PMC:7335494 / 16638-17523 JSONTXT

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T4","span":{"begin":578,"end":585},"obj":"https://glytoucan.org/Structures/Glycans/G15021LG"}],"text":"eoglycan (Nikitovic et al., 2014b), was shown to be overexpressed in ECM of subcutaneous fat of insulin resistant obese individuals. Lumican was demonstrated to alter the organization of collagen I, dysregulate adipogenesis and trigger oxidative stress, facilitating the pathology of obesity-associated insulin resistance (Guzman-Ruiz et al., 2020). A separate study showed that the effect of lumican was diet-dependent and correlated to adipose tissue inflammation. Indeed, the same authors suggest that the ECM protein lumican could pose a convergent point among the ECM, the glucose homeostasis and the metabolic syndrome (Wolff et al., 2019).\nOsteopontin, an ECM glycoprotein, excessively secreted by adipose tissue macrophages (Nomiyama et al., 2007) enhances adipose tissue inflammation and facilitates the onset of insulin resistance (Aouadi et al., 2013). Another important ECM"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T128","span":{"begin":69,"end":72},"obj":"Body_part"},{"id":"T129","span":{"begin":96,"end":103},"obj":"Body_part"},{"id":"T130","span":{"begin":133,"end":140},"obj":"Body_part"},{"id":"T131","span":{"begin":187,"end":195},"obj":"Body_part"},{"id":"T132","span":{"begin":303,"end":310},"obj":"Body_part"},{"id":"T133","span":{"begin":393,"end":400},"obj":"Body_part"},{"id":"T134","span":{"begin":438,"end":452},"obj":"Body_part"},{"id":"T135","span":{"begin":509,"end":512},"obj":"Body_part"},{"id":"T136","span":{"begin":513,"end":520},"obj":"Body_part"},{"id":"T137","span":{"begin":521,"end":528},"obj":"Body_part"},{"id":"T138","span":{"begin":569,"end":572},"obj":"Body_part"},{"id":"T139","span":{"begin":578,"end":585},"obj":"Body_part"},{"id":"T140","span":{"begin":663,"end":666},"obj":"Body_part"},{"id":"T141","span":{"begin":667,"end":679},"obj":"Body_part"},{"id":"T142","span":{"begin":705,"end":719},"obj":"Body_part"},{"id":"T143","span":{"begin":720,"end":731},"obj":"Body_part"},{"id":"T144","span":{"begin":765,"end":779},"obj":"Body_part"},{"id":"T145","span":{"begin":822,"end":829},"obj":"Body_part"},{"id":"T146","span":{"begin":882,"end":885},"obj":"Body_part"}],"attributes":[{"id":"A128","pred":"fma_id","subj":"T128","obj":"http://purl.org/sig/ont/fma/fma9672"},{"id":"A129","pred":"fma_id","subj":"T129","obj":"http://purl.org/sig/ont/fma/fma83365"},{"id":"A130","pred":"fma_id","subj":"T130","obj":"http://purl.org/sig/ont/fma/fma82827"},{"id":"A131","pred":"fma_id","subj":"T131","obj":"http://purl.org/sig/ont/fma/fma63891"},{"id":"A132","pred":"fma_id","subj":"T132","obj":"http://purl.org/sig/ont/fma/fma83365"},{"id":"A133","pred":"fma_id","subj":"T133","obj":"http://purl.org/sig/ont/fma/fma82827"},{"id":"A134","pred":"fma_id","subj":"T134","obj":"http://purl.org/sig/ont/fma/fma20110"},{"id":"A135","pred":"fma_id","subj":"T135","obj":"http://purl.org/sig/ont/fma/fma9672"},{"id":"A136","pred":"fma_id","subj":"T136","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A137","pred":"fma_id","subj":"T137","obj":"http://purl.org/sig/ont/fma/fma82827"},{"id":"A138","pred":"fma_id","subj":"T138","obj":"http://purl.org/sig/ont/fma/fma9672"},{"id":"A139","pred":"fma_id","subj":"T139","obj":"http://purl.org/sig/ont/fma/fma82743"},{"id":"A140","pred":"fma_id","subj":"T140","obj":"http://purl.org/sig/ont/fma/fma9672"},{"id":"A141","pred":"fma_id","subj":"T141","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A142","pred":"fma_id","subj":"T142","obj":"http://purl.org/sig/ont/fma/fma20110"},{"id":"A143","pred":"fma_id","subj":"T143","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A144","pred":"fma_id","subj":"T144","obj":"http://purl.org/sig/ont/fma/fma20110"},{"id":"A145","pred":"fma_id","subj":"T145","obj":"http://purl.org/sig/ont/fma/fma83365"},{"id":"A146","pred":"fma_id","subj":"T146","obj":"http://purl.org/sig/ont/fma/fma9672"}],"text":"eoglycan (Nikitovic et al., 2014b), was shown to be overexpressed in ECM of subcutaneous fat of insulin resistant obese individuals. Lumican was demonstrated to alter the organization of collagen I, dysregulate adipogenesis and trigger oxidative stress, facilitating the pathology of obesity-associated insulin resistance (Guzman-Ruiz et al., 2020). A separate study showed that the effect of lumican was diet-dependent and correlated to adipose tissue inflammation. Indeed, the same authors suggest that the ECM protein lumican could pose a convergent point among the ECM, the glucose homeostasis and the metabolic syndrome (Wolff et al., 2019).