PMC:7335494 / 17285-19479
Annnotations
LitCovid_Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T5 | 272-274 | https://glytoucan.org/Structures/Glycans/G00017MO | denotes | HA |
| T6 | 492-494 | https://glytoucan.org/Structures/Glycans/G00017MO | denotes | HA |
| T7 | 549-551 | https://glytoucan.org/Structures/Glycans/G00017MO | denotes | HA |
| T8 | 688-690 | https://glytoucan.org/Structures/Glycans/G00017MO | denotes | HA |
| T9 | 1141-1143 | https://glytoucan.org/Structures/Glycans/G00017MO | denotes | HA |
| T10 | 1460-1462 | https://glytoucan.org/Structures/Glycans/G00017MO | denotes | HA |
| T11 | 1583-1585 | https://glytoucan.org/Structures/Glycans/G00017MO | denotes | HA |
| T12 | 1710-1712 | https://glytoucan.org/Structures/Glycans/G00017MO | denotes | HA |
| T13 | 1811-1813 | https://glytoucan.org/Structures/Glycans/G00017MO | denotes | HA |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T140 | 16-19 | Body_part | denotes | ECM | http://purl.org/sig/ont/fma/fma9672 |
| T141 | 20-32 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T142 | 58-72 | Body_part | denotes | adipose tissue | http://purl.org/sig/ont/fma/fma20110 |
| T143 | 73-84 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
| T144 | 118-132 | Body_part | denotes | adipose tissue | http://purl.org/sig/ont/fma/fma20110 |
| T145 | 175-182 | Body_part | denotes | insulin | http://purl.org/sig/ont/fma/fma83365 |
| T146 | 235-238 | Body_part | denotes | ECM | http://purl.org/sig/ont/fma/fma9672 |
| T147 | 254-271 | Body_part | denotes | glycosaminoglycan | http://purl.org/sig/ont/fma/fma63011 |
| T148 | 272-274 | Body_part | denotes | HA | http://purl.org/sig/ont/fma/fma63014 |
| T149 | 492-494 | Body_part | denotes | HA | http://purl.org/sig/ont/fma/fma63014 |
| T150 | 549-551 | Body_part | denotes | HA | http://purl.org/sig/ont/fma/fma63014 |
| T151 | 589-594 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T152 | 614-620 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T153 | 688-690 | Body_part | denotes | HA | http://purl.org/sig/ont/fma/fma63014 |
| T154 | 1075-1080 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T155 | 1141-1143 | Body_part | denotes | HA | http://purl.org/sig/ont/fma/fma63014 |
| T156 | 1177-1184 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
| T157 | 1460-1462 | Body_part | denotes | HA | http://purl.org/sig/ont/fma/fma63014 |
| T158 | 1583-1585 | Body_part | denotes | HA | http://purl.org/sig/ont/fma/fma63014 |
| T159 | 1630-1639 | Body_part | denotes | adipocyte | http://purl.org/sig/ont/fma/fma63880 |
| T160 | 1710-1712 | Body_part | denotes | HA | http://purl.org/sig/ont/fma/fma63014 |
| T161 | 1781-1786 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T162 | 1811-1813 | Body_part | denotes | HA | http://purl.org/sig/ont/fma/fma63014 |
| T163 | 1824-1831 | Body_part | denotes | insulin | http://purl.org/sig/ont/fma/fma83365 |
| T164 | 2123-2137 | Body_part | denotes | adipose tissue | http://purl.org/sig/ont/fma/fma20110 |
| T165 | 2155-2162 | Body_part | denotes | insulin | http://purl.org/sig/ont/fma/fma83365 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T39 | 58-72 | Body_part | denotes | adipose tissue | http://purl.obolibrary.org/obo/UBERON_0001013 |
| T40 | 66-72 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T41 | 118-132 | Body_part | denotes | adipose tissue | http://purl.obolibrary.org/obo/UBERON_0001013 |
| T42 | 126-132 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T43 | 614-620 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T44 | 2123-2137 | Body_part | denotes | adipose tissue | http://purl.obolibrary.org/obo/UBERON_0001013 |
| T45 | 2131-2137 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T67 | 133-145 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T68 | 349-355 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T69 | 396-403 | Disease | denotes | sterile | http://purl.obolibrary.org/obo/MONDO_0005047 |
| T70 | 404-416 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T71 | 1188-1203 | Disease | denotes | type-2 diabetes | http://purl.obolibrary.org/obo/MONDO_0005148 |
