PMC:7335494 / 31755-32934 JSONTXT

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T20","span":{"begin":476,"end":483},"obj":"https://glytoucan.org/Structures/Glycans/G15021LG"}],"text":"On the other hand, long-term diets abundant in highly processed and high glycaemic index products seem also to induce a pro-inflammatory metabolic profile (Gomes et al., 2020; Luz et al., 2018). These recent reports suggest that not only the quantity, but also the type of carbohydrates and fats consumed is the major influencing factor of systemic inflammatory status. Thus, clinically, even a 4-day low-carbohydrate diet intervention improved the insulin and fasting plasma glucose levels in T2DM patients (Myette-Cote et al., 2018). When comparing low-carb to low-fat diets in diabetics, some older studies reported a similar effects on cardiovascular risk markers (Davis et al., 2011), while more recent ones asserted the beneficial effects of restricting carbohydrates on the systemic low-grade inflammation, reducing IL-6 (Asle Mohammadi Zadeh et al., 2018; Jonasson et al., 2014), resistin, leptin (Asle Mohammadi Zadeh et al., 2018), E-selectin, sICAM (Davis et al., 2011) and increasing adiponectin (Asle Mohammadi Zadeh et al., 2018). Furthermore, the improvement of systemic inflammatory status was also reported in obese adults, with no T2DM or CVD (Hu et al., 2015)."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T259","span":{"begin":13,"end":17},"obj":"Body_part"},{"id":"T260","span":{"begin":273,"end":286},"obj":"Body_part"},{"id":"T261","span":{"begin":405,"end":417},"obj":"Body_part"},{"id":"T262","span":{"begin":449,"end":456},"obj":"Body_part"},{"id":"T263","span":{"begin":469,"end":475},"obj":"Body_part"},{"id":"T264","span":{"begin":476,"end":483},"obj":"Body_part"},{"id":"T265","span":{"begin":760,"end":773},"obj":"Body_part"},{"id":"T266","span":{"begin":942,"end":952},"obj":"Body_part"}],"attributes":[{"id":"A259","pred":"fma_id","subj":"T259","obj":"http://purl.org/sig/ont/fma/fma9712"},{"id":"A260","pred":"fma_id","subj":"T260","obj":"http://purl.org/sig/ont/fma/fma82737"},{"id":"A261","pred":"fma_id","subj":"T261","obj":"http://purl.org/sig/ont/fma/fma82737"},{"id":"A262","pred":"fma_id","subj":"T262","obj":"http://purl.org/sig/ont/fma/fma83365"},{"id":"A263","pred":"fma_id","subj":"T263","obj":"http://purl.org/sig/ont/fma/fma62970"},{"id":"A264","pred":"fma_id","subj":"T264","obj":"http://purl.org/sig/ont/fma/fma82743"},{"id":"A265","pred":"fma_id","subj":"T265","obj":"http://purl.org/sig/ont/fma/fma82737"},{"id":"A266","pred":"fma_id","subj":"T266","obj":"http://purl.org/sig/ont/fma/fma62932"}],"text":"On the other hand, long-term diets abundant in highly processed and high glycaemic index products seem also to induce a pro-inflammatory metabolic profile (Gomes et al., 2020; Luz et al., 2018). These recent reports suggest that not only the quantity, but also the type of carbohydrates and fats consumed is the major influencing factor of systemic inflammatory status. Thus, clinically, even a 4-day low-carbohydrate diet intervention improved the insulin and fasting plasma glucose levels in T2DM patients (Myette-Cote et al., 2018). When comparing low-carb to low-fat diets in diabetics, some older studies reported a similar effects on cardiovascular risk markers (Davis et al., 2011), while more recent ones asserted the beneficial effects of restricting carbohydrates on the systemic low-grade inflammation, reducing IL-6 (Asle Mohammadi Zadeh et al., 2018; Jonasson et al., 2014), resistin, leptin (Asle Mohammadi Zadeh et al., 2018), E-selectin, sICAM (Davis et al., 2011) and increasing adiponectin (Asle Mohammadi Zadeh et al., 2018). Furthermore, the improvement of systemic inflammatory status was also reported in obese adults, with no T2DM or CVD (Hu et al., 2015)."