PMC:7335494 / 29313-31754 JSON TXT

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LitCovid_Glycan-Motif-Structure

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T19","span":{"begin":1347,"end":1354},"obj":"https://glytoucan.org/Structures/Glycans/G15021LG"}],"text":"Diet Species Treatment Observed effects References\nCarbohydrate-restricted diet Senescence-accelerated prone mice (SAMP8) 8-week treatment:➢ Control: standard chow\n➢ High fat diet group (HFD)\n➢ Carbohydrate-restricted diet group (CRD) CRD: ↑ IL-6 and IL-1β, ↓cecum short-chain fatty acids He et al. (2019)\nScandinavian low-carbohydrate high-fat (LCHF) diet Female C57BL/6J mice (n = 7/group) 4-week treatment:➢ standard chow\n➢ LCHF diet (75% fat 20% protein, and 5% carbohydrates) LCHF: no change in glycemia, TG, insulin, or non-esterified fatty acid plasma levels Nilsson et al. (2016)\nKetogenic diet Sprague-Dawley Rats with spinal cord injury (n = 18/group) 4-week treatment:➢ ketogenic diet (KD)\n➢ standard diet (SD)\n➢ control (C) KD: ↓ IL-1β, TNF-α, IFN-γ expression Lu et al. (2018)\nKetogenic diet Male C57BL/6J mice 22-weeks diet intervention:➢ Control: standard chow\n➢ Ketogenic diet group KD: ↑ triglycerides, cholesterol, leptin, MCP-1, IL-6, IL-1β,↓ α- and β-cell mass Ellenbroek et al. (2014)\nKetogenic versus Western diet C57BL/6J mice 12-week treatment:➢ very low-carbohydrate, low-protein, and high-fat ketogenic diet (KD)\n➢ high-simple-carbohydrate, high-fat Western diet (WD)\n➢ low-fat, polysaccharide-rich control (C) KD: euglycaemia and hypoinsulinemia + liver lipid accumulation (different pattern compared to WD)KD: systemic glucose intolerance, steatosis, cellular injury, endoplasmic reticulum stress (in liver), and macrophage accumulation, maintaining whole-body insulin responsiveness Garbow et al. (2011)\nHigh-saturated fat diet (HFD) male C57BL/6J mice 3-week treatment:➢ standard chow\n➢ HFD (60% fat 20% protein, and 20% carbohydrates)\n➢ Very HFD (80% fat 16% protein, and 4% carbohydrates) HFD: ↑ leptin, IL-1β Andre et al. (2017)\nDiet supplemented with ketones Knockout mice model for Muckle-Wells Syndrome and Familial Cold Autoinflammatory syndrome 1-week treatment:➢ Control: normal chow with 4.5% fat\n➢ Study group: normal chow supplemented with 20% 1,3-butanediol ketone diesters Study group: ↓ IL-1β release and caspase-1 activity Youm et al. (2015)\nHigh fat high sucrose diet (HFD) C57BL/6 J (wild type; WT) male mice 8-week treatment:➢ Young + normal diet (YND)\n➢ Young + HFD (YHFD)\n➢ Old + normal diet (OND)\n➢ Old + HFD (OHFD) HFD led to β-cell failure in aged mice, enhanced expression of pro-inflammatory cytokines and macrophage transformation to a more pro-inflammatory phenotype He et al. (2018)"}

