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PMC:7335494 / 29313-31754 JSONTXT

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LitCovid_Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T19 1347-1354 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T223 51-63 Body_part denotes Carbohydrate http://purl.org/sig/ont/fma/fma82737
T224 194-206 Body_part denotes Carbohydrate http://purl.org/sig/ont/fma/fma82737
T225 251-255 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T226 259-264 Body_part denotes cecum http://purl.org/sig/ont/fma/fma14541
T227 277-288 Body_part denotes fatty acids http://purl.org/sig/ont/fma/fma82738
T228 323-335 Body_part denotes carbohydrate http://purl.org/sig/ont/fma/fma82737
T229 450-457 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T230 466-479 Body_part denotes carbohydrates http://purl.org/sig/ont/fma/fma82737
T231 514-521 Body_part denotes insulin http://purl.org/sig/ont/fma/fma83365
T232 541-551 Body_part denotes fatty acid http://purl.org/sig/ont/fma/fma82738
T233 552-558 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T234 628-639 Body_part denotes spinal cord http://purl.org/sig/ont/fma/fma7647
T235 742-746 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T236 954-958 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T237 971-975 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T238 1079-1091 Body_part denotes carbohydrate http://purl.org/sig/ont/fma/fma82737
T239 1097-1104 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T240 1153-1165 Body_part denotes carbohydrate http://purl.org/sig/ont/fma/fma82737
T241 1205-1219 Body_part denotes polysaccharide http://purl.org/sig/ont/fma/fma82746
T242 1275-1280 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T243 1281-1286 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T244 1347-1354 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743
T245 1396-1417 Body_part denotes endoplasmic reticulum http://purl.org/sig/ont/fma/fma63842
T246 1429-1434 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T247 1441-1451 Body_part denotes macrophage http://purl.org/sig/ont/fma/fma63261
T248 1484-1488 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T249 1489-1496 Body_part denotes insulin http://purl.org/sig/ont/fma/fma83365
T250 1634-1641 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T251 1651-1664 Body_part denotes carbohydrates http://purl.org/sig/ont/fma/fma82737
T252 1690-1697 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T253 1706-1719 Body_part denotes carbohydrates http://purl.org/sig/ont/fma/fma82737
T254 1736-1740 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T255 2032-2036 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T256 2281-2285 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T257 2348-2357 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T258 2362-2372 Body_part denotes macrophage http://purl.org/sig/ont/fma/fma63261

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T53 628-639 Body_part denotes spinal cord http://purl.obolibrary.org/obo/UBERON_0002240
T54 1275-1280 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T55 1429-1434 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T101 628-646 Disease denotes spinal cord injury http://purl.obolibrary.org/obo/MONDO_0043797
T102 640-646 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T103 1347-1366 Disease denotes glucose intolerance http://purl.obolibrary.org/obo/MONDO_0001076
T104 1388-1394 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T105 1817-1838 Disease denotes Muckle-Wells Syndrome http://purl.obolibrary.org/obo/MONDO_0008633
T106 1843-1884 Disease denotes Familial Cold Autoinflammatory syndrome 1 http://purl.obolibrary.org/obo/MONDO_0007349
T107 1857-1882 Disease denotes Autoinflammatory syndrome http://purl.obolibrary.org/obo/MONDO_0019751

