansion of atherosclerosis is dyslipidemia, which together with increased ROS formation leads to LDL oxidation, which was correlated with the activation of pro-inflammatory pathways in the vascular wall. Likewise, it is well established that ROS and pro-inflammatory molecules generate a microenvironment predisposing to endothelial dysfunction. The increased expression of adhesion molecules (VCAM-1, ICAM-1, E-selectin) favours the adherence of monocytes to the endothelium and their infiltration within the vascular wall. As a result, of monocyte diapedesis pro-inflammatory molecules are released (TNF-α, IFNγ, MCP-1), NFκB is up-regulated, interleukins (IL-6 and IL-8) and metalloproteinases (MMPs) are synthesized (Gradinaru et al., 2017, 2018; Hansson and Libby, 2006; Libby, 2012; Libby et al., 2014; Ungurianu et al., 2019)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T229","span":{"begin":117,"end":135},"obj":"Disease"},{"id":"T230","span":{"begin":280,"end":295},"obj":"Disease"},{"id":"T231","span":{"begin":299,"end":311},"obj":"Disease"}],"attributes":[{"id":"A229","pred":"mondo_id","subj":"T229","obj":"http://purl.obolibrary.org/obo/MONDO_0004955"},{"id":"A230","pred":"mondo_id","subj":"T230","obj":"http://purl.obolibrary.org/obo/MONDO_0005311"},{"id":"A231","pred":"mondo_id","subj":"T231","obj":"http://purl.obolibrary.org/obo/MONDO_0002525"}],"text":"Polyphenols are key dietary components extensively studied for their involvement in preventing CVD, comorbidities of metabolic syndrome, malignancies, etc, all these diseases having an important etiological inflammatory component. For example, a central stage in the expansion of atherosclerosis is dyslipidemia, which together with increased ROS formation leads to LDL oxidation, which was correlated with the activation of pro-inflammatory pathways in the vascular wall. Likewise, it is well established that ROS and pro-inflammatory molecules generate a microenvironment predisposing to endothelial dysfunction. The increased expression of adhesion molecules (VCAM-1, ICAM-1, E-selectin) favours the adherence of monocytes to the endothelium and their infiltration within the vascular wall. As a result, of monocyte diapedesis pro-inflammatory molecules are released (TNF-α, IFNγ, MCP-1), NFκB is up-regulated, interleukins (IL-6 and IL-8) and metalloproteinases (MMPs) are synthesized (Gradinaru et al., 2017, 2018; Hansson and Libby, 2006; Libby, 2012; Libby et al., 2014; Ungurianu et al., 2019)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T823","span":{"begin":244,"end":245},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T824","span":{"begin":411,"end":421},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T825","span":{"begin":555,"end":556},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T826","span":{"begin":716,"end":725},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T827","span":{"begin":733,"end":744},"obj":"http://purl.obolibrary.org/obo/UBERON_0001986"},{"id":"T828","span":{"begin":797,"end":798},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T829","span":{"begin":810,"end":818},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T830","span":{"begin":895,"end":896},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T831","span":{"begin":937,"end":941},"obj":"http://purl.obolibrary.org/obo/CLO_0053704"},{"id":"T832","span":{"begin":1014,"end":1018},"obj":"http://purl.obolibrary.org/obo/CLO_0001185"}],"text":"Polyphenols are key dietary components extensively studied for their involvement in preventing CVD, comorbidities of metabolic syndrome, malignancies, etc, all these diseases having an important etiological inflammatory component. For example, a central stage in the expansion of atherosclerosis is dyslipidemia, which together with increased ROS formation leads to LDL oxidation, which was correlated with the activation of pro-inflammatory pathways in the vascular wall. Likewise, it is well established that ROS and