| T72 | 1195-1203 | Disease | denotes | diabetes | http://purl.obolibrary.org/obo/MONDO_0005015 |
| T73 | 1369-1381 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T74 | 2138-2150 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T170 | 0-11 | http://purl.obolibrary.org/obo/PR_000015561 | denotes | Osteopontin |
| T171 | 58-72 | http://purl.obolibrary.org/obo/UBERON_0001013 | denotes | adipose tissue |
| T172 | 118-132 | http://purl.obolibrary.org/obo/UBERON_0001013 | denotes | adipose tissue |
| T173 | 175-182 | http://purl.obolibrary.org/obo/PR_000009054 | denotes | insulin |
| T174 | 276-279 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T175 | 589-594 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T176 | 815-816 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T177 | 965-966 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T178 | 999-1000 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T179 | 1001-1011 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signalling |
| T180 | 1045-1050 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T181 | 1075-1080 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T182 | 1547-1552 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T183 | 1630-1639 | http://purl.obolibrary.org/obo/CL_0000136 | denotes | adipocyte |
| T184 | 1774-1780 | http://purl.obolibrary.org/obo/CLO_0001352 | denotes | 3T3-L1 |
| T185 | 1774-1780 | http://purl.obolibrary.org/obo/CLO_0052362 | denotes | 3T3-L1 |
| T186 | 1774-1780 | http://purl.obolibrary.org/obo/CLO_0052363 | denotes | 3T3-L1 |
| T187 | 1774-1780 | http://purl.obolibrary.org/obo/CLO_0052366 | denotes | 3T3-L1 |
| T188 | 1781-1786 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T189 | 1824-1831 | http://purl.obolibrary.org/obo/PR_000009054 | denotes | insulin |
| T190 | 1898-1901 | http://purl.obolibrary.org/obo/UBERON_0001013 | denotes | fat |
| T191 | 1926-1931 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
| T192 | 2004-2005 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T193 | 2042-2047 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T194 | 2112-2121 | http://purl.obolibrary.org/obo/UBERON_0001013 | denotes | adiposity |
| T195 | 2123-2137 | http://purl.obolibrary.org/obo/UBERON_0001013 | denotes | adipose tissue |
| T196 | 2155-2162 | http://purl.obolibrary.org/obo/PR_000009054 | denotes | insulin |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T153 | 20-32 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T154 | 175-182 | Chemical | denotes | insulin | http://purl.obolibrary.org/obo/CHEBI_145810 |
| T155 | 254-271 | Chemical | denotes | glycosaminoglycan | http://purl.obolibrary.org/obo/CHEBI_18085 |
| T156 | 272-274 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924|http://purl.obolibrary.org/obo/CHEBI_132153 |
| T158 | 492-494 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924|http://purl.obolibrary.org/obo/CHEBI_132153 |
| T160 | 549-551 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924|http://purl.obolibrary.org/obo/CHEBI_132153 |
| T162 | 688-690 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924|http://purl.obolibrary.org/obo/CHEBI_132153 |
| T164 | 995-997 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T167 | 1141-1143 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924|http://purl.obolibrary.org/obo/CHEBI_132153 |
| T169 | 1460-1462 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924|http://purl.obolibrary.org/obo/CHEBI_132153 |
| T171 | 1583-1585 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924|http://purl.obolibrary.org/obo/CHEBI_132153 |
| T173 | 1710-1712 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924|http://purl.obolibrary.org/obo/CHEBI_132153 |
| T175 | 1811-1813 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924|http://purl.obolibrary.org/obo/CHEBI_132153 |
| T177 | 1824-1831 | Chemical | denotes | insulin | http://purl.obolibrary.org/obo/CHEBI_145810 |
