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LitCovid_Glycan-Motif-Structure

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T16","span":{"begin":1006,"end":1013},"obj":"https://glytoucan.org/Structures/Glycans/G15021LG"}],"text":"Postprandial hyperglycaemic spikes are linked to ROS generation and inflammation, as ROS, via the NF-κB pathway, promote the expression of pro-inflammatory molecules such as MCP-1, TNF-α, IL-6, IL-1β, along AP-1, as well as FOXO. These molecules interfere with the insulin signalling pathway, add to the insulin resistance progress (Lumeng et al., 2008; Weisberg et al., 2003) and affect blood levels of some inflammatory biomarkers more than chronic hyperglycaemia (Barrea et al., 2018; Della Corte et al., 2018). Healthy diets, based on low glycaemic index food, resulting in a lesser increase of glycemia and lipemia in postprandial settings, induced a lower production of pro-inflammatory molecules (Barrea et al., 2018; Della Corte et al., 2018). In preclinical studies, a strict restriction of carbohydrate intake was shown to promote inflammation and shorten lifespan in senescence-prone mice, increasing IL-6 and IL-1β, compared to diets rich in fats (He et al., 2019), with no alteration of serum glucose or insulin versus a standard diet (Nilsson et al., 2016)."}

LitCovid-PD-FMA-UBERON

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T183","span":{"begin":194,"end":198},"obj":"Body_part"},{"id":"T184","span":{"begin":265,"end":272},"obj":"Body_part"},{"id":"T185","span":{"begin":304,"end":311},"obj":"Body_part"},{"id":"T186","span":{"begin":388,"end":393},"obj":"Body_part"},{"id":"T187","span":{"begin":800,"end":812},"obj":"Body_part"},{"id":"T188","span":{"begin":921,"end":925},"obj":"Body_part"},{"id":"T189","span":{"begin":1000,"end":1005},"obj":"Body_part"},{"id":"T190","span":{"begin":1006,"end":1013},"obj":"Body_part"},{"id":"T191","span":{"begin":1017,"end":1024},"obj":"Body_part"}],"attributes":[{"id":"A183","pred":"fma_id","subj":"T183","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A184","pred":"fma_id","subj":"T184","obj":"http://purl.org/sig/ont/fma/fma83365"},{"id":"A185","pred":"fma_id","subj":"T185","obj":"http://purl.org/sig/ont/fma/fma83365"},{"id":"A186","pred":"fma_id","subj":"T186","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A187","pred":"fma_id","subj":"T187","obj":"http://purl.org/sig/ont/fma/fma82737"},{"id":"A188","pred":"fma_id","subj":"T188","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A189","pred":"fma_id","subj":"T189","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A190","pred":"fma_id","subj":"T190","obj":"http://purl.org/sig/ont/fma/fma82743"},{"id":"A191","pred":"fma_id","subj":"T191","obj":"http://purl.org/sig/ont/fma/fma83365"}],"text":"Postprandial hyperglycaemic spikes are linked to ROS generation and inflammation, as ROS, via the NF-κB pathway, promote the expression of pro-inflammatory molecules such as MCP-1, TNF-α, IL-6, IL-1β, along AP-1, as well as FOXO. These molecules interfere with the insulin signalling pathway, add to the insulin resistance progress (Lumeng et al., 2008; Weisberg et al., 2003) and affect blood levels of some inflammatory biomarkers more than chronic hyperglycaemia (Barrea et al., 2018; Della Corte et al., 2018). Healthy diets, based on low glycaemic index food, resulting in a lesser increase of glycemia and lipemia in postprandial settings, induced a lower production of pro-inflammatory molecules (Barrea et al., 2018; Della Corte et al., 2018). In preclinical studies, a strict restriction of carbohydrate intake was shown to promote inflammation and shorten lifespan in senescence-prone mice, increasing IL-6 and IL-1β, compared to diets rich in fats (He et al., 2019), with no alteration of serum glucose or insulin versus a standard diet (Nilsson et al., 2016)."}