LitCovid-PD-FMA-UBERON

LitCovid-PD-UBERON

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T53","span":{"begin":628,"end":639},"obj":"Body_part"},{"id":"T54","span":{"begin":1275,"end":1280},"obj":"Body_part"},{"id":"T55","span":{"begin":1429,"end":1434},"obj":"Body_part"}],"attributes":[{"id":"A53","pred":"uberon_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/UBERON_0002240"},{"id":"A54","pred":"uberon_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"A55","pred":"uberon_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"}],"text":"Diet Species Treatment Observed effects References\nCarbohydrate-restricted diet Senescence-accelerated prone mice (SAMP8) 8-week treatment:➢ Control: standard chow\n➢ High fat diet group (HFD)\n➢ Carbohydrate-restricted diet group (CRD) CRD: ↑ IL-6 and IL-1β, ↓cecum short-chain fatty acids He et al. (2019)\nScandinavian low-carbohydrate high-fat (LCHF) diet Female C57BL/6J mice (n = 7/group) 4-week treatment:➢ standard chow\n➢ LCHF diet (75% fat 20% protein, and 5% carbohydrates) LCHF: no change in glycemia, TG, insulin, or non-esterified fatty acid plasma levels Nilsson et al. (2016)\nKetogenic diet Sprague-Dawley Rats with spinal cord injury (n = 18/group) 4-week treatment:➢ ketogenic diet (KD)\n➢ standard diet (SD)\n➢ control (C) KD: ↓ IL-1β, TNF-α, IFN-γ expression Lu et al. (2018)\nKetogenic diet Male C57BL/6J mice 22-weeks diet intervention:➢ Control: standard chow\n➢ Ketogenic diet group KD: ↑ triglycerides, cholesterol, leptin, MCP-1, IL-6, IL-1β,↓ α- and β-cell mass Ellenbroek et al. (2014)\nKetogenic versus Western diet C57BL/6J mice 12-week treatment:➢ very low-carbohydrate, low-protein, and high-fat ketogenic diet (KD)\n➢ high-simple-carbohydrate, high-fat Western diet (WD)\n➢ low-fat, polysaccharide-rich control (C) KD: euglycaemia and hypoinsulinemia + liver lipid accumulation (different pattern compared to WD)KD: systemic glucose intolerance, steatosis, cellular injury, endoplasmic reticulum stress (in liver), and macrophage accumulation, maintaining whole-body insulin responsiveness Garbow et al. (2011)\nHigh-saturated fat diet (HFD) male C57BL/6J mice 3-week treatment:➢ standard chow\n➢ HFD (60% fat 20% protein, and 20% carbohydrates)\n➢ Very HFD (80% fat 16% protein, and 4% carbohydrates) HFD: ↑ leptin, IL-1β Andre et al. (2017)\nDiet supplemented with ketones Knockout mice model for Muckle-Wells Syndrome and Familial Cold Autoinflammatory syndrome 1-week treatment:➢ Control: normal chow with 4.5% fat\n➢ Study group: normal chow supplemented with 20% 1,3-butanediol ketone diesters Study group: ↓ IL-1β release and caspase-1 activity Youm et al. (2015)\nHigh fat high sucrose diet (HFD) C57BL/6 J (wild type; WT) male mice 8-week treatment:➢ Young + normal diet (YND)\n➢ Young + HFD (YHFD)\n➢ Old + normal diet (OND)\n➢ Old + HFD (OHFD) HFD led to β-cell failure in aged mice, enhanced expression of pro-inflammatory cytokines and macrophage transformation to a more pro-inflammatory phenotype He et al. (2018)"}

