PMC:7317273 / 21443-22252 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T142","span":{"begin":156,"end":165},"obj":"Body_part"},{"id":"T143","span":{"begin":253,"end":262},"obj":"Body_part"},{"id":"T144","span":{"begin":279,"end":287},"obj":"Body_part"},{"id":"T145","span":{"begin":738,"end":743},"obj":"Body_part"}],"attributes":[{"id":"A142","pred":"fma_id","subj":"T142","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A143","pred":"fma_id","subj":"T143","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A144","pred":"fma_id","subj":"T144","obj":"http://purl.org/sig/ont/fma/fma12278"},{"id":"A145","pred":"fma_id","subj":"T145","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"In the light of above findings, herein, we propose that the mechanism of priming of MSC could be implied to the following: i) Licensing by pro-inflammatory cytokines such as IFN-γ, TNF-α, etc., to enhance immunosuppressive potential; ii) Priming by non-cytokines stimuli such as hormones/growth factors like HGF to boost defensive and protective cellular mechanisms; iii) Pre-conditioning by hypoxia, and/or pharmacological agents, e.g., sphingosine-1-phosphate, etc., to enhance engraftment and reparative effects; iv) Activation by spheroid culturing to enhance homing, survival, differentiation, and lineage specificity e.g. angiogenic mechanism; v) The timing of MSCs engraftment and engagement in the process of activation of immune cells to achieve the most excellent beneficial effect of MSCs infusion."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T250","span":{"begin":308,"end":311},"obj":"http://purl.obolibrary.org/obo/CLO_0003740"},{"id":"T251","span":{"begin":520,"end":530},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T252","span":{"begin":717,"end":727},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T253","span":{"begin":738,"end":743},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"In the light of above findings, herein, we propose that the mechanism of priming of MSC could be implied to the following: i) Licensing by pro-inflammatory cytokines such as IFN-γ, TNF-α, etc., to enhance immunosuppressive potential; ii) Priming by non-cytokines stimuli such as hormones/growth factors like HGF to boost defensive and protective cellular mechanisms; iii) Pre-conditioning by hypoxia, and/or pharmacological agents, e.g., sphingosine-1-phosphate, etc., to enhance engraftment and reparative effects; iv) Activation by spheroid culturing to enhance homing, survival, differentiation, and lineage specificity e.g. angiogenic mechanism; v) The timing of MSCs engraftment and engagement in the process of activation of immune cells to achieve the most excellent beneficial effect of MSCs infusion."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T86","span":{"begin":279,"end":287},"obj":"Chemical"},{"id":"T87","span":{"begin":438,"end":461},"obj":"Chemical"},{"id":"T88","span":{"begin":438,"end":449},"obj":"Chemical"},{"id":"T89","span":{"begin":452,"end":461},"obj":"Chemical"}],"attributes":[{"id":"A86","pred":"chebi_id","subj":"T86","obj":"http://purl.obolibrary.org/obo/CHEBI_24621"},{"id":"A87","pred":"chebi_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/CHEBI_37550"},{"id":"A88","pred":"chebi_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/CHEBI_16393"},{"id":"A89","pred":"chebi_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/CHEBI_18367"},{"id":"A90","pred":"chebi_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/CHEBI_26020"},{"id":"A91","pred":"chebi_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/CHEBI_35780"},{"id":"A92","pred":"chebi_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/CHEBI_43474"}],"text":"In the light of above findings, herein, we propose that the mechanism of priming of MSC could be implied to the following: i) Licensing by pro-inflammatory cytokines such as IFN-γ, TNF-α, etc., to enhance immunosuppressive potential; ii) Priming by non-cytokines stimuli such as hormones/growth factors like HGF to boost defensive and protective cellular mechanisms; iii) Pre-conditioning by hypoxia, and/or pharmacological agents, e.g., sphingosine-1-phosphate, etc., to enhance engraftment and reparative effects; iv) Activation by spheroid culturing to enhance homing, survival, differentiation, and lineage specificity e.g. angiogenic mechanism; v) The timing of MSCs engraftment and engagement in the process of activation of immune cells to achieve the most excellent beneficial effect of MSCs infusion."}

