PMC:7335494 / 30319-30845 JSONTXT

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T19","span":{"begin":341,"end":348},"obj":"https://glytoucan.org/Structures/Glycans/G15021LG"}],"text":"Ketogenic versus Western diet C57BL/6J mice 12-week treatment:➢ very low-carbohydrate, low-protein, and high-fat ketogenic diet (KD)\n➢ high-simple-carbohydrate, high-fat Western diet (WD)\n➢ low-fat, polysaccharide-rich control (C) KD: euglycaemia and hypoinsulinemia + liver lipid accumulation (different pattern compared to WD)KD: systemic glucose intolerance, steatosis, cellular injury, endoplasmic reticulum stress (in liver), and macrophage accumulation, maintaining whole-body insulin responsiveness Garbow et al. (2011)"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T238","span":{"begin":73,"end":85},"obj":"Body_part"},{"id":"T239","span":{"begin":91,"end":98},"obj":"Body_part"},{"id":"T240","span":{"begin":147,"end":159},"obj":"Body_part"},{"id":"T241","span":{"begin":199,"end":213},"obj":"Body_part"},{"id":"T242","span":{"begin":269,"end":274},"obj":"Body_part"},{"id":"T243","span":{"begin":275,"end":280},"obj":"Body_part"},{"id":"T244","span":{"begin":341,"end":348},"obj":"Body_part"},{"id":"T245","span":{"begin":390,"end":411},"obj":"Body_part"},{"id":"T246","span":{"begin":423,"end":428},"obj":"Body_part"},{"id":"T247","span":{"begin":435,"end":445},"obj":"Body_part"},{"id":"T248","span":{"begin":478,"end":482},"obj":"Body_part"},{"id":"T249","span":{"begin":483,"end":490},"obj":"Body_part"}],"attributes":[{"id":"A238","pred":"fma_id","subj":"T238","obj":"http://purl.org/sig/ont/fma/fma82737"},{"id":"A239","pred":"fma_id","subj":"T239","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A240","pred":"fma_id","subj":"T240","obj":"http://purl.org/sig/ont/fma/fma82737"},{"id":"A241","pred":"fma_id","subj":"T241","obj":"http://purl.org/sig/ont/fma/fma82746"},{"id":"A242","pred":"fma_id","subj":"T242","obj":"http://purl.org/sig/ont/fma/fma7197"},{"id":"A243","pred":"fma_id","subj":"T243","obj":"http://purl.org/sig/ont/fma/fma67264"},{"id":"A244","pred":"fma_id","subj":"T244","obj":"http://purl.org/sig/ont/fma/fma82743"},{"id":"A245","pred":"fma_id","subj":"T245","obj":"http://purl.org/sig/ont/fma/fma63842"},{"id":"A246","pred":"fma_id","subj":"T246","obj":"http://purl.org/sig/ont/fma/fma7197"},{"id":"A247","pred":"fma_id","subj":"T247","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A248","pred":"fma_id","subj":"T248","obj":"http://purl.org/sig/ont/fma/fma256135"},{"id":"A249","pred":"fma_id","subj":"T249","obj":"http://purl.org/sig/ont/fma/fma83365"}],"text":"Ketogenic versus Western diet C57BL/6J mice 12-week treatment:➢ very low-carbohydrate, low-protein, and high-fat ketogenic diet (KD)\n➢ high-simple-carbohydrate, high-fat Western diet (WD)\n➢ low-fat, polysaccharide-rich control (C) KD: euglycaemia and hypoinsulinemia + liver lipid accumulation (different pattern compared to WD)KD: systemic glucose intolerance, steatosis, cellular injury, endoplasmic reticulum stress (in liver), and macrophage accumulation, maintaining whole-body insulin responsiveness Garbow et al. (2011)"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T54","span":{"begin":269,"end":274},"obj":"Body_part"},{"id":"T55","span":{"begin":423,"end":428},"obj":"Body_part"}],"attributes":[{"id":"A54","pred":"uberon_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"A55","pred":"uberon_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"}],"text":"Ketogenic versus Western diet C57BL/6J mice 12-week treatment:➢ very low-carbohydrate, low-protein, and high-fat ketogenic diet (KD)\n➢ high-simple-carbohydrate, high-fat Western diet (WD)\n➢ low-fat, polysaccharide-rich control (C) KD: euglycaemia and hypoinsulinemia + liver lipid accumulation (different pattern compared to WD)KD: systemic glucose intolerance, steatosis, cellular injury, endoplasmic reticulum stress (in liver), and macrophage accumulation, maintaining whole-body insulin responsiveness Garbow et al. (2011)"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T103","span":{"begin":341,"end":360},"obj":"Disease"},{"id":"T104","span":{"begin":382,"end":388},"obj":"Disease"}],"attributes":[{"id":"A103","pred":"mondo_id","subj":"T103","obj":"http://purl.obolibrary.org/obo/MONDO_0001076"},{"id":"A104","pred":"mondo_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"}],"text":"Ketogenic