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PMC:7326463 / 3296-5030 JSONTXT

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LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T36 721-724 Disease denotes MEC http://purl.obolibrary.org/obo/MONDO_0003036|http://purl.obolibrary.org/obo/MONDO_0006860
T38 752-755 Disease denotes MEC http://purl.obolibrary.org/obo/MONDO_0003036|http://purl.obolibrary.org/obo/MONDO_0006860
T40 851-854 Disease denotes MEC http://purl.obolibrary.org/obo/MONDO_0003036|http://purl.obolibrary.org/obo/MONDO_0006860

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T24 194-195 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T25 253-254 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T26 265-269 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T27 367-368 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T28 499-500 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T29 675-676 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T30 709-710 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T31 794-802 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T32 898-899 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T33 1151-1153 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T34 1162-1164 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T35 1228-1229 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T36 1286-1287 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T37 1347-1354 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T38 1395-1396 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T39 1464-1466 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T40 1482-1483 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T41 1506-1514 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T42 1655-1656 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T43 1695-1696 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T44 1731-1733 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T17 81-93 Chemical denotes voriconazole http://purl.obolibrary.org/obo/CHEBI_10023
T18 162-173 Chemical denotes caspofungin http://purl.obolibrary.org/obo/CHEBI_474180
T19 240-254 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T20 354-368 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T21 373-384 Chemical denotes caspofungin http://purl.obolibrary.org/obo/CHEBI_474180
T22 390-393 Chemical denotes MIC http://purl.obolibrary.org/obo/CHEBI_59059
T23 402-406 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T24 658-661 Chemical denotes MIC http://purl.obolibrary.org/obo/CHEBI_59059
T25 662-676 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T26 692-695 Chemical denotes MIC http://purl.obolibrary.org/obo/CHEBI_59059
T27 696-710 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T28 725-736 Chemical denotes caspofungin http://purl.obolibrary.org/obo/CHEBI_474180
T29 756-767 Chemical denotes caspofungin http://purl.obolibrary.org/obo/CHEBI_474180
T30 807-818 Chemical denotes caspofungin http://purl.obolibrary.org/obo/CHEBI_474180
T31 871-874 Chemical denotes MIC http://purl.obolibrary.org/obo/CHEBI_59059
T32 885-899 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T33 1074-1085 Chemical denotes caspofungin http://purl.obolibrary.org/obo/CHEBI_474180
T34 1538-1548 Chemical denotes antibiotic http://purl.obolibrary.org/obo/CHEBI_33281
T35 1682-1696 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T3 1333-1346 GlycoEpitope denotes Galactomannan http://www.glycoepitope.jp/epitopes/EP0510

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
143 752-755 Gene denotes MEC Gene:56477
144 721-724 Gene denotes MEC Gene:56477
145 851-854 Gene denotes MEC Gene:56477
146 46-53 Species denotes patient Tax:9606
147 1028-1035 Species denotes patient Tax:9606
148 1181-1202 Species denotes Fusarium proliferatum Tax:948311
149 1564-1571 Species denotes patient Tax:9606
150 81-93 Chemical denotes voriconazole MESH:D065819
151 162-173 Chemical denotes caspofungin MESH:D000077336
152 240-254 Chemical denotes amphotericin B MESH:D000666
153 354-368 Chemical denotes amphotericin B MESH:D000666
154 373-384 Chemical denotes caspofungin MESH:D000077336
155 662-676 Chemical denotes amphotericin B MESH:D000666
156 696-710 Chemical denotes amphotericin B MESH:D000666
157 725-736 Chemical denotes caspofungin MESH:D000077336
158 756-767 Chemical denotes caspofungin MESH:D000077336
159 807-818 Chemical denotes caspofungin MESH:D000077336
160 885-899 Chemical denotes amphotericin B MESH:D000666
161 1074-1085 Chemical denotes caspofungin MESH:D000077336
162 1333-1346 Chemical denotes Galactomannan MESH:C012990
163 1682-1696 Chemical denotes amphotericin B MESH:D000666