\nOsteopontin, an ECM glycoprotein, excessively secreted by adipose tissue macrophages (Nomiyama et al., 2007) enhances adipose tissue inflammation and facilitates the onset of insulin resistance (Aouadi et al., 2013). Another important ECM"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T37","span":{"begin":438,"end":452},"obj":"Body_part"},{"id":"T38","span":{"begin":446,"end":452},"obj":"Body_part"},{"id":"T39","span":{"begin":705,"end":719},"obj":"Body_part"},{"id":"T40","span":{"begin":713,"end":719},"obj":"Body_part"},{"id":"T41","span":{"begin":765,"end":779},"obj":"Body_part"},{"id":"T42","span":{"begin":773,"end":779},"obj":"Body_part"}],"attributes":[{"id":"A37","pred":"uberon_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"A38","pred":"uberon_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A39","pred":"uberon_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"A40","pred":"uberon_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A41","pred":"uberon_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"A42","pred":"uberon_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"eoglycan (Nikitovic et al., 2014b), was shown to be overexpressed in ECM of subcutaneous fat of insulin resistant obese individuals. Lumican was demonstrated to alter the organization of collagen I, dysregulate adipogenesis and trigger oxidative stress, facilitating the pathology of obesity-associated insulin resistance (Guzman-Ruiz et al., 2020). A separate study showed that the effect of lumican was diet-dependent and correlated to adipose tissue inflammation. Indeed, the same authors suggest that the ECM protein lumican could pose a convergent point among the ECM, the glucose homeostasis and the metabolic syndrome (Wolff et al., 2019).\nOsteopontin, an ECM glycoprotein, excessively secreted by adipose tissue macrophages (Nomiyama et al., 2007) enhances adipose tissue inflammation and facilitates the onset of insulin resistance (Aouadi et al., 2013). Another important ECM"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T64","span":{"begin":284,"end":291},"obj":"Disease"},{"id":"T65","span":{"begin":453,"end":465},"obj":"Disease"},{"id":"T66","span":{"begin":606,"end":624},"obj":"Disease"},{"id":"T67","span":{"begin":780,"end":792},"obj":"Disease"}],"attributes":[{"id":"A64","pred":"mondo_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/MONDO_0011122"},{"id":"A65","pred":"mondo_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A66","pred":"mondo_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/MONDO_0004955"},{"id":"A67","pred":"mondo_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"}],"text":"eoglycan (Nikitovic et al., 2014b), was shown to be overexpressed in ECM of subcutaneous fat of insulin resistant obese individuals. Lumican was demonstrated to alter the organization of collagen I, dysregulate adipogenesis and trigger oxidative stress, facilitating the pathology of obesity-associated insulin resistance (Guzman-Ruiz et al., 2020). A separate study showed that the effect of lumican was diet-dependent and correlated to adipose tissue inflammation. Indeed, the same authors suggest that the ECM protein lumican could pose a convergent point among the ECM, the glucose homeostasis and the metabolic syndrome (Wolff et al., 2019).\nOsteopontin, an ECM glycoprotein, excessively secreted by adipose tissue macrophages (Nomiyama et al., 2007) enhances adipose tissue inflammation and facilitates the onset of insulin resistance (Aouadi et al., 2013). Another important