PMC:7335494 / 3344-4873
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T9 | 92-98 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T10 | 157-163 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T11 | 828-835 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
| T12 | 1072-1081 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T13 | 1109-1121 | Body_part | denotes | interleukins | http://purl.org/sig/ont/fma/fma86578 |
| T14 | 1123-1127 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T15 | 1180-1203 | Body_part | denotes | cell adhesion molecules | http://purl.org/sig/ont/fma/fma67214 |
| T16 | 1180-1184 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T17 | 1208-1218 | Body_part | denotes | chemokines | http://purl.org/sig/ont/fma/fma241981 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T5 | 92-98 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T6 | 157-163 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T26 | 32-44 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T27 | 320-332 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T28 | 549-561 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T16 | 48-49 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T17 | 109-110 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T18 | 701-702 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T19 | 786-787 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T20 | 849-850 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T21 | 944-950 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signal |
| T22 | 966-975 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activator |
| T23 | 1061-1062 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T24 | 1068-1069 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T25 | 1135-1139 | http://purl.obolibrary.org/obo/CLO_0053704 | denotes | IL-8 |
| T26 | 1180-1184 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T14 | 509-518 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T15 | 750-758 | Chemical | denotes | solution | http://purl.obolibrary.org/obo/CHEBI_75958 |
| T16 | 1032-1035 | Chemical | denotes | MMP | http://purl.obolibrary.org/obo/CHEBI_340824|http://purl.obolibrary.org/obo/CHEBI_59761 |
| T18 | 1064-1066 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T21 | 1109-1121 | Chemical | denotes | interleukins | http://purl.obolibrary.org/obo/CHEBI_52998 |
| T22 | 1123-1125 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T24 | 1129-1131 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T26 | 1135-1137 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T28 | 1165-1170 | Chemical | denotes | alpha | http://purl.obolibrary.org/obo/CHEBI_30216 |
| T29 | 1194-1203 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T30 | 1360-1369 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T31 | 1447-1456 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T6 | 32-44 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T7 | 157-175 | http://purl.obolibrary.org/obo/GO_0001894 | denotes | tissue homeostasis |
| T8 | 164-175 | http://purl.obolibrary.org/obo/GO_0042592 | denotes | homeostasis |
| T9 | 195-217 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | Inflammatory responses |
| T10 | 320-332 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T11 | 549-561 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T12 | 979-992 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T13 | 1149-1157 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
| T14 | 1149-1157 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
| T15 | 1149-1157 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
| T16 | 1149-1157 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
| T17 | 1180-1203 | http://purl.obolibrary.org/obo/GO_0098631 | denotes | cell adhesion molecules |
| T18 | 1180-1193 | http://purl.obolibrary.org/obo/GO_0007155 | denotes | cell adhesion |
| T19 | 1326-1335 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T21 | 0-194 | Sentence | denotes | Under physiological conditions, inflammation is a response to harmful stimuli (pathogens or tissue lesions), a cellular adaptive mechanism aiming to restore tissue homeostasis (Medzhitov, 2008). |
| T22 | 195-381 | Sentence | denotes | Inflammatory responses are self-limited through specific checkpoints that curb the progression and promote the resolution of inflammation (Basil and Levy, 2016; Serhan and Savill, 2005). |
