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PMC:7317273 / 2222-5242 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T6 373-376 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T7 523-540 Body_part denotes respiratory tract http://purl.org/sig/ont/fma/fma265130
T8 664-671 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T9 684-688 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T10 689-714 Body_part denotes alveolar epithelial cells http://purl.org/sig/ont/fma/fma62499
T11 709-714 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T12 761-773 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T13 853-862 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T14 968-972 Body_part denotes IL-2 http://purl.org/sig/ont/fma/fma84051
T15 1553-1575 Body_part denotes mesenchymal stem cells http://purl.org/sig/ont/fma/fma0326143
T16 1570-1575 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T17 1721-1725 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T18 2038-2060 Body_part denotes Mesenchymal+Stem+Cells http://purl.org/sig/ont/fma/fma0326143
T19 2055-2060 Body_part denotes Cells http://purl.org/sig/ont/fma/fma68646
T20 2161-2182 Body_part denotes mesenchymal+stem+cell http://purl.org/sig/ont/fma/fma0326143
T21 2178-2182 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T22 2289-2293 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T23 2557-2578 Body_part denotes mesenchymal+stem+cell http://purl.org/sig/ont/fma/fma0326143
T24 2574-2578 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T2 523-540 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T3 684-688 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T4 1721-1725 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T5 2289-2293 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T17 132-140 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T18 256-263 Disease denotes COVID19 http://purl.obolibrary.org/obo/MONDO_0100096
T19 301-309 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T20 482-490 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T21 742-750 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T22 795-810 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T23 801-810 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T24 926-933 Disease denotes COVID19 http://purl.obolibrary.org/obo/MONDO_0100096
T25 1119-1126 Disease denotes COVID19 http://purl.obolibrary.org/obo/MONDO_0100096
T26 1127-1136 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T27 1458-1466 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T28 1721-1734 Disease denotes lung diseases http://purl.obolibrary.org/obo/MONDO_0005275
T29 1772-1807 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T30 1778-1807 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T31 1809-1813 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T32 2033-2037 Disease denotes cond http://purl.obolibrary.org/obo/MONDO_0009358
T33 2156-2160 Disease denotes cond http://purl.obolibrary.org/obo/MONDO_0009358
T34 2300-2307 Disease denotes COVID19 http://purl.obolibrary.org/obo/MONDO_0100096
T35 2486-2493 Disease denotes COVID19 http://purl.obolibrary.org/obo/MONDO_0100096
T36 2552-2556 Disease denotes cond http://purl.obolibrary.org/obo/MONDO_0009358
T37 2584-2591 Disease denotes COVID19 http://purl.obolibrary.org/obo/MONDO_0100096
T38 2926-2933 Disease denotes COVID19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T16 71-72 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T17 143-148 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T18 377-384 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T19 684-688 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T20 684-688 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T21 698-708 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T22 709-714 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T23 834-843 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T24 968-972 http://purl.obolibrary.org/obo/PR_000001379 denotes IL-2
T25 1000-1004 http://purl.obolibrary.org/obo/PR_000005932 denotes GCSF
T26 1043-1044 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T27 1469-1474 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T28 1504-1505 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T29 1553-1575 http://purl.obolibrary.org/obo/CL_0000134 denotes mesenchymal stem cells
T30 1594-1595 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T31 1721-1725 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T32 1721-1725 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T33 1758-1763 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T34 2038-2060 http://purl.obolibrary.org/obo/CL_0000134 denotes Mesenchymal+Stem+Cells
T35 2161-2182 http://purl.obolibrary.org/obo/CL_0000134 denotes mesenchymal+stem+cell
T36 2359-2371 http://purl.obolibrary.org/obo/OBI_0000245 denotes Organization
T37 2446-2448 http://purl.obolibrary.org/obo/CLO_0037161 denotes en
T38 2557-2578 http://purl.obolibrary.org/obo/CL_0000134 denotes mesenchymal+stem+cell