LitCovid-PD-MONDO

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T101","span":{"begin":628,"end":646},"obj":"Disease"},{"id":"T102","span":{"begin":640,"end":646},"obj":"Disease"},{"id":"T103","span":{"begin":1347,"end":1366},"obj":"Disease"},{"id":"T104","span":{"begin":1388,"end":1394},"obj":"Disease"},{"id":"T105","span":{"begin":1817,"end":1838},"obj":"Disease"},{"id":"T106","span":{"begin":1843,"end":1884},"obj":"Disease"},{"id":"T107","span":{"begin":1857,"end":1882},"obj":"Disease"}],"attributes":[{"id":"A101","pred":"mondo_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/MONDO_0043797"},{"id":"A102","pred":"mondo_id","subj":"T102","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A103","pred":"mondo_id","subj":"T103","obj":"http://purl.obolibrary.org/obo/MONDO_0001076"},{"id":"A104","pred":"mondo_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A105","pred":"mondo_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/MONDO_0008633"},{"id":"A106","pred":"mondo_id","subj":"T106","obj":"http://purl.obolibrary.org/obo/MONDO_0007349"},{"id":"A107","pred":"mondo_id","subj":"T107","obj":"http://purl.obolibrary.org/obo/MONDO_0019751"}],"text":"Diet Species Treatment Observed effects References\nCarbohydrate-restricted diet Senescence-accelerated prone mice (SAMP8) 8-week treatment:➢ Control: standard chow\n➢ High fat diet group (HFD)\n➢ Carbohydrate-restricted diet group (CRD) CRD: ↑ IL-6 and IL-1β, ↓cecum short-chain fatty acids He et al. (2019)\nScandinavian low-carbohydrate high-fat (LCHF) diet Female C57BL/6J mice (n = 7/group) 4-week treatment:➢ standard chow\n➢ LCHF diet (75% fat 20% protein, and 5% carbohydrates) LCHF: no change in glycemia, TG, insulin, or non-esterified fatty acid plasma levels Nilsson et al. (2016)\nKetogenic diet Sprague-Dawley Rats with spinal cord injury (n = 18/group) 4-week treatment:➢ ketogenic diet (KD)\n➢ standard diet (SD)\n➢ control (C) KD: ↓ IL-1β, TNF-α, IFN-γ expression Lu et al. (2018)\nKetogenic diet Male C57BL/6J mice 22-weeks diet intervention:➢ Control: standard chow\n➢ Ketogenic diet group KD: ↑ triglycerides, cholesterol, leptin, MCP-1, IL-6, IL-1β,↓ α- and β-cell mass Ellenbroek et al. (2014)\nKetogenic versus Western diet C57BL/6J mice 12-week treatment:➢ very low-carbohydrate, low-protein, and high-fat ketogenic diet (KD)\n➢ high-simple-carbohydrate, high-fat Western diet (WD)\n➢ low-fat, polysaccharide-rich control (C) KD: euglycaemia and hypoinsulinemia + liver lipid accumulation (different pattern compared to WD)KD: systemic glucose intolerance, steatosis, cellular injury, endoplasmic reticulum stress (in liver), and macrophage accumulation, maintaining whole-body insulin responsiveness Garbow et al. (2011)\nHigh-saturated fat diet (HFD) male C57BL/6J mice 3-week treatment:➢ standard chow\n➢ HFD (60% fat 20% protein, and 20% carbohydrates)\n➢ Very HFD (80% fat 16% protein, and 4% carbohydrates) HFD: ↑ leptin, IL-1β Andre et al. (2017)\nDiet supplemented with ketones Knockout mice model for Muckle-Wells Syndrome and Familial Cold Autoinflammatory syndrome 1-week treatment:➢ Control: normal chow with 4.5% fat\n➢ Study group: normal chow supplemented with 20% 1,3-butanediol ketone diesters Study group: ↓ IL-1β release and caspase-1 activity Youm et al. (2015)\nHigh fat high sucrose diet (HFD) C57BL/6 J (wild type; WT) male mice 8-week treatment:➢ Young + normal diet (YND)\n➢ Young + HFD (YHFD)\n➢ Old + normal diet (OND)\n➢ Old + HFD (OHFD) HFD led to β-cell failure in aged mice, enhanced expression of pro-inflammatory cytokines and macrophage transformation to a more pro-inflammatory phenotype He et al. (2018)"}

