PMC:7335494 / 59294-60243
Annnotations
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T643 | 181-184 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T644 | 185-186 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T645 | 280-290 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T646 | 335-336 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
T647 | 482-483 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
T648 | 484-494 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T649 | 498-499 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T650 | 572-574 | http://purl.obolibrary.org/obo/UBERON_0003064 | denotes | Im |
T651 | 704-714 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signalling |
T652 | 723-724 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
T653 | 745-746 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
T654 | 780-790 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T655 | 813-821 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
T656 | 822-832 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T657 | 840-841 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
T658 | 915-925 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signalling |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T44030 | 0-3 | Chemical | denotes | DHA | http://purl.obolibrary.org/obo/CHEBI_16016|http://purl.obolibrary.org/obo/CHEBI_28125|http://purl.obolibrary.org/obo/CHEBI_28689|http://purl.obolibrary.org/obo/CHEBI_36005 |
T342 | 8-11 | Chemical | denotes | EPA | http://purl.obolibrary.org/obo/CHEBI_28364 |
T82658 | 23-31 | Chemical | denotes | agonists | http://purl.obolibrary.org/obo/CHEBI_48705 |
T344 | 83-94 | Chemical | denotes | metabolites | http://purl.obolibrary.org/obo/CHEBI_25212 |
T85681 | 104-116 | Chemical | denotes | protectin D1 | http://purl.obolibrary.org/obo/CHEBI_138655 |
T7860 | 170-173 | Chemical | denotes | ALA | http://purl.obolibrary.org/obo/CHEBI_16449|http://purl.obolibrary.org/obo/CHEBI_27432 |
T38169 | 177-180 | Chemical | denotes | ARA | http://purl.obolibrary.org/obo/CHEBI_15843 |
T54248 | 206-209 | Chemical | denotes | DHA | http://purl.obolibrary.org/obo/CHEBI_16016|http://purl.obolibrary.org/obo/CHEBI_28125|http://purl.obolibrary.org/obo/CHEBI_28689|http://purl.obolibrary.org/obo/CHEBI_36005 |
T353 | 213-216 | Chemical | denotes | EPA | http://purl.obolibrary.org/obo/CHEBI_28364 |
T19797 | 331-333 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
T28353 | 422-427 | Chemical | denotes | PUFAs | http://purl.obolibrary.org/obo/CHEBI_26208 |
T15370 | 446-451 | Chemical | denotes | PUFAs | http://purl.obolibrary.org/obo/CHEBI_26208 |
T68097 | 478-480 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
T362 | 673-678 | Chemical | denotes | PUFAs | http://purl.obolibrary.org/obo/CHEBI_26208 |
T2536 | 719-721 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
T66827 | 741-743 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
T369 | 836-838 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T199 | 299-321 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory responses |
T200 | 704-714 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T201 | 915-933 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signalling cascade |
T202 | 915-925 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T335 | 0-163 | Sentence | denotes | DHA and EPA are weaker agonists of PPAR-γ (EC50 ~ 10–100 μM), while their oxidized metabolites (such as protectin D1) are much more potent (Yamamoto et al., 2005). |
T336 | 164-269 | Sentence | denotes | Also, ALA or ARA has a similar potency to DHA or EPA for on PPAR-γ, and higher for PPAR-α (Calder, 2015). |
T337 | 270-428 | Sentence | denotes | As PPAR-γ activation reduces inflammatory responses, via the NF-κB pathway, this mechanism could partially explain the anti-inflammatory effects of n-3 PUFAs. |
T338 | 429-582 | Sentence | denotes | Furthermore, n-3 PUFAs were reported to suppress NF-κB activation in a PPAR-γ-independent manner by binding to TLR-4 under certain conditions (Im, 2012). |
T339 | 583-949 | Sentence | denotes | Taking into account all these reports, it looks like three mechanisms are employed by n-3 PUFAs to suppress inflammatory signalling via NF-κB: (1) preventing NF-κB nuclear translocation via PPAR-γ activation, (2) interfering with membrane activation of NF-κB via TLR4 and (3) interaction with GPR120 initiating an anti-inflammatory signalling cascade (Calder, 2015). |
MyTest
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32640331-15664804-30720928 | 157-161 | 15664804 | denotes | 2005 |
32640331-25149823-30720929 | 263-267 | 25149823 | denotes | 2015 |
32640331-22542696-30720930 | 576-580 | 22542696 | denotes | 2012 |
32640331-25149823-30720931 | 943-947 | 25149823 | denotes | 2015 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32640331-15664804-30720928 | 157-161 | 15664804 | denotes | 2005 |
32640331-25149823-30720929 | 263-267 | 25149823 | denotes | 2015 |
32640331-22542696-30720930 | 576-580 | 22542696 | denotes | 2012 |
32640331-25149823-30720931 | 943-947 | 25149823 | denotes | 2015 |