T39 2729-2732 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T40 2828-2829 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 664-671 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T2 761-773 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T3 875-884 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T4 968-970 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T6 974-976 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T8 980-982 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T10 986-988 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T12 1006-1009 Chemical denotes MCP http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099
T14 1080-1089 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T15 1282-1300 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T16 1305-1316 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T17 1360-1370 Chemical denotes antivirals http://purl.obolibrary.org/obo/CHEBI_22587
T18 1375-1394 Chemical denotes protease inhibitors http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T20 1384-1394 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T21 2446-2448 Chemical denotes en http://purl.obolibrary.org/obo/CHEBI_30347

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
81 659-663 Gene denotes ACE2 Gene:59272
82 968-972 Gene denotes IL-2 Gene:3558
83 974-978 Gene denotes IL-6 Gene:3569
84 980-984 Gene denotes IL-7 Gene:3574
85 986-991 Gene denotes IL-10 Gene:3586
86 993-998 Gene denotes TNF-α Gene:7124
87 1000-1004 Gene denotes GCSF Gene:1440
88 1006-1011 Gene denotes MCP-1 Gene:6347
89 1013-1019 Gene denotes MIP-1α Gene:6348
90 1025-1030 Gene denotes TNF-α Gene:7124
91 132-142 Species denotes SARS-CoV-2 Tax:2697049
92 301-311 Species denotes SARS-CoV-2 Tax:2697049
93 405-418 Species denotes β-coronavirus Tax:694002
94 482-492 Species denotes SARS-CoV-2 Tax:2697049
95 742-752 Species denotes SARS-CoV-2 Tax:2697049
96 934-942 Species denotes patients Tax:9606
97 1458-1468 Species denotes SARS-CoV-2 Tax:2697049
98 2866-2874 Species denotes patients Tax:9606
99 2934-2942 Species denotes patients Tax:9606
100 3007-3019 Species denotes participants Tax:9606
101 1282-1300 Chemical denotes hydroxychloroquine MESH:D006886
102 1305-1316 Chemical denotes chloroquine MESH:D002738
103 256-263 Disease denotes COVID19 MESH:C000657245
104 795-810 Disease denotes viral infection MESH:D001102
105 926-933 Disease denotes COVID19 MESH:C000657245
106 1119-1136 Disease denotes COVID19 infection MESH:C000657245
107 1721-1734 Disease denotes lung diseases MESH:D008171
108 1772-1807 Disease denotes acute respiratory distress syndrome MESH:D012128
109 1809-1813 Disease denotes ARDS MESH:D012128
110 2300-2307 Disease denotes COVID19 MESH:C000657245
111 2486-2493 Disease denotes COVID19 MESH:C000657245
112 2584-2591 Disease denotes COVID19 MESH:C000657245
113 2926-2933 Disease denotes COVID19 MESH:C000657245

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T3 199-208 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T4 199-208 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T5 213-225 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T6 586-596 http://purl.obolibrary.org/obo/GO_0046903 denotes secretions
T7 795-810 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T8 875-894 http://purl.obolibrary.org/obo/GO_0051607 denotes antiviral responses

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T16 0-104 Sentence denotes For any therapeutic intervention, the pathological cascade involved in a disease needs to be elucidated.
T17 105-277 Sentence denotes Therefore, identifying the SARS-CoV-2 virus receptor recognition mechanism that regulates its virulence and pathogenesis holds the key to confront the COVID19 epidemic [1].
T18 278-449 Sentence denotes Structural analysis of SARS-CoV-2 revealed that the enveloped, positive-sense, single-stranded RNA viruses belong to the genus β-coronavirus and have azoonotic origin [2].
T19 450-620 Sentence denotes Mounting evidence suggests that SARS-CoV-2 primarily spreads through the respiratory tract, either in the form of droplets, respiratory secretions, or direct contact [3].
T20 621-811 Sentence denotes In addition, the abundant presence of ACE2 protein receptor in lung alveolar epithelial cells facilitates the binding of SARS-CoV-2 spike-S-glycoprotein, and thus, expedites viral infection.
T21 812-895 Sentence denotes This interaction also activates distinct cytokines crucial for antiviral responses.
T22 896-1049 Sentence denotes The data of critically severe COVID19 patients revealed the presence of IL-2, IL-6, IL-7, IL-10, TNF-α, GCSF, MCP-1, MIP-1α, and TNF-α [4] to name a few.
T23 1050-1395 Sentence denotes To date, no specific approved antiviral therapy for the treatment of COVID19 infection is available, except standard supportive care e.g., oxygenation, ventilation, and fluid management, etc., and some non-specific treatments e.g., hydroxychloroquine and chloroquine etc., to ameliorate the symptoms, and some antivirals and protease inhibitors.
T24 1396-1523 Sentence denotes Thus, to reverse or combat the detrimental effect produced by SARS-CoV-2 virus, there is an urgent need for a reliable therapy.
T25 1524-1822 Sentence denotes In this context, multipotent mesenchymal stem cells (MSCs) have shown a strong safety and efficacy profile as they have been intensively investigated in preclinical and clinical studies of various lung diseases, including respiratory virus-induced acute respiratory distress syndrome (ARDS) [5, 6].
