PMC:7321036 / 20113-20957 JSONTXT

Annnotations TAB JSON ListView MergeView

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7321036","sourcedb":"PMC","sourceid":"7321036","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7321036","text":"Phosphorylation on SARS-CoV-2 Virus-Human Interacting Proteins\nThe SARS-CoV-2 virus-host protein-protein interaction map (Gordon et al., 2020) found 332 human proteins interacting with 27 (26 wild-type and 1 mutant) viral proteins. Here we found 40 of 332 proteins significantly differentially phosphorylated across at least two time points (adjusted p \u003c 0.05 and absolute value of log2 fold change [abs(log2FC)] \u003e 1). Viral proteins are shown as red diamonds. Interacting human proteins are shown as gray circles. PHs emanate from human proteins, colored by their log2 fold change compared with uninfected control samples (red, increase; blue, decrease) at each time point (0, 2, 4, 8, 12, and 24 h after infection) in a clockwise fashion. An interactive version of phosphorylation data can be found at https://kroganlab.ucsf.edu/network-maps.","divisions":[{"label":"p","span":{"begin":0,"end":62}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T153","span":{"begin":54,"end":62},"obj":"Body_part"},{"id":"T154","span":{"begin":89,"end":96},"obj":"Body_part"},{"id":"T155","span":{"begin":97,"end":104},"obj":"Body_part"},{"id":"T156","span":{"begin":117,"end":120},"obj":"Body_part"},{"id":"T157","span":{"begin":159,"end":167},"obj":"Body_part"},{"id":"T158","span":{"begin":222,"end":230},"obj":"Body_part"},{"id":"T159","span":{"begin":256,"end":264},"obj":"Body_part"},{"id":"T160","span":{"begin":425,"end":433},"obj":"Body_part"},{"id":"T161","span":{"begin":479,"end":487},"obj":"Body_part"},{"id":"T162","span":{"begin":538,"end":546},"obj":"Body_part"}],"attributes":[{"id":"A153","pred":"fma_id","subj":"T153","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A154","pred":"fma_id","subj":"T154","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A155","pred":"fma_id","subj":"T155","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A156","pred":"fma_id","subj":"T156","obj":"http://purl.org/sig/ont/fma/fma67847"},{"id":"A157","pred":"fma_id","subj":"T157","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A158","pred":"fma_id","subj":"T158","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A159","pred":"fma_id","subj":"T159","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A160","pred":"fma_id","subj":"T160","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A161","pred":"fma_id","subj":"T161","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A162","pred":"fma_id","subj":"T162","obj":"http://purl.org/sig/ont/fma/fma67257"},{"subj":"T153","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T154","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T155","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T156","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T157","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T158","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T159","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T160","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T161","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T162","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T104","span":{"begin":19,"end":27},"obj":"Disease"},{"id":"T105","span":{"begin":67,"end":75},"obj":"Disease"},{"id":"T106","span":{"begin":706,"end":715},"obj":"Disease"}],"attributes":[{"id":"A104","pred":"mondo_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A105","pred":"mondo_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A106","pred":"mondo_id","subj":"T106","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"subj":"T104","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T105","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T106","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T76801","span":{"begin":30,"end":35},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T10288","span":{"begin":36,"end":41},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T39350","span":{"begin":78,"end":83},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T96781","span":{"begin":153,"end":167},"obj":"http://purl.obolibrary.org/obo/PR_000029067"},{"id":"T23709","span":{"begin":185,"end":187},"obj":"http://purl.obolibrary.org/obo/CLO_0050509"},{"id":"T92566","span":{"begin":473,"end":487},"obj":"http://purl.obolibrary.org/obo/PR_000029067"},{"id":"T70112","span":{"begin":532,"end":546},"obj":"http://purl.obolibrary.org/obo/PR_000029067"},{"id":"T31688","span":{"begin":681,"end":685},"obj":"http://purl.obolibrary.org/obo/CLO_0001382"},{"id":"T99883","span":{"begin":720,"end":721},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T76801","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T10288","