{"project":"LitCovid-PubTator","denotations":[{"id":"324","span":{"begin":174,"end":179},"obj":"Gene"},{"id":"325","span":{"begin":181,"end":186},"obj":"Gene"},{"id":"326","span":{"begin":308,"end":311},"obj":"Gene"},{"id":"339","span":{"begin":392,"end":399},"obj":"Disease"}],"attributes":[{"id":"A324","pred":"tao:has_database_id","subj":"324","obj":"Gene:3458"},{"id":"A325","pred":"tao:has_database_id","subj":"325","obj":"Gene:7124"},{"id":"A326","pred":"tao:has_database_id","subj":"326","obj":"Gene:3082"},{"id":"A339","pred":"tao:has_database_id","subj":"339","obj":"MESH:D000860"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In the light of above findings, herein, we propose that the mechanism of priming of MSC could be implied to the following: i) Licensing by pro-inflammatory cytokines such as IFN-γ, TNF-α, etc., to enhance immunosuppressive potential; ii) Priming by non-cytokines stimuli such as hormones/growth factors like HGF to boost defensive and protective cellular mechanisms; iii) Pre-conditioning by hypoxia, and/or pharmacological agents, e.g., sphingosine-1-phosphate, etc., to enhance engraftment and reparative effects; iv) Activation by spheroid culturing to enhance homing, survival, differentiation, and lineage specificity e.g. angiogenic mechanism; v) The timing of MSCs engraftment and engagement in the process of activation of immune cells to achieve the most excellent beneficial effect of MSCs infusion."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T22","span":{"begin":288,"end":294},"obj":"http://purl.obolibrary.org/obo/GO_0040007"}],"text":"In the light of above findings, herein, we propose that the mechanism of priming of MSC could be implied to the following: i) Licensing by pro-inflammatory cytokines such as IFN-γ, TNF-α, etc., to enhance immunosuppressive potential; ii) Priming by non-cytokines stimuli such as hormones/growth factors like HGF to boost defensive and protective cellular mechanisms; iii) Pre-conditioning by hypoxia, and/or pharmacological agents, e.g., sphingosine-1-phosphate, etc., to enhance engraftment and reparative effects; iv) Activation by spheroid culturing to enhance homing, survival, differentiation, and lineage specificity e.g. angiogenic mechanism; v) The timing of MSCs engraftment and engagement in the process of activation of immune cells to achieve the most excellent beneficial effect of MSCs infusion."}

{"project":"LitCovid-sentences","denotations":[{"id":"T329","span":{"begin":0,"end":809},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In the light of above findings, herein, we propose that the mechanism of priming of MSC could be implied to the following: i) Licensing by pro-inflammatory cytokines such as IFN-γ, TNF-α, etc., to enhance immunosuppressive potential; ii) Priming by non-cytokines stimuli such as hormones/growth factors like HGF to boost defensive and protective cellular mechanisms; iii) Pre-conditioning by hypoxia, and/or pharmacological agents, e.g., sphingosine-1-phosphate, etc., to enhance engraftment and reparative effects; iv) Activation by spheroid culturing to enhance homing, survival, differentiation, and lineage specificity e.g. angiogenic mechanism; v) The timing of MSCs engraftment and engagement in the process of activation of immune cells to achieve the most excellent beneficial effect of MSCs infusion."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T27","span":{"begin":392,"end":399},"obj":"Phenotype"}],"attributes":[{"id":"A27","pred":"hp_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/HP_0012418"}],"text":"In the light of above findings, herein, we propose that the mechanism of priming of MSC could be implied to the following: i) Licensing by pro-inflammatory cytokines such as IFN-γ, TNF-α, etc., to enhance immunosuppressive potential; ii) Priming by non-cytokines stimuli such as hormones/growth factors like HGF to boost defensive and protective cellular mechanisms; iii) Pre-conditioning by hypoxia, and/or pharmacological agents, e.g., sphingosine-1-phosphate, etc., to enhance engraftment and reparative effects; iv) Activation by spheroid culturing to enhance homing, survival, differentiation, and lineage specificity e.g. angiogenic mechanism; v) The timing of MSCs engraftment and engagement in the process of activation of immune cells to achieve the most excellent beneficial effect of MSCs infusion."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T368","span":{"begin":174,"end":179},"obj":"PR:000000017"},{"id":"T369","span":{"begin":181,"end":186},"obj":"PR:000000134"},{"id":"T370","span":{"begin":205,"end":222},"obj":"CHEBI:35705;CHEBI:35705"},{"id":"T371","span":{"begin":308,"end":311},"obj":"PR:000008534"},{"id":"T372","span":{"begin":321,"end":330},"obj":"GO:0006952"},{"id":"T373","span":{"begin":408,"end":430},"obj":"CHEBI:52217;CHEBI:52217"},{"id":"T374","span":{"begin":438,"end":461},"obj":"CHEBI:37550;CHEBI:37550"},{"id":"T375","span":{"begin":628,"end":638},"obj":"GO:0001525"},{"id":"T376","span":{"begin":667,"end":671},"obj":"DG_47"},{"id":"T377","span":{"begin":731,"end":737},"obj":"UBERON:0002405"},{"id":"T378","span":{"begin":795,"end":799},"obj":"DG_47"}],"text":"In the light of above findings, herein, we propose that the mechanism of priming of MSC could be implied to the following: i) Licensing by pro-inflammatory cytokines such as IFN-γ, TNF-α, etc., to enhance immunosuppressive potential; ii) Priming by non-cytokines stimuli such as hormones/growth factors like HGF to boost defensive and protective cellular mechanisms; iii) Pre-conditioning by hypoxia, and/or pharmacological agents, e.g., sphingosine-1-phosphate, etc., to enhance engraftment and reparative effects; iv) Activation by spheroid culturing to enhance homing, survival, differentiation, and lineage specificity e.g. angiogenic mechanism; v) The timing of MSCs engraftment and engagement in the process of activation of immune cells to achieve the most excellent beneficial effect of MSCs infusion."}