PMC:7319613 / 6237-7420 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T109","span":{"begin":24,"end":28},"obj":"GO:0007567"},{"id":"T110","span":{"begin":29,"end":37},"obj":"SP_7"},{"id":"T111","span":{"begin":124,"end":128},"obj":"G_3;PG_10;PR:000003622"},{"id":"T112","span":{"begin":165,"end":170},"obj":"NCBITaxon:10239"},{"id":"T113","span":{"begin":320,"end":329},"obj":"MOP:0000568"},{"id":"T114","span":{"begin":343,"end":355},"obj":"CHEBI:33694;CHEBI:33694"},{"id":"T115","span":{"begin":366,"end":379},"obj":"CHEBI:16247;CHEBI:16247"},{"id":"T116","span":{"begin":420,"end":424},"obj":"UBERON:0002048"},{"id":"T117","span":{"begin":433,"end":442},"obj":"MOP:0000568"},{"id":"T118","span":{"begin":468,"end":480},"obj":"GO:0005739"},{"id":"T119","span":{"begin":501,"end":509},"obj":"SP_7"},{"id":"T120","span":{"begin":675,"end":693},"obj":"UBERON:0001004"},{"id":"T121","span":{"begin":713,"end":717},"obj":"GO:0007567"},{"id":"T122","span":{"begin":718,"end":728},"obj":"NCBITaxon:1"},{"id":"T123","span":{"begin":811,"end":815},"obj":"GO:0007567"},{"id":"T124","span":{"begin":816,"end":827},"obj":"NCBITaxon:1"},{"id":"T125","span":{"begin":872,"end":880},"obj":"SP_7"},{"id":"T126","span":{"begin":1063,"end":1074},"obj":"GO:0007567"},{"id":"T127","span":{"begin":1079,"end":1087},"obj":"SP_7"},{"id":"T72412","span":{"begin":24,"end":28},"obj":"GO:0007567"},{"id":"T97617","span":{"begin":29,"end":37},"obj":"SP_7"},{"id":"T27305","span":{"begin":124,"end":128},"obj":"G_3;PG_10;PR:000003622"},{"id":"T82968","span":{"begin":165,"end":170},"obj":"NCBITaxon:10239"},{"id":"T74303","span":{"begin":320,"end":329},"obj":"MOP:0000568"},{"id":"T53175","span":{"begin":343,"end":355},"obj":"CHEBI:33694;CHEBI:33694"},{"id":"T76689","span":{"begin":366,"end":379},"obj":"CHEBI:16247;CHEBI:16247"},{"id":"T77422","span":{"begin":420,"end":424},"obj":"UBERON:0002048"},{"id":"T14186","span":{"begin":433,"end":442},"obj":"MOP:0000568"},{"id":"T39931","span":{"begin":468,"end":480},"obj":"GO:0005739"},{"id":"T31003","span":{"begin":501,"end":509},"obj":"SP_7"},{"id":"T74764","span":{"begin":675,"end":693},"obj":"UBERON:0001004"},{"id":"T10239","span":{"begin":713,"end":717},"obj":"GO:0007567"},{"id":"T92930","span":{"begin":718,"end":728},"obj":"NCBITaxon:1"},{"id":"T11700","span":{"begin":811,"end":815},"obj":"GO:0007567"},{"id":"T48125","span":{"begin":816,"end":827},"obj":"NCBITaxon:1"},{"id":"T28108","span":{"begin":872,"end":880},"obj":"SP_7"},{"id":"T76303","span":{"begin":1063,"end":1074},"obj":"GO:0007567"},{"id":"T8584","span":{"begin":1079,"end":1087},"obj":"SP_7"}],"text":"In summary, prematurely born COVID-19 patients could be particularly vulnerable to both infection and adverse outcome. High ACE2 activity levels may enable enhanced virus-binding, thus increasing infection risk. A pre-existing adverse redox balance could then contribute to the aggravation of inflammatory mechanisms by oxidation of different biomolecules including phospholipids, incidentally exacerbating vascular and lung injury. Oxidative damage to oxygen-sensing mitochondria in conjunction with COVID-19-related hypoxemia and prematurity-associated ventilator response deficits may synergistically deteriorate the health status facilitated by a potentially compromised respiratory system of the prematurely born individual. We believe that the above-summarized data and mechanisms observed in prematurely born individuals should be considered when managing/treating COVID-19 patients. As no sound epidemiological data currently exist on the topic, future epidemiological and experimental efforts are urgently warranted to elucidate the relationship between prematurity and COVID-19 severity and thereby optimize therapeutic approaches for this, up-to-now neglected, population."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T15","span":{"begin":366,"end":379},"obj":"Body_part"},{"id":"T16","span":{"begin":420,"end":424},"obj":"Body_part"},{"id":"T17","span":{"begin":675,"end":693},"obj":"Body_part"}],"attributes":[{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma82779"},{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma7158"}],"text":"In summary, prematurely born COVID-19 patients could be particularly vulnerable to both infection and adverse outcome. High ACE2 activity levels may enable enhanced virus-binding, thus increasing infection risk. A pre-existing adverse redox balance could then contribute to the aggravation of inflammatory mechanisms by oxidation of different biomolecules including phospholipids, incidentally exacerbating vascular and lung injury. Oxidative damage