ECM"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T162","span":{"begin":89,"end":92},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T163","span":{"begin":96,"end":103},"obj":"http://purl.obolibrary.org/obo/PR_000009054"},{"id":"T164","span":{"begin":171,"end":183},"obj":"http://purl.obolibrary.org/obo/OBI_0000245"},{"id":"T165","span":{"begin":187,"end":195},"obj":"http://purl.obolibrary.org/obo/CHEBI_3815"},{"id":"T166","span":{"begin":303,"end":310},"obj":"http://purl.obolibrary.org/obo/PR_000009054"},{"id":"T167","span":{"begin":350,"end":351},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T168","span":{"begin":438,"end":452},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T169","span":{"begin":540,"end":541},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T170","span":{"begin":647,"end":658},"obj":"http://purl.obolibrary.org/obo/PR_000015561"},{"id":"T171","span":{"begin":705,"end":719},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T172","span":{"begin":765,"end":779},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T173","span":{"begin":822,"end":829},"obj":"http://purl.obolibrary.org/obo/PR_000009054"}],"text":"eoglycan (Nikitovic et al., 2014b), was shown to be overexpressed in ECM of subcutaneous fat of insulin resistant obese individuals. Lumican was demonstrated to alter the organization of collagen I, dysregulate adipogenesis and trigger oxidative stress, facilitating the pathology of obesity-associated insulin resistance (Guzman-Ruiz et al., 2020). A separate study showed that the effect of lumican was diet-dependent and correlated to adipose tissue inflammation. Indeed, the same authors suggest that the ECM protein lumican could pose a convergent point among the ECM, the glucose homeostasis and the metabolic syndrome (Wolff et al., 2019).\nOsteopontin, an ECM glycoprotein, excessively secreted by adipose tissue macrophages (Nomiyama et al., 2007) enhances adipose tissue inflammation and facilitates the onset of insulin resistance (Aouadi et al., 2013). Another important ECM"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T148","span":{"begin":96,"end":103},"obj":"Chemical"},{"id":"T149","span":{"begin":303,"end":310},"obj":"Chemical"},{"id":"T150","span":{"begin":513,"end":520},"obj":"Chemical"},{"id":"T151","span":{"begin":578,"end":585},"obj":"Chemical"},{"id":"T153","span":{"begin":667,"end":679},"obj":"Chemical"},{"id":"T154","span":{"begin":822,"end":829},"obj":"Chemical"}],"attributes":[{"id":"A148","pred":"chebi_id","subj":"T148","obj":"http://purl.obolibrary.org/obo/CHEBI_145810"},{"id":"A149","pred":"chebi_id","subj":"T149","obj":"http://purl.obolibrary.org/obo/CHEBI_145810"},{"id":"A150","pred":"chebi_id","subj":"T150","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A151","pred":"chebi_id","subj":"T151","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A152","pred":"chebi_id","subj":"T151","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A153","pred":"chebi_id","subj":"T153","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A154","pred":"chebi_id","subj":"T154","obj":"http://purl.obolibrary.org/obo/CHEBI_145810"}],"text":"eoglycan (Nikitovic et al., 2014b), was shown to be overexpressed in ECM of subcutaneous fat of insulin resistant obese individuals. Lumican was demonstrated to alter the organization of collagen I, dysregulate adipogenesis and trigger oxidative stress, facilitating the pathology of obesity-associated insulin resistance (Guzman-Ruiz et al., 2020). A separate study showed that the effect of lumican was diet-dependent and correlated to adipose tissue inflammation. Indeed, the same authors suggest that the ECM protein lumican could pose a convergent point among the ECM, the glucose homeostasis and the metabolic syndrome (Wolff et al., 2019).\nOsteopontin, an ECM glycoprotein, excessively secreted by adipose tissue macrophages (Nomiyama et al., 2007) enhances adipose tissue inflammation and facilitates the onset of insulin resistance (Aouadi et al., 2013). Another important ECM"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T81","span":{"begin":211,"end":223},"obj":"http://purl.obolibrary.org/obo/GO_0060612"},{"id":"T82","span":{"begin":211,"end":223},"obj":"http://purl.obolibrary.org/obo/GO_0045444"},{"id":"T83","span":{"begin":453,"end":465},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T84","span":{"begin":578,"end":597},"obj":"http://purl.obolibrary.org/obo/GO_0042593"},{"id":"T85","span":{"begin":586,"end":597},"obj":"http://purl.obolibrary.org/obo/GO_0042592"},{"id":"T86","span":{"begin":780,"end":792},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"eoglycan (Nikitovic et al., 2014b), was shown to be overexpressed in ECM of subcutaneous fat of insulin resistant obese individuals. Lumican was demonstrated to alter the organization of collagen I, dysregulate adipogenesis and trigger oxidative stress, facilitating the pathology of obesity-associated insulin resistance (Guzman-Ruiz et al., 2020). A separate study showed that the effect of lumican was diet-dependent and correlated to adipose tissue inflammation. Indeed, the same authors suggest that the ECM protein lumican could pose a convergent point among the ECM, the glucose homeostasis and the metabolic syndrome (Wolff et al., 2019).