versus Western diet C57BL/6J mice 12-week treatment:➢ very low-carbohydrate, low-protein, and high-fat ketogenic diet (KD)\n➢ high-simple-carbohydrate, high-fat Western diet (WD)\n➢ low-fat, polysaccharide-rich control (C) KD: euglycaemia and hypoinsulinemia + liver lipid accumulation (different pattern compared to WD)KD: systemic glucose intolerance, steatosis, cellular injury, endoplasmic reticulum stress (in liver), and macrophage accumulation, maintaining whole-body insulin responsiveness Garbow et al. (2011)"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T301","span":{"begin":109,"end":112},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T302","span":{"begin":166,"end":169},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T303","span":{"begin":194,"end":197},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T304","span":{"begin":269,"end":274},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"T305","span":{"begin":269,"end":274},"obj":"http://www.ebi.ac.uk/efo/EFO_0000887"},{"id":"T306","span":{"begin":423,"end":428},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"T307","span":{"begin":423,"end":428},"obj":"http://www.ebi.ac.uk/efo/EFO_0000887"},{"id":"T308","span":{"begin":472,"end":482},"obj":"http://purl.obolibrary.org/obo/UBERON_0013702"},{"id":"T309","span":{"begin":483,"end":490},"obj":"http://purl.obolibrary.org/obo/PR_000009054"}],"text":"Ketogenic versus Western diet C57BL/6J mice 12-week treatment:➢ very low-carbohydrate, low-protein, and high-fat ketogenic diet (KD)\n➢ high-simple-carbohydrate, high-fat Western diet (WD)\n➢ low-fat, polysaccharide-rich control (C) KD: euglycaemia and hypoinsulinemia + liver lipid accumulation (different pattern compared to WD)KD: systemic glucose intolerance, steatosis, cellular injury, endoplasmic reticulum stress (in liver), and macrophage accumulation, maintaining whole-body insulin responsiveness Garbow et al. (2011)"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T374","span":{"begin":73,"end":85},"obj":"Chemical"},{"id":"T375","span":{"begin":91,"end":98},"obj":"Chemical"},{"id":"T376","span":{"begin":129,"end":131},"obj":"Chemical"},{"id":"T377","span":{"begin":147,"end":159},"obj":"Chemical"},{"id":"T378","span":{"begin":184,"end":186},"obj":"Chemical"},{"id":"T379","span":{"begin":199,"end":213},"obj":"Chemical"},{"id":"T380","span":{"begin":231,"end":233},"obj":"Chemical"},{"id":"T381","span":{"begin":275,"end":280},"obj":"Chemical"},{"id":"T382","span":{"begin":325,"end":327},"obj":"Chemical"},{"id":"T383","span":{"begin":328,"end":330},"obj":"Chemical"},{"id":"T384","span":{"begin":341,"end":348},"obj":"Chemical"},{"id":"T386","span":{"begin":483,"end":490},"obj":"Chemical"}],"attributes":[{"id":"A374","pred":"chebi_id","subj":"T374","obj":"http://purl.obolibrary.org/obo/CHEBI_16646"},{"id":"A375","pred":"chebi_id","subj":"T375","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A376","pred":"chebi_id","subj":"T376","obj":"http://purl.obolibrary.org/obo/CHEBI_73601"},{"id":"A377","pred":"chebi_id","subj":"T377","obj":"http://purl.obolibrary.org/obo/CHEBI_16646"},{"id":"A378","pred":"chebi_id","subj":"T378","obj":"http://purl.obolibrary.org/obo/CHEBI_74868"},{"id":"A379","pred":"chebi_id","subj":"T379","obj":"http://purl.obolibrary.org/obo/CHEBI_18154"},{"id":"A380","pred":"chebi_id","subj":"T380","obj":"http://purl.obolibrary.org/obo/CHEBI_73601"},{"id":"A381","pred":"chebi_id","subj":"T381","obj":"http://purl.obolibrary.org/obo/CHEBI_18059"},{"id":"A382","pred":"chebi_id","subj":"T382","obj":"http://purl.obolibrary.org/obo/CHEBI_74868"},{"id":"A383","pred":"chebi_id","subj":"T383","obj":"http://purl.obolibrary.org/obo/CHEBI_73601"},{"id":"A384","pred":"chebi_id","subj":"T384","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A385","pred":"chebi_id","subj":"T384","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A386","pred":"chebi_id","subj":"T386","obj":"http://purl.obolibrary.org/obo/CHEBI_145810"}],"text":"Ketogenic versus Western diet C57BL/6J mice 12-week treatment:➢ very low-carbohydrate, low-protein, and high-fat ketogenic diet (KD)\n➢ high-simple-carbohydrate, high-fat Western diet (WD)\n➢ low-fat, polysaccharide-rich control (C) KD: euglycaemia and hypoinsulinemia + liver lipid accumulation (different pattern compared to WD)KD: systemic glucose intolerance, steatosis, cellular injury, endoplasmic reticulum stress (in liver), and macrophage accumulation, maintaining whole-body insulin responsiveness Garbow et al. (2011)"}