pro-inflammatory molecules generate a microenvironment predisposing to endothelial dysfunction. The increased expression of adhesion molecules (VCAM-1, ICAM-1, E-selectin) favours the adherence of monocytes to the endothelium and their infiltration within the vascular wall. As a result, of monocyte diapedesis pro-inflammatory molecules are released (TNF-α, IFNγ, MCP-1), NFκB is up-regulated, interleukins (IL-6 and IL-8) and metalloproteinases (MMPs) are synthesized (Gradinaru et al., 2017, 2018; Hansson and Libby, 2006; Libby, 2012; Libby et al., 2014; Ungurianu et al., 2019)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1041","span":{"begin":20,"end":38},"obj":"Chemical"},{"id":"T1042","span":{"begin":343,"end":346},"obj":"Chemical"},{"id":"T1043","span":{"begin":366,"end":369},"obj":"Chemical"},{"id":"T1044","span":{"begin":511,"end":514},"obj":"Chemical"},{"id":"T1045","span":{"begin":536,"end":545},"obj":"Chemical"},{"id":"T1046","span":{"begin":652,"end":661},"obj":"Chemical"},{"id":"T1047","span":{"begin":847,"end":856},"obj":"Chemical"},{"id":"T1048","span":{"begin":884,"end":887},"obj":"Chemical"},{"id":"T1050","span":{"begin":892,"end":894},"obj":"Chemical"},{"id":"T1053","span":{"begin":914,"end":926},"obj":"Chemical"},{"id":"T1054","span":{"begin":928,"end":930},"obj":"Chemical"},{"id":"T1056","span":{"begin":937,"end":939},"obj":"Chemical"}],"attributes":[{"id":"A1041","pred":"chebi_id","subj":"T1041","obj":"http://purl.obolibrary.org/obo/CHEBI_78295"},{"id":"A1042","pred":"chebi_id","subj":"T1042","obj":"http://purl.obolibrary.org/obo/CHEBI_26523"},{"id":"A1043","pred":"chebi_id","subj":"T1043","obj":"http://purl.obolibrary.org/obo/CHEBI_39026"},{"id":"A1044","pred":"chebi_id","subj":"T1044","obj":"http://purl.obolibrary.org/obo/CHEBI_26523"},{"id":"A1045","pred":"chebi_id","subj":"T1045","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A1046","pred":"chebi_id","subj":"T1046","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A1047","pred":"chebi_id","subj":"T1047","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A1048","pred":"chebi_id","subj":"T1048","obj":"http://purl.obolibrary.org/obo/CHEBI_132592"},{"id":"A1049","pred":"chebi_id","subj":"T1048","obj":"http://purl.obolibrary.org/obo/CHEBI_50099"},{"id":"A1050","pred":"chebi_id","subj":"T1050","obj":"http://purl.obolibrary.org/obo/CHEBI_141424"},{"id":"A1051","pred":"chebi_id","subj":"T1050","obj":"http://purl.obolibrary.org/obo/CHEBI_25573"},{"id":"A1052","pred":"chebi_id","subj":"T1050","obj":"http://purl.obolibrary.org/obo/CHEBI_1224"},{"id":"A1053","pred":"chebi_id","subj":"T1053","obj":"http://purl.obolibrary.org/obo/CHEBI_52998"},{"id":"A1054","pred":"chebi_id","subj":"T1054","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A1055","pred":"chebi_id","subj":"T1054","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A1056","pred":"chebi_id","subj":"T1056","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A1057","pred":"chebi_id","subj":"T1056","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"}],"text":"Polyphenols are key dietary components extensively studied for their involvement in preventing CVD, comorbidities of metabolic syndrome, malignancies, etc, all these diseases having an important etiological inflammatory component. For example, a central stage in the expansion of atherosclerosis is dyslipidemia, which together with increased ROS formation leads to LDL oxidation, which was correlated with the activation of pro-inflammatory pathways in the vascular wall. Likewise, it is well established that ROS and pro-inflammatory molecules generate a microenvironment predisposing to endothelial dysfunction. The increased expression of adhesion molecules (VCAM-1, ICAM-1, E-selectin) favours the adherence of monocytes to the endothelium and their infiltration within the vascular wall. As a result, of monocyte diapedesis pro-inflammatory molecules are released (TNF-α, IFNγ, MCP-1), NFκB is up-regulated, interleukins (IL-6 and IL-8) and metalloproteinases (MMPs) are synthesized (Gradinaru et al., 2017, 2018; Hansson and Libby, 2006; Libby, 2012; Libby et al., 2014; Ungurianu et al., 2019)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T251","span":{"begin":343,"end":356},"obj":"http://purl.obolibrary.org/obo/GO_1903409"},{"id":"T252","span":{"begin":347,"end":356},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T253","span":{"begin":819,"end":829},"obj":"http://purl.obolibrary.org/obo/GO_0050904"}],"text":"Polyphenols are key dietary components extensively studied for their involvement in preventing CVD, comorbidities of metabolic syndrome, malignancies, etc, all these diseases having an important etiological inflammatory component. For example, a central stage in the expansion of atherosclerosis is dyslipidemia, which together with increased ROS formation leads to LDL oxidation, which was correlated with the activation of pro-inflammatory pathways in the vascular wall. Likewise, it is well established that ROS and pro-inflammatory molecules generate a microenvironment predisposing to endothelial dysfunction. The increased expression of adhesion molecules (VCAM-1, ICAM-1, E-selectin) favours the adherence of monocytes to the endothelium and their infiltration within the vascular wall. As a result, of monocyte diapedesis pro-inflammatory molecules are released (TNF-α, IFNγ, MCP-1), NFκB is up-regulated, interleukins (IL-6 and IL-8) and metalloproteinases (MMPs) are synthesized (Gradinaru et al., 2017, 2018; Hansson and Libby, 2006; Libby, 2012; Libby et al., 2014; Ungurianu et al., 2019)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T481","span":{"begin":0,"end":230},"obj":"Sentence"},{"id":"T482","span":{"begin":231,"end":472},"obj":"Sentence"},{"id":"T483","span":{"begin":473,"end":614},"obj":"Sentence"},{"id":"T484","span":{"begin":615,"end":793},"obj":"Sentence"},{"id":"T485","span":{"begin":794,"end":1102},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Polyphenols are key dietary components extensively studied for their involvement in preventing CVD, comorbidities of metabolic syndrome, malignancies, etc, all these diseases having an important etiological inflammatory component. For example, a central stage in the expansion of atherosclerosis is dyslipidemia, which together with increased ROS formation leads to LDL oxidation, which was correlated with the activation of pro-inflammatory pathways in the vascular wall. Likewise, it is well established that ROS and pro-inflammatory molecules generate a microenvironment predisposing to endothelial dysfunction. The increased expression of adhesion molecules (VCAM-1, ICAM-1, E-selectin) favours the adherence of monocytes to the endothelium and their infiltration within the vascular wall. As a result, of monocyte diapedesis pro-inflammatory molecules are released (TNF-α, IFNγ, MCP-1), NFκB is up-regulated, interleukins (IL-6 and IL-8) and metalloproteinases (MMPs) are synthesized (Gradinaru et al., 2017, 2018; Hansson and Libby, 2006; Libby, 2012; Libby et al., 2014; Ungurianu et al., 2019)."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T132","span":{"begin":280,"end":295},"obj":"Phenotype"},{"id":"T133","span":{"begin":299,"end":311},"obj":"Phenotype"},{"id":"T134","span":{"begin":590,"end":613},"obj":"Phenotype"}],"attributes":[{"id":"A132","pred":"hp_id","subj":"T132","obj":"http://purl.obolibrary.org/obo/HP_0002621"},{"id":"A133","pred":"hp_id","subj":"T133","obj":"http://purl.obolibrary.org/obo/HP_0003119"},{"id":"A134","pred":"hp_id","subj":"T134","obj":"http://purl.obolibrary.org/obo/HP_0032654"}],"text":"Polyphenols are key dietary components extensively studied for their involvement in preventing CVD, comorbidities of metabolic syndrome, malignancies, etc, all these diseases having an important etiological inflammatory component. For example, a central stage in the expansion of atherosclerosis is dyslipidemia, which together