PMC:7335494 / 10373-11385 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7335494","sourcedb":"PMC","sourceid":"7335494","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7335494","text":"Physiologically, adipose tissue resident macrophages, displaying both a pro-inflammatory and anti-inflammatory phenotype, are involved in several housekeeping processes (differentiation of preadipocytes, abstraction of necrotic and apoptotic cells, angiogenesis adjustment, etc). The expansion of adipose tissue, due to long-lasting overnutrition, induces prolonged hypoxia (the activation of HIF-1α), and consequent inflammation as monocytes infiltrate in the hypoxic region and become pro-inflammatory macrophages, process during which TNF-α, monocyte chemotactic protein (MCP-1), IL-6, MMPs, IL-8, VEGF are released. Further, the inflammatory response elicited by dysfunctional adipocytes, hypoxia, adipocyte expansion, and impaired fatty acids storage is accelerated by formation of reactive species, either oxygen (ROS) or nitrogen (RNS) (Crewe et al., 2017; Demaria et al., 2014; Fujisaka et al., 2013; Margina et al., 2012; Pasarica et al., 2009; Paun et al., 2015; Schipper et al., 2012; Trayhurn, 2014).","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T42","span":{"begin":17,"end":31},"obj":"Body_part"},{"id":"T43","span":{"begin":41,"end":52},"obj":"Body_part"},{"id":"T44","span":{"begin":242,"end":247},"obj":"Body_part"},{"id":"T45","span":{"begin":297,"end":311},"obj":"Body_part"},{"id":"T46","span":{"begin":433,"end":442},"obj":"Body_part"},{"id":"T47","span":{"begin":504,"end":515},"obj":"Body_part"},{"id":"T48","span":{"begin":545,"end":553},"obj":"Body_part"},{"id":"T49","span":{"begin":566,"end":573},"obj":"Body_part"},{"id":"T50","span":{"begin":681,"end":691},"obj":"Body_part"},{"id":"T51","span":{"begin":702,"end":711},"obj":"Body_part"},{"id":"T52","span":{"begin":736,"end":747},"obj":"Body_part"}],"attributes":[{"id":"A42","pred":"fma_id","subj":"T42","obj":"http://purl.org/sig/ont/fma/fma20110"},{"id":"A43","pred":"fma_id","subj":"T43","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A44","pred":"fma_id","subj":"T44","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A45","pred":"fma_id","subj":"T45","obj":"http://purl.org/sig/ont/fma/fma20110"},{"id":"A46","pred":"fma_id","subj":"T46","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A47","pred":"fma_id","subj":"T47","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A48","pred":"fma_id","subj":"T48","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A49","pred":"fma_id","subj":"T49","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A50","pred":"fma_id","subj":"T50","obj":"http://purl.org/sig/ont/fma/fma63880"},{"id":"A51","pred":"fma_id","subj":"T51","obj":"http://purl.org/sig/ont/fma/fma63880"},{"id":"A52","pred":"fma_id","subj":"T52","obj":"http://purl.org/sig/ont/fma/fma82738"},{"subj":"T42","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T43","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T44","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T50","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T51","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T52","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T9","span":{"begin":17,"end":31},"obj":"Body_part"},{"id":"T10","span":{"begin":25,"end":31},"obj":"Body_part"},{"id":"T11","span":{"begin":297,"end":311},"obj":"Body_part"},{"id":"T12","span":{"begin":305,"end":311},"obj":"Body_part"}],"attributes":[{"id":"A9","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"A12","pred":"uberon_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T42","span":{"begin":333,"end":346},"obj":"Disease"},{"id":"T43","span":{"begin":417,"end":429},"obj":"Disease"},{"id":"T44","span":{"begin":838,"end":841},"obj":"Disease"}],"attributes":[{"id":"A42","pred":"mondo_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/MONDO_0003916"},{"id":"A43","pred":"mondo_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A44","pred":"mondo_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/MONDO_0009821"},{"id":"A45","pred":"mondo_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/MONDO_0019105"},{"subj":"T42","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T43","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T44","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T86","span":{"begin":17,"end":31},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T87","span":{"begin":70,"end":71},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T88","span":{"begin":242,"end":247},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T89","span":{"begin":297,"end":311},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T90","span":{"begin":379,"end":389},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T91","span":{"begin":433,"end":442},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