LitCovid-PD-CLO

LitCovid-PD-CHEBI

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T137","span":{"begin":0,"end":50},"obj":"Sentence"},{"id":"T138","span":{"begin":51,"end":163},"obj":"Sentence"},{"id":"T139","span":{"begin":164,"end":191},"obj":"Sentence"},{"id":"T140","span":{"begin":192,"end":305},"obj":"Sentence"},{"id":"T141","span":{"begin":306,"end":424},"obj":"Sentence"},{"id":"T142","span":{"begin":425,"end":587},"obj":"Sentence"},{"id":"T143","span":{"begin":588,"end":700},"obj":"Sentence"},{"id":"T144","span":{"begin":701,"end":721},"obj":"Sentence"},{"id":"T145","span":{"begin":722,"end":789},"obj":"Sentence"},{"id":"T146","span":{"begin":790,"end":875},"obj":"Sentence"},{"id":"T147","span":{"begin":876,"end":1005},"obj":"Sentence"},{"id":"T148","span":{"begin":1006,"end":1138},"obj":"Sentence"},{"id":"T149","span":{"begin":1139,"end":1193},"obj":"Sentence"},{"id":"T150","span":{"begin":1194,"end":1532},"obj":"Sentence"},{"id":"T151","span":{"begin":1533,"end":1614},"obj":"Sentence"},{"id":"T152","span":{"begin":1615,"end":1665},"obj":"Sentence"},{"id":"T153","span":{"begin":1666,"end":1761},"obj":"Sentence"},{"id":"T154","span":{"begin":1762,"end":1936},"obj":"Sentence"},{"id":"T155","span":{"begin":1937,"end":2087},"obj":"Sentence"},{"id":"T156","span":{"begin":2088,"end":2201},"obj":"Sentence"},{"id":"T157","span":{"begin":2202,"end":2222},"obj":"Sentence"},{"id":"T158","span":{"begin":2223,"end":2248},"obj":"Sentence"},{"id":"T159","span":{"begin":2249,"end":2441},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Diet Species Treatment Observed effects References\nCarbohydrate-restricted diet Senescence-accelerated prone mice (SAMP8) 8-week treatment:➢ Control: standard chow\n➢ High fat diet group (HFD)\n➢ Carbohydrate-restricted diet group (CRD) CRD: ↑ IL-6 and IL-1β, ↓cecum short-chain fatty acids He et al. (2019)\nScandinavian low-carbohydrate high-fat (LCHF) diet Female C57BL/6J mice (n = 7/group) 4-week treatment:➢ standard chow\n➢ LCHF diet (75% fat 20% protein, and 5% carbohydrates) LCHF: no change in glycemia, TG, insulin, or non-esterified fatty acid plasma levels Nilsson et al. (2016)\nKetogenic diet Sprague-Dawley Rats with spinal cord injury (n = 18/group) 4-week treatment:➢ ketogenic diet (KD)\n➢ standard diet (SD)\n➢ control (C) KD: ↓ IL-1β, TNF-α, IFN-γ expression Lu et al. (2018)\nKetogenic diet Male C57BL/6J mice 22-weeks diet intervention:➢ Control: standard chow\n➢ Ketogenic diet group KD: ↑ triglycerides, cholesterol, leptin, MCP-1, IL-6, IL-1β,↓ α- and β-cell mass Ellenbroek et al. (2014)\nKetogenic versus Western diet C57BL/6J mice 12-week treatment:➢ very low-carbohydrate, low-protein, and high-fat ketogenic diet (KD)\n➢ high-simple-carbohydrate, high-fat Western diet (WD)\n➢ low-fat, polysaccharide-rich control (C) KD: euglycaemia and hypoinsulinemia + liver lipid accumulation (different pattern compared to WD)KD: systemic glucose intolerance, steatosis, cellular injury, endoplasmic reticulum stress (in liver), and macrophage accumulation, maintaining whole-body insulin responsiveness Garbow et al. (2011)\nHigh-saturated fat diet (HFD) male C57BL/6J mice 3-week treatment:➢ standard chow\n➢ HFD (60% fat 20% protein, and 20% carbohydrates)\n➢ Very HFD (80% fat 16% protein, and 4% carbohydrates) HFD: ↑ leptin, IL-1β Andre et al. (2017)\nDiet supplemented with ketones Knockout mice model for Muckle-Wells Syndrome and Familial Cold Autoinflammatory syndrome 1-week treatment:➢ Control: normal chow with 4.5% fat\n➢ Study group: normal chow supplemented with 20% 1,3-butanediol ketone diesters Study group: ↓ IL-1β release and caspase-1 activity Youm et al. (2015)\nHigh fat high sucrose diet (HFD) C57BL/6 J (wild type; WT) male mice 8-week treatment:➢ Young + normal diet (YND)\n➢ Young + HFD (YHFD)\n➢ Old + normal diet (OND)\n➢ Old + HFD (OHFD) HFD led to β-cell failure in aged mice, enhanced expression of pro-inflammatory cytokines and macrophage transformation to a more pro-inflammatory phenotype He et al. (2018)"}