T26 1823-2275 Sentence denotes Over the past years, the MSCs infusion exhibited an excellent safety record as evident in the 871 clinical trials registered in the National Institute of Health database (https://clinicaltrials.gov/ct2/results?cond=Mesenchymal+Stem+Cells&term=&cntry=&state=&city=&dist=), including 117 trials (https://clinicaltrials.gov/ct2/results?cond=mesenchymal+stem+cell&term=pulmonary&cntry=&state=&city=&dist=&Search=Search) on pulmonary complications, to date.
T27 2276-2674 Sentence denotes On the other hand, 2845 COVID19 trials worldwide as of 23 May 2020 at World Health Organization-International Clinical Trial Registry Platform (https://www.who.int/ictrp/en/) and 29 clinical trials on MSCs and COVID19 as of 23 May 2020 (https://clinicaltrials.gov/ct2/results?cond=mesenchymal+stem+cell&term=COVID19&cntry=&state=&city=&dist=&Search=Search) have been registered at the NIH database.
T28 2675-2758 Sentence denotes Worth mentioning, that out of 29 clinical trials, one has been withdrawn (trial no.
T29 2759-2875 Sentence denotes NCT04293692), therefore, as yet, 28 trials have been registered with a participation of approximately 1525 patients.
T30 2876-3020 Sentence denotes All of the mentioned studies that employ MSCs and COVID19 patients are in early-phase, and either recruiting or yet to recruit the participants.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T8 1721-1734 Phenotype denotes lung diseases http://purl.obolibrary.org/obo/HP_0002088
T9 1778-1798 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098

2_test

Id Subject Object Predicate Lexical cue
32592163-32007145-140679168 446-447 32007145 denotes 2
32592163-32169119-140679169 617-618 32169119 denotes 3
32592163-31986264-140679170 1032-1033 31986264 denotes 4
32592163-32257537-140679171 1819-1820 32257537 denotes 6

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T31 132-142 SP_7 denotes SARS-CoV-2
T32 143-148 NCBITaxon:10239 denotes virus
T33 185-194 GO:0065007 denotes regulates
T34 256-263 SP_7 denotes COVID19
T35 301-311 SP_7 denotes SARS-CoV-2
T36 357-372 SO:0000984 denotes single-stranded
T37 377-384 NCBITaxon:10239 denotes viruses
T38 407-418 NCBITaxon:11118 denotes coronavirus
T39 482-492 SP_7 denotes SARS-CoV-2
T40 523-540 UBERON:0000065 denotes respiratory tract
T41 574-585 UBERON:0001004 denotes respiratory
T42 659-663 G_3;PG_10;PR:000003622 denotes ACE2
T43 684-688 CL:0000082;UBERON:0002048 denotes lung
T44 689-708 UBERON:0000115;CL:0000322 denotes alveolar epithelial
T45 709-714 CL:0000322 denotes cells
T46 742-746 PR:000014459;SP_7 denotes SARS
T47 746-752 SP_7 denotes -CoV-2
T48 759-761 PG_18 denotes S-
T49 761-773 PG_18;PR:000037069;CHEBI:17089;BV_11;CHEBI:17089 denotes glycoprotein
T50 795-800 NCBITaxon:10239 denotes viral
T51 926-933 SP_7 denotes COVID19
T52 968-972 PR:000001379 denotes IL-2
T53 974-978 PR:000001393 denotes IL-6
T54 980-984 PR:000001317 denotes IL-7
T55 986-991 PR:000001471 denotes IL-10
T56 993-998 PR:000000134 denotes TNF-α
T57 1006-1011 PR:000002122 denotes MCP-1
T58 1013-1019 PR:000002123 denotes MIP-1α
T59 1025-1030 PR:000000134 denotes TNF-α
T60 1119-1126 SP_7 denotes COVID19
T61 1189-1200 GO:0015671 denotes oxygenation
T62 1219-1224 UBERON:0006314 denotes fluid
T63 1282-1300 CHEBI:5801;DG_20;CHEBI:5801 denotes hydroxychloroquine
T64 1305-1316 CHEBI:3638;DG_10;CHEBI:3638 denotes chloroquine
T65 1458-1468 SP_7 denotes SARS-CoV-2
T66 1469-1474 NCBITaxon:10239 denotes virus
T67 1541-1552 CL:0000048 denotes multipotent