to oxygen-sensing mitochondria in conjunction with COVID-19-related hypoxemia and prematurity-associated ventilator response deficits may synergistically deteriorate the health status facilitated by a potentially compromised respiratory system of the prematurely born individual. We believe that the above-summarized data and mechanisms observed in prematurely born individuals should be considered when managing/treating COVID-19 patients. As no sound epidemiological data currently exist on the topic, future epidemiological and experimental efforts are urgently warranted to elucidate the relationship between prematurity and COVID-19 severity and thereby optimize therapeutic approaches for this, up-to-now neglected, population."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T6","span":{"begin":420,"end":424},"obj":"Body_part"},{"id":"T7","span":{"begin":675,"end":693},"obj":"Body_part"}],"attributes":[{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0001004"}],"text":"In summary, prematurely born COVID-19 patients could be particularly vulnerable to both infection and adverse outcome. High ACE2 activity levels may enable enhanced virus-binding, thus increasing infection risk. A pre-existing adverse redox balance could then contribute to the aggravation of inflammatory mechanisms by oxidation of different biomolecules including phospholipids, incidentally exacerbating vascular and lung injury. Oxidative damage to oxygen-sensing mitochondria in conjunction with COVID-19-related hypoxemia and prematurity-associated ventilator response deficits may synergistically deteriorate the health status facilitated by a potentially compromised respiratory system of the prematurely born individual. We believe that the above-summarized data and mechanisms observed in prematurely born individuals should be considered when managing/treating COVID-19 patients. As no sound epidemiological data currently exist on the topic, future epidemiological and experimental efforts are urgently warranted to elucidate the relationship between prematurity and COVID-19 severity and thereby optimize therapeutic approaches for this, up-to-now neglected, population."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T32","span":{"begin":29,"end":37},"obj":"Disease"},{"id":"T33","span":{"begin":88,"end":97},"obj":"Disease"},{"id":"T34","span":{"begin":196,"end":205},"obj":"Disease"},{"id":"T35","span":{"begin":425,"end":431},"obj":"Disease"},{"id":"T36","span":{"begin":501,"end":509},"obj":"Disease"},{"id":"T37","span":{"begin":872,"end":880},"obj":"Disease"},{"id":"T38","span":{"begin":1079,"end":1087},"obj":"Disease"}],"attributes":[{"id":"A32","pred":"mondo_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A33","pred":"mondo_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A34","pred":"mondo_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A35","pred":"mondo_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A36","pred":"mondo_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A37","pred":"mondo_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A38","pred":"mondo_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"In summary, prematurely born COVID-19 patients could be particularly vulnerable to both infection and adverse outcome. High ACE2 activity levels may enable enhanced virus-binding, thus increasing infection risk. A pre-existing adverse redox balance could then contribute to the aggravation of inflammatory mechanisms by oxidation of different biomolecules including phospholipids, incidentally exacerbating vascular and lung injury. Oxidative damage to oxygen-sensing mitochondria in conjunction with COVID-19-related hypoxemia and prematurity-associated ventilator response deficits may synergistically deteriorate the health status facilitated by a potentially compromised respiratory system of the prematurely born individual. We believe that the above-summarized data and mechanisms observed in prematurely born individuals should be considered when managing/treating COVID-19 patients. As no sound epidemiological data currently exist on the topic, future epidemiological and experimental efforts are urgently warranted to elucidate the relationship between prematurity and COVID-19 severity and thereby optimize therapeutic approaches for this, up-to-now neglected, population."