{"project":"LitCovid-sentences","denotations":[{"id":"T148","span":{"begin":0,"end":132},"obj":"Sentence"},{"id":"T149","span":{"begin":133,"end":187},"obj":"Sentence"},{"id":"T150","span":{"begin":188,"end":526},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Ketogenic versus Western diet C57BL/6J mice 12-week treatment:➢ very low-carbohydrate, low-protein, and high-fat ketogenic diet (KD)\n➢ high-simple-carbohydrate, high-fat Western diet (WD)\n➢ low-fat, polysaccharide-rich control (C) KD: euglycaemia and hypoinsulinemia + liver lipid accumulation (different pattern compared to WD)KD: systemic glucose intolerance, steatosis, cellular injury, endoplasmic reticulum stress (in liver), and macrophage accumulation, maintaining whole-body insulin responsiveness Garbow et al. (2011)"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T64","span":{"begin":251,"end":266},"obj":"Phenotype"},{"id":"T65","span":{"begin":341,"end":360},"obj":"Phenotype"},{"id":"T66","span":{"begin":362,"end":371},"obj":"Phenotype"}],"attributes":[{"id":"A64","pred":"hp_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/HP_0040216"},{"id":"A65","pred":"hp_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/HP_0001952"},{"id":"A66","pred":"hp_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/HP_0001397"}],"text":"Ketogenic versus Western diet C57BL/6J mice 12-week treatment:➢ very low-carbohydrate, low-protein, and high-fat ketogenic diet (KD)\n➢ high-simple-carbohydrate, high-fat Western diet (WD)\n➢ low-fat, polysaccharide-rich control (C) KD: euglycaemia and hypoinsulinemia + liver lipid accumulation (different pattern compared to WD)KD: systemic glucose intolerance, steatosis, cellular injury, endoplasmic reticulum stress (in liver), and macrophage accumulation, maintaining whole-body insulin responsiveness Garbow et al. (2011)"}

{"project":"MyTest","denotations":[{"id":"32640331-21454445-30720823","span":{"begin":521,"end":525},"obj":"21454445"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"Ketogenic versus Western diet C57BL/6J mice 12-week treatment:➢ very low-carbohydrate, low-protein, and high-fat ketogenic diet (KD)\n➢ high-simple-carbohydrate, high-fat Western diet (WD)\n➢ low-fat, polysaccharide-rich control (C) KD: euglycaemia and hypoinsulinemia + liver lipid accumulation (different pattern compared to WD)KD: systemic glucose intolerance, steatosis, cellular injury, endoplasmic reticulum stress (in liver), and macrophage accumulation, maintaining whole-body insulin responsiveness Garbow et al. (2011)"}

{"project":"2_test","denotations":[{"id":"32640331-21454445-30720823","span":{"begin":521,"end":525},"obj":"21454445"}],"text":"Ketogenic versus Western diet C57BL/6J mice 12-week treatment:➢ very low-carbohydrate, low-protein, and high-fat ketogenic diet (KD)\n➢ high-simple-carbohydrate, high-fat Western diet (WD)\n➢ low-fat, polysaccharide-rich control (C) KD: euglycaemia and hypoinsulinemia + liver lipid accumulation (different pattern compared to WD)KD: systemic glucose intolerance, steatosis, cellular injury, endoplasmic reticulum stress (in liver), and macrophage accumulation, maintaining whole-body insulin responsiveness Garbow et al. (2011)"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T2070","span":{"begin":349,"end":384},"obj":"PR:000009054"}],"text":"Ketogenic versus Western diet C57BL/6J mice 12-week treatment:➢ very low-carbohydrate, low-protein, and high-fat ketogenic diet (KD)\n➢ high-simple-carbohydrate, high-fat Western diet (WD)\n➢ low-fat, polysaccharide-rich control (C) KD: euglycaemia and hypoinsulinemia + liver lipid accumulation (different pattern compared to WD)KD: systemic glucose intolerance, steatosis, cellular injury, endoplasmic reticulum stress (in liver), and macrophage accumulation, maintaining whole-body insulin responsiveness Garbow et al. (2011)"}