| T178 | 2155-2162 | Chemical | denotes | insulin | http://purl.obolibrary.org/obo/CHEBI_145810 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T86 | 133-145 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T87 | 404-416 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T88 | 1001-1019 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signalling pathway |
| T89 | 1001-1011 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
| T90 | 1051-1064 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T91 | 1369-1381 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T92 | 1569-1579 | http://purl.obolibrary.org/obo/GO_0008152 | denotes | metabolism |
| T93 | 1630-1655 | http://purl.obolibrary.org/obo/GO_0045444 | denotes | adipocyte differentiation |
| T94 | 1758-1770 | http://purl.obolibrary.org/obo/GO_0060612 | denotes | adipogenesis |
| T95 | 1758-1770 | http://purl.obolibrary.org/obo/GO_0045444 | denotes | adipogenesis |
| T96 | 2138-2150 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T79 | 0-216 | Sentence | denotes | Osteopontin, an ECM glycoprotein, excessively secreted by adipose tissue macrophages (Nomiyama et al., 2007) enhances adipose tissue inflammation and facilitates the onset of insulin resistance (Aouadi et al., 2013). |
| T80 | 217-470 | Sentence | denotes | Another important ECM component, the glycosaminoglycan HA, has been strongly correlated to increased inflammatory burden, including cancer-associated (Nikitovic et al., 2015) and sterile inflammation (Kavasi et al., 2017, 2019; Nikitovic et al., 2014b). |
| T81 | 471-520 | Sentence | denotes | The biologic role of HA is dependent on its size. |
| T82 | 521-653 | Sentence | denotes | Thus, high molecular weight HA (HMWHA), physiologically secreted by cells facilitates normal tissue stability (Kavasi et al., 2017). |
| T83 | 654-914 | Sentence | denotes | In contrast, low molecular weight HA (LMWHA) fragments, produced via enzymatic action or chemical reactions, are pro-inflammatory and have been characterized as a danger-associated molecular patterns (DAMP) (Kavasi et al., 2017, 2019; Nikitovic et al., 2014a). |
| T84 | 915-1125 | Sentence | denotes | Indeed, the generated LMWHA fragments can trigger a Toll-like receptor 4 (TLR4)/NF-κB signalling pathway to regulate inflammatory genes transcription in immune cells (Kavasi et al., 2017; Termeer et al., 2002). |
| T85 | 1126-1292 | Sentence | denotes | Interestingly, HA levels were increased in various tissues of type-2 diabetes mellius (T2DM), but not in type-1 (T1DM) subjects, and independent of glycaemic control. |
| T86 | 1293-1490 | Sentence | denotes | Taking into account that T2DM, in contrast to T1DM, is linked with systemic inflammation, it was suggested that inflammatory factors and not hyperglycaemia upregulate HA levels (Nagy et al., 2019). |
| T87 | 1491-1681 | Sentence | denotes | Importantly, it was demonstrated that the expression of genes involved in the metabolism of HA was positively correlated to the process of adipocyte differentiation (Allingham et al., 2006). |
| T88 | 1682-1956 | Sentence | denotes | Recently, it was shown that HA exerts inhibitory effects in vitro regarding adipogenesis of 3T3-L1 cells, whereas downregulating HA prevented insulin resistance and NAFLD correlated to excess deposition of abdominal fat in HFD-feeding C57BL/6J mouse model (Ji et al., 2014). |
| T89 | 1957-2194 | Sentence | denotes | Moreover, treatment of HFD-fed obese mice with a stable hyaluronidase complex, where human recombinant hyaluronidase was Pegylated, was shown to decreases adiposity, adipose tissue inflammation and insulin resistance (Kang et al., 2013). |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T42 | 175-193 | Phenotype | denotes | insulin resistance | http://purl.obolibrary.org/obo/HP_0000855 |
| T43 | 349-355 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T44 | 1188-1203 | Phenotype | denotes | type-2 diabetes | http://purl.obolibrary.org/obo/HP_0005978 |
| T45 | 1824-1842 | Phenotype | denotes | insulin resistance | http://purl.obolibrary.org/obo/HP_0000855 |
| T46 | 2155-2173 | Phenotype | denotes | insulin resistance | http://purl.obolibrary.org/obo/HP_0000855 |
MyTest