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T32","span":{"begin":129,"end":137},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T33","span":{"begin":165,"end":170},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T34","span":{"begin":212,"end":213},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T35","span":{"begin":420,"end":424},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T36","span":{"begin":420,"end":424},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T37","span":{"begin":649,"end":650},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T38","span":{"begin":675,"end":693},"obj":"http://purl.obolibrary.org/obo/UBERON_0001004"}],"text":"In summary, prematurely born COVID-19 patients could be particularly vulnerable to both infection and adverse outcome. High ACE2 activity levels may enable enhanced virus-binding, thus increasing infection risk. A pre-existing adverse redox balance could then contribute to the aggravation of inflammatory mechanisms by oxidation of different biomolecules including phospholipids, incidentally exacerbating vascular and lung injury. Oxidative damage to oxygen-sensing mitochondria in conjunction with COVID-19-related hypoxemia and prematurity-associated ventilator response deficits may synergistically deteriorate the health status facilitated by a potentially compromised respiratory system of the prematurely born individual. We believe that the above-summarized data and mechanisms observed in prematurely born individuals should be considered when managing/treating COVID-19 patients. As no sound epidemiological data currently exist on the topic, future epidemiological and experimental efforts are urgently warranted to elucidate the relationship between prematurity and COVID-19 severity and thereby optimize therapeutic approaches for this, up-to-now neglected, population."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T17","span":{"begin":366,"end":379},"obj":"Chemical"},{"id":"T18","span":{"begin":453,"end":459},"obj":"Chemical"}],"attributes":[{"id":"A17","pred":"chebi_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/CHEBI_16247"},{"id":"A18","pred":"chebi_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/CHEBI_25805"}],"text":"In summary, prematurely born COVID-19 patients could be particularly vulnerable to both infection and adverse outcome. High ACE2 activity levels may enable enhanced virus-binding, thus increasing infection risk. A pre-existing adverse redox balance could then contribute to the aggravation of inflammatory mechanisms by oxidation of different biomolecules including phospholipids, incidentally exacerbating vascular and lung injury. Oxidative damage to oxygen-sensing mitochondria in conjunction with COVID-19-related hypoxemia and prematurity-associated ventilator response deficits may synergistically deteriorate the health status facilitated by a potentially compromised respiratory system of the prematurely born individual. We believe that the above-summarized data and mechanisms observed in prematurely born individuals should be considered when managing/treating COVID-19 patients. As no sound epidemiological data currently exist on the topic, future epidemiological and experimental efforts are urgently warranted to elucidate the relationship between prematurity and COVID-19 severity and thereby optimize therapeutic approaches for this, up-to-now neglected, population."}

{"project":"LitCovid-PubTator","denotations":[{"id":"147","span":{"begin":124,"end":128},"obj":"Gene"},{"id":"148","span":{"begin":38,"end":46},"obj":"Species"},{"id":"149","span":{"begin":881,"end":889},"obj":"Species"},{"id":"150","span":{"begin":366,"end":379},"obj":"Chemical"},{"id":"151","span":{"begin":453,"end":459},"obj":"Chemical"},{"id":"152","span":{"begin":29,"end":37},"obj":"Disease"},{"id":"153","span":{"begin":88,"end":97},"obj":"Disease"},{"id":"154","span":{"begin":196,"end":205},"obj":"Disease"},{"id":"155","span":{"begin":420,"end":431},"obj":"Disease"},{"id":"156","span":{"begin":501,"end":509},"obj":"Disease"},{"id":"157","span":{"begin":518,"end":527},"obj":"Disease"},{"id":"158","span":{"begin":872,"end":880},"obj":"Disease"},{"id":"159","span":{"begin":1079,"end":1087},"obj":"Disease"}],"attributes":[{"id":"A147","pred":"tao:has_database_id","subj":"147","obj":"Gene:59272"},{"id":"A148","pred":"tao:has_database_id","subj":"148","obj":"Tax:9606"},{"id":"A149","pred":"tao:has_database_id","subj":"149","obj":"Tax:9606"},{"id":"A150","pred":"tao:has_database_id","subj":"150","obj":"MESH:D010743"},{"id":"A151","pred":"tao:has_database_id","subj":"151","obj":"MESH:D010100"},{"id":"A152","pred":"tao:has_database_id","subj":"152","obj":"MESH:C000657245"},{"id":"A153","pred":"tao:has_database_id","subj":"153","obj":"MESH:D007239"},{"id":"A154","pred":"tao:has_database_id","subj":"154","obj":"MESH:D007239"},{"id":"A155","pred":"tao:has_database_id","subj":"155","obj":"MESH:D055370"},{"id":"A156","pred":"tao:has_database_id","subj":"156","obj":"MESH:C000657245"},{"id":"A157","pred":"tao:has_database_id","subj":"157","obj":"MESH:D000860"},{"id":"A158","pred":"tao:has_database_id","subj":"158","obj":"MESH:C000657245"},{"id":"A159","pred":"tao:has_database_id","subj":"159","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In