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T56","span":{"begin":13,"end":17},"obj":"Body_part"}],"attributes":[{"id":"A56","pred":"uberon_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/UBERON_0002398"}],"text":"On the other hand, long-term diets abundant in highly processed and high glycaemic index products seem also to induce a pro-inflammatory metabolic profile (Gomes et al., 2020; Luz et al., 2018). These recent reports suggest that not only the quantity, but also the type of carbohydrates and fats consumed is the major influencing factor of systemic inflammatory status. Thus, clinically, even a 4-day low-carbohydrate diet intervention improved the insulin and fasting plasma glucose levels in T2DM patients (Myette-Cote et al., 2018). When comparing low-carb to low-fat diets in diabetics, some older studies reported a similar effects on cardiovascular risk markers (Davis et al., 2011), while more recent ones asserted the beneficial effects of restricting carbohydrates on the systemic low-grade inflammation, reducing IL-6 (Asle Mohammadi Zadeh et al., 2018; Jonasson et al., 2014), resistin, leptin (Asle Mohammadi Zadeh et al., 2018), E-selectin, sICAM (Davis et al., 2011) and increasing adiponectin (Asle Mohammadi Zadeh et al., 2018). Furthermore, the improvement of systemic inflammatory status was also reported in obese adults, with no T2DM or CVD (Hu et al., 2015)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T108","span":{"begin":800,"end":812},"obj":"Disease"}],"attributes":[{"id":"A108","pred":"mondo_id","subj":"T108","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"}],"text":"On the other hand, long-term diets abundant in highly processed and high glycaemic index products seem also to induce a pro-inflammatory metabolic profile (Gomes et al., 2020; Luz et al., 2018). These recent reports suggest that not only the quantity, but also the type of carbohydrates and fats consumed is the major influencing factor of systemic inflammatory status. Thus, clinically, even a 4-day low-carbohydrate diet intervention improved the insulin and fasting plasma glucose levels in T2DM patients (Myette-Cote et al., 2018). When comparing low-carb to low-fat diets in diabetics, some older studies reported a similar effects on cardiovascular risk markers (Davis et al., 2011), while more recent ones asserted the beneficial effects of restricting carbohydrates on the systemic low-grade inflammation, reducing IL-6 (Asle Mohammadi Zadeh et al., 2018; Jonasson et al., 2014), resistin, leptin (Asle Mohammadi Zadeh et al., 2018), E-selectin, sICAM (Davis et al., 2011) and increasing adiponectin (Asle Mohammadi Zadeh et al., 2018). Furthermore, the improvement of systemic inflammatory status was also reported in obese adults, with no T2DM or CVD (Hu et al., 2015)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T323","span":{"begin":118,"end":119},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T324","span":{"begin":188,"end":192},"obj":"http://purl.obolibrary.org/obo/CLO_0001185"},{"id":"T325","span":{"begin":291,"end":295},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T326","span":{"begin":393,"end":394},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T327","span":{"begin":449,"end":456},"obj":"http://purl.obolibrary.org/obo/PR_000009054"},{"id":"T328","span":{"begin":469,"end":475},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T329","span":{"begin":529,"end":533},"obj":"http://purl.obolibrary.org/obo/CLO_0001185"},{"id":"T330","span":{"begin":567,"end":570},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T331","span":{"begin":619,"end":620},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T332","span":{"begin":858,"end":862},"obj":"http://purl.obolibrary.org/obo/CLO_0001185"},{"id":"T333","span":{"begin":935,"end":939},"obj":"http://purl.obolibrary.org/obo/CLO_0001185"},{"id":"T334","span":{"begin":1038,"end":1042},"obj":"http://purl.obolibrary.org/obo/CLO_0001185"}],"text":"On