T68 1553-1564 CL:0000134;UBERON:0003104 denotes mesenchymal
T69 1565-1575 CL:0000034 denotes stem cells
T70 1577-1581 DG_47 denotes MSCs
T71 1721-1725 UBERON:0002048 denotes lung
T72 1746-1757 UBERON:0001004 denotes respiratory
T73 1758-1763 NCBITaxon:10239 denotes virus
T74 1778-1789 UBERON:0001004 denotes respiratory
T75 1848-1852 DG_47 denotes MSCs
T76 2038-2049 UBERON:0003104 denotes Mesenchymal
T77 2161-2172 UBERON:0003104 denotes mesenchymal
T78 2188-2197 UBERON:0002048 denotes pulmonary
T79 2242-2251 UBERON:0002048 denotes pulmonary
T80 2300-2307 SP_7 denotes COVID19
T81 2477-2481 DG_47 denotes MSCs
T82 2486-2493 SP_7 denotes COVID19
T83 2557-2568 CL:0000134;UBERON:0003104 denotes mesenchymal
T84 2569-2573 CL:0000034 denotes stem
T85 2584-2591 SP_7 denotes COVID19
T86 2917-2921 DG_47 denotes MSCs
T87 2926-2933 SP_7 denotes COVID19
T31709 132-142 SP_7 denotes SARS-CoV-2
T31944 143-148 NCBITaxon:10239 denotes virus
T13615 185-194 GO:0065007 denotes regulates
T24070 256-263 SP_7 denotes COVID19
T76581 301-311 SP_7 denotes SARS-CoV-2
T17886 357-372 SO:0000984 denotes single-stranded
T34955 377-384 NCBITaxon:10239 denotes viruses
T26641 407-418 NCBITaxon:11118 denotes coronavirus
T54626 482-492 SP_7 denotes SARS-CoV-2
T71862 523-540 UBERON:0000065 denotes respiratory tract
T82557 574-585 UBERON:0001004 denotes respiratory
T89446 659-663 G_3;PG_10;PR:000003622 denotes ACE2
T78564 684-688 CL:0000082;UBERON:0002048 denotes lung
T89339 689-708 UBERON:0000115;CL:0000322 denotes alveolar epithelial
T64598 709-714 CL:0000322 denotes cells
T83482 742-746 PR:000014459;SP_7 denotes SARS
T56430 746-752 SP_7 denotes -CoV-2
T24666 759-761 PG_18 denotes S-
T95371 761-773 PG_18;PR:000037069;CHEBI:17089;BV_11;CHEBI:17089 denotes glycoprotein
T61299 795-800 NCBITaxon:10239 denotes viral
T85492 926-933 SP_7 denotes COVID19
T37084 968-972 PR:000001379 denotes IL-2
T94398 974-978 PR:000001393 denotes IL-6
T73574 980-984 PR:000001317 denotes IL-7
T92808 986-991 PR:000001471 denotes IL-10
T77103 993-998 PR:000000134 denotes TNF-α
T82374 1006-1011 PR:000002122 denotes MCP-1
T47575 1013-1019 PR:000002123 denotes MIP-1α
T50737 1025-1030 PR:000000134 denotes TNF-α
T77760 1119-1126 SP_7 denotes COVID19
T98290 1189-1200 GO:0015671 denotes oxygenation
T23159 1219-1224 UBERON:0006314 denotes fluid
T79576 1282-1300 CHEBI:5801;DG_20;CHEBI:5801 denotes hydroxychloroquine
T27123 1305-1316 CHEBI:3638;DG_10;CHEBI:3638 denotes chloroquine
T83352 1458-1468 SP_7 denotes SARS-CoV-2
T93068 1469-1474 NCBITaxon:10239 denotes virus
T34959 1541-1552 CL:0000048 denotes multipotent
T76035 1553-1564 CL:0000134;UBERON:0003104 denotes mesenchymal
T25168 1565-1575 CL:0000034 denotes stem cells
T21937 1577-1581 DG_47 denotes MSCs
T81093 1721-1725 UBERON:0002048 denotes lung
T42154 1746-1757 UBERON:0001004 denotes respiratory
T99714 1758-1763 NCBITaxon:10239 denotes virus
T60707 1778-1789 UBERON:0001004 denotes respiratory
T21016 1848-1852 DG_47 denotes MSCs
T44123 2038-2049 UBERON:0003104 denotes Mesenchymal
T14290 2161-2172 UBERON:0003104 denotes mesenchymal
T84657 2188-2197 UBERON:0002048 denotes pulmonary
T22824 2242-2251 UBERON:0002048 denotes pulmonary
T85879 2300-2307 SP_7 denotes COVID19
T80525 2477-2481 DG_47 denotes MSCs
T90267 2486-2493 SP_7 denotes COVID19
T97762 2557-2568 CL:0000134;UBERON:0003104 denotes mesenchymal
T35650 2569-2573 CL:0000034 denotes stem
T80035 2584-2591 SP_7 denotes COVID19
T80898 2917-2921 DG_47 denotes MSCs
T13628 2926-2933 SP_7 denotes COVID19