summary, prematurely born COVID-19 patients could be particularly vulnerable to both infection and adverse outcome. High ACE2 activity levels may enable enhanced virus-binding, thus increasing infection risk. A pre-existing adverse redox balance could then contribute to the aggravation of inflammatory mechanisms by oxidation of different biomolecules including phospholipids, incidentally exacerbating vascular and lung injury. Oxidative damage to oxygen-sensing mitochondria in conjunction with COVID-19-related hypoxemia and prematurity-associated ventilator response deficits may synergistically deteriorate the health status facilitated by a potentially compromised respiratory system of the prematurely born individual. We believe that the above-summarized data and mechanisms observed in prematurely born individuals should be considered when managing/treating COVID-19 patients. As no sound epidemiological data currently exist on the topic, future epidemiological and experimental efforts are urgently warranted to elucidate the relationship between prematurity and COVID-19 severity and thereby optimize therapeutic approaches for this, up-to-now neglected, population."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T23","span":{"begin":518,"end":527},"obj":"Phenotype"}],"attributes":[{"id":"A23","pred":"hp_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/HP_0012418"}],"text":"In summary, prematurely born COVID-19 patients could be particularly vulnerable to both infection and adverse outcome. High ACE2 activity levels may enable enhanced virus-binding, thus increasing infection risk. A pre-existing adverse redox balance could then contribute to the aggravation of inflammatory mechanisms by oxidation of different biomolecules including phospholipids, incidentally exacerbating vascular and lung injury. Oxidative damage to oxygen-sensing mitochondria in conjunction with COVID-19-related hypoxemia and prematurity-associated ventilator response deficits may synergistically deteriorate the health status facilitated by a potentially compromised respiratory system of the prematurely born individual. We believe that the above-summarized data and mechanisms observed in prematurely born individuals should be considered when managing/treating COVID-19 patients. As no sound epidemiological data currently exist on the topic, future epidemiological and experimental efforts are urgently warranted to elucidate the relationship between prematurity and COVID-19 severity and thereby optimize therapeutic approaches for this, up-to-now neglected, population."}

{"project":"LitCovid-sentences","denotations":[{"id":"T38","span":{"begin":0,"end":118},"obj":"Sentence"},{"id":"T39","span":{"begin":119,"end":211},"obj":"Sentence"},{"id":"T40","span":{"begin":212,"end":432},"obj":"Sentence"},{"id":"T41","span":{"begin":433,"end":729},"obj":"Sentence"},{"id":"T42","span":{"begin":730,"end":890},"obj":"Sentence"},{"id":"T43","span":{"begin":891,"end":1183},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In summary, prematurely born COVID-19 patients could be particularly vulnerable to both infection and adverse outcome. High ACE2 activity levels may enable enhanced virus-binding, thus increasing infection risk. A pre-existing adverse redox balance could then contribute to the aggravation of inflammatory mechanisms by oxidation of different biomolecules including phospholipids, incidentally exacerbating vascular and lung injury. Oxidative damage to oxygen-sensing mitochondria in conjunction with COVID-19-related hypoxemia and prematurity-associated ventilator response deficits may synergistically deteriorate the health status facilitated by a potentially compromised respiratory system of the prematurely born individual. We believe that the above-summarized data and mechanisms observed in prematurely born individuals should be considered when managing/treating COVID-19 patients. As no sound epidemiological data currently exist on the topic, future epidemiological and experimental efforts are urgently warranted to elucidate the relationship between prematurity and COVID-19 severity and thereby optimize therapeutic approaches for this, up-to-now neglected, population."}