the other hand, long-term diets abundant in highly processed and high glycaemic index products seem also to induce a pro-inflammatory metabolic profile (Gomes et al., 2020; Luz et al., 2018). These recent reports suggest that not only the quantity, but also the type of carbohydrates and fats consumed is the major influencing factor of systemic inflammatory status. Thus, clinically, even a 4-day low-carbohydrate diet intervention improved the insulin and fasting plasma glucose levels in T2DM patients (Myette-Cote et al., 2018). When comparing low-carb to low-fat diets in diabetics, some older studies reported a similar effects on cardiovascular risk markers (Davis et al., 2011), while more recent ones asserted the beneficial effects of restricting carbohydrates on the systemic low-grade inflammation, reducing IL-6 (Asle Mohammadi Zadeh et al., 2018; Jonasson et al., 2014), resistin, leptin (Asle Mohammadi Zadeh et al., 2018), E-selectin, sICAM (Davis et al., 2011) and increasing adiponectin (Asle Mohammadi Zadeh et al., 2018). Furthermore, the improvement of systemic inflammatory status was also reported in obese adults, with no T2DM or CVD (Hu et al., 2015)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T405","span":{"begin":273,"end":286},"obj":"Chemical"},{"id":"T406","span":{"begin":405,"end":417},"obj":"Chemical"},{"id":"T407","span":{"begin":449,"end":456},"obj":"Chemical"},{"id":"T408","span":{"begin":476,"end":483},"obj":"Chemical"},{"id":"T410","span":{"begin":760,"end":773},"obj":"Chemical"},{"id":"T411","span":{"begin":823,"end":825},"obj":"Chemical"}],"attributes":[{"id":"A405","pred":"chebi_id","subj":"T405","obj":"http://purl.obolibrary.org/obo/CHEBI_16646"},{"id":"A406","pred":"chebi_id","subj":"T406","obj":"http://purl.obolibrary.org/obo/CHEBI_16646"},{"id":"A407","pred":"chebi_id","subj":"T407","obj":"http://purl.obolibrary.org/obo/CHEBI_145810"},{"id":"A408","pred":"chebi_id","subj":"T408","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A409","pred":"chebi_id","subj":"T408","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A410","pred":"chebi_id","subj":"T410","obj":"http://purl.obolibrary.org/obo/CHEBI_16646"},{"id":"A411","pred":"chebi_id","subj":"T411","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A412","pred":"chebi_id","subj":"T411","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"}],"text":"On the other hand, long-term diets abundant in highly processed and high glycaemic index products seem also to induce a pro-inflammatory metabolic profile (Gomes et al., 2020; Luz et al., 2018). These recent reports suggest that not only the quantity, but also the type of carbohydrates and fats consumed is the major influencing factor of systemic inflammatory status. Thus, clinically, even a 4-day low-carbohydrate diet intervention improved the insulin and fasting plasma glucose levels in T2DM patients (Myette-Cote et al., 2018). When comparing low-carb to low-fat diets in diabetics, some older studies reported a similar effects on cardiovascular risk markers (Davis et al., 2011), while more recent ones asserted the beneficial effects of restricting carbohydrates on the systemic low-grade inflammation, reducing IL-6 (Asle Mohammadi Zadeh et al., 2018; Jonasson et al., 2014), resistin, leptin (Asle Mohammadi Zadeh et al., 2018), E-selectin, sICAM (Davis et al., 2011) and increasing adiponectin (Asle Mohammadi Zadeh et al., 2018). Furthermore, the improvement of systemic inflammatory status was also reported in obese adults, with no T2DM or CVD (Hu et al., 2015)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T114","span":{"begin":800,"end":812},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"On the other hand, long-term diets