LitCovid-PD-UBERON

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T46","span":{"begin":388,"end":393},"obj":"Body_part"},{"id":"T47","span":{"begin":1000,"end":1005},"obj":"Body_part"}],"attributes":[{"id":"A46","pred":"uberon_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A47","pred":"uberon_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"}],"text":"Postprandial hyperglycaemic spikes are linked to ROS generation and inflammation, as ROS, via the NF-κB pathway, promote the expression of pro-inflammatory molecules such as MCP-1, TNF-α, IL-6, IL-1β, along AP-1, as well as FOXO. These molecules interfere with the insulin signalling pathway, add to the insulin resistance progress (Lumeng et al., 2008; Weisberg et al., 2003) and affect blood levels of some inflammatory biomarkers more than chronic hyperglycaemia (Barrea et al., 2018; Della Corte et al., 2018). Healthy diets, based on low glycaemic index food, resulting in a lesser increase of glycemia and lipemia in postprandial settings, induced a lower production of pro-inflammatory molecules (Barrea et al., 2018; Della Corte et al., 2018). In preclinical studies, a strict restriction of carbohydrate intake was shown to promote inflammation and shorten lifespan in senescence-prone mice, increasing IL-6 and IL-1β, compared to diets rich in fats (He et al., 2019), with no alteration of serum glucose or insulin versus a standard diet (Nilsson et al., 2016)."}

LitCovid-PD-MONDO

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T84","span":{"begin":68,"end":80},"obj":"Disease"},{"id":"T85","span":{"begin":612,"end":619},"obj":"Disease"},{"id":"T86","span":{"begin":841,"end":853},"obj":"Disease"}],"attributes":[{"id":"A84","pred":"mondo_id","subj":"T84","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A85","pred":"mondo_id","subj":"T85","obj":"http://purl.obolibrary.org/obo/MONDO_0021187"},{"id":"A86","pred":"mondo_id","subj":"T86","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"}],"text":"Postprandial hyperglycaemic spikes are linked to ROS generation and inflammation, as ROS, via the NF-κB pathway, promote the expression of pro-inflammatory molecules such as MCP-1, TNF-α, IL-6, IL-1β, along AP-1, as well as FOXO. These molecules interfere with the insulin signalling pathway, add to the insulin resistance progress (Lumeng et al., 2008; Weisberg et al., 2003) and affect blood levels of some inflammatory biomarkers more than chronic hyperglycaemia (Barrea et al., 2018; Della Corte et al., 2018). Healthy diets, based on low glycaemic index food, resulting in a lesser increase of glycemia and lipemia in postprandial settings, induced a lower production of pro-inflammatory molecules (Barrea et al., 2018; Della Corte et al., 2018). In preclinical studies, a strict restriction of carbohydrate intake was shown to promote inflammation and shorten lifespan in senescence-prone mice, increasing IL-6 and IL-1β, compared to diets rich in fats (He et al., 2019), with no alteration of serum glucose or insulin versus a standard diet (Nilsson et al., 2016)."}

LitCovid-PD-CLO

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T208","span":{"begin":102,"end":103},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T209","span":{"begin":207,"end":209},"obj":"http://purl.obolibrary.org/obo/CLO_0001547"},{"id":"T210","span":{"begin":265,"end":272},"obj":"http://purl.obolibrary.org/obo/PR_000009054"},{"id":"T211","span":{"begin":273,"end":283},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T212","span":{"begin":304,"end":311},"obj":"http://purl.obolibrary.org/obo/PR_000009054"},{"id":"T213","span":{"begin":388,"end":393},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T214","span":{"begin":388,"end":393},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T215","span":{"begin":482,"end":486},"obj":"http://purl.obolibrary.org/obo/CLO_0001185"},{"id":"T216","span":{"begin":508,"end":512},"obj":"http://purl.obolibrary.org/obo/CLO_0001185"},{"id":"T217","span":{"begin":578,"end":579},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T218","span":{"begin":654,"end":655},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T219","span":{"begin":719,"end":723},"obj":"http://purl.obolibrary.org/obo/CLO_0001185"},{"id":"T220","span":{"begin":745,"end":749},"obj":"http://purl.obolibrary.org/obo/CLO_0001185"},{"id":"T221","span":{"begin":776,"end":777},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T222","span":{"begin":954,"end":958},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T223","span":{"begin":1017,"end":1024},"obj":"http://purl.obolibrary.org/obo/PR_000009054"},{"id":"T224","span":{"begin":1032,"end":1033},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Postprandial hyperglycaemic spikes are linked to ROS generation and inflammation, as ROS, via the NF-κB pathway, promote the expression of pro-inflammatory molecules such as MCP-1, TNF-α, IL-6, IL-1β, along AP-1, as well as FOXO. These molecules interfere with the insulin signalling pathway, add to the insulin resistance progress (Lumeng et al., 2008; Weisberg et al., 2003) and affect blood levels of some inflammatory biomarkers more than chronic hyperglycaemia (Barrea et al., 2018; Della Corte et al., 2018). Healthy diets, based on low glycaemic index food, resulting in a lesser increase of glycemia and lipemia in postprandial settings, induced a lower production of pro-inflammatory molecules (Barrea et al., 2018; Della Corte et al., 2018). In preclinical studies, a strict restriction of carbohydrate intake was shown to promote inflammation and shorten lifespan in senescence-prone mice, increasing IL-6 and IL-1β, compared to diets rich in fats (He et al., 2019), with no alteration of serum glucose or insulin versus a standard diet (Nilsson et al., 2016)."}

