PMC:7335494 / 5496-6795
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T18 | 116-125 | Body_part | denotes | cytoplasm | http://purl.org/sig/ont/fma/fma66835 |
| T19 | 182-191 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T20 | 200-204 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T21 | 677-686 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T22 | 688-692 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T30 | 881-893 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T31 | 1220-1227 | Disease | denotes | obesity | http://purl.obolibrary.org/obo/MONDO_0011122 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T29 | 7-8 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T30 | 10-11 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T31 | 73-74 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T32 | 194-198 | http://purl.obolibrary.org/obo/CLO_0053704 | denotes | IL-8 |
| T33 | 273-274 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T34 | 399-404 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T35 | 545-550 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T36 | 568-586 | http://purl.obolibrary.org/obo/UBERON_0001474 | denotes | B are the ones for |
| T37 | 568-582 | http://www.ebi.ac.uk/efo/EFO_0000298 | denotes | B are the ones |
| T38 | 703-707 | http://purl.obolibrary.org/obo/CLO_0053704 | denotes | IL-8 |
| T39 | 791-796 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T40 | 955-959 | http://purl.obolibrary.org/obo/CLO_0001185 | denotes | 2018 |
| T41 | 978-982 | http://purl.obolibrary.org/obo/CLO_0001185 | denotes | 2018 |
| T42 | 1062-1063 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T43 | 1080-1089 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T44 | 1179-1185 | http://purl.obolibrary.org/obo/NCBITaxon_33208 | denotes | animal |
| T45 | 1199-1202 | http://purl.obolibrary.org/obo/UBERON_0001013 | denotes | fat |
| T46 | 1284-1285 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T32 | 3-5 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T35 | 194-196 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T37 | 200-202 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T39 | 207-209 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T41 | 347-354 | Chemical | denotes | nucleus | http://purl.obolibrary.org/obo/CHEBI_33252 |
| T42 | 564-566 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T45 | 619-622 | Chemical | denotes | MMP | http://purl.obolibrary.org/obo/CHEBI_340824|http://purl.obolibrary.org/obo/CHEBI_59761 |
| T47 | 626-638 | Chemical | denotes | nitric oxide | http://purl.obolibrary.org/obo/CHEBI_16480 |
| T48 | 633-638 | Chemical | denotes | oxide | http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356 |
| T50 | 688-690 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T52 | 694-696 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T54 | 703-705 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T56 | 1058-1060 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T21 | 506-518 | http://purl.obolibrary.org/obo/GO_0001525 | denotes | angiogenesis |
| T22 | 756-762 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T23 | 881-893 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T24 | 1122-1138 | http://purl.obolibrary.org/obo/GO_0007623 | denotes | circadian rhythm |
| T25 | 1132-1138 | http://purl.obolibrary.org/obo/GO_0048511 | denotes | rhythm |
| T26 | 1148-1153 | http://purl.obolibrary.org/obo/GO_0007568 | denotes | aging |
| T27 | 1157-1162 | http://purl.obolibrary.org/obo/GO_0030431 | denotes | sleep |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T31 | 127-534 | Sentence | denotes | Under the effect of inflammatory stimuli (for instance cytokines – IL-8, IL-1β, IL-6, or TNF-α, UV exposure, etc), the heterodimer dissociates, IκBα is degraded, and the two components, p50 and p65, translocate into the nucleus binding the promoter regions from different genes that are involved in initiating several cellular pathways linked to chronic diseases, tumorigenesis, angiogenesis and metastasis. |
| T32 | 535-1038 | Sentence | denotes | Among the genes regulated by NF-κB are the ones for the expression of TNF-α, COX-2, MMP-9, nitric oxide synthase – the inducible form (iNOS), cytokines (IL-1, IL-6 and IL-8), 5-lipooxigenase (5-LOX), vascular endothelial growth factor (VEGF); all of these genes, when up-regulated fire-up the vicious circle constituted from oxidative stress and inflammation (Aggarwal, 2009; Kawabata et al., 2012; Kunnumakkara et al., 2018; Nimigean et al., 2018, 2019; Poll et al., 2018a, 2018b; Reuter et al., 2010). |
| T33 | 1039-1175 | Sentence | denotes | Interestingly, the NF-κB cascade is also activated by some factors that affect the circadian rhythm, such as aging or sleep deprivation. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T13 | 860-876 | Phenotype | denotes | oxidative stress | http://purl.obolibrary.org/obo/HP_0025464 |
| T14 | 1220-1227 | Phenotype | denotes | obesity | http://purl.obolibrary.org/obo/HP_0001513 |
MyTest
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32640331-19671496-30720720 | 905-909 | 19671496 | denotes | 2009 |
| 32640331-29370858-30720721 | 955-959 | 29370858 | denotes | 2018 |
| 32640331-20840865-30720722 | 1032-1036 | 20840865 | denotes | 2010 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32640331-19671496-30720720 | 905-909 | 19671496 | denotes | 2009 |
| 32640331-29370858-30720721 | 955-959 | 29370858 | denotes | 2018 |
| 32640331-20840865-30720722 | 1032-1036 | 20840865 | denotes | 2010 |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T69 | 3-5 | GO:0005883 | denotes | NF |
| T70 | 30-33 | PR:Q9FJR1 | denotes | p65 |
| T71 | 38-41 | PR:Q43731 | denotes | p50 |
| T72 | 71-75 | PR:000003293 | denotes | IκBα |
| T73 | 116-125 | GO:0005737 | denotes | cytoplasm |
| T74 | 194-198 | PR:000001395 | denotes | IL-8 |
| T75 | 200-205 | PR:000001136 | denotes | IL-1β |
| T76 | 207-211 | PR:000001393 | denotes | IL-6 |
| T77 | 216-221 | PR:000000134 | denotes | TNF-α |
| T78 | 271-275 | PR:000003293 | denotes | IκBα |
| T79 | 313-316 | PR:Q43731 | denotes | p50 |
| T80 | 321-324 | PR:Q9FJR1 | denotes | p65 |
| T81 | 347-354 | GO:0005634 | denotes | nucleus |
| T82 | 367-375 | SO:0000167 | denotes | promoter |
| T83 | 399-404 | SO:0000704 | denotes | genes |
| T84 | 506-518 | GO:0001525 | denotes | angiogenesis |
| T85 | 545-550 | SO:0000704 | denotes | genes |
| T86 | 551-560 | GO:0065007 | denotes | regulated |
| T87 | 564-566 | GO:0005883 | denotes | NF |
| T88 | 591-601 | GO:0010467 | denotes | expression |
| T89 | 605-610 | PR:000000134 | denotes | TNF-α |
| T90 | 612-617 | PR:000013428 | denotes | COX-2 |
| T91 | 619-624 | PR:000010491 | denotes | MMP-9 |
| T92 | 626-638 | CHEBI:16480;CHEBI:16480 | denotes | nitric oxide |
| T93 | 694-698 | PR:000001393 | denotes | IL-6 |
| T94 | 703-707 | PR:000001395 | denotes | IL-8 |
| T95 | 744-755 | UBERON:0001986 | denotes | endothelial |
| T96 | 771-775 | PR:000017284 | denotes | VEGF |
| T97 | 791-796 | SO:0000704 | denotes | genes |
| T98 | 860-869 | MOP:0000568 | denotes | oxidative |
| T99 | 1058-1060 | GO:0005883 | denotes | NF |
| T100 | 1122-1138 | GO:0007623 | denotes | circadian rhythm |
| T101 | 1148-1153 | GO:0007568 | denotes | aging |
| T102 | 1179-1185 | NCBITaxon:33208 | denotes | animal |