PMC:7324763 / 6604-8150 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7324763","sourcedb":"PMC","sourceid":"7324763","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7324763","text":"Like SARS-CoV-1 and MERS-CoV, SARS-CoV-2 is thought to have originated in bats through an unknown intermediary host (43). At the time of writing, the number of global infections is estimated to be over 5,000,000 with over 340,000 deaths (44) and the R0 is roughly 2.2 (45). Like other diseases caused by infectious CoVs, most patients present with flu-like symptoms including fever, cough, and lethargy, with the development of pneumonia and ARDS often proving fatal (46). Furthermore, patients with underlying conditions are at risk for further complications if infected with COVID-19, such as those with cardiovascular disease (47). SARS-CoV-2 has been posthumously detected in not only the lungs, but the pharynx, heart, liver, brain, and kidneys (48). Transmission of SARS-CoV-2 is thought to mainly occur through direct contact/inhalation of respiratory droplets and aerosols from infected carriers, but indirect transmission by fomites has also been reported, although less efficient (49, 50). SARS-CoV-2 viral entrance is thought to be mediated by binding of the S protein to the ACE2 receptor (51, 52), although this is still under debate (53). While direct cytopathic effects are thought to play a major role in CoV pathology, studies have suggested that a dysregulated immune response resulting in pathological inflammation is also partly responsible (19). With the current pandemic already surpassing the previous CoV outbreaks (54), rapid deployment of novel approaches to understanding and treating coronavirus infections are 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