| T23 | 382-630 | Sentence | denotes | Failure due to the deleterious alterations of the inflammatory pathways brings about the excessive release of pro-inflammatory molecules, leading to chronic low-grade inflammation and fibrosis (Norling and Serhan, 2010; Russell and Schwarze, 2014). |
| T24 | 631-836 | Sentence | denotes | The persistence of this usually short-term defence mechanism leads to a chronic inflammatory state, transitioning from solution to cause, becoming in fact a lesion-inducing factor for the affected tissues. |
| T25 | 837-1224 | Sentence | denotes | This may be a result of the dysregulation of several cellular pathways involving cyclooxygenase-2 (COX-2), signal transducer and activator of transcription 3 (STAT3), matrix metalloproteinase-9 (MMP-9), nuclear factor kappa-B (NF-κB), cytokines with inflammatory outcome: interleukins (IL-1, IL-6, IL-8), tumour necrosis factor alpha (TNF-α), cell adhesion molecules and chemokines, etc. |
| T26 | 1225-1529 | Sentence | denotes | Of note, the resolution of the inflammatory process cannot be simply switched off by restricting the synthesis of the pro-inflammatory molecules, requiring cellular intervention through anti-inflammatory and pro-resolving molecules (Minihane et al., 2015; Ortega-Gomez et al., 2013; Serhan et al., 2008). |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T12 | 1142-1148 | Phenotype | denotes | tumour | http://purl.obolibrary.org/obo/HP_0002664 |
MyTest
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32640331-18650913-30720712 | 188-192 | 18650913 | denotes | 2008 |
| 32640331-26688348-30720713 | 350-354 | 26688348 | denotes | 2016 |
| 32640331-16369558-30720714 | 375-379 | 16369558 | denotes | 2005 |
| 32640331-20497301-30720715 | 596-600 | 20497301 | denotes | 2010 |
| 32640331-24400794-30720716 | 624-628 | 24400794 | denotes | 2014 |
| 32640331-26228057-30720717 | 1475-1479 | 26228057 | denotes | 2015 |
| 32640331-23592557-30720718 | 1502-1506 | 23592557 | denotes | 2013 |
| 32640331-18437155-30720719 | 1523-1527 | 18437155 | denotes | 2008 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32640331-18650913-30720712 | 188-192 | 18650913 | denotes | 2008 |
| 32640331-26688348-30720713 | 350-354 | 26688348 | denotes | 2016 |
| 32640331-16369558-30720714 | 375-379 | 16369558 | denotes | 2005 |
| 32640331-20497301-30720715 | 596-600 | 20497301 | denotes | 2010 |
| 32640331-24400794-30720716 | 624-628 | 24400794 | denotes | 2014 |
| 32640331-26228057-30720717 | 1475-1479 | 26228057 | denotes | 2015 |
| 32640331-23592557-30720718 | 1502-1506 | 23592557 | denotes | 2013 |
| 32640331-18437155-30720719 | 1523-1527 | 18437155 | denotes | 2008 |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T37 | 92-98 | UBERON:0000479 | denotes | tissue |
| T38 | 111-128 | GO:0051866 | denotes | cellular adaptive |
| T39 | 157-163 | UBERON:0000479;GO:0001894 | denotes | tissue |
| T40 | 164-175 | GO:0001894 | denotes | homeostasis |
| T41 | 208-217 | GO:0002437 | denotes | responses |
| T42 | 252-263 | GO:0000075 | denotes | checkpoints |
| T43 | 492-508 | CHEBI:67079;CHEBI:67079 | denotes | pro-inflammatory |
| T44 | 509-518 | CHEBI:36357;CHEBI:36357 | denotes | molecules |
| T45 | 674-681 | GO:0006952 | denotes | defence |
| T46 | 750-758 | CHEBI:75958;CHEBI:75958 | denotes | solution |
| T47 | 828-835 | UBERON:0000479 | denotes | tissues |
| T48 | 865-878 | GO:0065007 | denotes | dysregulation |
| T49 | 918-934 | PR:000013428 | denotes | cyclooxygenase-2 |
| T50 | 936-941 | PR:000013428 | denotes | COX-2 |
| T51 | 944-994 | PR:000002089 | denotes | signal transducer and activator of transcription 3 |
| T52 | 996-1001 | PR:000002089 | denotes | STAT3 |
| T53 | 1004-1010 | GO:0031012;PR:000010491 | denotes | matrix |
| T54 | 1011-1030 | PR:000010491 | denotes | metalloproteinase-9 |
| T55 | 1032-1037 | PR:000010491 | denotes | MMP-9 |
| T56 | 1064-1066 | GO:0005883 | denotes | NF |
| T57 | 1129-1133 | PR:000001393 | denotes | IL-6 |
| T58 | 1135-1139 | PR:000001395 | denotes | IL-8 |
| T59 | 1172-1177 | PR:000000134 | denotes | TNF-α |
| T60 | 1194-1203 | CHEBI:36357;CHEBI:36357 | denotes | molecules |
| T61 | 1346-1359 | CHEBI:67079;CHEBI:67079 | denotes | -inflammatory |
| T62 | 1360-1369 | CHEBI:36357;CHEBI:36357 | denotes | molecules |
| T63 | 1416-1428 | CHEBI:67079;CHEBI:67079 | denotes | inflammatory |
| T64 | 1447-1456 | CHEBI:36357;CHEBI:36357 | denotes | molecules |