T92","span":{"begin":545,"end":553},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T93","span":{"begin":595,"end":599},"obj":"http://purl.obolibrary.org/obo/CLO_0053704"},{"id":"T94","span":{"begin":681,"end":691},"obj":"http://purl.obolibrary.org/obo/CL_0000136"},{"id":"T95","span":{"begin":702,"end":711},"obj":"http://purl.obolibrary.org/obo/CL_0000136"}],"attributes":[{"subj":"T86","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T87","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T88","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T89","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T90","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T91","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T92","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T93","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T94","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T95","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T89","span":{"begin":566,"end":573},"obj":"Chemical"},{"id":"T90","span":{"begin":575,"end":578},"obj":"Chemical"},{"id":"T92","span":{"begin":583,"end":585},"obj":"Chemical"},{"id":"T94","span":{"begin":595,"end":597},"obj":"Chemical"},{"id":"T96","span":{"begin":736,"end":747},"obj":"Chemical"},{"id":"T97","span":{"begin":742,"end":747},"obj":"Chemical"},{"id":"T98","span":{"begin":812,"end":818},"obj":"Chemical"},{"id":"T99","span":{"begin":820,"end":823},"obj":"Chemical"},{"id":"T100","span":{"begin":828,"end":836},"obj":"Chemical"},{"id":"T101","span":{"begin":838,"end":841},"obj":"Chemical"}],"attributes":[{"id":"A89","pred":"chebi_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A90","pred":"chebi_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/CHEBI_132592"},{"id":"A91","pred":"chebi_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/CHEBI_50099"},{"id":"A92","pred":"chebi_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A93","pred":"chebi_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A94","pred":"chebi_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A95","pred":"chebi_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A96","pred":"chebi_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/CHEBI_35366"},{"id":"A97","pred":"chebi_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A98","pred":"chebi_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/CHEBI_25805"},{"id":"A99","pred":"chebi_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/CHEBI_26523"},{"id":"A100","pred":"chebi_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/CHEBI_25555"},{"id":"A101","pred":"chebi_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/CHEBI_33697"},{"id":"A102","pred":"chebi_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/CHEBI_62764"},{"subj":"T89","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T90","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T92","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T94","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T96","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T97","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T98","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T99","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T100","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T101","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T51","span":{"begin":249,"end":261},"obj":"http://purl.obolibrary.org/obo/GO_0001525"},{"id":"T52","span":{"begin":417,"end":429},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T53","span":{"begin":633,"end":654},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T54","span":{"begin":748,"end":755},"obj":"http://purl.obolibrary.org/obo/GO_0051235"},{"id":"T55","span":{"begin":774,"end":783},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"attributes":[{"subj":"T51","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T52","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T53","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T54","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T55","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T47","span":{"begin":0,"end":279},"obj":"Sentence"},{"id":"T48","span":{"begin":280,"end":619},"obj":"Sentence"},{"id":"T49","span":{"begin":620,"end":1012},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T47","pred":"source","obj":"LitCovid-sentences"},{"subj":"T48","pred":"source","obj":"LitCovid-sentences"},{"subj":"T49","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T24","span":{"begin":366,"end":373},"obj":"Phenotype"},{"id":"T25","span":{"begin":693,"end":700},"obj":"Phenotype"}],"attributes":[{"id":"A24","pred":"hp_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/HP_0012418"},{"id":"A25","pred":"hp_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/HP_0012418"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"MyTest","denotations":[{"id":"32640331-28045400-30720734","span":{"begin":858,"end":862},"obj":"28045400"},{"id":"32640331-25499914-30720735","span":{"begin":880,"end":884},"obj":"25499914"},{"id":"32640331-23494472-30720736","span":{"begin":903,"end":907},"obj":"23494472"},{"id":"32640331-22606013-30720737","span":{"begin":925,"end":929},"obj":"22606013"},{"id":"32640331-19074987-30720738","span":{"begin":948,"end":952},"obj":"19074987"},{"id":"32640331-26610855-30720739","span":{"begin":967,"end":971},"obj":"26610855"},{"id":"32640331-24819450-30720740","span":{"begin":1006,"end":1010},"obj":"24819450"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"32640331-28045400-30720734","pred":"source","obj":"MyTest"},{"subj":"32640331-25499914-30720735","pred":"source","obj":"MyTest"},{"subj":"32640331-23494472-30720736","pred":"source","obj":"MyTest"},{"subj":"32640331-22606013-30720737","pred":"source","obj":"MyTest"},{"subj":"32640331-19074987-30720738","pred":"source","obj":"MyTest"},{"subj":"32640331-26610855-30720739","pred":"source","obj":"MyTest"},{"subj":"32640331-24819450-30720740","pred":"source","obj":"MyTest"}]},{"project":"2_test","denotations":[{"id":"32640331-28045400-30720734","span":{"begin":858,"end":862},"obj":"28045400"},{"id":"32640331-25499914-30720735","span":{"begin":880,"end":884},"obj":"25499914"},{"id":"32640331-23494472-30720736","span":{"begin":903,"end":907},"obj":"23494472"},{"id":"32640331-22606013-30720737","span":{"begin":925,"end":929},"obj":"22606013"},{"id":"32640331-19074987-30720738","span":{"begin":948,"end":952},"obj":"19074987"},{"id":"32640331-26610855-30720739","span":{"begin":967,"end":971},"obj":"26610855"},{"id":"32640331-24819450-30720740","span":{"begin":1006,"end":1010},"obj":"24819450"}],"attributes":[{"subj":"32640331-28045400-30720734","pred":"source","obj":"2_test"},{"subj":"32640331-25499914-30720735","pred":"source","obj":"2_test"},{"subj":"32640331-23494472-30720736","pred":"source","obj":"2_test"},{"subj":"32640331-22606013-30720737","pred":"source","obj":"2_test"},{"subj":"32640331-19074987-30720738","pred":"source","obj":"2_test"},{"subj":"32640331-26610855-30720739","pred":"source","obj":"2_test"},{"subj":"32640331-24819450-30720740","pred":"source","obj":"2_test"}]},{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T200","span":{"begin":17,"end":31},"obj":"UBERON:0001013"},{"id":"T201","span":{"begin":41,"end":52},"obj":"CL:0000864"},{"id":"T202","span":{"begin":189,"end":202},"obj":"CL:0002334"},{"id":"T203","span":{"begin":232,"end":247},"obj":"CL:0000445"},{"id":"T204","span":{"begin":249,"end":261},"obj":"GO:0001525"},{"id":"T205","span":{"begin":297,"end":311},"obj":"UBERON:0001013"},{"id":"T206","span":{"begin":393,"end":399},"obj":"PR:000008555"},{"id":"T207","span":{"begin":433,"end":442},"obj":"CL:0000576"},{"id":"T208","span":{"begin":504,"end":515},"obj":"CL:0000863"},{"id":"T209","span":{"begin":538,"end":543},"obj":"PR:000000134"},{"id":"T210","span":{"begin":545,"end":553},"obj":"CL:0000576"},{"id":"T211","span":{"begin":575,"end":580},"obj":"PR:000002122"},{"id":"T212","span":{"begin":595,"end":599},"obj":"PR:000001395"},{"id":"T213","span":{"begin":681,"end":691},"obj":"CL:0000136"},{"id":"T214","span":{"begin":702,"end":711},"obj":"CL:0000136"},{"id":"T215","span":{"begin":736,"end":747},"obj":"CHEBI:35366;CHEBI:35366"},{"id":"T216","span":{"begin":787,"end":803},"obj":"CHEBI:26523;CHEBI:26523"}],"attributes":[{"subj":"T200","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T201","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T202","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T203","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T204","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T205","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T206","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T207","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T208","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T209","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T210","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T211","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T212","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T213","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T214","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T215","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T216","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#e4ec93","default":true},{"id":"LitCovid-PD-UBERON","color":"#da93ec"},{"id":"LitCovid-PD-MONDO","color":"#93ecbf"},{"id":"LitCovid-PD-CLO","color":"#eca593"},{"id":"LitCovid-PD-CHEBI","color":"#939aec"},{"id":"LitCovid-PD-GO-BP","color":"#b4ec93"},{"id":"LitCovid-sentences","color":"#ec93ce"},{"id":"LitCovid-PD-HP","color":"#93e8ec"},{"id":"MyTest","color":"#ecd693"},{"id":"2_test","color":"#bc93ec"},{"id":"LitCovid-PMC-OGER-BB","color":"#93eca2"}]}]}}