\nOsteopontin, an ECM glycoprotein, excessively secreted by adipose tissue macrophages (Nomiyama et al., 2007) enhances adipose tissue inflammation and facilitates the onset of insulin resistance (Aouadi et al., 2013). Another important ECM"}

{"project":"LitCovid-sentences","denotations":[{"id":"T76","span":{"begin":133,"end":349},"obj":"Sentence"},{"id":"T77","span":{"begin":350,"end":466},"obj":"Sentence"},{"id":"T78","span":{"begin":467,"end":646},"obj":"Sentence"},{"id":"T79","span":{"begin":647,"end":863},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"eoglycan (Nikitovic et al., 2014b), was shown to be overexpressed in ECM of subcutaneous fat of insulin resistant obese individuals. Lumican was demonstrated to alter the organization of collagen I, dysregulate adipogenesis and trigger oxidative stress, facilitating the pathology of obesity-associated insulin resistance (Guzman-Ruiz et al., 2020). A separate study showed that the effect of lumican was diet-dependent and correlated to adipose tissue inflammation. Indeed, the same authors suggest that the ECM protein lumican could pose a convergent point among the ECM, the glucose homeostasis and the metabolic syndrome (Wolff et al., 2019).\nOsteopontin, an ECM glycoprotein, excessively secreted by adipose tissue macrophages (Nomiyama et al., 2007) enhances adipose tissue inflammation and facilitates the onset of insulin resistance (Aouadi et al., 2013). Another important ECM"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T38","span":{"begin":96,"end":113},"obj":"Phenotype"},{"id":"T39","span":{"begin":236,"end":252},"obj":"Phenotype"},{"id":"T40","span":{"begin":284,"end":291},"obj":"Phenotype"},{"id":"T41","span":{"begin":303,"end":321},"obj":"Phenotype"},{"id":"T42","span":{"begin":822,"end":840},"obj":"Phenotype"}],"attributes":[{"id":"A38","pred":"hp_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/HP_0000855"},{"id":"A39","pred":"hp_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/HP_0025464"},{"id":"A40","pred":"hp_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/HP_0001513"},{"id":"A41","pred":"hp_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/HP_0000855"},{"id":"A42","pred":"hp_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/HP_0000855"}],"text":"eoglycan (Nikitovic et al., 2014b), was shown to be overexpressed in ECM of subcutaneous fat of insulin resistant obese individuals. Lumican was demonstrated to alter the organization of collagen I, dysregulate adipogenesis and trigger oxidative stress, facilitating the pathology of obesity-associated insulin resistance (Guzman-Ruiz et al., 2020). A separate study showed that the effect of lumican was diet-dependent and correlated to adipose tissue inflammation. Indeed, the same authors suggest that the ECM protein lumican could pose a convergent point among the ECM, the glucose homeostasis and the metabolic syndrome (Wolff et al., 2019).\nOsteopontin, an ECM glycoprotein, excessively secreted by adipose tissue macrophages (Nomiyama et al., 2007) enhances adipose tissue inflammation and facilitates the onset of insulin resistance (Aouadi et al., 2013). Another important ECM"}

{"project":"MyTest","denotations":[{"id":"32640331-32293066-30720760","span":{"begin":343,"end":347},"obj":"32293066"},{"id":"32640331-30409703-30720761","span":{"begin":640,"end":644},"obj":"30409703"},{"id":"32640331-17823662-30720762","span":{"begin":750,"end":754},"obj":"17823662"},{"id":"32640331-23630254-30720763","span":{"begin":857,"end":861},"obj":"23630254"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"eoglycan (Nikitovic et al., 2014b), was shown to be overexpressed in ECM of subcutaneous fat of insulin resistant obese individuals. Lumican was demonstrated to alter the organization of collagen I, dysregulate adipogenesis and trigger oxidative stress, facilitating the pathology of obesity-associated insulin resistance (Guzman-Ruiz et al., 2020). A separate study showed that the effect of lumican was diet-dependent and correlated to adipose tissue inflammation. Indeed, the same authors suggest that the ECM protein lumican could pose a convergent point among the ECM, the glucose homeostasis and the metabolic syndrome (Wolff et al., 2019).\nOsteopontin, an ECM glycoprotein, excessively secreted by adipose tissue macrophages (Nomiyama et al., 2007) enhances adipose tissue inflammation and facilitates the onset of insulin resistance (Aouadi et al., 2013). Another important ECM"}