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T39350","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T96781","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T23709","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T92566","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T70112","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T31688","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T99883","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T133","span":{"begin":89,"end":96},"obj":"Chemical"},{"id":"T134","span":{"begin":97,"end":104},"obj":"Chemical"},{"id":"T135","span":{"begin":159,"end":167},"obj":"Chemical"},{"id":"T136","span":{"begin":222,"end":230},"obj":"Chemical"},{"id":"T137","span":{"begin":256,"end":264},"obj":"Chemical"},{"id":"T138","span":{"begin":425,"end":433},"obj":"Chemical"},{"id":"T139","span":{"begin":479,"end":487},"obj":"Chemical"},{"id":"T140","span":{"begin":538,"end":546},"obj":"Chemical"}],"attributes":[{"id":"A133","pred":"chebi_id","subj":"T133","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A134","pred":"chebi_id","subj":"T134","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A135","pred":"chebi_id","subj":"T135","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A136","pred":"chebi_id","subj":"T136","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A137","pred":"chebi_id","subj":"T137","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A138","pred":"chebi_id","subj":"T138","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A139","pred":"chebi_id","subj":"T139","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A140","pred":"chebi_id","subj":"T140","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"subj":"T133","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T134","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T135","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T136","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T137","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T138","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T139","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T140","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T109","span":{"begin":0,"end":15},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T110","span":{"begin":767,"end":782},"obj":"http://purl.obolibrary.org/obo/GO_0016310"}],"attributes":[{"subj":"T109","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T110","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"312","span":{"begin":19,"end":29},"obj":"Species"},{"id":"313","span":{"begin":36,"end":41},"obj":"Species"},{"id":"319","span":{"begin":67,"end":77},"obj":"Species"},{"id":"320","span":{"begin":153,"end":158},"obj":"Species"},{"id":"321","span":{"begin":473,"end":478},"obj":"Species"},{"id":"322","span":{"begin":532,"end":537},"obj":"Species"},{"id":"323","span":{"begin":706,"end":715},"obj":"Disease"}],"attributes":[{"id":"A312","pred":"tao:has_database_id","subj":"312","obj":"Tax:2697049"},{"id":"A313","pred":"tao:has_database_id","subj":"313","obj":"Tax:9606"},{"id":"A319","pred":"tao:has_database_id","subj":"319","obj":"Tax:2697049"},{"id":"A320","pred":"tao:has_database_id","subj":"320","obj":"Tax:9606"},{"id":"A321","pred":"tao:has_database_id","subj":"321","obj":"Tax:9606"},{"id":"A322","pred":"tao:has_database_id","subj":"322","obj":"Tax:9606"},{"id":"A323","pred":"tao:has_database_id","subj":"323","obj":"MESH:D007239"},{"subj":"312","pred":"source","obj":"LitCovid-PubTator"},{"subj":"313","pred":"source","obj":"LitCovid-PubTator"},{"subj":"319","pred":"source","obj":"LitCovid-PubTator"},{"subj":"320","pred":"source","obj":"LitCovid-PubTator"},{"subj":"321","pred":"source","obj":"LitCovid-PubTator"},{"subj":"322","pred":"source","obj":"LitCovid-PubTator"},{"subj":"323","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T135","span":{"begin":63,"end":231},"obj":"Sentence"},{"id":"T136","span":{"begin":232,"end":418},"obj":"Sentence"},{"id":"T137","span":{"begin":419,"end":460},"obj":"Sentence"},{"id":"T138","span":{"begin":461,"end":514},"obj":"Sentence"},{"id":"T139","span":{"begin":515,"end":740},"obj":"Sentence"},{"id":"T140","span":{"begin":741,"end":844},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T135","pred":"source","obj":"LitCovid-sentences"},{"subj":"T136","pred":"source","obj":"LitCovid-sentences"},{"subj":"T137","pred":"source","obj":"LitCovid-sentences"},{"subj":"T138","pred":"source","obj":"LitCovid-sentences"},{"subj":"T139","pred":"source","obj":"LitCovid-sentences"},{"subj":"T140","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#ecce93","default":true},{"id":"LitCovid-PD-MONDO","color":"#b493ec"},{"id":"LitCovid-PD-CLO","color":"#93ec9a"},{"id":"LitCovid-PD-CHEBI","color":"#ec93a6"},{"id":"LitCovid-PD-GO-BP","color":"#93c0ec"},{"id":"LitCovid-PubTator","color":"#daec93"},{"id":"LitCovid-sentences","color":"#e493ec"}]}]}}