PMC:7321036 / 50717-51268 JSONTXT

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T253","span":{"begin":94,"end":103},"obj":"Disease"},{"id":"T254","span":{"begin":303,"end":318},"obj":"Disease"},{"id":"T255","span":{"begin":309,"end":318},"obj":"Disease"},{"id":"T256","span":{"begin":410,"end":418},"obj":"Disease"},{"id":"T257","span":{"begin":421,"end":430},"obj":"Disease"}],"attributes":[{"id":"A253","pred":"mondo_id","subj":"T253","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A254","pred":"mondo_id","subj":"T254","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A255","pred":"mondo_id","subj":"T255","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A256","pred":"mondo_id","subj":"T256","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A257","pred":"mondo_id","subj":"T257","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Changes in phosphorylation reflect altered activities of kinases that are hijacked during the infection. Based on changes in phosphorylation of their annotated substrates, we estimated changes in activity of 97 of the 518 human kinases. The changes in kinase activity offer insights into the biology of viral infection. Kinases represent ideal drug targets; here, we identified kinases and pathways altered by SARS-CoV-2 infection that can be targeted by 87 FDA-approved drugs and compounds in clinical trials or in preclinical development (Table S8)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T676","span":{"begin":43,"end":53},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T677","span":{"begin":196,"end":204},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T678","span":{"begin":222,"end":227},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T679","span":{"begin":259,"end":267},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"Changes in phosphorylation reflect altered activities of kinases that are hijacked during the infection. Based on changes in phosphorylation of their annotated substrates, we estimated changes in activity of 97 of the 518 human kinases. The changes in kinase activity offer insights into the biology of viral infection. Kinases represent ideal drug targets; here, we identified kinases and pathways altered by SARS-CoV-2 infection that can be targeted by 87 FDA-approved drugs and compounds in clinical trials or in preclinical development (Table S8)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T19979","span":{"begin":344,"end":348},"obj":"Chemical"},{"id":"T28590","span":{"begin":471,"end":476},"obj":"Chemical"},{"id":"T71374","span":{"begin":547,"end":549},"obj":"Chemical"}],"attributes":[{"id":"A95523","pred":"chebi_id","subj":"T19979","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A87444","pred":"chebi_id","subj":"T28590","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A96031","pred":"chebi_id","subj":"T71374","obj":"http://purl.obolibrary.org/obo/CHEBI_29385"}],"text":"Changes in phosphorylation reflect altered activities of kinases that are hijacked during the infection. Based on changes in phosphorylation of their annotated substrates, we estimated changes in activity of 97 of the 518 human kinases. The changes in kinase activity offer insights into the biology of viral infection. Kinases represent ideal drug targets; here, we identified kinases and pathways altered by SARS-CoV-2 infection that can be targeted by 87 FDA-approved drugs and compounds in clinical trials or in preclinical development (Table S8)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T359","span":{"begin":11,"end":26},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T360","span":{"begin":125,"end":140},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T361","span":{"begin":252,"end":267},"obj":"http://purl.obolibrary.org/obo/GO_0016301"},{"id":"T362","span":{"begin":303,"end":318},"obj":"http://purl.obolibrary.org/obo/GO_0016032"}],"text":"Changes in phosphorylation reflect altered activities of kinases that are hijacked during the infection. Based on changes in phosphorylation of their annotated substrates, we estimated changes in activity of 97 of the 518 human kinases. The changes in kinase activity offer insights into the biology of viral infection. Kinases represent ideal drug targets; here, we identified kinases and pathways altered by SARS-CoV-2 infection that can be targeted by 87 FDA-approved drugs and compounds in clinical trials or in preclinical development (Table S8)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1124","span":{"begin":222,"end":227},"obj":"Species"},{"id":"1125","span":{"begin":94,"end":103},"obj":"Disease"},{"id":"1126","span":{"begin":303,"end":318},"obj":"Disease"},{"id":"1127","span":{"begin":410,"end":430},"obj":"Disease"}],"attributes":[{"id":"A1124","pred":"tao:has_database_id","subj":"1124","obj":"Tax:9606"},{"id":"A1125","pred":"tao:has_database_id","subj":"1125","obj":"MESH:D007239"},{"id":"A1126","pred":"tao:has_database_id","subj":"1126","obj":"MESH:D001102"},{"id":"A1127","pred":"tao:has_database_id","subj":"1127","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Changes in phosphorylation reflect altered activities of kinases that are hijacked during the infection. Based on changes in phosphorylation of their annotated substrates, we estimated changes in activity of 97 of the 518 human kinases. The changes in kinase activity offer insights into the biology of viral infection. Kinases represent ideal drug targets; here, we identified kinases and pathways altered by SARS-CoV-2 infection that can be targeted by 87 FDA-approved drugs and compounds in clinical trials or in preclinical development (Table S8)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T334","span":{"begin":0,"end":104},"obj":"Sentence"},{"id":"T335","span":{"begin":105,"end":236},"obj":"Sentence"},{"id":"T336","span":{"begin":237,"end":319},"obj":"Sentence"},{"id":"T337","span":{"begin":320,"end":551},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Changes in phosphorylation reflect altered activities of kinases that are hijacked during the infection. Based on changes in phosphorylation of their annotated substrates, we estimated changes in activity of 97 of the 518 human kinases. The changes in kinase activity offer insights into the biology of viral infection. Kinases represent ideal drug targets; here, we identified kinases and pathways altered by SARS-CoV-2 infection that can be targeted by 87 FDA-approved drugs and compounds in clinical trials or in preclinical development (Table S8)."}