Ketogenic versus Western diet C57BL/6J mice 12-week treatment:➢ very low-carbohydrate, low-protein, and high-fat ketogenic diet (KD)
➢ high-simple-carbohydrate, high-fat Western diet (WD)
➢ low-fat, polysaccharide-rich control (C) KD: euglycaemia and hypoinsulinemia + liver lipid accumulation (different pattern compared to WD)KD: systemic glucose intolerance, steatosis, cellular injury, endoplasmic reticulum stress (in liver), and macrophage accumulation, maintaining whole-body insulin responsiveness Garbow et al. (2011)