{"project":"2_test","denotations":[{"id":"32640331-32293066-30720760","span":{"begin":343,"end":347},"obj":"32293066"},{"id":"32640331-30409703-30720761","span":{"begin":640,"end":644},"obj":"30409703"},{"id":"32640331-17823662-30720762","span":{"begin":750,"end":754},"obj":"17823662"},{"id":"32640331-23630254-30720763","span":{"begin":857,"end":861},"obj":"23630254"}],"text":"eoglycan (Nikitovic et al., 2014b), was shown to be overexpressed in ECM of subcutaneous fat of insulin resistant obese individuals. Lumican was demonstrated to alter the organization of collagen I, dysregulate adipogenesis and trigger oxidative stress, facilitating the pathology of obesity-associated insulin resistance (Guzman-Ruiz et al., 2020). A separate study showed that the effect of lumican was diet-dependent and correlated to adipose tissue inflammation. Indeed, the same authors suggest that the ECM protein lumican could pose a convergent point among the ECM, the glucose homeostasis and the metabolic syndrome (Wolff et al., 2019).\nOsteopontin, an ECM glycoprotein, excessively secreted by adipose tissue macrophages (Nomiyama et al., 2007) enhances adipose tissue inflammation and facilitates the onset of insulin resistance (Aouadi et al., 2013). Another important ECM"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T330","span":{"begin":52,"end":65},"obj":"GO:0010467"},{"id":"T331","span":{"begin":69,"end":72},"obj":"GO:0044420"},{"id":"T332","span":{"begin":76,"end":88},"obj":"UBERON:0002190"},{"id":"T333","span":{"begin":89,"end":92},"obj":"UBERON:0001013"},{"id":"T334","span":{"begin":96,"end":103},"obj":"PR:000009054"},{"id":"T335","span":{"begin":120,"end":131},"obj":"NCBITaxon:1"},{"id":"T336","span":{"begin":199,"end":210},"obj":"GO:0065007"},{"id":"T337","span":{"begin":211,"end":223},"obj":"GO:0060612"},{"id":"T338","span":{"begin":236,"end":245},"obj":"MOP:0000568"},{"id":"T339","span":{"begin":303,"end":310},"obj":"PR:000009054"},{"id":"T340","span":{"begin":438,"end":452},"obj":"UBERON:0001013"},{"id":"T341","span":{"begin":509,"end":512},"obj":"GO:0044420"},{"id":"T342","span":{"begin":569,"end":572},"obj":"GO:0044420"},{"id":"T343","span":{"begin":578,"end":585},"obj":"CHEBI:17234;CHEBI:17234;GO:0042593"},{"id":"T344","span":{"begin":586,"end":597},"obj":"GO:0042593"},{"id":"T345","span":{"begin":606,"end":615},"obj":"GO:0008152"},{"id":"T346","span":{"begin":647,"end":658},"obj":"PR:000015561"},{"id":"T347","span":{"begin":663,"end":666},"obj":"GO:0044420"},{"id":"T348","span":{"begin":667,"end":679},"obj":"CHEBI:17089;BV_11;CHEBI:17089"},{"id":"T349","span":{"begin":693,"end":701},"obj":"GO:0046903"},{"id":"T350","span":{"begin":705,"end":719},"obj":"UBERON:0001013"},{"id":"T351","span":{"begin":720,"end":731},"obj":"CL:0000235"},{"id":"T352","span":{"begin":765,"end":779},"obj":"UBERON:0001013"},{"id":"T353","span":{"begin":822,"end":829},"obj":"PR:000009054"}],"text":"eoglycan (Nikitovic et al., 2014b), was shown to be overexpressed in ECM of subcutaneous fat of insulin resistant obese individuals. Lumican was demonstrated to alter the organization of collagen I, dysregulate adipogenesis and trigger oxidative stress, facilitating the pathology of obesity-associated insulin resistance (Guzman-Ruiz et al., 2020). A separate study showed that the effect of lumican was diet-dependent and correlated to adipose tissue inflammation. Indeed, the same authors suggest that the ECM protein lumican could pose a convergent point among the ECM, the glucose homeostasis and the metabolic syndrome (Wolff et al., 2019).\nOsteopontin, an ECM glycoprotein, excessively secreted by adipose tissue macrophages (Nomiyama et al., 2007) enhances adipose tissue inflammation and facilitates the onset of insulin resistance (Aouadi et al., 2013). Another important ECM"}