LitCovid-PD-HP

{"project":"LitCovid-PD-HP","denotations":[{"id":"T64","span":{"begin":1257,"end":1272},"obj":"Phenotype"},{"id":"T65","span":{"begin":1347,"end":1366},"obj":"Phenotype"},{"id":"T66","span":{"begin":1368,"end":1377},"obj":"Phenotype"}],"attributes":[{"id":"A64","pred":"hp_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/HP_0040216"},{"id":"A65","pred":"hp_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/HP_0001952"},{"id":"A66","pred":"hp_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/HP_0001397"}],"text":"Diet Species Treatment Observed effects References\nCarbohydrate-restricted diet Senescence-accelerated prone mice (SAMP8) 8-week treatment:➢ Control: standard chow\n➢ High fat diet group (HFD)\n➢ Carbohydrate-restricted diet group (CRD) CRD: ↑ IL-6 and IL-1β, ↓cecum short-chain fatty acids He et al. (2019)\nScandinavian low-carbohydrate high-fat (LCHF) diet Female C57BL/6J mice (n = 7/group) 4-week treatment:➢ standard chow\n➢ LCHF diet (75% fat 20% protein, and 5% carbohydrates) LCHF: no change in glycemia, TG, insulin, or non-esterified fatty acid plasma levels Nilsson et al. (2016)\nKetogenic diet Sprague-Dawley Rats with spinal cord injury (n = 18/group) 4-week treatment:➢ ketogenic diet (KD)\n➢ standard diet (SD)\n➢ control (C) KD: ↓ IL-1β, TNF-α, IFN-γ expression Lu et al. (2018)\nKetogenic diet Male C57BL/6J mice 22-weeks diet intervention:➢ Control: standard chow\n➢ Ketogenic diet group KD: ↑ triglycerides, cholesterol, leptin, MCP-1, IL-6, IL-1β,↓ α- and β-cell mass Ellenbroek et al. (2014)\nKetogenic versus Western diet C57BL/6J mice 12-week treatment:➢ very low-carbohydrate, low-protein, and high-fat ketogenic diet (KD)\n➢ high-simple-carbohydrate, high-fat Western diet (WD)\n➢ low-fat, polysaccharide-rich control (C) KD: euglycaemia and hypoinsulinemia + liver lipid accumulation (different pattern compared to WD)KD: systemic glucose intolerance, steatosis, cellular injury, endoplasmic reticulum stress (in liver), and macrophage accumulation, maintaining whole-body insulin responsiveness Garbow et al. (2011)\nHigh-saturated fat diet (HFD) male C57BL/6J mice 3-week treatment:➢ standard chow\n➢ HFD (60% fat 20% protein, and 20% carbohydrates)\n➢ Very HFD (80% fat 16% protein, and 4% carbohydrates) HFD: ↑ leptin, IL-1β Andre et al. (2017)\nDiet supplemented with ketones Knockout mice model for Muckle-Wells Syndrome and Familial Cold Autoinflammatory syndrome 1-week treatment:➢ Control: normal chow with 4.5% fat\n➢ Study group: normal chow supplemented with 20% 1,3-butanediol ketone diesters Study group: ↓ IL-1β release and caspase-1 activity Youm et al. (2015)\nHigh fat high sucrose diet (HFD) C57BL/6 J (wild type; WT) male mice 8-week treatment:➢ Young + normal diet (YND)\n➢ Young + HFD (YHFD)\n➢ Old + normal diet (OND)\n➢ Old + HFD (OHFD) HFD led to β-cell failure in aged mice, enhanced expression of pro-inflammatory cytokines and macrophage transformation to a more pro-inflammatory phenotype He et al. (2018)"}