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T287 171-174 http://purl.obolibrary.org/obo/UBERON_0001013 denotes fat
T288 341-344 http://purl.obolibrary.org/obo/UBERON_0001013 denotes fat
T289 357-363 http://purl.obolibrary.org/obo/UBERON_0003100 denotes Female
T290 442-445 http://purl.obolibrary.org/obo/UBERON_0001013 denotes fat
T291 514-521 http://purl.obolibrary.org/obo/PR_000009054 denotes insulin
T292 552-558 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T293 628-639 http://purl.obolibrary.org/obo/UBERON_0002240 denotes spinal cord
T294 648-654 http://purl.obolibrary.org/obo/CLO_0007919 denotes n = 18
T295 648-654 http://purl.obolibrary.org/obo/CLO_0007920 denotes n = 18
T296 784-788 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T297 805-809 http://purl.obolibrary.org/obo/UBERON_0003101 denotes Male
T298 805-809 http://www.ebi.ac.uk/efo/EFO_0000970 denotes Male
T299 824-826 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T300 971-975 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T301 1115-1118 http://purl.obolibrary.org/obo/UBERON_0001013 denotes fat
T302 1172-1175 http://purl.obolibrary.org/obo/UBERON_0001013 denotes fat
T303 1200-1203 http://purl.obolibrary.org/obo/UBERON_0001013 denotes fat
T304 1275-1280 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T305 1275-1280 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T306 1429-1434 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T307 1429-1434 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T308 1478-1488 http://purl.obolibrary.org/obo/UBERON_0013702 denotes whole-body
T309 1489-1496 http://purl.obolibrary.org/obo/PR_000009054 denotes insulin
T310 1548-1551 http://purl.obolibrary.org/obo/UBERON_0001013 denotes fat
T311 1563-1567 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T312 1563-1567 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T313 1626-1629 http://purl.obolibrary.org/obo/UBERON_0001013 denotes fat
T314 1682-1685 http://purl.obolibrary.org/obo/UBERON_0001013 denotes fat
T315 1933-1936 http://purl.obolibrary.org/obo/UBERON_0001013 denotes fat
T316 2060-2068 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T317 2093-2096 http://purl.obolibrary.org/obo/UBERON_0001013 denotes fat
T318 2147-2151 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T319 2147-2151 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T320 2281-2285 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T321 2391-2392 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T322 2436-2440 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T339 180-185 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T340 223-228 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T341 242-244 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T343 251-253 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T345 265-288 Chemical denotes short-chain fatty acids http://purl.obolibrary.org/obo/CHEBI_26666
T346 277-288 Chemical denotes fatty acids http://purl.obolibrary.org/obo/CHEBI_35366
T347 283-288 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T348 323-335 Chemical denotes carbohydrate http://purl.obolibrary.org/obo/CHEBI_16646
T349 385-390 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T350 450-457 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T351 466-479 Chemical denotes carbohydrates http://purl.obolibrary.org/obo/CHEBI_16646
T352 510-512 Chemical denotes TG http://purl.obolibrary.org/obo/CHEBI_74859|http://purl.obolibrary.org/obo/CHEBI_9555
T354 514-521 Chemical denotes insulin http://purl.obolibrary.org/obo/CHEBI_145810
T355 541-551 Chemical denotes fatty acid http://purl.obolibrary.org/obo/CHEBI_35366
T356 547-551 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T357 655-660 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T358 697-699 Chemical denotes KD http://purl.obolibrary.org/obo/CHEBI_73601
T359 718-720 Chemical denotes SD http://purl.obolibrary.org/obo/CHEBI_74807
T360 736-738 Chemical denotes KD http://purl.obolibrary.org/obo/CHEBI_73601
T361 742-744 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T363 773-775 Chemical denotes Lu http://purl.obolibrary.org/obo/CHEBI_33382
T364 893-898 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T365 899-901 Chemical denotes KD http://purl.obolibrary.org/obo/CHEBI_73601
T366 905-918 Chemical denotes triglycerides http://purl.obolibrary.org/obo/CHEBI_17855
T367 920-931 Chemical denotes cholesterol http://purl.obolibrary.org/obo/CHEBI_16113
T368 941-944 Chemical denotes MCP http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099
T370 948-950 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T372 954-956 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T374 1079-1091 Chemical denotes carbohydrate http://purl.obolibrary.org/obo/CHEBI_16646
T375 1097-1104 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T376 1135-1137 Chemical denotes KD http://purl.obolibrary.org/obo/CHEBI_73601
T377 1153-1165 Chemical denotes carbohydrate http://purl.obolibrary.org/obo/CHEBI_16646
