PMC:7335494 / 5496-6795 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7335494","sourcedb":"PMC","sourceid":"7335494","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7335494","text":"s, NF-κB (a heterotrimer with p65 and p50 subunits associated with the IκBα inhibitory subunit) is localized to the cytoplasm. Under the effect of inflammatory stimuli (for instance cytokines – IL-8, IL-1β, IL-6, or TNF-α, UV exposure, etc), the heterodimer dissociates, IκBα is degraded, and the two components, p50 and p65, translocate into the nucleus binding the promoter regions from different genes that are involved in initiating several cellular pathways linked to chronic diseases, tumorigenesis, angiogenesis and metastasis. Among the genes regulated by NF-κB are the ones for the expression of TNF-α, COX-2, MMP-9, nitric oxide synthase – the inducible form (iNOS), cytokines (IL-1, IL-6 and IL-8), 5-lipooxigenase (5-LOX), vascular endothelial growth factor (VEGF); all of these genes, when up-regulated fire-up the vicious circle constituted from oxidative stress and inflammation (Aggarwal, 2009; Kawabata et al., 2012; Kunnumakkara et al., 2018; Nimigean et al., 2018, 2019; Poll et al., 2018a, 2018b; Reuter et al., 2010). Interestingly, the NF-κB cascade is also activated by some factors that affect the circadian rhythm, such as aging or sleep deprivation. In animal models, high-fat diets as well as obesity – pro-inflammatory states, are directly correlated with a decrease of t","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T18","span":{"begin":116,"end":125},"obj":"Body_part"},{"id":"T19","span":{"begin":182,"end":191},"obj":"Body_part"},{"id":"T20","span":{"begin":200,"end":204},"obj":"Body_part"},{"id":"T21","span":{"begin":677,"end":686},"obj":"Body_part"},{"id":"T22","span":{"begin":688,"end":692},"obj":"Body_part"}],"attributes":[{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma66835"},{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A20","pred":"fma_id","subj":"T20","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A21","pred":"fma_id","subj":"T21","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A22","pred":"fma_id","subj":"T22","obj":"http://purl.org/sig/ont/fma/fma86583"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T30","span":{"begin":881,"end":893},"obj":"Disease"},{"id":"T31","span":{"begin":1220,"end":1227},"obj":"Disease"}],"attributes":[{"id":"A30","pred":"mondo_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A31","pred":"mondo_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/MONDO_0011122"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T29","span":{"begin":7,"end":8},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T30","span":{"begin":10,"end":11},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T31","span":{"begin":73,"end":74},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T32","span":{"begin":194,"end":198},"obj":"http://purl.obolibrary.org/obo/CLO_0053704"},{"id":"T33","span":{"begin":273,"end":274},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T34","span":{"begin":399,"end":404},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T35","span":{"begin":545,"end":550},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T36","span":{"begin":568,"end":586},"obj":"http://purl.obolibrary.org/obo/UBERON_0001474"},{"id":"T37","span":{"begin":568,"end":582},"obj":"http://www.ebi.ac.uk/efo/EFO_0000298"},{"id":"T38","span":{"begin":703,"end":707},"obj":"http://purl.obolibrary.org/obo/CLO_0053704"},{"id":"T39","span":{"begin":791,"end":796},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T40","span":{"begin":955,"end":959},"obj":"http://purl.obolibrary.org/obo/CLO_0001185"},{"id":"T41","span":{"begin":978,"end":982},"obj":"http://purl.obolibrary.org/obo/CLO_0001185"},{"id":"T42","span":{"begin":1062,"end":1063},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T43","span":{"begin":1080,"end":1089},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T44","span":{"begin":1179,"end":1185},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"},{"id":"T45","span":{"begin":1199,"end":1202},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T46","span":{"begin":1284,"end":1285},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T29","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T32","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T33","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T34","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T35","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T36","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T42","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T43","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T44","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T32","span":{"begin":3,"end":5},"obj":"Chemical"},{"id":"T35","span":{"begin":194,"end":196},"obj":"Chemical"},{"id":"T37","span":{"begin":200,"end":202},"obj":"Chemical"},{"id":"T39","span":{"begin":207,"end":209},"obj":"Chemical"},{"id":"T41","span":{"begin":347,"end":354},"obj":"Chemical"},{"id":"T42","span":{"begin":564,"end":566