MyTest

{"project":"MyTest","denotations":[{"id":"32640331-31952014-30720819","span":{"begin":300,"end":304},"obj":"31952014"},{"id":"32640331-27891164-30720820","span":{"begin":582,"end":586},"obj":"27891164"},{"id":"32640331-29894768-30720821","span":{"begin":784,"end":788},"obj":"29894768"},{"id":"32640331-24398402-30720822","span":{"begin":1000,"end":1004},"obj":"24398402"},{"id":"32640331-21454445-30720823","span":{"begin":1527,"end":1531},"obj":"21454445"},{"id":"32640331-27903745-30720824","span":{"begin":1756,"end":1760},"obj":"27903745"},{"id":"32640331-25686106-30720825","span":{"begin":2082,"end":2086},"obj":"25686106"},{"id":"32640331-29426925-30720826","span":{"begin":2436,"end":2440},"obj":"29426925"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"Diet Species Treatment Observed effects References\nCarbohydrate-restricted diet Senescence-accelerated prone mice (SAMP8) 8-week treatment:➢ Control: standard chow\n➢ High fat diet group (HFD)\n➢ Carbohydrate-restricted diet group (CRD) CRD: ↑ IL-6 and IL-1β, ↓cecum short-chain fatty acids He et al. (2019)\nScandinavian low-carbohydrate high-fat (LCHF) diet Female C57BL/6J mice (n = 7/group) 4-week treatment:➢ standard chow\n➢ LCHF diet (75% fat 20% protein, and 5% carbohydrates) LCHF: no change in glycemia, TG, insulin, or non-esterified fatty acid plasma levels Nilsson et al. (2016)\nKetogenic diet Sprague-Dawley Rats with spinal cord injury (n = 18/group) 4-week treatment:➢ ketogenic diet (KD)\n➢ standard diet (SD)\n➢ control (C) KD: ↓ IL-1β, TNF-α, IFN-γ expression Lu et al. (2018)\nKetogenic diet Male C57BL/6J mice 22-weeks diet intervention:➢ Control: standard chow\n➢ Ketogenic diet group KD: ↑ triglycerides, cholesterol, leptin, MCP-1, IL-6, IL-1β,↓ α- and β-cell mass Ellenbroek et al. (2014)\nKetogenic versus Western diet C57BL/6J mice 12-week treatment:➢ very low-carbohydrate, low-protein, and high-fat ketogenic diet (KD)\n➢ high-simple-carbohydrate, high-fat Western diet (WD)\n➢ low-fat, polysaccharide-rich control (C) KD: euglycaemia and hypoinsulinemia + liver lipid accumulation (different pattern compared to WD)KD: systemic glucose intolerance, steatosis, cellular injury, endoplasmic reticulum stress (in liver), and macrophage accumulation, maintaining whole-body insulin responsiveness Garbow et al. (2011)\nHigh-saturated fat diet (HFD) male C57BL/6J mice 3-week treatment:➢ standard chow\n➢ HFD (60% fat 20% protein, and 20% carbohydrates)\n➢ Very HFD (80% fat 16% protein, and 4% carbohydrates) HFD: ↑ leptin, IL-1β Andre et al. (2017)\nDiet supplemented with ketones Knockout mice model for Muckle-Wells Syndrome and Familial Cold Autoinflammatory syndrome 1-week treatment:➢ Control: normal chow with 4.5% fat\n➢ Study group: normal chow supplemented with 20% 1,3-butanediol ketone diesters Study group: ↓ IL-1β release and caspase-1 activity Youm et al. (2015)\nHigh fat high sucrose diet (HFD) C57BL/6 J (wild type; WT) male mice 8-week treatment:➢ Young + normal diet (YND)\n➢ Young + HFD (YHFD)\n➢ Old + normal diet (OND)\n➢ Old + HFD (OHFD) HFD led to β-cell failure in aged mice, enhanced expression of pro-inflammatory cytokines and macrophage transformation to a more pro-inflammatory phenotype He et al. (2018)"}

