Postprandial hyperglycaemic spikes are linked to ROS generation and inflammation, as ROS, via the NF-κB pathway, promote the expression of pro-inflammatory molecules such as MCP-1, TNF-α, IL-6, IL-1β, along AP-1, as well as FOXO. These molecules interfere with the insulin signalling pathway, add to the insulin resistance progress (Lumeng et al., 2008; Weisberg et al., 2003) and affect blood levels of some inflammatory biomarkers more than chronic hyperglycaemia (Barrea et al., 2018; Della Corte et al., 2018). Healthy diets, based on low glycaemic index food, resulting in a lesser increase of glycemia and lipemia in postprandial settings, induced a lower production of pro-inflammatory molecules (Barrea et al., 2018; Della Corte et al., 2018). In preclinical studies, a strict restriction of carbohydrate intake was shown to promote inflammation and shorten lifespan in senescence-prone mice, increasing IL-6 and IL-1β, compared to diets rich in fats (He et al., 2019), with no alteration of serum glucose or insulin versus a standard diet (Nilsson et al., 2016).