},"obj":"Chemical"},{"id":"T45","span":{"begin":619,"end":622},"obj":"Chemical"},{"id":"T47","span":{"begin":626,"end":638},"obj":"Chemical"},{"id":"T48","span":{"begin":633,"end":638},"obj":"Chemical"},{"id":"T50","span":{"begin":688,"end":690},"obj":"Chemical"},{"id":"T52","span":{"begin":694,"end":696},"obj":"Chemical"},{"id":"T54","span":{"begin":703,"end":705},"obj":"Chemical"},{"id":"T56","span":{"begin":1058,"end":1060},"obj":"Chemical"}],"attributes":[{"id":"A32","pred":"chebi_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/CHEBI_141424"},{"id":"A33","pred":"chebi_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/CHEBI_25573"},{"id":"A34","pred":"chebi_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/CHEBI_1224"},{"id":"A35","pred":"chebi_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A36","pred":"chebi_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A37","pred":"chebi_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A38","pred":"chebi_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A39","pred":"chebi_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A40","pred":"chebi_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A41","pred":"chebi_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/CHEBI_33252"},{"id":"A42","pred":"chebi_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/CHEBI_141424"},{"id":"A43","pred":"chebi_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/CHEBI_25573"},{"id":"A44","pred":"chebi_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/CHEBI_1224"},{"id":"A45","pred":"chebi_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/CHEBI_340824"},{"id":"A46","pred":"chebi_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/CHEBI_59761"},{"id":"A47","pred":"chebi_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/CHEBI_16480"},{"id":"A48","pred":"chebi_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/CHEBI_25741"},{"id":"A49","pred":"chebi_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/CHEBI_29356"},{"id":"A50","pred":"chebi_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A51","pred":"chebi_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A52","pred":"chebi_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A53","pred":"chebi_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A54","pred":"chebi_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A55","pred":"chebi_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A56","pred":"chebi_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/CHEBI_141424"},{"id":"A57","pred":"chebi_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/CHEBI_25573"},{"id":"A58","pred":"chebi_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/CHEBI_1224"},{"subj":"T32","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T35","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T42","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T50","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T52","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T54","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T21","span":{"begin":506,"end":518},"obj":"http://purl.obolibrary.org/obo/GO_0001525"},{"id":"T22","span":{"begin":756,"end":762},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T23","span":{"begin":881,"end":893},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T24","span":{"begin":1122,"end":1138},"obj":"http://purl.obolibrary.org/obo/GO_0007623"},{"id":"T25","span":{"begin":1132,"end":1138},"obj":"http://purl.obolibrary.org/obo/GO_0048511"},{"id":"T26","span":{"begin":1148,"end":1153},"obj":"http://purl.obolibrary.org/obo/GO_0007568"},{"id":"T27","span":{"begin":1157,"end":1162},"obj":"http://purl.obolibrary.org/obo/GO_0030431"}],"attributes":[{"subj":"T21","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T31","span":{"begin":127,"end":534},"obj":"Sentence"},{"id":"T32","span":{"begin":535,"end":1038},"obj":"Sentence"},{"id":"T33","span":{"begin":1039,"end":1175},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T31","pred":"source","obj":"LitCovid-sentences"},{"subj":"T32","pred":"source","obj":"LitCovid-sentences"},{"subj":"T33","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T13","span":{"begin":860,"end":876},"obj":"Phenotype"},{"id":"T14","span":{"begin":1220,"end":1227},"obj":"Phenotype"}],"attributes":[{"id":"A13","pred":"hp_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/HP_0025464"},{"id":"A14","pred":"hp_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/HP_0001513"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"MyTest","denotations":[{"id":"32640331-19671496-30720720","span":{"begin":905,"end":909},"obj":"19671496"},{"id":"32640331-29370858-30720721","span":{"begin":955,"end":959},"obj":"29370858"},{"id":"32640331-20840865-30720722","span":{"begin":1032,"end":1036},"obj":"20840865"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"32640331-19671496-30720720","pred":"source","obj":"MyTest"},{"subj":"32640331-29370858-30720721","pred":"source","obj":"MyTest"},{"subj":"32640331-20840865-30720722","pred":"source","obj":"MyTest"}]},{"project":"2_test","denotations":[{