2_test

{"project":"2_test","denotations":[{"id":"32640331-31952014-30720819","span":{"begin":300,"end":304},"obj":"31952014"},{"id":"32640331-27891164-30720820","span":{"begin":582,"end":586},"obj":"27891164"},{"id":"32640331-29894768-30720821","span":{"begin":784,"end":788},"obj":"29894768"},{"id":"32640331-24398402-30720822","span":{"begin":1000,"end":1004},"obj":"24398402"},{"id":"32640331-21454445-30720823","span":{"begin":1527,"end":1531},"obj":"21454445"},{"id":"32640331-27903745-30720824","span":{"begin":1756,"end":1760},"obj":"27903745"},{"id":"32640331-25686106-30720825","span":{"begin":2082,"end":2086},"obj":"25686106"},{"id":"32640331-29426925-30720826","span":{"begin":2436,"end":2440},"obj":"29426925"}],"text":"Diet Species Treatment Observed effects References\nCarbohydrate-restricted diet Senescence-accelerated prone mice (SAMP8) 8-week treatment:➢ Control: standard chow\n➢ High fat diet group (HFD)\n➢ Carbohydrate-restricted diet group (CRD) CRD: ↑ IL-6 and IL-1β, ↓cecum short-chain fatty acids He et al. (2019)\nScandinavian low-carbohydrate high-fat (LCHF) diet Female C57BL/6J mice (n = 7/group) 4-week treatment:➢ standard chow\n➢ LCHF diet (75% fat 20% protein, and 5% carbohydrates) LCHF: no change in glycemia, TG, insulin, or non-esterified fatty acid plasma levels Nilsson et al. (2016)\nKetogenic diet Sprague-Dawley Rats with spinal cord injury (n = 18/group) 4-week treatment:➢ ketogenic diet (KD)\n➢ standard diet (SD)\n➢ control (C) KD: ↓ IL-1β, TNF-α, IFN-γ expression Lu et al. (2018)\nKetogenic diet Male C57BL/6J mice 22-weeks diet intervention:➢ Control: standard chow\n➢ Ketogenic diet group KD: ↑ triglycerides, cholesterol, leptin, MCP-1, IL-6, IL-1β,↓ α- and β-cell mass Ellenbroek et al. (2014)\nKetogenic versus Western diet C57BL/6J mice 12-week treatment:➢ very low-carbohydrate, low-protein, and high-fat ketogenic diet (KD)\n➢ high-simple-carbohydrate, high-fat Western diet (WD)\n➢ low-fat, polysaccharide-rich control (C) KD: euglycaemia and hypoinsulinemia + liver lipid accumulation (different pattern compared to WD)KD: systemic glucose intolerance, steatosis, cellular injury, endoplasmic reticulum stress (in liver), and macrophage accumulation, maintaining whole-body insulin responsiveness Garbow et al. (2011)\nHigh-saturated fat diet (HFD) male C57BL/6J mice 3-week treatment:➢ standard chow\n➢ HFD (60% fat 20% protein, and 20% carbohydrates)\n➢ Very HFD (80% fat 16% protein, and 4% carbohydrates) HFD: ↑ leptin, IL-1β Andre et al. (2017)\nDiet supplemented with ketones Knockout mice model for Muckle-Wells Syndrome and Familial Cold Autoinflammatory syndrome 1-week treatment:➢ Control: normal chow with 4.5% fat\n➢ Study group: normal chow supplemented with 20% 1,3-butanediol ketone diesters Study group: ↓ IL-1β release and caspase-1 activity Youm et al. (2015)\nHigh fat high sucrose diet (HFD) C57BL/6 J (wild type; WT) male mice 8-week treatment:➢ Young + normal diet (YND)\n➢ Young + HFD (YHFD)\n➢ Old + normal diet (OND)\n➢ Old + HFD (OHFD) HFD led to β-cell failure in aged mice, enhanced expression of pro-inflammatory cytokines and macrophage transformation to a more pro-inflammatory phenotype He et al. (2018)"}