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32640331-17823662-30720762 | 103-107 | 17823662 | denotes | 2007 |
| 32640331-23630254-30720763 | 210-214 | 23630254 | denotes | 2013 |
| 32640331-25926834-30720764 | 386-390 | 25926834 | denotes | 2015 |
| 32640331-28109952-30720765 | 433-437 | 28109952 | denotes | 2017 |
| 32640331-31226360-30720766 | 439-443 | 31226360 | denotes | 2019 |
| 32640331-28109952-30720768 | 647-651 | 28109952 | denotes | 2017 |
| 32640331-28109952-30720769 | 877-881 | 28109952 | denotes | 2017 |
| 32640331-31226360-30720770 | 883-887 | 31226360 | denotes | 2019 |
| 32640331-28109952-30720772 | 1097-1101 | 28109952 | denotes | 2017 |
| 32640331-11781369-30720773 | 1119-1123 | 11781369 | denotes | 2002 |
| 32640331-30196101-30720774 | 1484-1488 | 30196101 | denotes | 2019 |
| 32640331-16824481-30720775 | 1675-1679 | 16824481 | denotes | 2006 |
| 32640331-23349492-30720776 | 2188-2192 | 23349492 | denotes | 2013 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32640331-17823662-30720762 | 103-107 | 17823662 | denotes | 2007 |
| 32640331-23630254-30720763 | 210-214 | 23630254 | denotes | 2013 |
| 32640331-25926834-30720764 | 386-390 | 25926834 | denotes | 2015 |
| 32640331-28109952-30720765 | 433-437 | 28109952 | denotes | 2017 |
| 32640331-31226360-30720766 | 439-443 | 31226360 | denotes | 2019 |
| 32640331-28109952-30720768 | 647-651 | 28109952 | denotes | 2017 |
| 32640331-28109952-30720769 | 877-881 | 28109952 | denotes | 2017 |
| 32640331-31226360-30720770 | 883-887 | 31226360 | denotes | 2019 |
| 32640331-28109952-30720772 | 1097-1101 | 28109952 | denotes | 2017 |
| 32640331-11781369-30720773 | 1119-1123 | 11781369 | denotes | 2002 |
| 32640331-30196101-30720774 | 1484-1488 | 30196101 | denotes | 2019 |
| 32640331-16824481-30720775 | 1675-1679 | 16824481 | denotes | 2006 |
| 32640331-23349492-30720776 | 2188-2192 | 23349492 | denotes | 2013 |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T346 | 0-11 | PR:000015561 | denotes | Osteopontin |
| T347 | 16-19 | GO:0044420 | denotes | ECM |
| T348 | 20-32 | CHEBI:17089;BV_11;CHEBI:17089 | denotes | glycoprotein |
| T349 | 46-54 | GO:0046903 | denotes | secreted |
| T350 | 58-72 | UBERON:0001013 | denotes | adipose tissue |
| T351 | 73-84 | CL:0000235 | denotes | macrophages |
| T352 | 118-132 | UBERON:0001013 | denotes | adipose tissue |
| T353 | 175-182 | PR:000009054 | denotes | insulin |
| T354 | 235-248 | GO:0044420 | denotes | ECM component |
| T355 | 254-271 | CHEBI:18085;CHEBI:18085 | denotes | glycosaminoglycan |
| T356 | 577-585 | GO:0032940 | denotes | secreted |
| T357 | 614-620 | UBERON:0000479 | denotes | tissue |
| T358 | 967-987 | PR:000001155 | denotes | Toll-like receptor 4 |
| T359 | 989-993 | PR:000001155 | denotes | TLR4 |
| T360 | 995-997 | GO:0005883 | denotes | NF |
| T361 | 1023-1031 | GO:0065007 | denotes | regulate |
| T362 | 1045-1050 | SO:0000704 | denotes | genes |
| T363 | 1068-1074 | UBERON:0002405;CL:0000738 | denotes | immune |
| T364 | 1075-1080 | CL:0000738 | denotes | cells |
| T365 | 1177-1184 | UBERON:0000479 | denotes | tissues |
| T366 | 1274-1291 | GO:0042593 | denotes | glycaemic control |
| T367 | 1533-1543 | GO:0010467 | denotes | expression |
| T368 | 1547-1552 | SO:0000704 | denotes | genes |
| T369 | 1569-1579 | GO:0008152 | denotes | metabolism |
| T370 | 1580-1585 | GO:0009081 | denotes | of HA |
| T371 | 1630-1639 | CL:0000136 | denotes | adipocyte |
| T372 | 1758-1773 | GO:0060612 | denotes | adipogenesis of |
| T373 | 1824-1831 | PR:000009054 | denotes | insulin |
| T374 | 1888-1897 | UBERON:0007808 | denotes | abdominal |
| T375 | 1898-1901 | UBERON:0001013 | denotes | fat |
| T376 | 1909-1916 | GO:0007631 | denotes | feeding |
| T377 | 1926-1931 | NCBITaxon:10088 | denotes | mouse |
| T378 | 1984-1987 | GO:0007631 | denotes | fed |
| T379 | 1994-1998 | NCBITaxon:10088 | denotes | mice |
| T380 | 2027-2034 | GO:0032991 | denotes | complex |
| T381 | 2042-2047 | SP_6;NCBITaxon:9606 | denotes | human |
| T382 | 2123-2137 | UBERON:0001013 | denotes | adipose tissue |
| T383 | 2155-2162 | PR:000009054 | denotes | insulin |