T378 1190-1192 Chemical denotes WD http://purl.obolibrary.org/obo/CHEBI_74868
T379 1205-1219 Chemical denotes polysaccharide http://purl.obolibrary.org/obo/CHEBI_18154
T380 1237-1239 Chemical denotes KD http://purl.obolibrary.org/obo/CHEBI_73601
T381 1281-1286 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T382 1331-1333 Chemical denotes WD http://purl.obolibrary.org/obo/CHEBI_74868
T383 1334-1336 Chemical denotes KD http://purl.obolibrary.org/obo/CHEBI_73601
T384 1347-1354 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167
T386 1489-1496 Chemical denotes insulin http://purl.obolibrary.org/obo/CHEBI_145810
T387 1563-1567 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T388 1634-1641 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T389 1651-1664 Chemical denotes carbohydrates http://purl.obolibrary.org/obo/CHEBI_16646
T390 1690-1697 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T391 1706-1719 Chemical denotes carbohydrates http://purl.obolibrary.org/obo/CHEBI_16646
T392 1736-1738 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T394 1785-1792 Chemical denotes ketones http://purl.obolibrary.org/obo/CHEBI_17087
T395 1945-1950 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T396 1990-2000 Chemical denotes butanediol http://purl.obolibrary.org/obo/CHEBI_52684
T397 2001-2007 Chemical denotes ketone http://purl.obolibrary.org/obo/CHEBI_17087
T398 2008-2016 Chemical denotes diesters http://purl.obolibrary.org/obo/CHEBI_51307
T399 2023-2028 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T400 2032-2034 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T402 2102-2109 Chemical denotes sucrose http://purl.obolibrary.org/obo/CHEBI_17992
T403 2143-2145 Chemical denotes WT http://purl.obolibrary.org/obo/CHEBI_141450
T404 2147-2151 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T137 0-50 Sentence denotes Diet Species Treatment Observed effects References
T138 51-163 Sentence denotes Carbohydrate-restricted diet Senescence-accelerated prone mice (SAMP8) 8-week treatment:➢ Control: standard chow
T139 164-191 Sentence denotes ➢ High fat diet group (HFD)
T140 192-305 Sentence denotes ➢ Carbohydrate-restricted diet group (CRD) CRD: ↑ IL-6 and IL-1β, ↓cecum short-chain fatty acids He et al. (2019)
T141 306-424 Sentence denotes Scandinavian low-carbohydrate high-fat (LCHF) diet Female C57BL/6J mice (n = 7/group) 4-week treatment:➢ standard chow
T142 425-587 Sentence denotes ➢ LCHF diet (75% fat 20% protein, and 5% carbohydrates) LCHF: no change in glycemia, TG, insulin, or non-esterified fatty acid plasma levels Nilsson et al. (2016)
T143 588-700 Sentence denotes Ketogenic diet Sprague-Dawley Rats with spinal cord injury (n = 18/group) 4-week treatment:➢ ketogenic diet (KD)
T144 701-721 Sentence denotes ➢ standard diet (SD)
T145 722-789 Sentence denotes ➢ control (C) KD: ↓ IL-1β, TNF-α, IFN-γ expression Lu et al. (2018)
T146 790-875 Sentence denotes Ketogenic diet Male C57BL/6J mice 22-weeks diet intervention:➢ Control: standard chow
T147 876-1005 Sentence denotes ➢ Ketogenic diet group KD: ↑ triglycerides, cholesterol, leptin, MCP-1, IL-6, IL-1β,↓ α- and β-cell mass Ellenbroek et al. (2014)
T148 1006-1138 Sentence denotes Ketogenic versus Western diet C57BL/6J mice 12-week treatment:➢ very low-carbohydrate, low-protein, and high-fat ketogenic diet (KD)
T149 1139-1193 Sentence denotes ➢ high-simple-carbohydrate, high-fat Western diet (WD)
T150 1194-1532 Sentence denotes ➢ low-fat, polysaccharide-rich control (C) KD: euglycaemia and hypoinsulinemia + liver lipid accumulation (different pattern compared to WD)KD: systemic glucose intolerance, steatosis, cellular injury, endoplasmic reticulum stress (in liver), and macrophage accumulation, maintaining whole-body insulin responsiveness Garbow et al. (2011)
T151 1533-1614 Sentence denotes High-saturated fat diet (HFD) male C57BL/6J mice 3-week treatment:➢ standard chow
T152 1615-1665 Sentence denotes ➢ HFD (60% fat 20% protein, and 20% carbohydrates)
T153 1666-1761 Sentence denotes ➢ Very HFD (80% fat 16% protein, and 4% carbohydrates) HFD: ↑ leptin, IL-1β Andre et al. (2017)
T154 1762-1936 Sentence denotes Diet supplemented with ketones Knockout mice model for Muckle-Wells Syndrome and Familial Cold Autoinflammatory syndrome 1-week treatment:➢ Control: normal chow with 4.5% fat
T155 1937-2087 Sentence denotes ➢ Study group: normal chow supplemented with 20% 1,3-butanediol ketone diesters Study group: ↓ IL-1β release and caspase-1 activity Youm et al. (2015)
T156 2088-2201 Sentence denotes High fat high sucrose diet (HFD) C57BL/6 J (wild type; WT) male mice 8-week treatment:➢ Young + normal diet (YND)
T157 2202-2222 Sentence denotes ➢ Young + HFD (YHFD)
T158 2223-2248 Sentence denotes ➢ Old + normal diet (OND)
T159 2249-2441 Sentence denotes ➢ Old + HFD (OHFD) HFD led to β-cell failure in aged mice, enhanced expression of pro-inflammatory cytokines and macrophage transformation to a more pro-inflammatory phenotype He et al. (2018)