abundant in highly processed and high glycaemic index products seem also to induce a pro-inflammatory metabolic profile (Gomes et al., 2020; Luz et al., 2018). These recent reports suggest that not only the quantity, but also the type of carbohydrates and fats consumed is the major influencing factor of systemic inflammatory status. Thus, clinically, even a 4-day low-carbohydrate diet intervention improved the insulin and fasting plasma glucose levels in T2DM patients (Myette-Cote et al., 2018). When comparing low-carb to low-fat diets in diabetics, some older studies reported a similar effects on cardiovascular risk markers (Davis et al., 2011), while more recent ones asserted the beneficial effects of restricting carbohydrates on the systemic low-grade inflammation, reducing IL-6 (Asle Mohammadi Zadeh et al., 2018; Jonasson et al., 2014), resistin, leptin (Asle Mohammadi Zadeh et al., 2018), E-selectin, sICAM (Davis et al., 2011) and increasing adiponectin (Asle Mohammadi Zadeh et al., 2018). Furthermore, the improvement of systemic inflammatory status was also reported in obese adults, with no T2DM or CVD (Hu et al., 2015)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T160","span":{"begin":0,"end":194},"obj":"Sentence"},{"id":"T161","span":{"begin":195,"end":369},"obj":"Sentence"},{"id":"T162","span":{"begin":370,"end":535},"obj":"Sentence"},{"id":"T163","span":{"begin":536,"end":1044},"obj":"Sentence"},{"id":"T164","span":{"begin":1045,"end":1179},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"On the other hand, long-term diets abundant in highly processed and high glycaemic index products seem also to induce a pro-inflammatory metabolic profile (Gomes et al., 2020; Luz et al., 2018). These recent reports suggest that not only the quantity, but also the type of carbohydrates and fats consumed is the major influencing factor of systemic inflammatory status. Thus, clinically, even a 4-day low-carbohydrate diet intervention improved the insulin and fasting plasma glucose levels in T2DM patients (Myette-Cote et al., 2018). When comparing low-carb to low-fat diets in diabetics, some older studies reported a similar effects on cardiovascular risk markers (Davis et al., 2011), while more recent ones asserted the beneficial effects of restricting carbohydrates on the systemic low-grade inflammation, reducing IL-6 (Asle Mohammadi Zadeh et al., 2018; Jonasson et al., 2014), resistin, leptin (Asle Mohammadi Zadeh et al., 2018), E-selectin, sICAM (Davis et al., 2011) and increasing adiponectin (Asle Mohammadi Zadeh et al., 2018). Furthermore, the improvement of systemic inflammatory status was also reported in obese adults, with no T2DM or CVD (Hu et al., 2015)."}

{"project":"MyTest","denotations":[{"id":"32640331-32004874-30720827","span":{"begin":170,"end":174},"obj":"32004874"},{"id":"32640331-30303707-30720828","span":{"begin":529,"end":533},"obj":"30303707"},{"id":"32640331-30918861-30720829","span":{"begin":858,"end":862},"obj":"30918861"},{"id":"32640331-24779961-30720830","span":{"begin":881,"end":885},"obj":"24779961"},{"id":"32640331-30918861-30720831","span":{"begin":935,"end":939},"obj":"30918861"},{"id":"32640331-30918861-30720832","span":{"begin":1038,"end":1042},"obj":"30918861"},{"id":"32640331-26393645-30720833","span":{"begin":1173,"end":1177},"obj":"26393645"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"On the other hand, long-term diets abundant in highly processed and high glycaemic index products seem also to induce a pro-inflammatory metabolic profile (Gomes et al., 2020; Luz et al., 2018). These recent reports suggest that not only the quantity, but also the type of carbohydrates and fats consumed is the major influencing factor of systemic inflammatory status. Thus, clinically, even a 4-day low-carbohydrate diet intervention improved the insulin