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T27 0-261 Sentence denotes Considering the very serious condition of the patient, and despite the fact that voriconazole is suggested as first-line treatment (alone or in combination) [3], caspofungin was added, assuming a potential synergistic effect with liposomal amphotericin B [4,5].
T28 262-385 Sentence denotes To test this hypothesis in vitro, we used the checkerboard method to assess combinations of amphotericin B and caspofungin.
T29 386-542 Sentence denotes The MIC of each drug alone and the combinations of the two were determined concomitantly on the same plate using a method adapted from the EUCAST procedure.
T30 543-775 Sentence denotes Interaction was determined by calculating the fractional inhibitory concentration index (FICI) as follows: FICI = (MIC amphotericin B in combination/MIC amphotericin B alone) + (MEC caspofungin in combination/MEC caspofungin alone).
T31 776-866 Sentence denotes Results showed no activity for caspofungin either alone or in combination (MEC > 32 mg/L).
T32 867-942 Sentence denotes The MIC value for amphotericin B was 1 mg/L either alone or in combination.
T33 943-1010 Sentence denotes The FICI value was equal to 2, which is indicative of indifference.
T34 1011-1108 Sentence denotes Moreover, as the patient's condition was beginning to improve, caspofungin was stopped on day 29.
T35 1109-1203 Sentence denotes Three other BALs performed on day 15, day 22 and day 27 still grew with Fusarium proliferatum.
T36 1204-1332 Sentence denotes Importantly, we noticed a gradual increase in the delay of culture positivity and a decrease in the number of colonies obtained.
T37 1333-1426 Sentence denotes Galactomannan testing became negative, all of which indicated a reduction of the fungal load.
T38 1427-1559 Sentence denotes The BALs performed on day 15 and day 27 also grew with a significant amount of bacteria, which led to specific antibiotic treatment.
T39 1560-1608 Sentence denotes The patient's general condition slowly improved.
T40 1609-1671 Sentence denotes He was extubated on day 30 then discharged to a post-ICU area.
T41 1672-1734 Sentence denotes Liposomal amphotericin B administration was stopped on day 35.

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T57 81-93 CHEBI:10023;CHEBI:10023 denotes voriconazole
T58 240-254 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T59 354-368 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T60 402-406 CHEBI:23888;CHEBI:23888 denotes drug
T61 662-676 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T62 696-710 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T63 885-899 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T64 1171-1175 GO:0040007 denotes grew
T65 1181-1202 NCBITaxon:948311 denotes Fusarium proliferatum
T66 1333-1346 CHEBI:27680;CHEBI:27680 denotes Galactomannan
T67 1472-1476 GO:0040007 denotes grew
T68 1506-1514 NCBITaxon:2 denotes bacteria
T69 1538-1548 CHEBI:33282;CHEBI:33282 denotes antibiotic
T70 1672-1681 GO:0005764 denotes Liposomal
T71 1682-1696 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T971 81-93 CHEBI:10023;CHEBI:10023 denotes voriconazole
T98852 240-254 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T82144 354-368 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T89447 402-406 CHEBI:23888;CHEBI:23888 denotes drug
T33586 662-676 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T76702 696-710 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T42104 885-899 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T33396 1171-1175 GO:0040007 denotes grew
T78053 1181-1202 NCBITaxon:948311 denotes Fusarium proliferatum
T89176 1333-1346 CHEBI:27680;CHEBI:27680 denotes Galactomannan
T7633 1472-1476 GO:0040007 denotes grew
T99376 1506-1514 NCBITaxon:2 denotes bacteria
T48876 1538-1548 CHEBI:33282;CHEBI:33282 denotes antibiotic
T84617 1672-1681 GO:0005764 denotes Liposomal
T4681 1682-1696 CHEBI:2682;CHEBI:2682 denotes amphotericin B