LitCovid-PD-CHEBI

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T103","span":{"begin":49,"end":63},"obj":"http://purl.obolibrary.org/obo/GO_1903409"},{"id":"T104","span":{"begin":68,"end":80},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T105","span":{"begin":273,"end":291},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T106","span":{"begin":273,"end":283},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T107","span":{"begin":841,"end":853},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"Postprandial hyperglycaemic spikes are linked to ROS generation and inflammation, as ROS, via the NF-κB pathway, promote the expression of pro-inflammatory molecules such as MCP-1, TNF-α, IL-6, IL-1β, along AP-1, as well as FOXO. These molecules interfere with the insulin signalling pathway, add to the insulin resistance progress (Lumeng et al., 2008; Weisberg et al., 2003) and affect blood levels of some inflammatory biomarkers more than chronic hyperglycaemia (Barrea et al., 2018; Della Corte et al., 2018). Healthy diets, based on low glycaemic index food, resulting in a lesser increase of glycemia and lipemia in postprandial settings, induced a lower production of pro-inflammatory molecules (Barrea et al., 2018; Della Corte et al., 2018). In preclinical studies, a strict restriction of carbohydrate intake was shown to promote inflammation and shorten lifespan in senescence-prone mice, increasing IL-6 and IL-1β, compared to diets rich in fats (He et al., 2019), with no alteration of serum glucose or insulin versus a standard diet (Nilsson et al., 2016)."}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T100","span":{"begin":0,"end":229},"obj":"Sentence"},{"id":"T101","span":{"begin":230,"end":514},"obj":"Sentence"},{"id":"T102","span":{"begin":515,"end":751},"obj":"Sentence"},{"id":"T103","span":{"begin":752,"end":1071},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Postprandial hyperglycaemic spikes are linked to ROS generation and inflammation, as ROS, via the NF-κB pathway, promote the expression of pro-inflammatory molecules such as MCP-1, TNF-α, IL-6, IL-1β, along AP-1, as well as FOXO. These molecules interfere with the insulin signalling pathway, add to the insulin resistance progress (Lumeng et al., 2008; Weisberg et al., 2003) and affect blood levels of some inflammatory biomarkers more than chronic hyperglycaemia (Barrea et al., 2018; Della Corte et al., 2018). Healthy diets, based on low glycaemic index food, resulting in a lesser increase of glycemia and lipemia in postprandial settings, induced a lower production of pro-inflammatory molecules (Barrea et al., 2018; Della Corte et al., 2018). In preclinical studies, a strict restriction of carbohydrate intake was shown to promote inflammation and shorten lifespan in senescence-prone mice, increasing IL-6 and IL-1β, compared to diets rich in fats (He et al., 2019), with no alteration of serum glucose or insulin versus a standard diet (Nilsson et al., 2016)."}