"id":"32640331-19671496-30720720","span":{"begin":905,"end":909},"obj":"19671496"},{"id":"32640331-29370858-30720721","span":{"begin":955,"end":959},"obj":"29370858"},{"id":"32640331-20840865-30720722","span":{"begin":1032,"end":1036},"obj":"20840865"}],"attributes":[{"subj":"32640331-19671496-30720720","pred":"source","obj":"2_test"},{"subj":"32640331-29370858-30720721","pred":"source","obj":"2_test"},{"subj":"32640331-20840865-30720722","pred":"source","obj":"2_test"}]},{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T69","span":{"begin":3,"end":5},"obj":"GO:0005883"},{"id":"T70","span":{"begin":30,"end":33},"obj":"PR:Q9FJR1"},{"id":"T71","span":{"begin":38,"end":41},"obj":"PR:Q43731"},{"id":"T72","span":{"begin":71,"end":75},"obj":"PR:000003293"},{"id":"T73","span":{"begin":116,"end":125},"obj":"GO:0005737"},{"id":"T74","span":{"begin":194,"end":198},"obj":"PR:000001395"},{"id":"T75","span":{"begin":200,"end":205},"obj":"PR:000001136"},{"id":"T76","span":{"begin":207,"end":211},"obj":"PR:000001393"},{"id":"T77","span":{"begin":216,"end":221},"obj":"PR:000000134"},{"id":"T78","span":{"begin":271,"end":275},"obj":"PR:000003293"},{"id":"T79","span":{"begin":313,"end":316},"obj":"PR:Q43731"},{"id":"T80","span":{"begin":321,"end":324},"obj":"PR:Q9FJR1"},{"id":"T81","span":{"begin":347,"end":354},"obj":"GO:0005634"},{"id":"T82","span":{"begin":367,"end":375},"obj":"SO:0000167"},{"id":"T83","span":{"begin":399,"end":404},"obj":"SO:0000704"},{"id":"T84","span":{"begin":506,"end":518},"obj":"GO:0001525"},{"id":"T85","span":{"begin":545,"end":550},"obj":"SO:0000704"},{"id":"T86","span":{"begin":551,"end":560},"obj":"GO:0065007"},{"id":"T87","span":{"begin":564,"end":566},"obj":"GO:0005883"},{"id":"T88","span":{"begin":591,"end":601},"obj":"GO:0010467"},{"id":"T89","span":{"begin":605,"end":610},"obj":"PR:000000134"},{"id":"T90","span":{"begin":612,"end":617},"obj":"PR:000013428"},{"id":"T91","span":{"begin":619,"end":624},"obj":"PR:000010491"},{"id":"T92","span":{"begin":626,"end":638},"obj":"CHEBI:16480;CHEBI:16480"},{"id":"T93","span":{"begin":694,"end":698},"obj":"PR:000001393"},{"id":"T94","span":{"begin":703,"end":707},"obj":"PR:000001395"},{"id":"T95","span":{"begin":744,"end":755},"obj":"UBERON:0001986"},{"id":"T96","span":{"begin":771,"end":775},"obj":"PR:000017284"},{"id":"T97","span":{"begin":791,"end":796},"obj":"SO:0000704"},{"id":"T98","span":{"begin":860,"end":869},"obj":"MOP:0000568"},{"id":"T99","span":{"begin":1058,"end":1060},"obj":"GO:0005883"},{"id":"T100","span":{"begin":1122,"end":1138},"obj":"GO:0007623"},{"id":"T101","span":{"begin":1148,"end":1153},"obj":"GO:0007568"},{"id":"T102","span":{"begin":1179,"end":1185},"obj":"NCBITaxon:33208"}],"attributes":[{"subj":"T69","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T70","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T71","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T72","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T73","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T74","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T75","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T76","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T77","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T78","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T79","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T80","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T81","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T82","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T83","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T84","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T85","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T86","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T87","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T88","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T89","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T90","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T91","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T92","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T93","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T94","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T95","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T96","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T97","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T98","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T99","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T100","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T101","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T102","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#beec93","default":true},{"id":"LitCovid-PD-MONDO","color":"#ec93d8"},{"id":"LitCovid-PD-CLO","color":"#93ece6"},{"id":"LitCovid-PD-CHEBI","color":"#eccc93"},{"id":"LitCovid-PD-GO-BP","color":"#b193ec"},{"id":"LitCovid-sentences","color":"#93ec97"},{"id":"LitCovid-PD-HP","color":"#ec93a8"},{"id":"MyTest","color":"#93c2ec"},{"id":"2_test","color":"#dcec93"},{"id":"LitCovid-PMC-OGER-BB","color":"#e293ec"}]}]}}