with increased ROS formation leads to LDL oxidation, which was correlated with the activation of pro-inflammatory pathways in the vascular wall. Likewise, it is well established that ROS and pro-inflammatory molecules generate a microenvironment predisposing to endothelial dysfunction. The increased expression of adhesion molecules (VCAM-1, ICAM-1, E-selectin) favours the adherence of monocytes to the endothelium and their infiltration within the vascular wall. As a result, of monocyte diapedesis pro-inflammatory molecules are released (TNF-α, IFNγ, MCP-1), NFκB is up-regulated, interleukins (IL-6 and IL-8) and metalloproteinases (MMPs) are synthesized (Gradinaru et al., 2017, 2018; Hansson and Libby, 2006; Libby, 2012; Libby et al., 2014; Ungurianu et al., 2019)."}

{"project":"MyTest","denotations":[{"id":"32640331-27688246-30721016","span":{"begin":1008,"end":1012},"obj":"27688246"},{"id":"32640331-16778830-30721017","span":{"begin":1039,"end":1043},"obj":"16778830"},{"id":"32640331-22895665-30721018","span":{"begin":1052,"end":1056},"obj":"22895665"},{"id":"32640331-24902971-30721019","span":{"begin":1072,"end":1076},"obj":"24902971"},{"id":"32640331-30701670-30721020","span":{"begin":1096,"end":1100},"obj":"30701670"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"Polyphenols are key dietary components extensively studied for their involvement in preventing CVD, comorbidities of metabolic syndrome, malignancies, etc, all these diseases having an important etiological inflammatory component. For example, a central stage in the expansion of atherosclerosis is dyslipidemia, which together with increased ROS formation leads to LDL oxidation, which was correlated with the activation of pro-inflammatory pathways in the vascular wall. Likewise, it is well established that ROS and pro-inflammatory molecules generate a microenvironment predisposing to endothelial dysfunction. The increased expression of adhesion molecules (VCAM-1, ICAM-1, E-selectin) favours the adherence of monocytes to the endothelium and their infiltration within the vascular wall. As a result, of monocyte diapedesis pro-inflammatory molecules are released (TNF-α, IFNγ, MCP-1), NFκB is up-regulated, interleukins (IL-6 and IL-8) and metalloproteinases (MMPs) are synthesized (Gradinaru et al., 2017, 2018; Hansson and Libby, 2006; Libby, 2012; Libby et al., 2014; Ungurianu et al., 2019)."}

{"project":"2_test","denotations":[{"id":"32640331-27688246-30721016","span":{"begin":1008,"end":1012},"obj":"27688246"},{"id":"32640331-16778830-30721017","span":{"begin":1039,"end":1043},"obj":"16778830"},{"id":"32640331-22895665-30721018","span":{"begin":1052,"end":1056},"obj":"22895665"},{"id":"32640331-24902971-30721019","span":{"begin":1072,"end":1076},"obj":"24902971"},{"id":"32640331-30701670-30721020","span":{"begin":1096,"end":1100},"obj":"30701670"}],"text":"Polyphenols are key dietary components extensively studied for their involvement in preventing CVD, comorbidities of metabolic syndrome, malignancies, etc, all these diseases having an important etiological inflammatory component. For example, a central stage in the expansion of atherosclerosis is dyslipidemia, which together with increased ROS formation leads to LDL oxidation, which was correlated with the activation of pro-inflammatory pathways in the vascular wall. Likewise, it is well established that ROS and pro-inflammatory molecules generate a microenvironment predisposing to endothelial dysfunction. The increased expression of adhesion molecules (VCAM-1, ICAM-1, E-selectin) favours the adherence of monocytes to the endothelium and their infiltration within the vascular wall. As a result, of monocyte diapedesis pro-inflammatory molecules are released (TNF-α, IFNγ, MCP-1), NFκB is up-regulated, interleukins (IL-6 and IL-8) and metalloproteinases (MMPs) are synthesized (Gradinaru et al., 2017, 2018; Hansson and Libby, 2006; Libby, 2012; Libby et al., 2014; Ungurianu et al., 2019)."}