LitCovid-PD-HP

{"project":"LitCovid-PD-HP","denotations":[{"id":"T53","span":{"begin":304,"end":322},"obj":"Phenotype"}],"attributes":[{"id":"A53","pred":"hp_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/HP_0000855"}],"text":"Postprandial hyperglycaemic spikes are linked to ROS generation and inflammation, as ROS, via the NF-κB pathway, promote the expression of pro-inflammatory molecules such as MCP-1, TNF-α, IL-6, IL-1β, along AP-1, as well as FOXO. These molecules interfere with the insulin signalling pathway, add to the insulin resistance progress (Lumeng et al., 2008; Weisberg et al., 2003) and affect blood levels of some inflammatory biomarkers more than chronic hyperglycaemia (Barrea et al., 2018; Della Corte et al., 2018). Healthy diets, based on low glycaemic index food, resulting in a lesser increase of glycemia and lipemia in postprandial settings, induced a lower production of pro-inflammatory molecules (Barrea et al., 2018; Della Corte et al., 2018). In preclinical studies, a strict restriction of carbohydrate intake was shown to promote inflammation and shorten lifespan in senescence-prone mice, increasing IL-6 and IL-1β, compared to diets rich in fats (He et al., 2019), with no alteration of serum glucose or insulin versus a standard diet (Nilsson et al., 2016)."}

MyTest

{"project":"MyTest","denotations":[{"id":"32640331-18829989-30720780","span":{"begin":348,"end":352},"obj":"18829989"},{"id":"32640331-14679176-30720781","span":{"begin":371,"end":375},"obj":"14679176"},{"id":"32640331-30033891-30720782","span":{"begin":482,"end":486},"obj":"30033891"},{"id":"32640331-30033891-30720783","span":{"begin":719,"end":723},"obj":"30033891"},{"id":"32640331-31952014-30720784","span":{"begin":971,"end":975},"obj":"31952014"},{"id":"32640331-27891164-30720785","span":{"begin":1065,"end":1069},"obj":"27891164"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"Postprandial hyperglycaemic spikes are linked to ROS generation and inflammation, as ROS, via the NF-κB pathway, promote the expression of pro-inflammatory molecules such as MCP-1, TNF-α, IL-6, IL-1β, along AP-1, as well as FOXO. These molecules interfere with the insulin signalling pathway, add to the insulin resistance progress (Lumeng et al., 2008; Weisberg et al., 2003) and affect blood levels of some inflammatory biomarkers more than chronic hyperglycaemia (Barrea et al., 2018; Della Corte et al., 2018). Healthy diets, based on low glycaemic index food, resulting in a lesser increase of glycemia and lipemia in postprandial settings, induced a lower production of pro-inflammatory molecules (Barrea et al., 2018; Della Corte et al., 2018). In preclinical studies, a strict restriction of carbohydrate intake was shown to promote inflammation and shorten lifespan in senescence-prone mice, increasing IL-6 and IL-1β, compared to diets rich in fats (He et al., 2019), with no alteration of serum glucose or insulin versus a standard diet (Nilsson et al., 2016)."}

2_test

{"project":"2_test","denotations":[{"id":"32640331-18829989-30720780","span":{"begin":348,"end":352},"obj":"18829989"},{"id":"32640331-14679176-30720781","span":{"begin":371,"end":375},"obj":"14679176"},{"id":"32640331-30033891-30720782","span":{"begin":482,"end":486},"obj":"30033891"},{"id":"32640331-30033891-30720783","span":{"begin":719,"end":723},"obj":"30033891"},{"id":"32640331-31952014-30720784","span":{"begin":971,"end":975},"obj":"31952014"},{"id":"32640331-27891164-30720785","span":{"begin":1065,"end":1069},"obj":"27891164"}],"text":"Postprandial hyperglycaemic spikes are linked to ROS generation and inflammation, as ROS, via the NF-κB pathway, promote the expression of pro-inflammatory molecules such as MCP-1, TNF-α, IL-6, IL-1β, along AP-1, as well as FOXO. These molecules interfere with the insulin signalling pathway, add to the insulin resistance progress (Lumeng et al., 2008; Weisberg et al., 2003) and affect blood levels of some inflammatory biomarkers more than chronic hyperglycaemia (Barrea et al., 2018; Della Corte et al., 2018). Healthy diets, based on low glycaemic index food, resulting in a lesser increase of glycemia and lipemia in postprandial settings, induced a lower production of pro-inflammatory molecules (Barrea et al., 2018; Della Corte et al., 2018). In preclinical studies, a strict restriction of carbohydrate intake was shown to promote inflammation and shorten lifespan in senescence-prone mice, increasing IL-6 and IL-1β, compared to diets rich in fats (He et al., 2019), with no alteration of serum glucose or insulin versus a standard diet (Nilsson et al., 2016)."}

LitCovid-PMC-OGER-BB

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T421","span":{"begin":49,"end":52},"obj":"CHEBI:26523;CHEBI:26523"},{"id":"T422","span":{"begin":98,"end":100},"obj":"GO:0005883"},{"id":"T423","span":{"begin":125,"end":135},"obj":"GO:0010467"},{"id":"T424","span":{"begin":142,"end":155},"obj":"CHEBI:67079;CHEBI:67079"},{"id":"T425","span":{"begin":156,"end":165},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T426","span":{"begin":174,"end":179},"obj":"PR:000002122"},{"id":"T427","span":{"begin":181,"end":186},"obj":"PR:000000134"},{"id":"T428","span":{"begin":188,"end":192},"obj":"PR:000001393"},{"id":"T429","span":{"begin":194,"end":199},"obj":"PR:000001136"},{"id":"T430","span":{"begin":207,"end":211},"obj":"PR:000009232"},{"id":"T431","span":{"begin":236,"end":245},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T432","span":{"begin":265,"end":272},"obj":"PR:000009054"},{"id":"T433","span":{"begin":304,"end":311},"obj":"PR:000009054"},{"id":"T434","span":{"begin":388,"end":393},"obj":"UBERON:0000178"},{"id":"T435","span":{"begin":543,"end":552},"obj":"GO:0006096"},{"id":"T436","span":{"begin":559,"end":563},"obj":"CHEBI:33290;CHEBI:33290"},{"id":"T437","span":{"begin":680,"end":692},"obj":"CHEBI:35472;CHEBI:35472"},{"id":"T438","span":{"begin":693,"end":702},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T439","span":{"begin":800,"end":812},"obj":"CHEBI:16646;CHEBI:16646"},{"id":"T440","span":{"begin":813,"end":819},"obj":"GO:0007631"},{"id":"T441","span":{"begin":866,"end":874},"obj":"UBERON:0000104"},{"id":"T442","span":{"begin":895,"end":899},"obj":"NCBITaxon:10088"},{"id":"T443","span":{"begin":912,"end":916},"obj":"PR:000001393"},{"id":"T444","span":{"begin":923,"end":926},"obj":"PR:000001136"},{"id":"T445","span":{"begin":1000,"end":1005},"obj":"UBERON:0001977"},{"id":"T446","span":{"begin":1006,"end":1013},"obj":"CHEBI:17234;CHEBI:17234"},{"id":"T447","span":{"begin":1017,"end":1024},"obj":"PR:000009054"}],"text":"Postprandial hyperglycaemic spikes are linked to ROS generation and inflammation, as ROS, via the NF-κB pathway, promote the expression of pro-inflammatory molecules such as MCP-1, TNF-α, IL-6, IL-1β, along AP-1, as well as FOXO. These molecules interfere with the insulin signalling pathway, add to the insulin resistance progress (Lumeng et al., 2008; Weisberg et al., 2003) and affect blood levels of some inflammatory biomarkers more than chronic hyperglycaemia (Barrea et al., 2018; Della Corte et al., 2018). Healthy diets, based on low glycaemic index food, resulting in a lesser increase of glycemia and lipemia in postprandial settings, induced a lower production of pro-inflammatory molecules (Barrea et al., 2018; Della Corte et al., 2018). In preclinical studies, a strict restriction of carbohydrate intake was shown to promote inflammation and shorten lifespan in senescence-prone mice, increasing IL-6 and IL-1β, compared to diets rich in fats (He et al., 2019), with no alteration of serum glucose or insulin versus a standard diet (Nilsson et al., 2016)."}

PMC:7335494 / 21096-22167 JSONTXT

Annnotations TAB JSON ListView MergeView

PMC:7335494 / 21096-22167 JSON TXT