LitCovid-PMC-OGER-BB

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T2064","span":{"begin":9,"end":20},"obj":"GO:0007631"},{"id":"T2065","span":{"begin":277,"end":331},"obj":"CHEBI:33290;CHEBI:33290"},{"id":"T2066","span":{"begin":497,"end":521},"obj":"PR:000009054"},{"id":"T2067","span":{"begin":853,"end":939},"obj":"CHEBI:35218;CHEBI:35218"},{"id":"T2068","span":{"begin":969,"end":990},"obj":"CHEBI:24043;CHEBI:24043"},{"id":"T2069","span":{"begin":992,"end":1008},"obj":"GO:0007631"},{"id":"T2070","span":{"begin":1355,"end":1390},"obj":"PR:000009054"},{"id":"T2071","span":{"begin":1902,"end":1946},"obj":"GO:0007631"},{"id":"T2072","span":{"begin":1993,"end":2007},"obj":"CHEBI:35218;CHEBI:35218"},{"id":"T2074","span":{"begin":2317,"end":2323},"obj":"CHEBI:16412;CHEBI:16412"}],"text":"Diet Species Treatment Observed effects References\nCarbohydrate-restricted diet Senescence-accelerated prone mice (SAMP8) 8-week treatment:➢ Control: standard chow\n➢ High fat diet group (HFD)\n➢ Carbohydrate-restricted diet group (CRD) CRD: ↑ IL-6 and IL-1β, ↓cecum short-chain fatty acids He et al. (2019)\nScandinavian low-carbohydrate high-fat (LCHF) diet Female C57BL/6J mice (n = 7/group) 4-week treatment:➢ standard chow\n➢ LCHF diet (75% fat 20% protein, and 5% carbohydrates) LCHF: no change in glycemia, TG, insulin, or non-esterified fatty acid plasma levels Nilsson et al. (2016)\nKetogenic diet Sprague-Dawley Rats with spinal cord injury (n = 18/group) 4-week treatment:➢ ketogenic diet (KD)\n➢ standard diet (SD)\n➢ control (C) KD: ↓ IL-1β, TNF-α, IFN-γ expression Lu et al. (2018)\nKetogenic diet Male C57BL/6J mice 22-weeks diet intervention:➢ Control: standard chow\n➢ Ketogenic diet group KD: ↑ triglycerides, cholesterol, leptin, MCP-1, IL-6, IL-1β,↓ α- and β-cell mass Ellenbroek et al. (2014)\nKetogenic versus Western diet C57BL/6J mice 12-week treatment:➢ very low-carbohydrate, low-protein, and high-fat ketogenic diet (KD)\n➢ high-simple-carbohydrate, high-fat Western diet (WD)\n➢ low-fat, polysaccharide-rich control (C) KD: euglycaemia and hypoinsulinemia + liver lipid accumulation (different pattern compared to WD)KD: systemic glucose intolerance, steatosis, cellular injury, endoplasmic reticulum stress (in liver), and macrophage accumulation, maintaining whole-body insulin responsiveness Garbow et al. (2011)\nHigh-saturated fat diet (HFD) male C57BL/6J mice 3-week treatment:➢ standard chow\n➢ HFD (60% fat 20% protein, and 20% carbohydrates)\n➢ Very HFD (80% fat 16% protein, and 4% carbohydrates) HFD: ↑ leptin, IL-1β Andre et al. (2017)\nDiet supplemented with ketones Knockout mice model for Muckle-Wells Syndrome and Familial Cold Autoinflammatory syndrome 1-week treatment:➢ Control: normal chow with 4.5% fat\n➢ Study group: normal chow supplemented with 20% 1,3-butanediol ketone diesters Study group: ↓ IL-1β release and caspase-1 activity Youm et al. (2015)\nHigh fat high sucrose diet (HFD) C57BL/6 J (wild type; WT) male mice 8-week treatment:➢ Young + normal diet (YND)\n➢ Young + HFD (YHFD)\n➢ Old + normal diet (OND)\n➢ Old + HFD (OHFD) HFD led to β-cell failure in aged mice, enhanced expression of pro-inflammatory cytokines and macrophage transformation to a more pro-inflammatory phenotype He et al. (2018)"}

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