and fasting plasma glucose levels in T2DM patients (Myette-Cote et al., 2018). When comparing low-carb to low-fat diets in diabetics, some older studies reported a similar effects on cardiovascular risk markers (Davis et al., 2011), while more recent ones asserted the beneficial effects of restricting carbohydrates on the systemic low-grade inflammation, reducing IL-6 (Asle Mohammadi Zadeh et al., 2018; Jonasson et al., 2014), resistin, leptin (Asle Mohammadi Zadeh et al., 2018), E-selectin, sICAM (Davis et al., 2011) and increasing adiponectin (Asle Mohammadi Zadeh et al., 2018). Furthermore, the improvement of systemic inflammatory status was also reported in obese adults, with no T2DM or CVD (Hu et al., 2015)."}

{"project":"2_test","denotations":[{"id":"32640331-32004874-30720827","span":{"begin":170,"end":174},"obj":"32004874"},{"id":"32640331-30303707-30720828","span":{"begin":529,"end":533},"obj":"30303707"},{"id":"32640331-30918861-30720829","span":{"begin":858,"end":862},"obj":"30918861"},{"id":"32640331-24779961-30720830","span":{"begin":881,"end":885},"obj":"24779961"},{"id":"32640331-30918861-30720831","span":{"begin":935,"end":939},"obj":"30918861"},{"id":"32640331-30918861-30720832","span":{"begin":1038,"end":1042},"obj":"30918861"},{"id":"32640331-26393645-30720833","span":{"begin":1173,"end":1177},"obj":"26393645"}],"text":"On the other hand, long-term diets abundant in highly processed and high glycaemic index products seem also to induce a pro-inflammatory metabolic profile (Gomes et al., 2020; Luz et al., 2018). These recent reports suggest that not only the quantity, but also the type of carbohydrates and fats consumed is the major influencing factor of systemic inflammatory status. Thus, clinically, even a 4-day low-carbohydrate diet intervention improved the insulin and fasting plasma glucose levels in T2DM patients (Myette-Cote et al., 2018). When comparing low-carb to low-fat diets in diabetics, some older studies reported a similar effects on cardiovascular risk markers (Davis et al., 2011), while more recent ones asserted the beneficial effects of restricting carbohydrates on the systemic low-grade inflammation, reducing IL-6 (Asle Mohammadi Zadeh et al., 2018; Jonasson et al., 2014), resistin, leptin (Asle Mohammadi Zadeh et al., 2018), E-selectin, sICAM (Davis et al., 2011) and increasing adiponectin (Asle Mohammadi Zadeh et al., 2018). Furthermore, the improvement of systemic inflammatory status was also reported in obese adults, with no T2DM or CVD (Hu et al., 2015)."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T2075","span":{"begin":265,"end":300},"obj":"CHEBI:26195;CHEBI:26195"}],"text":"On the other hand, long-term diets abundant in highly processed and high glycaemic index products seem also to induce a pro-inflammatory metabolic profile (Gomes et al., 2020; Luz et al., 2018). These recent reports suggest that not only the quantity, but also the type of carbohydrates and fats consumed is the major influencing factor of systemic inflammatory status. Thus, clinically, even a 4-day low-carbohydrate diet intervention improved the insulin and fasting plasma glucose levels in T2DM patients (Myette-Cote et al., 2018). When comparing low-carb to low-fat diets in diabetics, some older studies reported a similar effects on cardiovascular risk markers (Davis et al., 2011), while more recent ones asserted the beneficial effects of restricting carbohydrates on the systemic low-grade inflammation, reducing IL-6 (Asle Mohammadi Zadeh et al., 2018; Jonasson et al., 2014), resistin, leptin (Asle Mohammadi Zadeh et al., 2018), E-selectin, sICAM (Davis et al., 2011) and increasing adiponectin (Asle Mohammadi Zadeh et al., 2018). Furthermore, the improvement of systemic inflammatory status was also reported in obese adults, with no T2DM or CVD (Hu et al., 2015)."}