PMC:7317273 / 21443-22252
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T142 | 156-165 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T143 | 253-262 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T144 | 279-287 | Body_part | denotes | hormones | http://purl.org/sig/ont/fma/fma12278 |
| T145 | 738-743 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T250 | 308-311 | http://purl.obolibrary.org/obo/CLO_0003740 | denotes | HGF |
| T251 | 520-530 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | Activation |
| T252 | 717-727 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T253 | 738-743 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T86 | 279-287 | Chemical | denotes | hormones | http://purl.obolibrary.org/obo/CHEBI_24621 |
| T87 | 438-461 | Chemical | denotes | sphingosine-1-phosphate | http://purl.obolibrary.org/obo/CHEBI_37550 |
| T88 | 438-449 | Chemical | denotes | sphingosine | http://purl.obolibrary.org/obo/CHEBI_16393 |
| T89 | 452-461 | Chemical | denotes | phosphate | http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 324 | 174-179 | Gene | denotes | IFN-γ | Gene:3458 |
| 325 | 181-186 | Gene | denotes | TNF-α | Gene:7124 |
| 326 | 308-311 | Gene | denotes | HGF | Gene:3082 |
| 339 | 392-399 | Disease | denotes | hypoxia | MESH:D000860 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T22 | 288-294 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T329 | 0-809 | Sentence | denotes | In the light of above findings, herein, we propose that the mechanism of priming of MSC could be implied to the following: i) Licensing by pro-inflammatory cytokines such as IFN-γ, TNF-α, etc., to enhance immunosuppressive potential; ii) Priming by non-cytokines stimuli such as hormones/growth factors like HGF to boost defensive and protective cellular mechanisms; iii) Pre-conditioning by hypoxia, and/or pharmacological agents, e.g., sphingosine-1-phosphate, etc., to enhance engraftment and reparative effects; iv) Activation by spheroid culturing to enhance homing, survival, differentiation, and lineage specificity e.g. angiogenic mechanism; v) The timing of MSCs engraftment and engagement in the process of activation of immune cells to achieve the most excellent beneficial effect of MSCs infusion. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T27 | 392-399 | Phenotype | denotes | hypoxia | http://purl.obolibrary.org/obo/HP_0012418 |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T368 | 174-179 | PR:000000017 | denotes | IFN-γ |
| T369 | 181-186 | PR:000000134 | denotes | TNF-α |
| T370 | 205-222 | CHEBI:35705;CHEBI:35705 | denotes | immunosuppressive |
| T371 | 308-311 | PR:000008534 | denotes | HGF |
| T372 | 321-330 | GO:0006952 | denotes | defensive |
| T373 | 408-430 | CHEBI:52217;CHEBI:52217 | denotes | pharmacological agents |
| T374 | 438-461 | CHEBI:37550;CHEBI:37550 | denotes | sphingosine-1-phosphate |
| T375 | 628-638 | GO:0001525 | denotes | angiogenic |
| T376 | 667-671 | DG_47 | denotes | MSCs |
| T377 | 731-737 | UBERON:0002405 | denotes | immune |
| T378 | 795-799 | DG_47 | denotes | MSCs |