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T64 1257-1272 Phenotype denotes hypoinsulinemia http://purl.obolibrary.org/obo/HP_0040216
T65 1347-1366 Phenotype denotes glucose intolerance http://purl.obolibrary.org/obo/HP_0001952
T66 1368-1377 Phenotype denotes steatosis http://purl.obolibrary.org/obo/HP_0001397

MyTest

Id Subject Object Predicate Lexical cue
32640331-31952014-30720819 300-304 31952014 denotes 2019
32640331-27891164-30720820 582-586 27891164 denotes 2016
32640331-29894768-30720821 784-788 29894768 denotes 2018
32640331-24398402-30720822 1000-1004 24398402 denotes 2014
32640331-21454445-30720823 1527-1531 21454445 denotes 2011
32640331-27903745-30720824 1756-1760 27903745 denotes 2017
32640331-25686106-30720825 2082-2086 25686106 denotes 2015
32640331-29426925-30720826 2436-2440 29426925 denotes 2018

2_test

Id Subject Object Predicate Lexical cue
32640331-31952014-30720819 300-304 31952014 denotes 2019
32640331-27891164-30720820 582-586 27891164 denotes 2016
32640331-29894768-30720821 784-788 29894768 denotes 2018
32640331-24398402-30720822 1000-1004 24398402 denotes 2014
32640331-21454445-30720823 1527-1531 21454445 denotes 2011
32640331-27903745-30720824 1756-1760 27903745 denotes 2017
32640331-25686106-30720825 2082-2086 25686106 denotes 2015
32640331-29426925-30720826 2436-2440 29426925 denotes 2018

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T2064 9-20 GO:0007631 denotes ies Treatme
T2065 277-331 CHEBI:33290;CHEBI:33290 denotes fatty acids He et al. (2019) Scandinavian low-carbohyd
T2066 497-521 PR:000009054 denotes in glycemia, TG, insulin
T2067 853-939 CHEBI:35218;CHEBI:35218 denotes Control: standard chow ➢ Ketogenic diet group KD: ↑ triglycerides, cholesterol, leptin
T2068 969-990 CHEBI:24043;CHEBI:24043 denotes β-cell mass Ellenbroe
T2069 992-1008 GO:0007631 denotes et al. (2014) Ke
T2070 1355-1390 PR:000009054 denotes intolerance, steatosis, cellular in
T2071 1902-1946 GO:0007631 denotes Control: normal chow with 4.5% fat ➢ Study g
T2072 1993-2007 CHEBI:35218;CHEBI:35218 denotes anediol ketone
T2074 2317-2323 CHEBI:16412;CHEBI:16412 denotes expres